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| PMID |
|
|
| TITLE |
|
| Predicting adolescent disordered eating and behaviours: exploring environmental moderators of polygenic risk. |
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| ABSTRACT |
|
| BACKGROUND |
NlmCategory: BACKGROUND |
| Both genetic and environmental factors contribute to the risk of developing disordered eating, with twin studies demonstrating environmental factors moderate genetic susceptibility. To date, gene-environment interactions leveraging polygenic risk scores (PRS) have not been studied in disordered eating phenotypes beyond anorexia nervosa (AN). This study investigated if polygenic risk for AN interacts with established environmental eating disorder risk factors (parental expectations, parental criticism, parental conflict, parental care and weight-related peer teasing) to predict overall levels of disordered eating in the general population or specific lifetime disordered eating behaviours (avoidance of eating, objective bulimic episodes, self-induced vomiting and driven exercise). |
| METHODS |
NlmCategory: METHODS |
| Both genetic and environmental factors contribute to the risk of developing disordered eating, with twin studies demonstrating environmental factors moderate genetic susceptibility. To date, gene-environment interactions leveraging polygenic risk scores (PRS) have not been studied in disordered eating phenotypes beyond anorexia nervosa (AN). This study investigated if polygenic risk for AN interacts with established environmental eating disorder risk factors (parental expectations, parental criticism, parental conflict, parental care and weight-related peer teasing) to predict overall levels of disordered eating in the general population or specific lifetime disordered eating behaviours (avoidance of eating, objective bulimic episodes, self-induced vomiting and driven exercise). PRS were calculated using summary statistics from the largest AN genome-wide association study. Environmental factors were assessed via telephone interview using standardized measures. Analyses were performed using genome-wide complex trait analysis to test whether parental expectations, criticism, conflict or care, or weight-related peer teasing interacted with AN PRS to predict disordered eating outcomes in our sample (n = 383). |
| RESULTS |
NlmCategory: RESULTS |
| Both genetic and environmental factors contribute to the risk of developing disordered eating, with twin studies demonstrating environmental factors moderate genetic susceptibility. To date, gene-environment interactions leveraging polygenic risk scores (PRS) have not been studied in disordered eating phenotypes beyond anorexia nervosa (AN). This study investigated if polygenic risk for AN interacts with established environmental eating disorder risk factors (parental expectations, parental criticism, parental conflict, parental care and weight-related peer teasing) to predict overall levels of disordered eating in the general population or specific lifetime disordered eating behaviours (avoidance of eating, objective bulimic episodes, self-induced vomiting and driven exercise). PRS were calculated using summary statistics from the largest AN genome-wide association study. Environmental factors were assessed via telephone interview using standardized measures. Analyses were performed using genome-wide complex trait analysis to test whether parental expectations, criticism, conflict or care, or weight-related peer teasing interacted with AN PRS to predict disordered eating outcomes in our sample (n = 383). The analyses revealed significant main effects of parental expectations, parental criticism, parental care, and weight-related peer teasing on at least one disordered eating outcome. All environmental variables moderated the association between AN PRS and at least one disordered eating outcome by either increasing risk (parental expectations, parental criticism, parental conflict, weight-related peer teasing) or lowering risk (parental care). |
| CONCLUSIONS |
NlmCategory: CONCLUSIONS |
| Both genetic and environmental factors contribute to the risk of developing disordered eating, with twin studies demonstrating environmental factors moderate genetic susceptibility. To date, gene-environment interactions leveraging polygenic risk scores (PRS) have not been studied in disordered eating phenotypes beyond anorexia nervosa (AN). This study investigated if polygenic risk for AN interacts with established environmental eating disorder risk factors (parental expectations, parental criticism, parental conflict, parental care and weight-related peer teasing) to predict overall levels of disordered eating in the general population or specific lifetime disordered eating behaviours (avoidance of eating, objective bulimic episodes, self-induced vomiting and driven exercise). PRS were calculated using summary statistics from the largest AN genome-wide association study. Environmental factors were assessed via telephone interview using standardized measures. Analyses were performed using genome-wide complex trait analysis to test whether parental expectations, criticism, conflict or care, or weight-related peer teasing interacted with AN PRS to predict disordered eating outcomes in our sample (n = 383). The analyses revealed significant main effects of parental expectations, parental criticism, parental care, and weight-related peer teasing on at least one disordered eating outcome. All environmental variables moderated the association between AN PRS and at least one disordered eating outcome by either increasing risk (parental expectations, parental criticism, parental conflict, weight-related peer teasing) or lowering risk (parental care). Findings highlight the complex interplay between genetic and environmental factors in disordered eating development and emphasize the importance of personalized interventions that consider both genetic predisposition and environmental influences. |
| © 2025 The Author(s). Journal of Child Psychology and Psychiatry published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| accepted |
2025/05/08 |
| medline |
2025/11/18 18:30 |
| pubmed |
2025/07/10 00:36 |
| entrez |
2025/07/09 19:35 |
| pmc-release |
2025/11/18 |
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| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Curtis M |
|
Curtis |
Madeleine |
M |
|
Blackbird Initiative, Flinders Institute for Mental Health and Wellbeing, Flinders University, Adelaide, SA, Australia. |
| Colodro-Conde L |
|
Colodro-Conde |
Lucia |
L |
|
School of Psychology, The University of Queensland, Brisbane, Qld, Australia. |
| Medland SE |
|
Medland |
Sarah E |
SE |
|
School of Psychology, The University of Queensland, Brisbane, Qld, Australia. |
| Gordon S |
|
Gordon |
Scott |
S |
|
QIMR Berghofer Medical Research Institute, Brisbane, Qld, Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
QIMR Berghofer Medical Research Institute, Brisbane, Qld, Australia. |
| Wade TD |
|
Wade |
Tracey D |
TD |
|
Blackbird Initiative, Flinders Institute for Mental Health and Wellbeing, Flinders University, Adelaide, SA, Australia. |
| Cohen-Woods S |
|
Cohen-Woods |
Sarah |
S |
|
Flinders Centre for Innovation in Cancer, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia. |
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| INVESTIGATORS |
|
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| JOURNAL |
|
| VOLUME: 66 |
| ISSUE: 12 |
| TITLE: Journal of child psychology and psychiatry, and allied disciplines |
| ISOABBREVIATION: J Child Psychol Psychiatry |
| YEAR: 2025 |
| MONTH: Dec |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1469-7610 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
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| MEDLINETA: J Child Psychol Psychiatry |
| COUNTRY: England |
| ISSNLINKING: 0021-9630 |
| NLMUNIQUEID: 0375361 |
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| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GRANTID |
AGENCY |
COUNTRY |
| 2030216 |
National Health and Medical Research Council |
|
| 310667 |
National Health and Medical Research Council |
|
| 324715 |
National Health and Medical Research Council |
|
| 480420 |
National Health and Medical Research Council |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| Eating disorder |
| anorexia nervosa |
| behavioural genetics |
| gene-environment interaction (GxE) |
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| MESH HEADINGS |
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| DESCRIPTORNAME |
QUALIFIERNAME |
| Humans |
|
| Adolescent |
|
| Female |
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| Feeding and Eating Disorders |
etiology |
| Multifactorial Inheritance |
genetics |
| Gene-Environment Interaction |
genetics |
| Male |
genetics |
| Genome-Wide Association Study |
genetics |
| Genetic Predisposition to Disease |
genetics |
| Parent-Child Relations |
genetics |
| Adolescent Behavior |
physiology |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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