Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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42687878
TITLE
Genomic dimensions deconstruct the clinical heterogeneity of bipolar disorder.
ABSTRACT
Bipolar disorder's (BD) clinical heterogeneity has an unresolved genetic basis. We meta-analyzed genome-wide association studies (GWAS) of 16 BD subphenotypes in 226,032 individuals from 57 cohorts (38,022 cases); 10 advanced to multivariate and multi-trait analyses. Four factors (compulsive, psychotic, dysregulated, internalizing) explained 82.8% of shared genetic variance. BD1 and BD2 loaded on distinct factors despite a high genetic correlation; 87.0% of common-factor loci were significant in neither subtype. Unipolar mania aligned with psychosis over internalizing, and was distinguishable from BD1, and rapid cycling showed heritable cross-domain liability. We identified 356 risk loci, 158 novel, including the first univariate-GWAS associations for psychosis, unipolar mania, rapid cycling and schizoaffective disorder-and 249 credible genes (89 high-confidence), 12 with approved-drug or clinical-phase annotations. Cell-type association showed a midbrain dopaminergic-GABAergic gradient along the psychotic factor. BD's genetic architecture appears hierarchical-a general liability resolving into dimensions of course and comorbidity, beyond subtypes.
DATE PUBLISHED
2026 Aug 26
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2026/09/03 12:09
medline 2026/09/03 12:10
entrez 2026/09/03 05:04
pmc-release 2026/09/01
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
van der Veen T van der Veen Tracey T These authors contributed as first authors: Tracey van der Veen, Markos Tesfaye.
Tesfaye M Tesfaye Markos M These authors contributed as first authors: Tracey van der Veen, Markos Tesfaye.
Yang JMK Yang Jessica Mei Kay JMK These authors contributed as second authors: Jessica Mei Kay Yang, Toni Boltz, Friederike S. David, Shane Crinion, Maria Koromina.
Boltz T Boltz Toni T These authors contributed as second authors: Jessica Mei Kay Yang, Toni Boltz, Friederike S. David, Shane Crinion, Maria Koromina.
David FS David Friederike S FS These authors contributed as second authors: Jessica Mei Kay Yang, Toni Boltz, Friederike S. David, Shane Crinion, Maria Koromina.
Crinion S Crinion Shane S These authors contributed as second authors: Jessica Mei Kay Yang, Toni Boltz, Friederike S. David, Shane Crinion, Maria Koromina.
Koromina M Koromina Maria M These authors contributed as second authors: Jessica Mei Kay Yang, Toni Boltz, Friederike S. David, Shane Crinion, Maria Koromina.
Andlauer TFM Andlauer Till F M TFM Max Planck Institute of Psychiatry, Munich, Germany.
Bigdeli TB Bigdeli Tim B TB Department of Epidemiology and Biostatistics, School of Public Health, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.
Coombes BJ Coombes Brandon J BJ Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Greenwood TA Greenwood Tiffany A TA Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Panagiotaropoulou G Panagiotaropoulou Georgia G Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin, Berlin, Germany.
Parker N Parker Nadine N Center for Precision Psychiatry, University of Oslo, Oslo, Norway.
Sung H Sung Heejong H Human Genetics Branch, Intramural Research Program, National Institute of Mental Health, NIH, US Dept of HHS, Bethesda MD USA.
Bass N Bass Nicholas N Division of Psychiatry, University College London, London, UK.
Coleman JRI Coleman Jonathan R I JRI NIHR Maudsley BRC, King's College London, London, UK.
Guzman-Parra J Guzman-Parra José J Mental Health Department, University Regional Hospital, Biomedicine Institute (IBIMA), Málaga, Spain.
Kalman JL Kalman Janos L JL Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.
McGrouther CC McGrouther Caroline C CC New York University, New York, NY, USA.
Mitchell BL Mitchell Brittany L BL School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
Rangan AV Rangan Aaditya V AV Flatiron Institute, New York, NY, USA.
Scott K Scott Katie K Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Shadrin A Shadrin Alexey A KG Jebsen Centre for Neurodevelopmental disorders, University of Oslo, Oslo, Norway.
Smith DJ Smith Daniel J DJ Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Vreeker A Vreeker Annabel A Department of Psychology Education and Child Studies, Erasmus School of Social and Behavioral Sciences, Erasmus University Rotterdam, The Netherlands.
Adorjan K Adorjan Kristina K University Hospital of Psychiatry and Psychotherapy, University of Bern, Switzerland.
Albani D Albani Diego D Department of Neuroscience, Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy.
Alemany S Alemany Silvia S Psychiatric Genetics Unit, Group of Psychiatry Mental Health and Addictions, Vall d'Hebron Research Institut (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.
Alliey-Rodriguez N Alliey-Rodriguez Ney N Northwestern University, Chicago, IL, USA.
Antoniou A Antoniou Anastasia A National and Kapodistrian University of Athens, 2nd Department of Psychiatry, Attikon General Hospital, Athens, Greece.
Bauer M Bauer Michael M Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Beins EC Beins Eva C EC Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.
Boks MP Boks Marco P MP Psychiatry, Brain Center UMC Utrecht, Utrecht, The Netherlands.
Bosch R Bosch Rosa R Programa SJD MIND Escoles, Hospital Sant Joan de Déu, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain.
Brumpton BM Brumpton Ben M BM K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Brunkhorst-Kanaan N Brunkhorst-Kanaan Nathalie N Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany.
Budde M Budde Monika M Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich, Germany.
Byerley W Byerley William W Psychiatry, University of California San Francisco, San Francisco, CA, USA.
Cabana-Domínguez J Cabana-Domínguez Judit J Psychiatric Genetics Unit, Group of Psychiatry Mental Health and Addictions, Vall d'Hebron Research Institut (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.
Cairns MJ Cairns Murray J MJ Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton, NSW, Australia.
Carpiniello B Carpiniello Bernardo B Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Italy.
Casas M Casas Miquel M Fundació Privada d'Investigació Sant Pau (FISP), Barcelona, Spain.
Cervantes P Cervantes Pablo P Department of Psychiatry, Mood Disorders Program, McGill University Health Center, Montreal, QC, Canada.
Chatzinakos C Chatzinakos Chris C Institute for Genomics in Health, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.
Clarke TK Clarke Toni-Kim TK Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
Claus I Claus Isabelle I Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.
Cruceanu C Cruceanu Cristiana C Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Cuellar-Barboza A Cuellar-Barboza Alfredo A Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.
Czerski PM Czerski Piotr M PM Department of Psychiatry, Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland.
Dafnas K Dafnas Konstantinos K National and Kapodistrian University of Athens, 2nd Department of Psychiatry, Attikon General Hospital, Athens, Greece.
Dale AM Dale Anders M AM Center for Multimodal Imaging and Genetics, Departments of Neurosciences, Radiology, and Psychiatry, University of California, San Diego, CA, USA.
Dalkner N Dalkner Nina N Medical University of Graz, Division of Psychiatry and Psychotherapeutic Medicine, Graz, Austria.
DePaulo JR DePaulo J Raymond JR Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Degenhardt F Degenhardt Franziska F Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Duisburg, Germany.
Djurovic S Djurovic Srdjan S Department of Medical Genetics, Oslo University Hospital Ullevål, Oslo, Norway.
Escott-Price V Escott-Price Valentina V Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Fanous AH Fanous Ayman H AH Banner-University Medical Center, Phoenix, AZ, USA.
Fellendorf FT Fellendorf Frederike T FT Medical University of Graz, Division of Psychiatry and Psychotherapeutic Medicine, Graz, Austria.
Ferrier IN Ferrier I Nicol IN Academic Psychiatry, Newcastle University, Newcastle upon Tyne, UK.
Forty L Forty Liz L Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Frank J Frank Josef J Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Frei O Frei Oleksandr O Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Freimer NB Freimer Nelson B NB Department of Psychiatry and Biobehavioral Science, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Garnham J Garnham Julie J Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Gizer IR Gizer Ian R IR Department of Psychological Sciences, University of Missouri, Columbia, MO, USA.
Gordon SD Gordon Scott D SD Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Gordon-Smith K Gordon-Smith Katherine K Psychological Medicine, University of Worcester, Worcester, UK.
Hahn T Hahn Tim T Institute for Translational Psychiatry, University of Münster, Münster, Germany.
Hamshere ML Hamshere Marian L ML Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Harder A Harder Arvid A Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Hautzinger M Hautzinger Martin M Department of Psychology, Eberhard Karls Universität Tübingen, Tubingen, Germany.
Heilbronner U Heilbronner Urs U Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich, Germany.
Hellgren D Hellgren Dennis D Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Herms S Herms Stefan S Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.
Hickie IB Hickie Ian B IB Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia.
Hoffmann P Hoffmann Per P Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.
Holmans PA Holmans Peter A PA Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Jamain S Jamain Stéphane S Univ Paris Est Créteil, INSERM, IMRB, Translational Neuropsychiatry, Créteil, France.
Jonsson L Jonsson Lina L Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.
Kennedy JL Kennedy James L JL Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada.
Kittel-Schneider S Kittel-Schneider Sarah S Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany.
Knowles JA Knowles James A JA Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ, USA.
Koch E Koch Elise E Center for Precision Psychiatry, University of Oslo, Oslo, Norway.
Kogevinas M Kogevinas Manolis M ISGlobal, Barcelona, Spain.
Kranz TM Kranz Thorsten M TM Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany.
Kushner SA Kushner Steven A SA Department of Psychiatry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Lavebratt C Lavebratt Catharina C Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Lawrence J Lawrence Jacob J Psychiatry, North East London NHS Foundation Trust, Ilford, UK.
Leber M Leber Markus M Clinic for Psychiatry and Psychotherapy, University Hospital Cologne, Cologne, Germany.
Lind PA Lind Penelope A PA School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, Australia.
Lucae S Lucae Susanne S Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.
Lundberg M Lundberg Martin M Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
MacIntyre DJ MacIntyre Donald J DJ Division of Psychiatry, Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK.
Maier W Maier Wolfgang W Department of Psychiatry and Psychotherapy, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.
Maihofer AX Maihofer Adam X AX Research/Psychiatry, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.
Malaspina D Malaspina Dolores D Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Manchia M Manchia Mirko M Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada.
Maratou E Maratou Eirini E National and Kapodistrian University of Athens, Medical School, Clinical Biochemistry Laboratory, Attikon General Hospital, Athens, Greece.
Martinsson L Martinsson Lina L Centre for Psychiatry Research, SLSO Region Stockholm, Sweden.
McInnis MG McInnis Melvin G MG Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
McKay JD McKay James D JD Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon, France.
Medeiros H Medeiros Helena H Institute for Genomic Health, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, USA.
Meyer-Lindenberg A Meyer-Lindenberg Andreas A German Centre for Mental Health (DZPG), Germany.
Millischer V Millischer Vincent V Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Vienna, Austria.
Morris DW Morris Derek W DW Centre for Neuroimaging and Cognitive Genomics (NICOG), School of Biological and Chemical Sciences, University of Galway, Galway, Ireland.
Moutsatsou P Moutsatsou Paraskevi P National and Kapodistrian University of Athens, Medical School, Clinical Biochemistry Laboratory, Attikon General Hospital, Athens, Greece.
Mühleisen TW Mühleisen Thomas W TW Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.
O'Donovan C O'Donovan Claire C Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Olsen CM Olsen Catherine M CM Population Health, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Papiol S Papiol Sergi S Instituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain.
Pardiñas AF Pardiñas Antonio F AF Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Perry A Perry Amy A Psychological Medicine, University of Worcester, Worcester, UK.
Pfennig A Pfennig Andrea A Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Pisanu C Pisanu Claudia C Department of Biomedical Sciences, University of Cagliari, Italy.
Potash JB Potash James B JB Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Quested D Quested Digby D Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.
Rapaport MH Rapaport Mark H MH Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Regeer EJ Regeer Eline J EJ Outpatient Clinic for Bipolar Disorder, Altrecht, Utrecht, The Netherlands.
Rice JP Rice John P JP Department of Psychiatry, Washington University in Saint Louis, Saint Louis, MO, USA.
Rivera M Rivera Margarita M Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain.
Schulte EC Schulte Eva C EC German Center for Mental Health (DZPG), partner site Munich/Augsburg, 80336, Munich, Germany.
Senner F Senner Fanny F Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.
Shilling PD Shilling Paul D PD Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Sindermann L Sindermann Lisa L Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.
Sirignano L Sirignano Lea L Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Siskind D Siskind Dan D Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia.
Slaney C Slaney Claire C Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Smeland OB Smeland Olav B OB Center for Precision Psychiatry, University of Oslo, Oslo, Norway.
Sobell JL Sobell Janet L JL Psychiatry and the Behavioral Sciences, University of Southern California, Los Angeles, CA, USA.
Artigas MS Artigas Maria Soler MS Department of Genetics, Microbiology, and Statistics, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain.
Stein DJ Stein Dan J DJ SAMRC Unit on Risk and Resilience in Mental Disorders, Dept of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Stein F Stein Frederike F Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Swiatkowska B Swiatkowska Beata B Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland.
Thorp JG Thorp Jackson G JG Brain and Mental Health, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Toma C Toma Claudio C Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid and CSIC, Madrid, Spain.
Tondo L Tondo Leonardo L Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Tooney PA Tooney Paul A PA School of Biomedical Science and Pharmacy, University of Newcastle, Newcastle, NSW, Australia.
Vawter MP Vawter Marquis P MP Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, USA.
Vedder H Vedder Helmut H Psychiatry, Psychiatrisches Zentrum Nordbaden, Wiesloch, Germany.
Walters JTR Walters James T R JTR Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Witt SH Witt Stephanie H SH Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Young AH Young Allan H AH South London and Maudsley NHS Foundation Trust, Bethlem Royal Hospital, Monks Orchard Road, Beckenham, Kent, UK.
Zandi PP Zandi Peter P PP Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Zillich L Zillich Lea L Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Estonian Biobank research team
Genomic Psychiatry Cohort (GPC) Investigators
HUNT All-In Psychiatry
Adolfsson R Adolfsson Rolf R Department of Clinical Sciences, Psychiatry, Umeå University Medical Faculty, Umeå, Sweden.
Alfredsson L Alfredsson Lars L Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Backlund L Backlund Lena L Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Baune BT Baune Bernhard T BT The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Bellivier F Bellivier Frank F APHP Nord, DMU Neurosciences, GHU Saint Louis-Lariboisiére-Fernand Widal, Département de Psychiatrie et de Médecine Addictologique, Paris, France.
Bengesser S Bengesser Susanne S Medical University of Graz, Division of Psychiatry and Psychotherapeutic Medicine, Graz, Austria.
Berrettini WH Berrettini Wade H WH Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
Biernacka JM Biernacka Joanna M JM Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.
Blackwood D Blackwood Douglas D Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
Boehnke M Boehnke Michael M Center for Statistical Genetics and Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Breen G Breen Gerome G Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
Carr VJ Carr Vaughan J VJ Discipline of Psychiatry and Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia.
Catts S Catts Stanley S University of Queensland, Brisbane, QLD, Australia.
Cichon S Cichon Sven S Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.
Corvin A Corvin Aiden A Neuropsychiatric Genetics Research Group, Dept of Psychiatry and Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
Craddock N Craddock Nicholas N Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Dannlowski U Dannlowski Udo U Institute for Translational Psychiatry, University of Münster, Münster, Germany.
Dikeos D Dikeos Dimitris D National and Kapodistrian University of Athens, 1st Department of Psychiatry, Eginition Hospital, Athens, Greece.
Esko T Esko Tõnu T Neuroscience Therapeutic Area, Janssen Research and Development, LLC, Titusville, NJ, USA.
Etain B Etain Bruno B APHP Nord, DMU Neurosciences, GHU Saint Louis-Lariboisiére-Fernand Widal, Département de Psychiatrie et de Médecine Addictologique, Paris, France.
Ferentinos P Ferentinos Panagiotis P Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
Frye M Frye Mark M Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.
Fullerton JM Fullerton Janice M JM School of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia.
Gawlik M Gawlik Micha M Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany.
Gershon ES Gershon Elliot S ES Department of Human Genetics, University of Chicago, Chicago, IL, USA.
Goes FS Goes Fernando S FS Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Green MJ Green Melissa J MJ Discipline of Psychiatry and Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia.
Hauser J Hauser Joanna J Department of Psychiatry, Department of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland.
Henskens FA Henskens Frans A FA School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia.
Hjerling-Leffler J Hjerling-Leffler Jens J Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Jones I Jones Ian I Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Jones LA Jones Lisa A LA Psychological Medicine, University of Worcester, Worcester, UK.
Kahn RS Kahn René S RS Psychiatry, Brain Center UMC Utrecht, Utrecht, The Netherlands.
Kelsoe JR Kelsoe John R JR Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Kircher T Kircher Tilo T Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Kirov G Kirov George G Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Kobayashi N Kobayashi Nene N Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany.
Landén M Landén Mikael M Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.
Leboyer M Leboyer Marion M Univ Paris Est Créteil, INSERM, IMRB, Translational Neuropsychiatry, Créteil, France.
Lenger M Lenger Melanie M Medical University of Graz, Division of Psychiatry and Psychotherapeutic Medicine, Graz, Austria.
Li QS Li Qingqin S QS JRD Data Science, Janssen Research and Development, LLC, Titusville, NJ, USA.
Lissowska J Lissowska Jolanta J Cancer Epidemiology and Prevention, M. Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.
Loughland C Loughland Carmel C University of Newcastle, Newcastle, NSW, Australia.
Luykx JJ Luykx Jurjen J JJ Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands.
Martin NG Martin Nicholas G NG School of Psychology, The University of Queensland, Brisbane, QLD, Australia.
Mathews CA Mathews Carol A CA Department of Psychiatry and Genetics Institute, University of Florida, Gainesville, FL, USA.
Mayoral F Mayoral Fermin F Mental Health Department, University Regional Hospital, Biomedicine Institute (IBIMA), Málaga, Spain.
McElroy SL McElroy Susan L SL Research Institute, Lindner Center of HOPE, Mason, OH, USA.
McIntosh AM McIntosh Andrew M AM Division of Psychiatry, Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK.
Medland SE Medland Sarah E SE School of Psychology and Counselling, Queensland University of Technology, Brisbane, QLD, Australia.
Melle I Melle Ingrid I Division of Mental Health and Addiction, University of Oslo, Institute of Clinical Medicine, Oslo, Norway.
Mitchell PB Mitchell Philip B PB Discipline of Psychiatry and Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia.
Morken G Morken Gunnar G Psychiatry, St Olavs University Hospital, Trondheim, Norway.
Myers RM Myers Richard M RM HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
Möser C Möser Chiara C Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany.
Müller-Myhsok B Müller-Myhsok Bertram B University of Liverpool, Liverpool, UK.
Neale BM Neale Benjamin M BM Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Nievergelt CM Nievergelt Caroline M CM Research/Psychiatry, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.
Nurnberger JI Nurnberger John I JI Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA.
Nöthen MM Nöthen Markus M MM Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.
O'Donovan MC O'Donovan Michael C MC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Oedegaard KJ Oedegaard Ketil J KJ Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway.
Olsson T Olsson Tomas T Department of Clinical Neuroscience and Center for Molecular Medicine, Karolinska Institutet at Karolinska University Hospital, Solna, Sweden.
Owen MJ Owen Michael J MJ Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Paciga SA Paciga Sara A SA Human Genetics and Computational Biomedicine, Pfizer Global Research and Development, Groton, CT, USA.
Pantelis C Pantelis Christos C Monash Institute of Pharmaceutical Sciences (MIPS), Monash University, Parkville, VIC, Australia.
Pato CN Pato Carlos N CN Rutgers Health, Rutgers University, Piscataway, New Jersey, USA.
Pato MT Pato Michele T MT Rutgers Health, Rutgers University, Piscataway, New Jersey, USA.
Patrinos GP Patrinos George P GP Erasmus University Medical Center Rotterdam, Faculty of Medicine and Health Sciences, Department of Pathology, Clinical Bioinformatics Unit, Rotterdam, The Netherlands.
Pawlak JM Pawlak Joanna M JM Department of Psychiatry, Department of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland.
Perlis R Perlis Roy R Center for Quantitative Health and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Ramos-Quiroga JA Ramos-Quiroga Josep Antoni JA Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.
Reif A Reif Andreas A Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany.
Reininghaus EZ Reininghaus Eva Z EZ Medical University of Graz, Division of Psychiatry and Psychotherapeutic Medicine, Graz, Austria.
Ribasés M Ribasés Marta M Department of Genetics, Microbiology, and Statistics, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain.
Rietschel M Rietschel Marcella M Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Ripke S Ripke Stephan S Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Rouleau GA Rouleau Guy A GA Montreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada.
Schall U Schall Ulrich U Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
Schalling M Schalling Martin M Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Schofield PR Schofield Peter R PR School of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia.
Schulze TG Schulze Thomas G TG Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA.
Scott LJ Scott Laura J LJ Pritzker Neuropsychiatric Disorders Research Consortium, University of Michigan, USA.
Scott RJ Scott Rodney J RJ Cancer Detection and Therapies Program, Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia.
Serretti A Serretti Alessandro A Oasi Research Institute-IRCCS, Troina, Italy.
Smoller JW Smoller Jordan W JW Psychiatric and Neurodevelopmental Genetics Unit (PNGU), Massachusetts General Hospital, Boston, MA, USA.
Squassina A Squassina Alessio A Department of Biomedical Sciences, University of Cagliari, Italy.
Stahl EA Stahl Eli A EA Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
Stordal E Stordal Eystein E Department of Neuroscience, Norges Teknisk Naturvitenskapelige Universitet Fakultet for naturvitenskap og teknologi, Trondheim, Norway.
Streit F Streit Fabian F Hector Institute for Artificial Intelligence in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Sullivan PF Sullivan Patrick F PF Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Turecki G Turecki Gustavo G Department of Psychiatry, McGill University, Montreal, QC, Canada.
Vaaler AE Vaaler Arne E AE Dept of Psychiatry, Sankt Olavs Hospital Universitetssykehuset i Trondheim, Trondheim, Norway.
Vieta E Vieta Eduard E Clinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
Vincent JB Vincent John B JB Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Waldman ID Waldman Irwin D ID Department of Psychology, Emory University, Atlanta, GA, USA.
Weickert CS Weickert Cynthia S CS Department of Neuroscience, SUNY Upstate Medical University, Syracuse, NY, USA.
Weickert TW Weickert Thomas W TW Department of Neuroscience, SUNY Upstate Medical University, Syracuse, NY, USA.
Whiteman DC Whiteman David C DC Population Health, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Alda M Alda Martin M These authors jointly supervised this work: Martin Alda, Roel A. Ophoff, Kevin S. O'Connell, Niamh Mullins, Andreas J. Forstner, Maria Grigoroiu-Serbanescu, Howard J. Edenberg, Francis J. McMahon, Ole A. Andreassen, Arianna Di Florio, Andrew McQuillin.
Ophoff RA Ophoff Roel A RA These authors jointly supervised this work: Martin Alda, Roel A. Ophoff, Kevin S. O'Connell, Niamh Mullins, Andreas J. Forstner, Maria Grigoroiu-Serbanescu, Howard J. Edenberg, Francis J. McMahon, Ole A. Andreassen, Arianna Di Florio, Andrew McQuillin.
O'Connell KS O'Connell Kevin S KS These authors jointly supervised this work: Martin Alda, Roel A. Ophoff, Kevin S. O'Connell, Niamh Mullins, Andreas J. Forstner, Maria Grigoroiu-Serbanescu, Howard J. Edenberg, Francis J. McMahon, Ole A. Andreassen, Arianna Di Florio, Andrew McQuillin.
Mullins N Mullins Niamh N These authors jointly supervised this work: Martin Alda, Roel A. Ophoff, Kevin S. O'Connell, Niamh Mullins, Andreas J. Forstner, Maria Grigoroiu-Serbanescu, Howard J. Edenberg, Francis J. McMahon, Ole A. Andreassen, Arianna Di Florio, Andrew McQuillin.
Forstner AJ Forstner Andreas J AJ These authors jointly supervised this work: Martin Alda, Roel A. Ophoff, Kevin S. O'Connell, Niamh Mullins, Andreas J. Forstner, Maria Grigoroiu-Serbanescu, Howard J. Edenberg, Francis J. McMahon, Ole A. Andreassen, Arianna Di Florio, Andrew McQuillin.
Grigoroiu-Serbanescu M Grigoroiu-Serbanescu Maria M These authors jointly supervised this work: Martin Alda, Roel A. Ophoff, Kevin S. O'Connell, Niamh Mullins, Andreas J. Forstner, Maria Grigoroiu-Serbanescu, Howard J. Edenberg, Francis J. McMahon, Ole A. Andreassen, Arianna Di Florio, Andrew McQuillin.
Edenberg HJ Edenberg Howard J HJ These authors jointly supervised this work: Martin Alda, Roel A. Ophoff, Kevin S. O'Connell, Niamh Mullins, Andreas J. Forstner, Maria Grigoroiu-Serbanescu, Howard J. Edenberg, Francis J. McMahon, Ole A. Andreassen, Arianna Di Florio, Andrew McQuillin.
McMahon FJ McMahon Francis J FJ These authors jointly supervised this work: Martin Alda, Roel A. Ophoff, Kevin S. O'Connell, Niamh Mullins, Andreas J. Forstner, Maria Grigoroiu-Serbanescu, Howard J. Edenberg, Francis J. McMahon, Ole A. Andreassen, Arianna Di Florio, Andrew McQuillin.
Andreassen OA Andreassen Ole A OA These authors jointly supervised this work: Martin Alda, Roel A. Ophoff, Kevin S. O'Connell, Niamh Mullins, Andreas J. Forstner, Maria Grigoroiu-Serbanescu, Howard J. Edenberg, Francis J. McMahon, Ole A. Andreassen, Arianna Di Florio, Andrew McQuillin.
Di Florio A Di Florio Arianna A These authors jointly supervised this work: Martin Alda, Roel A. Ophoff, Kevin S. O'Connell, Niamh Mullins, Andreas J. Forstner, Maria Grigoroiu-Serbanescu, Howard J. Edenberg, Francis J. McMahon, Ole A. Andreassen, Arianna Di Florio, Andrew McQuillin.
McQuillin A McQuillin Andrew A These authors jointly supervised this work: Martin Alda, Roel A. Ophoff, Kevin S. O'Connell, Niamh Mullins, Andreas J. Forstner, Maria Grigoroiu-Serbanescu, Howard J. Edenberg, Francis J. McMahon, Ole A. Andreassen, Arianna Di Florio, Andrew McQuillin.
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TITLE: Research square
ISOABBREVIATION: Res Sq
YEAR: 2026
MONTH: Aug
DAY: 26
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CITEDMEDIUM: Internet
ISSN: 2693-5015
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