|
|
| PMID |
|
|
| TITLE |
|
| Genome-wide insights into generalised anxiety using a dimensional symptom severity approach. |
|
| ABSTRACT |
|
|
|
| We performed a genome-wide association meta-analysis of generalised anxiety symptom severity in 696,563 individuals of European ancestry from 14 cohorts. We identified 82 independent genome-wide significant variants within 76 loci, 41 of which were novel for anxiety. SNP-based heritability was 5.9% (SE = 0.19%). Polygenic scores were significantly associated with anxiety symptom severity and disorder in European, African, and South Asian ancestry samples (r2=1.2%-3.4%). Significant genetic correlations were estimated with numerous mental and physical health traits, including case-control anxiety, neuroticism and depression (rg=0.71-0.86), irritable bowel syndrome (rg=0.57), coronary artery disease, endometriosis, and migraine (rg=0.20-0.27). Gene-based and pathway analyses implicated synaptic and axonal processes, with enriched expression in the brain. These findings highlight the additional value of a dimensional approach in anxiety genetics. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| medline |
2025/07/17 06:28 |
| pubmed |
2025/07/17 06:27 |
| entrez |
2025/07/17 05:36 |
| pmc-release |
2025/07/16 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Skelton M |
|
Skelton |
Megan |
M |
|
|
| Mitchell BL |
|
Mitchell |
Brittany L |
BL |
|
|
| Assary E |
|
Assary |
Elham |
E |
|
|
| Li D |
|
Li |
Danyang |
D |
|
|
| Morneau-Vaillancourt G |
|
Morneau-Vaillancourt |
Genevieve |
G |
|
|
| Murphy AE |
|
Murphy |
Alan E |
AE |
|
|
| Ter Kuile AR |
|
Ter Kuile |
Abigail R |
AR |
|
|
| Wang R |
|
Wang |
Rujia |
R |
|
|
| Adams MJ |
|
Adams |
Mark J |
MJ |
|
|
| Byrne EM |
|
Byrne |
Enda M |
EM |
|
|
| Corfield EC |
|
Corfield |
Elizabeth C |
EC |
|
|
| Grimes PZ |
|
Grimes |
Poppy Z |
PZ |
|
|
| Hannigan LJ |
|
Hannigan |
Laurie J |
LJ |
|
|
| Hu J |
|
Hu |
Jihua |
J |
|
|
| Koiv K |
|
Koiv |
Kadri |
K |
|
|
| Kwong AS |
|
Kwong |
Alex Sf |
AS |
|
|
| Papiol S |
|
Papiol |
Sergi |
S |
|
|
| Pettersen JH |
|
Pettersen |
Johanne H |
JH |
|
|
| Pistis G |
|
Pistis |
Giorgio |
G |
|
|
| Castelao E |
|
Castelao |
Enrique |
E |
|
|
| Strom NI |
|
Strom |
Nora I |
NI |
|
|
| van der Most PJ |
|
van der Most |
Peter J |
PJ |
|
|
|
Anxiety Disorders Working Group of the Psychiatric Genomics Consortium |
|
|
|
|
|
|
GLAD+ authors |
|
|
|
|
|
|
Lifelines Cohort Study |
|
|
|
|
|
|
NIHR Bioresource |
|
|
|
|
|
|
Protect-AD Consortium |
|
|
|
|
|
| Andreassen OA |
|
Andreassen |
Ole A |
OA |
|
|
| Erhardt-Lehmann A |
|
Erhardt-Lehmann |
Angelika |
A |
|
|
| Havdahl A |
|
Havdahl |
Alexandra |
A |
|
|
| Skene N |
|
Skene |
Nathan |
N |
|
|
| Verhulst B |
|
Verhulst |
Brad |
B |
|
|
| Weber H |
|
Weber |
Heike |
H |
|
|
| Armour C |
|
Armour |
Cherie |
C |
|
|
| Ask H |
|
Ask |
Helga |
H |
|
|
| Copeland WE |
|
Copeland |
William E |
WE |
|
|
| Dannlowski U |
|
Dannlowski |
Udo |
U |
|
|
| Deckert J |
|
Deckert |
Jurgen |
J |
|
|
| Domschke K |
|
Domschke |
Katharina |
K |
|
|
| Hickie IB |
|
Hickie |
Ian B |
IB |
|
|
| Lehto K |
|
Lehto |
Kelli |
K |
|
|
| Lonsdorf TB |
|
Lonsdorf |
Tina B |
TB |
|
|
| Lueken U |
|
Lueken |
Ulrike |
U |
|
|
| Lupton MK |
|
Lupton |
Michelle K |
MK |
|
|
| Medland SE |
|
Medland |
Sarah E |
SE |
|
|
| McIntosh AM |
|
McIntosh |
Andrew M |
AM |
|
|
| Oldehinkel AJ |
|
Oldehinkel |
Albertine J |
AJ |
|
|
| Preisig M |
|
Preisig |
Martin |
M |
|
|
| Reif A |
|
Reif |
Andreas |
A |
|
|
| Snieder H |
|
Snieder |
Harold |
H |
|
|
| Walters JTR |
|
Walters |
James T R |
JTR |
|
|
| Wray NR |
|
Wray |
Naomi R |
NR |
|
|
| Hartman CA |
|
Hartman |
Catharina A |
CA |
|
|
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
|
| Hettema JM |
|
Hettema |
John M |
JM |
|
|
| Breen G |
|
Breen |
Gerome |
G |
|
|
| Coleman JR |
|
Coleman |
Jonathan Ri |
JR |
|
|
| Eley TC |
|
Eley |
Thalia C |
TC |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: |
| ISSUE: |
| TITLE: medRxiv : the preprint server for health sciences |
| ISOABBREVIATION: medRxiv |
| YEAR: 2025 |
| MONTH: Jul |
| DAY: 11 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: |
| ISSNTYPE: |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: medRxiv |
| COUNTRY: United States |
| ISSNLINKING: |
| NLMUNIQUEID: 101767986 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Preprint |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
|
|
