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| PMID |
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| TITLE |
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| Unravelling the causal link between gut microbiota and acne risk using a genetic approach. |
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| ABSTRACT |
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| BACKGROUND |
NlmCategory: UNASSIGNED |
| Acne is a common inflammatory dermatological condition that can have detrimental psychological consequences due to its visible lesions and scarring. Recent studies suggest a potential role of gut microbiota in acne development; however, the evidence remains inconclusive and might be subject to various confounders. |
| OBJECTIVES |
NlmCategory: UNASSIGNED |
| Acne is a common inflammatory dermatological condition that can have detrimental psychological consequences due to its visible lesions and scarring. Recent studies suggest a potential role of gut microbiota in acne development; however, the evidence remains inconclusive and might be subject to various confounders. To investigate the causal relationship between gut microbiota and acne. |
| METHODS |
NlmCategory: UNASSIGNED |
| Acne is a common inflammatory dermatological condition that can have detrimental psychological consequences due to its visible lesions and scarring. Recent studies suggest a potential role of gut microbiota in acne development; however, the evidence remains inconclusive and might be subject to various confounders. To investigate the causal relationship between gut microbiota and acne. This study investigated the causal relationship between gut microbiota and acne using a two-sample Mendelian randomization (MR) approach with large-scale genome-wide association study summary statistics. To ascertain the direction of causality and the independent effect of gut microbiota, reverse MR and multivariable MR accounting for dietary phenotypes were performed. |
| RESULTS |
NlmCategory: UNASSIGNED |
| Acne is a common inflammatory dermatological condition that can have detrimental psychological consequences due to its visible lesions and scarring. Recent studies suggest a potential role of gut microbiota in acne development; however, the evidence remains inconclusive and might be subject to various confounders. To investigate the causal relationship between gut microbiota and acne. This study investigated the causal relationship between gut microbiota and acne using a two-sample Mendelian randomization (MR) approach with large-scale genome-wide association study summary statistics. To ascertain the direction of causality and the independent effect of gut microbiota, reverse MR and multivariable MR accounting for dietary phenotypes were performed. Higher abundances of the phylum and class, order, family and -genus were associated with a reduced risk of acne [odds ratios (ORs) ranging from 0.54 to 0.63]. In contrast, higher levels of the order, family and genus were positively associated with an increased risk of acne (OR 1.12-1.36). Notably, associations for and its upstream taxa remained robust even after accounting for dietary factors. |
| CONCLUSIONS |
NlmCategory: UNASSIGNED |
| Acne is a common inflammatory dermatological condition that can have detrimental psychological consequences due to its visible lesions and scarring. Recent studies suggest a potential role of gut microbiota in acne development; however, the evidence remains inconclusive and might be subject to various confounders. To investigate the causal relationship between gut microbiota and acne. This study investigated the causal relationship between gut microbiota and acne using a two-sample Mendelian randomization (MR) approach with large-scale genome-wide association study summary statistics. To ascertain the direction of causality and the independent effect of gut microbiota, reverse MR and multivariable MR accounting for dietary phenotypes were performed. Higher abundances of the phylum and class, order, family and -genus were associated with a reduced risk of acne [odds ratios (ORs) ranging from 0.54 to 0.63]. In contrast, higher levels of the order, family and genus were positively associated with an increased risk of acne (OR 1.12-1.36). Notably, associations for and its upstream taxa remained robust even after accounting for dietary factors. These findings provide further evidence of a causal relationship between gut microbial composition and acne, highlighting the role of gut microbiota in developing more targeted and possibly less harmful alternatives to current acne management strategies. |
| © The Author(s) 2025. Published by Oxford University Press on behalf of British Association of Dermatologists. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| accepted |
2025/09/29 |
| medline |
2025/11/28 06:28 |
| pubmed |
2025/11/28 06:27 |
| entrez |
2025/11/28 04:48 |
| pmc-release |
2025/11/05 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Cao F |
|
Cao |
Fangyuan |
F |
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School of Biomedical Sciences, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland, Brisbane, QLD, Australia. |
| Ogonowski NS |
|
Ogonowski |
Natalia S |
NS |
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School of Biomedical Sciences, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland, Brisbane, QLD, Australia. |
| Díaz-Torres S |
|
Díaz-Torres |
Santiago |
S |
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Population Health Program, QIMR Berghofer, Brisbane, QLD, Australia. |
| Mitchell BL |
|
Mitchell |
Brittany L |
BL |
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School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, QLD, Australia. |
| Gharhakhani P |
|
Gharhakhani |
Puya |
P |
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School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, QLD, Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
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School of Biomedical Sciences, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland, Brisbane, QLD, Australia. |
| Simpson MA |
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Simpson |
Michael A |
MA |
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Department of Medical and Molecular Genetics, King's College London, London, UK. |
| Ong JS |
|
Ong |
Jue-Sheng |
JS |
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Population Health Program, QIMR Berghofer, Brisbane, QLD, Australia. |
| Rentería ME |
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Rentería |
Miguel E |
ME |
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School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, QLD, Australia. |
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| JOURNAL |
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| VOLUME: 5 |
| ISSUE: 6 |
| TITLE: Skin health and disease |
| ISOABBREVIATION: Skin Health Dis |
| YEAR: 2025 |
| MONTH: Dec |
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| CITEDMEDIUM: Internet |
| ISSN: 2690-442X |
| ISSNTYPE: Electronic |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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