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| PMID |
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| TITLE |
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| Polygenic Scores for Dizygotic Twinning: Insights into the Genetic Architecture of Female Fertility. |
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| ABSTRACT |
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| Natural dizygotic twinning (DZT) results from hyper-ovulation and is considered an indicator of female fertility. DZT has low polygenicity, with only 0.20% of SNPs estimated to have a nonzero effect. A polygenic score (PGS) for DZT explains 1.6% of variance in DZT liability and we observe an odds ratio of 2.29 between the 1 and the 10 PGS decile. The PGS is higher in mothers of naturally conceived twins compared to mothers who received fertility (MAR) treatments in both the Netherlands and Norway. The largest differences were observed for mothers who received hormonal ovulation induction, indicating maternal fertility issues. A higher PGS was also linked to shorter time to pregnancy. DZT showed significant negative genetic correlations with anovulatory infertility (r = -0.698) and PCOS (r = -0.278), and a positive genetic correlation with endometriosis (r = 0.279). These findings suggest DZT PGS is an important, yet under-recognized fertility marker. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
2025/03/17 15:20 |
| medline |
2025/03/17 15:21 |
| entrez |
2025/03/17 06:30 |
| pmc-release |
2025/03/14 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Hubers N |
|
Hubers |
Nikki |
N |
|
Department of Complex Trait Genetics, Centre for Neurogenomics and Cognitive Research, Amsterdam, Vrije Universiteit Amsterdam. |
| Page CM |
|
Page |
Christian M |
CM |
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Department of Physical Health and Aging, Norwegian Institute of Public Health, Oslo, Norway. |
| Pool R |
|
Pool |
René |
R |
|
Amsterdam Public Health Research Institute, Amsterdam, the Netherlands. |
| Mbarek H |
|
Mbarek |
Hamdi |
H |
|
Qatar Genome Program, Qatar Foundation Research, Development and Innovation, Qatar Foundation, Doha, Qatar. |
| Lambalk N |
|
Lambalk |
Nils |
N |
|
Amsterdam Reproduction & Development (AR&D) Research Institute, Amsterdam, the Netherlands. |
| Mijatovic V |
|
Mijatovic |
Velja |
V |
|
Amsterdam Reproduction & Development (AR&D) Research Institute, Amsterdam, the Netherlands. |
| Ligthart L |
|
Ligthart |
Lannie |
L |
|
Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. |
| van Dongen J |
|
van Dongen |
Jenny |
J |
|
Amsterdam Public Health Research Institute, Amsterdam, the Netherlands. |
| Corfield EC |
|
Corfield |
Elizabeth C |
EC |
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Nic Waals Institute, Lovisenberg Diaconal Hospital & PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health. |
| Beck JJ |
|
Beck |
Jeffrey J |
JJ |
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Avera McKennan Hospital & University Health Center, Sioux Falls, South Dakota, USA. |
| Ehli EA |
|
Ehli |
Erik A |
EA |
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Avera McKennan Hospital & University Health Center, Sioux Falls, South Dakota, USA. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
| Willemsen G |
|
Willemsen |
Gonneke |
G |
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Faculty of Health, Sports and Social Work, Inholland University of Applied Sciences, Haarlem, the Netherlands. |
| Håberg S |
|
Håberg |
Siri |
S |
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Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway. |
| Harris JR |
|
Harris |
Jennifer R |
JR |
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Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway. |
| Hottenga JJ |
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Hottenga |
Jouke-Jan |
JJ |
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Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. |
| Boomsma DI |
|
Boomsma |
Dorret I |
DI |
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Amsterdam Public Health Research Institute, Amsterdam, the Netherlands. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: |
| ISSUE: |
| TITLE: medRxiv : the preprint server for health sciences |
| ISOABBREVIATION: medRxiv |
| YEAR: 2025 |
| MONTH: Mar |
| DAY: 05 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: |
| ISSNTYPE: |
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| MEDLINE JOURNAL |
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| MEDLINETA: medRxiv |
| COUNTRY: United States |
| ISSNLINKING: |
| NLMUNIQUEID: 101767986 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
| Preprint |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GRANTID |
AGENCY |
COUNTRY |
| EP-C-15-001 |
EPA |
United States |
| RC2 MH089995 |
NIMH NIH HHS |
United States |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| Dizygotic Twinning |
| Female Fertility |
| Medically Assisted reproduction (MAR) |
| Polygenic Scores (PGS) |
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| MESH HEADINGS |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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