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| PMID |
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| TITLE |
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| Genetic and environmental influences on alcohol consumption in middle to late life. |
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| ABSTRACT |
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| OBJECTIVE |
NlmCategory: OBJECTIVE |
| Alcohol use is common in older adults and linked to poor health and aging outcomes. Studies have demonstrated genetic and environmental contributions to the quantity of alcohol consumption in mid-to-late life, but less is known about whether these influences are moderated by sociodemographic factors such as age, sex, and educational attainment. This study sought to better understand sociodemographic trends in alcohol consumption across the second half of the life course and their underlying genetic and environmental influences. |
| METHOD |
NlmCategory: METHODS |
| Alcohol use is common in older adults and linked to poor health and aging outcomes. Studies have demonstrated genetic and environmental contributions to the quantity of alcohol consumption in mid-to-late life, but less is known about whether these influences are moderated by sociodemographic factors such as age, sex, and educational attainment. This study sought to better understand sociodemographic trends in alcohol consumption across the second half of the life course and their underlying genetic and environmental influences. Primary analyses were based on 64,140 middle-aged or older adult twins (40-102 years) from 14 studies in the Interplay of Genes and Environment Across Multiple Studies consortium. We harmonized a measure of weekly alcohol consumption (in grams of ethanol per week) across all studies. |
| RESULTS |
NlmCategory: RESULTS |
| Alcohol use is common in older adults and linked to poor health and aging outcomes. Studies have demonstrated genetic and environmental contributions to the quantity of alcohol consumption in mid-to-late life, but less is known about whether these influences are moderated by sociodemographic factors such as age, sex, and educational attainment. This study sought to better understand sociodemographic trends in alcohol consumption across the second half of the life course and their underlying genetic and environmental influences. Primary analyses were based on 64,140 middle-aged or older adult twins (40-102 years) from 14 studies in the Interplay of Genes and Environment Across Multiple Studies consortium. We harmonized a measure of weekly alcohol consumption (in grams of ethanol per week) across all studies. Older age was associated with lower alcohol consumption, primarily for adults over age 75, for individuals with higher education, and for males. Trends were similar across birth cohorts and after excluding current abstainers. At mean age 56, alcohol use was moderately heritable in females (.34, 95% CI [.26, .41]) and more heritable in males (.42, 95% CI [.38, .45]). Heritability was lower in older aged adults and in females with higher education. |
| CONCLUSIONS |
NlmCategory: CONCLUSIONS |
| Alcohol use is common in older adults and linked to poor health and aging outcomes. Studies have demonstrated genetic and environmental contributions to the quantity of alcohol consumption in mid-to-late life, but less is known about whether these influences are moderated by sociodemographic factors such as age, sex, and educational attainment. This study sought to better understand sociodemographic trends in alcohol consumption across the second half of the life course and their underlying genetic and environmental influences. Primary analyses were based on 64,140 middle-aged or older adult twins (40-102 years) from 14 studies in the Interplay of Genes and Environment Across Multiple Studies consortium. We harmonized a measure of weekly alcohol consumption (in grams of ethanol per week) across all studies. Older age was associated with lower alcohol consumption, primarily for adults over age 75, for individuals with higher education, and for males. Trends were similar across birth cohorts and after excluding current abstainers. At mean age 56, alcohol use was moderately heritable in females (.34, 95% CI [.26, .41]) and more heritable in males (.42, 95% CI [.38, .45]). Heritability was lower in older aged adults and in females with higher education. This study represents the largest twin study of alcohol consumption in middle-aged and older adults. Results highlight that genetic and environmental factors influence alcohol consumption differently across age, sex, and educational attainment and that intervention efforts may need to be tailored based on individuals' backgrounds. (PsycInfo Database Record (c) 2025 APA, all rights reserved). |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
2025/01/09 16:58 |
| medline |
2025/01/09 16:58 |
| entrez |
2025/01/09 11:54 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Gustavson DE |
|
Gustavson |
Daniel E |
DE |
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Department of Psychology and Neuroscience, Institute for Behavioral Genetics, University of Colorado Boulder. |
| Bell TR |
|
Bell |
Tyler R |
TR |
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Department of Psychiatry, Center for Behavior Genetics of Aging, University of California, San Diego. |
| Buchholz EJ |
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Buchholz |
Erik J |
EJ |
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Department of Psychiatry, Center for Behavior Genetics of Aging, University of California, San Diego. |
| Zellers S |
|
Zellers |
Stephanie |
S |
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Institute for Molecular Medicine Finland, University of Helsinki. |
| Luczak SE |
|
Luczak |
Susan E |
SE |
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Department of Psychology, University of Southern California. |
| Reynolds CA |
|
Reynolds |
Chandra A |
CA |
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Department of Psychology and Neuroscience, Institute for Behavioral Genetics, University of Colorado Boulder. |
| Finch BK |
|
Finch |
Brian K |
BK |
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Department of Sociology, Center for Economic and Social Research, University of Southern California. |
| Nygaard M |
|
Nygaard |
Marianne |
M |
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Department of Public Health, Danish Twin Registry, University of Southern Denmark. |
| Catts VS |
|
Catts |
Vibeke S |
VS |
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Centre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, University of New South Wales Sydney. |
| Christensen K |
|
Christensen |
Kaare |
K |
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Department of Public Health, Danish Twin Registry, University of Southern Denmark. |
| Finkel D |
|
Finkel |
Deborah |
D |
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Department of Psychology, Center for Economic and Social Research, University of Southern California. |
| Kremen WS |
|
Kremen |
William S |
WS |
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Department of Psychiatry, Center for Behavior Genetics of Aging, University of California, San Diego. |
| Latvala A |
|
Latvala |
Antti |
A |
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Institute of Criminology and Legal Policy, University of Helsinki. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
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Queensland Institute of Medical Research Berghofer Medical Research Institute. |
| McGue M |
|
McGue |
Matt |
M |
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Department of Psychology, University of Southern California. |
| Mewton L |
|
Mewton |
Louise |
L |
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Centre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, University of New South Wales Sydney. |
| Mosing MA |
|
Mosing |
Miriam A |
MA |
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Department of Neuroscience, Karolinska Institutet. |
| Panizzon MS |
|
Panizzon |
Matthew S |
MS |
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Department of Psychiatry, Center for Behavior Genetics of Aging, University of California, San Diego. |
| Plassman BL |
|
Plassman |
Brenda L |
BL |
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Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine. |
| Kaprio J |
|
Kaprio |
Jaakko |
J |
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Institute for Molecular Medicine Finland, University of Helsinki. |
| Gatz M |
|
Gatz |
Margaret |
M |
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Department of Psychology, Center for Economic and Social Research, University of Southern California. |
| Franz CE |
|
Franz |
Carol E |
CE |
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Department of Psychiatry, Center for Behavior Genetics of Aging, University of California, San Diego. |
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IGEMS Consortium |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: |
| ISSUE: |
| TITLE: Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors |
| ISOABBREVIATION: Psychol Addict Behav |
| YEAR: 2025 |
| MONTH: Jan |
| DAY: 09 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1939-1501 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Psychol Addict Behav |
| COUNTRY: United States |
| ISSNLINKING: 0893-164X |
| NLMUNIQUEID: 8802734 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GRANTID |
AGENCY |
COUNTRY |
| R56 AG037985 |
NIA NIH HHS |
United States |
| R01 AG060470 |
NIA NIH HHS |
United States |
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National Institutes of Health; National Institute on Aging |
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| R01 AG076838 |
NIA NIH HHS |
United States |
| RF1 AG058068 |
NIA NIH HHS |
United States |
| R01 AG050595 |
NIA NIH HHS |
United States |
| R01 AG089666 |
NIA NIH HHS |
United States |
| R01 AG059329 |
NIA NIH HHS |
United States |
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| GENERAL NOTE |
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