Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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40360802
TITLE
Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder.
ABSTRACT
Obsessive-compulsive disorder (OCD) affects ~1% of children and adults and is partly caused by genetic factors. We conducted a genome-wide association study (GWAS) meta-analysis combining 53,660 OCD cases and 2,044,417 controls and identified 30 independent genome-wide significant loci. Gene-based approaches identified 249 potential effector genes for OCD, with 25 of these classified as the most likely causal candidates, including WDR6, DALRD3 and CTNND1 and multiple genes in the major histocompatibility complex (MHC) region. We estimated that ~11,500 genetic variants explained 90% of OCD genetic heritability. OCD genetic risk was associated with excitatory neurons in the hippocampus and the cortex, along with D and D type dopamine receptor-containing medium spiny neurons. OCD genetic risk was shared with 65 of 112 additional phenotypes, including all the psychiatric disorders we examined. In particular, OCD shared genetic risk with anxiety, depression, anorexia nervosa and Tourette syndrome and was negatively associated with inflammatory bowel diseases, educational attainment and body mass index.
© 2025. The Author(s).
DATE PUBLISHED
2025 Jun
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2024/03/13
accepted 2025/04/07
medline 2025/06/14 16:47
pubmed 2025/05/14 11:40
entrez 2025/05/13 23:32
pmc-release 2025/05/13
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Strom NI Strom Nora I NI University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland. nora.strom@hu-berlin.de.
Gerring ZF Gerring Zachary F ZF Department of Population Health and Immunity, Healthy Development and Ageing, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Galimberti M Galimberti Marco M VA Connecticut Healthcare System, West Haven, CT, USA.
Yu D Yu Dongmei D Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Halvorsen MW Halvorsen Matthew W MW Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Abdellaoui A Abdellaoui Abdel A Department of Psychiatry, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.
Rodriguez-Fontenla C Rodriguez-Fontenla Cristina C Grupo de Medicina Xenómica, Genetics, Instituto de Investigación Sanitaria de Santiago de Compostela (FIDIS), Santiago de Compostela, Spain.
Sealock JM Sealock Julia M JM Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA.
Bigdeli T Bigdeli Tim T VA NY Harbor Healthcare System, Brooklyn, NY, USA.
Coleman JR Coleman Jonathan R JR National Institute for Health and Care Research Maudsley Biomedical Research Centre, South London and Maudsley NHS Trust, London, UK.
Mahjani B Mahjani Behrang B Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Thorp JG Thorp Jackson G JG Faculty of Medicine, School of Biomedical Sciences, University of Queensland, Brisbane, Queensland, Australia.
Bey K Bey Katharina K Department of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany.
Burton CL Burton Christie L CL Department of Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada.
Luykx JJ Luykx Jurjen J JJ Second Opinion Outpatient Clinic, GGNet, Warnsveld, the Netherlands.
Zai G Zai Gwyneth G Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Alemany S Alemany Silvia S Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain.
Andre C Andre Christine C Obsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA, USA.
Askland KD Askland Kathleen D KD Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Hamilton, Ontario, Canada.
Bäckman J Bäckman Julia J Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Services, Region Stockholm, Stockholm, Sweden.
Banaj N Banaj Nerisa N Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.
Barlassina C Barlassina Cristina C Department of Health Sciences, University of Milano, Milano, Italy.
Nissen JB Nissen Judith Becker JB Institute of Clinical Medicine, Health, Aarhus University, Aarhus, Denmark.
Bienvenu OJ Bienvenu O Joseph OJ Department of Psychiatry and Behavioral Sciences, General Hospital Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Black D Black Donald D Departments of Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Bloch MH Bloch Michael H MH Department of Child Study Center and Psychiatry, Yale University, New Haven, CT, USA.
Børte S Børte Sigrid S Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.
Bosch R Bosch Rosa R Instituto de Salut Carlos III, Centro de Investigación Biomédica en Red de Salut Mental (CIBERSAM), Madrid, Spain.
Breen M Breen Michael M The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Brennan BP Brennan Brian P BP Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Brentani H Brentani Helena H Department of Psychiatry, Universidade de São Paulo, São Paulo, Brazil.
Buxbaum JD Buxbaum Joseph D JD Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Bybjerg-Grauholm J Bybjerg-Grauholm Jonas J Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
Byrne EM Byrne Enda M EM Child Health Research Centre, University of Queensland, Brisbane, Queensland, Australia.
Cabana-Dominguez J Cabana-Dominguez Judit J Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain.
Camarena B Camarena Beatriz B Pharmacogenetics Department, Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramon de la Fuente Muñiz, Mexico City, México.
Camarena A Camarena Adrian A Department of Surgery, Duke University, Durham, NC, USA.
Cappi C Cappi Carolina C Department of Psychiatry, University of São Paulo, São Paulo, Brazil.
Carracedo A Carracedo Angel A Medicina Genómica, Centro de Investigación Biomédica en Red, Enfermedades Raras (CIBERER), Santiago de Compostela, Spain.
Casas M Casas Miguel M Departamento de Psiquiatría y Medicina Legal, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Cavallini MC Cavallini Maria Cristina MC Department of Psychiatry, Ospedale San Raffaele, Milano, Italy.
Ciullo V Ciullo Valentina V Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.
Cook EH Cook Edwin H EH Department of Psychiatry, University of Illinois Chicago, Chicago, IL, USA.
Crosby J Crosby Jesse J Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Cullen BA Cullen Bernadette A BA Department of Mental Health, Bloomberg School of Public Health, Baltimore, MD, USA.
De Schipper EJ De Schipper Elles J EJ Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Services, Region Stockholm, Stockholm, Sweden.
Delorme R Delorme Richard R Child and Adolesccent Psychiatry Department, APHP, Paris, France.
Djurovic S Djurovic Srdjan S Department of Clinical Science, University of Bergen, Bergen, Norway.
Elias JA Elias Jason A JA Adult Psychological Services, CBTeam LLC, Lexington, MA, USA.
Estivill X Estivill Xavier X qGenomics (Quantitative Genomics Laboratories), Esplugues de Llobregat, Spain.
Falkenstein MJ Falkenstein Martha J MJ Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Fundin BT Fundin Bengt T BT Department of Medical Epidemiology and Biostatistics, Center for Eating Disorders Innovation, Karolinska Institutet, Stockholm, Sweden.
Garner L Garner Lauryn L Obsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA, USA.
Gironda C Gironda Christina C Obsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA, USA.
Goes FS Goes Fernando S FS Department of Psychiatry, Johns Hopkins University, Baltimore, MD, USA.
Grados MA Grados Marco A MA Department of Psychiatry and Behavioral Sciences, Child and Adolescent Psychiatry, Johns Hopkins University, Baltimore, MD, USA.
Grove J Grove Jakob J Bioinformatics Research Centre, Aarhus, Denmark.
Guo W Guo Wei W Genetic Epidemiology Research Branch, National Institute of Mental Health, Bethesda, MD, USA.
Haavik J Haavik Jan J Bergen Center for Brain Plasticity, Division of Psychiatry, Haukeland University Hospital, Bergen, Norway.
Hagen K Hagen Kristen K Department of Mental Health, Norwegian University for Science and Technology, Trondheim, Norway.
Harrington K Harrington Kelly K Department of Psychiatry, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.
Havdahl A Havdahl Alexandra A Nic Waals Institute, Lovisenberg Diaconal Hospital, Oslo, Norway.
Höffler KD Höffler Kira D KD Department of Medical Genetics, Dr. Einar Martens Research Group for Biological Psychiatry, Haukeland University Hospital, Bergen, Norway.
Hounie AG Hounie Ana G AG Department of Psychiatry, University of São Paulo, São Paulo, Brazil.
Hucks D Hucks Donald D Department of Medicine, Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Hultman C Hultman Christina C Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Janecka M Janecka Magdalena M Department of Child and Adolescent Psychiatry, NYU Grossman School of Medicine, New York, NY, USA.
Jenike E Jenike Eric E Obsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA, USA.
Karlsson EK Karlsson Elinor K EK Department of Vertebrate Genomics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Kelley K Kelley Kara K Obsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA, USA.
Klawohn J Klawohn Julia J Department of Medicine, MSB Medical School Berlin, Berlin, Germany.
Krasnow JE Krasnow Janice E JE Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
Krebs K Krebs Kristi K Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Lange C Lange Christoph C Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Lanzagorta N Lanzagorta Nuria N Research Department, Grupo Medico Carracci, Mexico City, Mexico.
Levey D Levey Daniel D Office of Research and Development, United States Department of Veterans Affairs, West Haven, CT, USA.
Lindblad-Toh K Lindblad-Toh Kerstin K SciLifeLab, Uppsala University, Uppsala, Sweden.
Macciardi F Macciardi Fabio F Department of Psychiatry, University of California, Irvine, Irvine, CA, USA.
Maher B Maher Brion B Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Mathes B Mathes Brittany B Obsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA, USA.
McArthur E McArthur Evonne E Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
McGregor N McGregor Nathaniel N COBRE Center for Neuromodulation, Butler Hospital, Providence, RI, USA.
McLaughlin NC McLaughlin Nicole C NC Butler Hospital, Providence, RI, USA.
Meier S Meier Sandra S Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Miguel EC Miguel Euripedes C EC Department of Psychiatry, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Mulhern M Mulhern Maureen M Department of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany.
Nestadt PS Nestadt Paul S PS Department of Psychiatry and Behavioral Science, Johns Hopkins University, Baltimore, MD, USA.
Nurmi EL Nurmi Erika L EL Department of Psychiatry and Biobehavioral Sciences, Division of Child and Adolescent Psychiatry, University of California, Los Angeles, Los Angeles, CA, USA.
O'Connell KS O'Connell Kevin S KS NORMENT, University of Oslo, Oslo, Norway.
Osiecki L Osiecki Lisa L Psychiatric and Neurodevelopmental Genetics Unit, Harvard Medical School, Boston, MA, USA.
Ousdal OT Ousdal Olga Therese OT Department of Biomedicine, Haukeland University Hospital, Bergen, Norway.
Palviainen T Palviainen Teemu T Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Pedersen NL Pedersen Nancy L NL Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Piras F Piras Fabrizio F Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.
Piras F Piras Federica F Department of Clinical Neuroscience and Neurorehabilitation, Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy.
Potluri S Potluri Sriramya S Obsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA, USA.
Rabionet R Rabionet Raquel R Department of Human Molecular Genetics, Institut de Recerca Sant Joan de Déu, Barcelona, Spain.
Ramirez A Ramirez Alfredo A Cologne Excellence Cluster for Stress Responses in Ageing-associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Rauch S Rauch Scott S Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA.
Reichenberg A Reichenberg Abraham A Department of Mental Disorders, Norwegian Institute of Public Health, New York, NY, USA.
Riddle MA Riddle Mark A MA Department of Psychiatry and Behavioral Sciences, Child and Adolescent, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ripke S Ripke Stephan S Site Berlin-Potsdam, German Center for Mental Health (DZPG), Berlin, Germany.
Rosário MC Rosário Maria C MC Department of Psychiatry, Child and Adolescent Psychiatry Unit (UPIA), Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
Sampaio AS Sampaio Aline S AS Department of Neurosciences and Mental Health, Medical School, Federal University of Bahia, Salvador, Brazil.
Schiele MA Schiele Miriam A MA Department of Psychiatry and Psychotherapy, Faculty of Medicine, University of Freiburg, Medical Center-University of Freiburg, Freiburg, Germany.
Skogholt AH Skogholt Anne Heidi AH Department of Public Health and Nursing, HUNT Center for Molecular and Clinical Epidemiology, Trondheim, Norway.
Sloofman LG Sloofman Laura G LG Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Smit J Smit Jan J Department of Psychiatry, Faculty of Medicine, Locaion VUmc, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Artigas MS Artigas María Soler MS Department of Genetics, Microbiology, and Statistics, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain.
Thomas LF Thomas Laurent F LF Clinic of Laboratory Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Tifft E Tifft Eric E Obsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA, USA.
Vallada H Vallada Homero H Department of Molecular Medicine and Surgery, CMM, Karolinska Institutet, Stockholm, Sweden.
van Kirk N van Kirk Nathanial N Department of Psychiatry, Harvard Medical School, Belmont, MA, USA.
Veenstra-VanderWeele J Veenstra-VanderWeele Jeremy J Department of Child and Adolescent Psychiatry, New York State Psychiatric Institute, New York, NY, USA.
Vulink NN Vulink Nienke N NN Department of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Walker CP Walker Christopher P CP Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ, USA.
Wang Y Wang Ying Y Department of Neurology, the Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Wendland JR Wendland Jens R JR Laboratory of Clinical Science, NIMH Intramural Research Program, Bethesda, MD, USA.
Winsvold BS Winsvold Bendik S BS HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU, Trondheim, Norway.
Yao Y Yao Yin Y Department of Computional Biology, Institute of Life Science, Fudan University, Fudan, China.
Zhou H Zhou Hang H Section of Biomedical Informatics and Data Science, Yale School of Medicine, New Haven, CT, USA.
Estonian Biobank
23andMe Inc.
Agrawal A Agrawal Arpana A Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.
Alonso P Alonso Pino P CIBERSAM, Mental Health Network Biomedical Research Center, Madrid, Spain.
Berberich G Berberich Götz G Psychosomatic Department, Windach Hospital of Neurobehavioural Research and Therapy, Windach, Germany.
Bucholz KK Bucholz Kathleen K KK Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Bulik CM Bulik Cynthia M CM Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Cath D Cath Danielle D Department of Specialized Training, Drenthe Mental Health Care Institute, Groningen, the Netherlands.
Denys D Denys Damiaan D Department of Psychiatry, Institute of the Royal Netherlands Academy of Arts and Sciences (NIN-KNAW), Amsterdam, the Netherlands.
Eapen V Eapen Valsamma V Academic Unit of Child Psychiatry South-West Sydney, South-West Sydney Clinical School, SWSLHD and Ingham Institute, Sydney, New South Wales, Australia.
Edenberg H Edenberg Howard H Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Falkai P Falkai Peter P Department of Psychiatry, Max Planck Institute, Munich, Germany.
Fernandez TV Fernandez Thomas V TV Child Study Center and Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Fyer AJ Fyer Abby J AJ Department of Psychiatry, Columbia University Medical Center, New York, NY, USA.
Gaziano JM Gaziano J M JM Department of Medicine, Mass General Brigham, Boston, MA, USA.
Geller DA Geller Dan A DA Department of Psychiatry, Child Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Grabe HJ Grabe Hans J HJ Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Greenberg BD Greenberg Benjamin D BD Department of Psychiatry and Human Behavior, Alpert Medical School, Brown University, Providence, RI, USA.
Hanna GL Hanna Gregory L GL Department of Psychiatry, Child and Adolescent Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Hickie IB Hickie Ian B IB Brain and Mind Centre, the University of Sydney, Sydney, New South Wales, Australia.
Hougaard DM Hougaard David M DM Center for Genomics and Personalized Medicine, Aarhus, Denmark.
Kathmann N Kathmann Norbert N Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
Kennedy J Kennedy James J Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Lai D Lai Dongbing D Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Landén M Landén Mikael M Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, University of Gothenburg, Gothenburg, Sweden.
Hellard SL Hellard Stéphanie Le SL Bergen Center for Brain Plasticity, Division of Psychiatry, Haukeland University Hospital, Bergen, Norway.
Leboyer M Leboyer Marion M Department of Addictology and Psychiatry, Université Paris-Est Créteil, AP-HP, Inserm, Paris, France.
Lochner C Lochner Christine C Department of Psychiatry, SA MRC Unit on Risk and Resilience in Mental Disorders, Stellenbosch University, Stellenbosch, South Africa.
McCracken JT McCracken James T JT Department of Psychiatry and Biobehavioral Sciences, Division of Child and Adolescent Psychiatry, University of California, Los Angeles, Los Angeles, CA, USA.
Medland SE Medland Sarah E SE Department of Mental Health, Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Mortensen PB Mortensen Preben B PB Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark.
Neale BM Neale Benjamin M BM Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Nicolini H Nicolini Humberto H Psiquiatría, Instituto Nacional de Medicina Genómica, Mexico City, México.
Nordentoft M Nordentoft Merete M Faculty of Health and Medical Sciences, Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Pato M Pato Michele M Department of Psychiatry, Rutgers University, Piscataway, NJ, USA.
Pato C Pato Carlos C Department of Psychiatry, Rutgers University, Piscataway, NJ, USA.
Pauls DL Pauls David L DL Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Piacentini J Piacentini John J Department of Psychiatry and Biobehavioral Sciences, Child and Adolescent Psychiatry, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA.
Pittenger C Pittenger Christopher C Department of Psychiatry, Yale University, New Haven, CT, USA.
Posthuma D Posthuma Danielle D Department of Child and Adolescent Psychiatric, Section Complex Trait Genetics, VU Medical Center Amsterdam, Amsterdam, the Netherlands.
Ramos-Quiroga JA Ramos-Quiroga Josep Antoni JA Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.
Rasmussen SA Rasmussen Steven A SA Department of Psychiatry and Human Behavior, Alpert Medical School, Brown University, Providence, RI, USA.
Richter MA Richter Margaret A MA Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Rosenberg DR Rosenberg David R DR Department of Psychiatry and Behavioral Neurosciences, Child and Adolescent Psychiatry, Wayne State University School of Medicine, Detroit, MI, USA.
Ruhrmann S Ruhrmann Stephan S Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.
Samuels JF Samuels Jack F JF Department of Psychiatry and Behavioral Sciences, the Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sandin S Sandin Sven S Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Sandor P Sandor Paul P Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Spalletta G Spalletta Gianfranco G Department of Psychiatry and Behavioral Sciences, Division of Neuropsychiatry, Baylor College of Medicine, Houston, TX, USA.
Stein DJ Stein Dan J DJ Department of Psychiatry and Neuroscience Institute, SAMRC Unit on Risk and Resilience in Mental Disorders, University of Cape Town, Cape Town, South Africa.
Stewart SE Stewart S Evelyn SE British Columbia Mental Health and Substance Use Services Research Institute, Vancouver, British Columbia, Canada.
Storch EA Storch Eric A EA Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.
Stranger BE Stranger Barbara E BE Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Turiel M Turiel Maurizio M Department of Cardiology, University of Milan, Milan, Italy.
Werge T Werge Thomas T Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Andreassen OA Andreassen Ole A OA Division of Mental Health and Addiction, Center for Precision Psychiatry, Oslo University Hospital, Oslo, Norway.
Børglum AD Børglum Anders D AD Center for Genomics and Personalized Medicine, Aarhus University, Aarhus, Denmark.
Walitza S Walitza Susanne S Zurich Center for Integrative Human Physiology, University of Zurich, Zürich, Switzerland.
Hveem K Hveem Kristian K Department of Research, Innovation and Education, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Hansen BK Hansen Bjarne K BK Centre for Crisis Psychology, Psychology, University of Bergen, Bergen, Norway.
Rück C Rück Christian C Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Services, Region Stockholm, Stockholm, Sweden.
Martin NG Martin Nicholas G NG Department of Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Milani L Milani Lili L Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Mors O Mors Ole O Psychosis Research Unit, Psychiatry, Aarhus University Hospital, Aarhus, Denmark.
Reichborn-Kjennerud T Reichborn-Kjennerud Ted T Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Ribasés M Ribasés Marta M Department of Genetics, Microbiology, and Statistics, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain.
Kvale G Kvale Gerd G Department of Clinical Psychology, Faculty of Psychology, University of Bergen, Bergen, Norway.
Mataix-Cols D Mataix-Cols David D Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Services, Region Stockholm, Stockholm, Sweden.
Domschke K Domschke Katharina K Partner Site Berlin, DZPG, Berlin, Germany.
Grünblatt E Grünblatt Edna E Zurich Center for Integrative Human Physiology, University of Zurich, Zürich, Switzerland.
Wagner M Wagner Michael M DZNE, Bonn, Germany.
Zwart JA Zwart John-Anker JA Department of Research and Innovation, Clinical Neuroscience, Oslo University Hospital and University of Oslo, Oslo, Norway.
Breen G Breen Gerome G Social, Genetic and Developmental Psychiatric Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Nestadt G Nestadt Gerald G Department of Psychiatry and Behavioral Science, Johns Hopkins University, Baltimore, MD, USA.
Kaprio J Kaprio Jaakko J FIMM, University of Helsinki, Helsinki, Finland.
Arnold PD Arnold Paul D PD Program in Genetics and Genome Biology, Hospital for Sick Children, Toronto, Ontario, Canada.
Grice DE Grice Dorothy E DE Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Knowles JA Knowles James A JA Department of Genetics, Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ, USA.
Ask H Ask Helga H PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
Verweij KJ Verweij Karin J KJ Department of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Davis LK Davis Lea K LK Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Smit DJ Smit Dirk J DJ Department of Psychiatry, Amsterdam UMC location AMC, Amsterdam, the Netherlands.
Crowley JJ Crowley James J JJ Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Scharf JM Scharf Jeremiah M JM Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Stein MB Stein Murray B MB Department of Psychiatry and School of Public Health, University of California San Diego, La Jolla, CA, USA.
Gelernter J Gelernter Joel J Department of Psychiatry, Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA.
Mathews CA Mathews Carol A CA Psychiatry and Genetics Institute, Evelyn F. and William L. Mc Knight Brain Institute, Center for OCD, Anxiety and Related Disorders, University of Florida, Gainesville, FL, USA.
Derks EM Derks Eske M EM Department of Mental Health and Neuroscience, QIMR Berghofer, Brisbane, Queensland, Australia.
Mattheisen M Mattheisen Manuel M Department of Community Health and Epidemiology and Faculty of Computer Science, Dalhousie University, Halifax, Nova Scotia, Canada. manuel.mattheisen@dal.ca.
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
German Chris C
JOURNAL
VOLUME: 57
ISSUE: 6
TITLE: Nature genetics
ISOABBREVIATION: Nat Genet
YEAR: 2025
MONTH: Jun
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1546-1718
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Genet
COUNTRY: United States
ISSNLINKING: 1061-4036
NLMUNIQUEID: 9216904
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Meta-Analysis
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
UpdateOf medRxiv. 2024 Mar 13:2024.03.13.24304161. doi: 10.1101/2024.03.13.24304161. 38712091
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R21 MH109938 NIMH NIH HHS United States
R01 MH079489 NIMH NIH HHS United States
R01 MH085321 NIMH NIH HHS United States
R01 MH059299 NIMH NIH HHS United States
R01 MH124873 NIMH NIH HHS United States
R01 MH093381 NIMH NIH HHS United States
R01 AA026364 NIAAA NIH HHS United States
R01 HD074711 NICHD NIH HHS United States
R01 MH114927 NIMH NIH HHS United States
U01 HG006378 NHGRI NIH HHS United States
K23 MH066284 NIMH NIH HHS United States
R01 MH058376 NIMH NIH HHS United States
UL1 RR024975 NCRR NIH HHS United States
R01 MH105500 NIMH NIH HHS United States
R01 NS032830 NINDS NIH HHS United States
U01 HG004798 NHGRI NIH HHS United States
U10 AA008401 NIAAA NIH HHS United States
R01 MH110427 NIMH NIH HHS United States
UL1 TR002243 NCATS NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Humans
Obsessive-Compulsive Disorder genetics
Genome-Wide Association Study genetics
Genetic Predisposition to Disease genetics
Polymorphism, Single Nucleotide genetics
Adult genetics
Female genetics
Male genetics
Genetic Loci genetics
Case-Control Studies genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
Designed by: GenEpi IT
Maintained by: GenEpi IT
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Last Modified: Oct 15 2007