|
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| PMID |
|
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| TITLE |
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| Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group. |
|
| ABSTRACT |
|
|
|
| Suicidality phenotypes, consisting of suicidal ideation (SI), suicide attempt (SA), and suicide death (SD), are all heritable but present unique challenges in genome-wide association studies (GWAS) due to their individual complexity, overlap with each other and with related self-harm phenotypes, and varying associations with psychiatric disorders. GWAS have uncovered several loci associated with suicidality phenotypes by meta-analyzing data from multiple cohorts. However, combining datasets from many research groups, where each group may use different study designs, phenotyping instruments, and definitions of suicidality phenotypes, presents challenges. Heterogeneity resulting from these differences can limit genetic discovery; harmonizing phenotype definitions to ensure consistency will greatly improve results. Here, we describe a standardized phenotyping protocol that draws on the expertise of a subgroup of clinicians, researchers, and experts from the Psychiatric Genomics Consortium Suicide Working Group to propose consensus definitions for SI, SA, and SD for genetic studies. |
| © 2025. The Author(s). |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| received |
2025/04/17 |
| accepted |
2025/09/11 |
| revised |
2025/08/18 |
| medline |
2025/09/26 00:30 |
| pubmed |
2025/09/26 00:30 |
| entrez |
2025/09/25 23:40 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Colbert SMC |
|
Colbert |
Sarah M C |
SMC |
|
Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. sarah.colbert@icahn.mssm.edu. |
| Monson ET |
|
Monson |
Eric T |
ET |
|
Huntsman Mental Health Institute, Salt Lake City, UT, USA. |
| Andreassen OA |
|
Andreassen |
Ole A |
OA |
|
NORMENT Centre, University of Oslo, Oslo, Norway. |
| Ayinde OO |
|
Ayinde |
Olatunde O |
OO |
|
Department of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria. |
| Barr PB |
|
Barr |
Peter B |
PB |
|
Department of Epidemiology and Biostatistics, School of Public Health, SUNY Downstate Health Sciences University, Brooklyn, NY, USA. |
| Bejan CA |
|
Bejan |
Cosmin A |
CA |
|
Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA. |
| Ceja Z |
|
Ceja |
Zuriel |
Z |
|
School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia. |
| Coon H |
|
Coon |
Hilary |
H |
|
Huntsman Mental Health Institute, Salt Lake City, UT, USA. |
| DiBlasi E |
|
DiBlasi |
Emily |
E |
|
Huntsman Mental Health Institute, Salt Lake City, UT, USA. |
| Edenberg HJ |
|
Edenberg |
Howard J |
HJ |
|
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Bloomington, IN, USA. |
| Gelernter J |
|
Gelernter |
Joel |
J |
|
Department of Psychiatry, VA CT Healthcare System, West Haven, CT, USA. |
| Hatoum A |
|
Hatoum |
Alexander |
A |
|
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. |
| Izotova A |
|
Izotova |
Anastasia |
A |
|
Department of Psychology, University of Oslo, Oslo, Norway. |
| Johnson EC |
|
Johnson |
Emma C |
EC |
|
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. |
| Kaufman EA |
|
Kaufman |
Erin A |
EA |
|
Huntsman Mental Health Institute, Salt Lake City, UT, USA. |
| Kranzler HR |
|
Kranzler |
Henry R |
HR |
|
Mental Illness Research, Education and Clinical Center, Crescenz VA Medical Center, Philadelphia, PA, USA. |
| Koromina M |
|
Koromina |
Maria |
M |
|
Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. |
| Lehto K |
|
Lehto |
Kelli |
K |
|
Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia. |
| Myung W |
|
Myung |
Woojae |
W |
|
Department of Psychiatry, Seoul National University College of Medicine, Seongnam, South Korea. |
| Nurnberger JI Jr |
|
Nurnberger |
John I |
JI |
|
Department of Psychiatry, Indiana University School of Medicine, Bloomington, IN, USA. |
| Serretti A |
|
Serretti |
Alessandro |
A |
|
Oasi Research Institute-IRCCS, Troina, Italy. |
| Smoller JW |
|
Smoller |
Jordan W |
JW |
|
Psychiatric and Neurodevelopmental Genetics Unit (PNGU), Massachusetts General Hospital, Boston, MA, USA. |
| Stein MB |
|
Stein |
Murray B |
MB |
|
Department of Psychiatry and School of Public Health, University of California San Diego, La Jolla, CA, USA. |
| Zai CC |
|
Zai |
Clement C |
CC |
|
Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. |
| Erlangsen A |
|
Erlangsen |
Annette |
A |
|
Danish Research Institute for Suicide Prevention, Mental Health Centre Copenhagen, Copenhagen, Denmark. |
| Gaine M |
|
Gaine |
Marie |
M |
|
Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA. |
| Martorell L |
|
Martorell |
Lourdes |
L |
|
Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain. |
| Sud R |
|
Sud |
Reeteka |
R |
|
Molecular Genetics Laboratory, Department of Psychiatry, NIMHANS, Bangalore, India. |
| Toma C |
|
Toma |
Claudio |
C |
|
School of Clinical Medicine, Discipline of Psychiatry and Mental Health, University of New South Wales, Sydney, NSW, Australia. |
| Bigdeli TB |
|
Bigdeli |
Tim B |
TB |
|
Department of Epidemiology and Biostatistics, School of Public Health, SUNY Downstate Health Sciences University, Brooklyn, NY, USA. |
| Kimbrel NA |
|
Kimbrel |
Nathan A |
NA |
|
Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA. |
| Ruderfer D |
|
Ruderfer |
Douglas |
D |
|
Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA. |
| Docherty AR |
|
Docherty |
Anna R |
AR |
|
Clinical and Translational Science Institute & the Center for Genomic Medicine, University of Utah, Salt Lake City, UT, USA. |
| Mann JJ |
|
Mann |
J John |
JJ |
|
Departments of Psychiatry and Radiology, Columbia University, New York, NY, USA. |
| Mullins N |
|
Mullins |
Niamh |
N |
|
Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. niamh.mullins@mssm.edu. |
|
Psychiatric Genomics Consortium Suicide Working Group |
|
|
|
|
|
|
| INVESTIGATORS |
|
| LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
| Colbert |
Sarah Mc |
SM |
|
| Ayinde |
Olatunde |
O |
|
| Hatoum |
Alexander S |
AS |
|
| Ruderfer |
Douglas M |
DM |
|
| Adams |
Mark |
M |
|
| Adolfsson |
Rolf |
R |
|
| Agartz |
Ingrid |
I |
|
| Agerbo |
Esben |
E |
|
| Air |
Tracy M |
TM |
|
| Alda |
Martin |
M |
|
| Alfredsson |
Lars |
L |
|
| Anjorin |
Adebayo |
A |
|
| Appadurai |
Vivek |
V |
|
| Artigas |
María Soler |
MS |
|
| Ashley-Koch |
Allison E |
AE |
|
| Awasthi |
Swapnil |
S |
|
| Azevedo |
M Helena |
MH |
|
| García |
Enrique Baca |
EB |
|
| Bakian |
Amanda |
A |
|
| Bass |
Nicholas |
N |
|
| Bau |
Claiton Hd |
CH |
|
| Baune |
Bernhard T |
BT |
|
| Beckham |
Jean C |
JC |
|
| Bellivier |
Frank |
F |
|
| Bergen |
Andrew W |
AW |
|
| Berger |
Klaus |
K |
|
| Berrettini |
Wade H |
WH |
|
| Biernacka |
Joanna M |
JM |
|
| Bigdeli |
Tim B |
TB |
|
| Binder |
Elisabeth B |
EB |
|
| Boehnke |
Michael |
M |
|
| Bohus |
Martin |
M |
|
| Boks |
Marco P |
MP |
|
| Børglum |
Anders D |
AD |
|
| Bosch |
Rosa |
R |
|
| Braff |
David L |
DL |
|
| Brandt |
Harry |
H |
|
| Breen |
Gerome |
G |
|
| Bryant |
Richard |
R |
|
| Budde |
Monika |
M |
|
| Bulik |
Cynthia M |
CM |
|
| Byrne |
Enda M |
EM |
|
| Cahn |
Wiepke |
W |
|
| Campos |
Adrian I |
AI |
|
| Casas |
Miguel |
M |
|
| Castelao |
Enrique |
E |
|
| Cervilla |
Jorge A |
JA |
|
| Chang |
Xiao |
X |
|
| Chaumette |
Boris |
B |
|
| Chen |
Hsi-Chung |
HC |
|
| Chen |
Wei J |
WJ |
|
| Christensen |
Erik D |
ED |
|
| Cichon |
Sven |
S |
|
| Coleman |
Jonathan R I |
JRI |
|
| Corvin |
Aiden |
A |
|
| Craddock |
Nicholas |
N |
|
| Craig |
David |
D |
|
| Crawford |
Steven |
S |
|
| Crow |
Scott |
S |
|
| Degenhardt |
Franziska |
F |
|
| Demontis |
Ditte |
D |
|
| Dennis |
Michelle |
M |
|
| Djurovic |
Srdjan |
S |
|
| Duriez |
Philibert |
P |
|
| Edwards |
Alexis |
A |
|
| Esko |
Tõnu |
T |
|
| Fanelli |
Giuseppe |
G |
|
| Fanous |
Ayman H |
AH |
|
| Fernández-Aranda |
Fernando |
F |
|
| Fichter |
Manfred M |
MM |
|
| Foo |
Jerome C |
JC |
|
| Forstner |
Andreas J |
AJ |
|
| Fries |
Gabriel R |
GR |
|
| Frye |
Mark |
M |
|
| Fullerton |
Janice M |
JM |
|
| Galfalvy |
Hanga |
H |
|
| Gallinger |
Steven |
S |
|
| Gandal |
Michael |
M |
|
| Garrett |
Melanie |
M |
|
| Gatt |
Justine M |
JM |
|
| Gejman |
Pablo V |
PV |
|
| Giegling |
Ina |
I |
|
| Glatt |
Stephen J |
SJ |
|
| Gorwood |
Philip |
P |
|
| Grabe |
Hans J |
HJ |
|
| Green |
Melissa J |
MJ |
|
| Grevet |
Eugenio H |
EH |
|
| Grigoroiu-Serbanescu |
Maria |
M |
|
| Guo |
Yiran |
Y |
|
| Gutierrez |
Blanca |
B |
|
| Gutierrez-Zotes |
Alfonso |
A |
|
| Guzman-Parra |
Jose |
J |
|
| Hafferty |
Jonathan D |
JD |
|
| Hair |
Lauren |
L |
|
| Hakonarson |
Hakon |
H |
|
| Halmi |
Katherine A |
KA |
|
| Hamilton |
Steven P |
SP |
|
| Hamshere |
Marian L |
ML |
|
| Hartmann |
Annette M |
AM |
|
| Harvey |
Philip |
P |
|
| Hauser |
Elizabeth R |
ER |
|
| Hauser |
Michael A |
MA |
|
| Hauser |
Joanna |
J |
|
| Heilmann-Heimbach |
Stefanie |
S |
|
| Hishimoto |
Akitoyo |
A |
|
| Hoffmann |
Per |
P |
|
| Hougaard |
David M |
DM |
|
| Huffman |
Jennifer |
J |
|
| Hwu |
Hai-Gwo |
HG |
|
| Ising |
Marcus |
M |
|
| Jacobson |
Daniel |
D |
|
| Jain |
Sonia |
S |
|
| Jamain |
Stéphane |
S |
|
| Ji |
Min |
M |
|
| Jiménez-Murcia |
Susana |
S |
|
| Johnson |
Craig |
C |
|
| Jones |
Ian |
I |
|
| Jones |
Lisa A |
LA |
|
| Jonsson |
Lina |
L |
|
| Kahn |
René S |
RS |
|
| Kang |
JooEun |
J |
|
| Kaplan |
Allan S |
AS |
|
| Kaye |
Walter H |
WH |
|
| Keel |
Pamela K |
PK |
|
| Kelsoe |
John R |
JR |
|
| Kendler |
Kenneth S |
KS |
|
| Kennedy |
James L |
JL |
|
| Kessler |
Ronald C |
RC |
|
| Kim |
Minsoo |
M |
|
| Kloiber |
Stefan |
S |
|
| Klump |
Kelly L |
KL |
|
| Koenen |
Karestan C |
KC |
|
| Kogevinas |
Manolis |
M |
|
| Konte |
Bettina |
B |
|
| Krebs |
Marie-Odile |
MO |
|
| Kuo |
Po-Hsiu |
PH |
|
| Landén |
Mikael |
M |
|
| Lannoy |
Séverine |
S |
|
| Lawrence |
Jacob |
J |
|
| Leboyer |
Marion |
M |
|
| Lee |
Phil H |
PH |
|
| Levey |
Daniel F |
DF |
|
| Levinson |
Douglas F |
DF |
|
| Lewis |
Cathryn M |
CM |
|
| Li |
Dong |
D |
|
| Li |
Qingqin S |
QS |
|
| Liao |
Shih-Cheng |
SC |
|
| Liao |
Calwing |
C |
|
| Lieb |
Klaus |
K |
|
| Lilenfeld |
Lisa |
L |
|
| Lindquist |
Jennifer H |
JH |
|
| Lissowska |
Jolanta |
J |
|
| Liu |
Chih-Min |
CM |
|
| Lori |
Adriana |
A |
|
| Lucae |
Susanne |
S |
|
| Madduri |
Ravi |
R |
|
| Magistretti |
Pierre J |
PJ |
|
| Marshall |
Christian R |
CR |
|
| Martin |
Nicholas G |
NG |
|
| Mayoral |
Fermin |
F |
|
| McElroy |
Susan L |
SL |
|
| McGrath |
Patrick |
P |
|
| McGuffin |
Peter |
P |
|
| McIntosh |
Andrew M |
AM |
|
| McMahon |
Benjamin |
B |
|
| McQuillin |
Andrew |
A |
|
| Medland |
Sarah E |
SE |
|
| Mehta |
Divya |
D |
|
| Melle |
Ingrid |
I |
|
| Milaneschi |
Yuri |
Y |
|
| Mitchell |
James E |
JE |
|
| Mitchell |
Philip B |
PB |
|
| Molina |
Esther |
E |
|
| Morken |
Gunnar |
G |
|
| Mors |
Ole |
O |
|
| Mortensen |
Preben Bo |
PB |
|
| Müller-Myhsok |
Bertram |
B |
|
| Muntané |
Gerard |
G |
|
| Murnyak |
Balasz |
B |
|
| Myers |
Richard M |
RM |
|
| Nievergelt |
Caroline |
C |
|
| Nimgaonkar |
Vishwajit |
V |
|
| Nordentoft |
Merete |
M |
|
| Nöthen |
Markus M |
MM |
|
| O'Donovan |
Michael C |
MC |
|
| Okazaki |
Satoshi |
S |
|
| Olsen |
Catherine M |
CM |
|
| Ophoff |
Roel A |
RA |
|
| Oslin |
David W |
DW |
|
| Otsuka |
Ikuo |
I |
|
| Owen |
Michael J |
MJ |
|
| Papiol |
Sergi |
S |
|
| Pato |
Carlos |
C |
|
| Pato |
Michele T |
MT |
|
| Penninx |
Brenda Wjh |
BW |
|
| Pimm |
Jonathan |
J |
|
| Pinto |
Dalila |
D |
|
| Pistis |
Giorgio |
G |
|
| Polimanti |
Renato |
R |
|
| Porteous |
David |
D |
|
| Potash |
James B |
JB |
|
| Power |
Robert A |
RA |
|
| Powers |
Abigail |
A |
|
| Preisig |
Martin |
M |
|
| Qin |
Xuejun |
X |
|
| Quested |
Digby |
D |
|
| Ramos-Quiroga |
Josep Antoni |
JA |
|
| Ramoz |
Nicolas |
N |
|
| Reif |
Andreas |
A |
|
| Rentería |
Miguel E |
ME |
|
| Ribasés |
Marta |
M |
|
| Richarte |
Vanesa |
V |
|
| Rietschel |
Marcella |
M |
|
| Ripke |
Stephan |
S |
|
| Rivera |
Margarita |
M |
|
| Roberts |
Andrea |
A |
|
| Roberts |
Gloria |
G |
|
| Roepke |
Stefan |
S |
|
| Rouleau |
Guy A |
GA |
|
| Rovaris |
Diego L |
DL |
|
| Rozanov |
Vsevolod |
V |
|
| Rujescu |
Dan |
D |
|
| Sànchez-Gistau |
Vanessa |
V |
|
| Sánchez-Mora |
Cristina |
C |
|
| Sanders |
Alan R |
AR |
|
| Sawyers |
Chelsea |
C |
|
| Scherer |
Stephen W |
SW |
|
| Schmahl |
Christian |
C |
|
| Schofield |
Peter R |
PR |
|
| Schulze |
Thomas G |
TG |
|
| Scott |
Laura J |
LJ |
|
| Shabalin |
Andrey |
A |
|
| Shi |
Jianxin |
J |
|
| Shyn |
Stanley I |
SI |
|
| Sirignano |
Lea |
L |
|
| Sklar |
Pamela |
P |
|
| Smeland |
Olav B |
OB |
|
| Smith |
Daniel J |
DJ |
|
| Sokolowski |
Marcus |
M |
|
| Sonuga-Barke |
Edmund J S |
EJS |
|
| Spalletta |
Gianfranco |
G |
|
| Stahl |
Eli A |
EA |
|
| Starnawska |
Anna |
A |
|
| Stephenson |
Mallory |
M |
|
| Strauss |
John S |
JS |
|
| Streit |
Fabian |
F |
|
| Strober |
Michael |
M |
|
| Su |
Mei-Hsin |
MH |
|
| Świątkowska |
Beata |
B |
|
| Thornton |
Laura M |
LM |
|
| Trafton |
Jodie |
J |
|
| Treasure |
Janet |
J |
|
| Trzaskowski |
Maciej |
M |
|
| Tsuang |
Ming T |
MT |
|
| Turecki |
Gustavo |
G |
|
| Ursano |
Robert J |
RJ |
|
| Van der Auwera |
Sandra |
S |
|
| Vilar-Ribó |
Laura |
L |
|
| Vilella |
Elisabet |
E |
|
| Vincent |
John B |
JB |
|
| Völzke |
Henry |
H |
|
| Walss-Bass |
Consuelo |
C |
|
| Walters |
James Tr |
JT |
|
| Ware |
Erin B |
EB |
|
| Wasserman |
Danuta |
D |
|
| Watson |
Hunna J |
HJ |
|
| Weickert |
Cynthia Shannon |
CS |
|
| Weickert |
Thomas W |
TW |
|
| Weissman |
Myrna M |
MM |
|
| Wendt |
Frank |
F |
|
| Werge |
Thomas |
T |
|
| Whiteman |
David C |
DC |
|
| Williams |
Leanne M |
LM |
|
| Willour |
Virginia |
V |
|
| Witt |
Stephanie H |
SH |
|
| Woodside |
D Blake |
DB |
|
| Wray |
Naomi R |
NR |
|
| Yilmaz |
Zeynep |
Z |
|
| Zillich |
Lea |
L |
|
|
| JOURNAL |
|
| VOLUME: |
| ISSUE: |
| TITLE: Molecular psychiatry |
| ISOABBREVIATION: Mol Psychiatry |
| YEAR: 2025 |
| MONTH: Sep |
| DAY: 25 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1476-5578 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Mol Psychiatry |
| COUNTRY: England |
| ISSNLINKING: 1359-4184 |
| NLMUNIQUEID: 9607835 |
|
| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
| Review |
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| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| R01 MH132733 |
NIMH NIH HHS |
United States |
| R01MH132733 |
U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) |
|
| 1842169 |
National Science Foundation (NSF) |
|
|
| GENERAL NOTE |
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| KEYWORDS |
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| MESH HEADINGS |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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