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| PMID |
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| TITLE |
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| as a New Gene Influencing DZT. |
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| ABSTRACT |
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| Dizygotic twinning (DZT) is an important marker of female fertility. The Twinning Genetics Consortium (TGC) recently reported the largest genomewide association meta-analysis (GWAMA) of DZT, identifying six genomewide significant loci and a seventh supported by functional evidence, in 8265 mothers of spontaneous DZ twins (MoDZTs) and 264,567 European-ancestry controls. To identify additional loci, we continued recruitment of MoDZTs in Australia and New Zealand (ANZ). Here, we report a GWAS of a new ANZ2026 sample (1598 MoDZTs and 5317 controls) and a GWAMA combining this sample with the previously reported ANZ2023 dataset. A new locus near on chromosome 13 was tentatively identified. Because is associated with vitamin B12 levels linked to fertility, it represents a plausible candidate. However, despite a 51% increase in ANZ cases, only one additional locus emerged, supporting the hypothesis that DZT is an oligogenic rather than highly polygenic trait. Meta-analysis with the TGC2024, the largest existing GWAS of DZT, strengthened signals at several loci, including HLA-G, while weakening others, such as . |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| medline |
2026/10/26 11:29 |
| pubmed |
2026/10/26 11:29 |
| entrez |
2026/10/26 09:23 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Gordon SD |
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Gordon |
Scott D |
SD |
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Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Australia. |
| Adsett JM |
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Adsett |
Jessica M |
JM |
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Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Australia. |
| List-Armitage SE |
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List-Armitage |
Susan E |
SE |
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Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Australia. |
| de Guzman E |
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de Guzman |
Erika |
E |
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Australian Translational Genomics Centre, Queensland University of Technology, Australia. |
| Montgomery GW |
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Montgomery |
Grant W |
GW |
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Department of Health Science and Technology, Aalborg Universitet, Denmark. |
| Vlasiuk E |
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Vlasiuk |
Emma |
E |
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Department of Pathology and Molecular Medicine, University of Otago, New Zealand. |
| Kennedy MA |
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Kennedy |
Martin A |
MA |
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Department of Pathology and Molecular Medicine, University of Otago, New Zealand. |
| Hubers N |
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Hubers |
Nikki |
N |
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SMARTBiomed Pioneer Centre, Denmark. |
| Martin NG |
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Martin |
Nicholas G |
NG |
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Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Australia. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: |
| ISSUE: |
| TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies |
| ISOABBREVIATION: Twin Res Hum Genet |
| YEAR: 2026 |
| MONTH: Oct |
| DAY: 26 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1839-2628 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Twin Res Hum Genet |
| COUNTRY: England |
| ISSNLINKING: 1832-4274 |
| NLMUNIQUEID: 101244624 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| Dizygotic twinning |
| Fertility |
| GWAS |
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