|
|
| PMID |
|
|
| TITLE |
|
| Caffeine Consumption, Psychological Distress, and Insomnia in a Cohort of Individuals with Depression. |
|
| ABSTRACT |
|
| INTRODUCTION |
NlmCategory: UNASSIGNED |
| Caffeine is a widely consumed psychoactive compound that can cause anxiety and sleep difficulties, in part due to genetic variation. We investigated the association between caffeine consumption, psychological distress, and sleep difficulties in a genetically informative cohort of individuals with a history of depression. |
| METHODS |
NlmCategory: UNASSIGNED |
| Caffeine is a widely consumed psychoactive compound that can cause anxiety and sleep difficulties, in part due to genetic variation. We investigated the association between caffeine consumption, psychological distress, and sleep difficulties in a genetically informative cohort of individuals with a history of depression. Survey data and genetic information were sourced from the Australian Genetics of Depression Study (AGDS [ = 20,689, % = 75%, mean age = 43 ± 15 years]). Associations between caffeine consumption and symptoms of distress and sleep disturbance, as well as 9 genetic variants associated with caffeine consumption behaviour, were assessed using linear regression. |
| RESULTS |
NlmCategory: UNASSIGNED |
| Caffeine is a widely consumed psychoactive compound that can cause anxiety and sleep difficulties, in part due to genetic variation. We investigated the association between caffeine consumption, psychological distress, and sleep difficulties in a genetically informative cohort of individuals with a history of depression. Survey data and genetic information were sourced from the Australian Genetics of Depression Study (AGDS [ = 20,689, % = 75%, mean age = 43 ± 15 years]). Associations between caffeine consumption and symptoms of distress and sleep disturbance, as well as 9 genetic variants associated with caffeine consumption behaviour, were assessed using linear regression. The highest consumers of caffeine reported higher psychological distress measured by the Kessler 10 scale (β = 1.21, SE = 0.25, = 1.4 × 10 ) compared to the lowest consumers. Consumption was associated with 2 genetic variants with effect sizes ∼0.35 additional caffeinated drinks/day between opposite homozygotes ( < 0.005). A deletion near was associated with 10% increased odds of reporting caffeine susceptibility (OR = 1.1 per deletion [95% CI: 1.04-1.17], = 0.002). |
| CONCLUSIONS |
NlmCategory: UNASSIGNED |
| Caffeine is a widely consumed psychoactive compound that can cause anxiety and sleep difficulties, in part due to genetic variation. We investigated the association between caffeine consumption, psychological distress, and sleep difficulties in a genetically informative cohort of individuals with a history of depression. Survey data and genetic information were sourced from the Australian Genetics of Depression Study (AGDS [ = 20,689, % = 75%, mean age = 43 ± 15 years]). Associations between caffeine consumption and symptoms of distress and sleep disturbance, as well as 9 genetic variants associated with caffeine consumption behaviour, were assessed using linear regression. The highest consumers of caffeine reported higher psychological distress measured by the Kessler 10 scale (β = 1.21, SE = 0.25, = 1.4 × 10 ) compared to the lowest consumers. Consumption was associated with 2 genetic variants with effect sizes ∼0.35 additional caffeinated drinks/day between opposite homozygotes ( < 0.005). A deletion near was associated with 10% increased odds of reporting caffeine susceptibility (OR = 1.1 per deletion [95% CI: 1.04-1.17], = 0.002). Higher rates of caffeine consumption were associated with higher levels of psychological distress, but not insomnia, in individuals with a history of depression. While the direction of causality is unclear, caffeine consumption may be a modifiable factor to reduce distress in individuals susceptible to mental health problems. Some of the previous findings of common variant associations with caffeine consumption and susceptibility were replicated. |
| © 2025 The Author(s). Published by S. Karger AG, Basel. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| received |
2024/11/01 |
| accepted |
2025/03/13 |
| pmc-release |
2025/09/24 |
| medline |
2025/05/02 11:07 |
| pubmed |
2025/05/02 11:06 |
| entrez |
2025/05/02 04:28 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| McIntosh HA |
|
McIntosh |
Harry A |
HA |
|
Child Health Research Centre, The University of Queensland, Brisbane, QLD, Australia. |
| Borgas AJ |
|
Borgas |
Aleah J |
AJ |
|
School of Psychology, The University of Queensland, Brisbane, QLD, Australia. |
| Aouira N |
|
Aouira |
Nisreen |
N |
|
School of Public Health, The University of Queensland, Brisbane, QLD, Australia. |
| Mitchell BL |
|
Mitchell |
Brittany L |
BL |
|
QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
| Crouse JJ |
|
Crouse |
Jacob J |
JJ |
|
Youth Mental Health and Technology Team, Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia. |
| Medland SE |
|
Medland |
Sarah E |
SE |
|
QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
| Hickie IB |
|
Hickie |
Ian B |
IB |
|
Youth Mental Health and Technology Team, Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia. |
| Wray NR |
|
Wray |
Naomi R |
NR |
|
Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
| Middeldorp CM |
|
Middeldorp |
Christel M |
CM |
|
Child and Youth Mental Health Service, Children's Health Queensland Hospital and Health Service, Brisbane, QLD, Australia. |
| Byrne EM |
|
Byrne |
Enda M |
EM |
|
Child Health Research Centre, The University of Queensland, Brisbane, QLD, Australia. |
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 11 |
| ISSUE: 1 |
| TITLE: Complex psychiatry |
| ISOABBREVIATION: Complex Psychiatry |
| YEAR: 2025 |
| MONTH: |
| DAY: |
| MEDLINEDATE: |
| SEASON: Jan-Dec |
| CITEDMEDIUM: Print |
| ISSN: 2673-3005 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
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| MEDLINETA: Complex Psychiatry |
| COUNTRY: Switzerland |
| ISSNLINKING: 2673-298X |
| NLMUNIQUEID: 101764441 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| ADORA2A |
| AHR |
| CYP1A1 |
| CYP1A2 |
| Caffeine |
| Insomnia |
| Psychiatric disorders |
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| MESH HEADINGS |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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