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| PMID |
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| TITLE |
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| Polygenic risk scores and help-seeking behaviour in young people with recent onset of mood and psychotic disorders. |
|
| ABSTRACT |
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| OBJECTIVES |
NlmCategory: OBJECTIVE |
| We examined associations between polygenic risk scores (PRS) for depression (PRS-MDD), psychosis (PRS-SCZ), bipolar disorders (PRS-BD) and neuroticism (PRS-NEU) and (i) help-seeking, and (ii) new onset cases of full-threshold mood or psychotic disorders in youth. |
| METHODS |
NlmCategory: METHODS |
| We examined associations between polygenic risk scores (PRS) for depression (PRS-MDD), psychosis (PRS-SCZ), bipolar disorders (PRS-BD) and neuroticism (PRS-NEU) and (i) help-seeking, and (ii) new onset cases of full-threshold mood or psychotic disorders in youth. Help-seeking for mental health problems was assessed by self-report and mood and psychotic disorders were identified using the Composite International Diagnostic Interview. A principal component analysis of the four selected PRS identified two dimensions (BD-SCZ; MDD-NEU) that accounted for 69.9 % of the explained variance. We explored the associations between these PRS dimensions and help-seeking and diagnostic subgroup using analyses of co-variance (ANCOVA) adjusted for variables of influence (such as age, sex, twin status). |
| RESULTS |
NlmCategory: RESULTS |
| We examined associations between polygenic risk scores (PRS) for depression (PRS-MDD), psychosis (PRS-SCZ), bipolar disorders (PRS-BD) and neuroticism (PRS-NEU) and (i) help-seeking, and (ii) new onset cases of full-threshold mood or psychotic disorders in youth. Help-seeking for mental health problems was assessed by self-report and mood and psychotic disorders were identified using the Composite International Diagnostic Interview. A principal component analysis of the four selected PRS identified two dimensions (BD-SCZ; MDD-NEU) that accounted for 69.9 % of the explained variance. We explored the associations between these PRS dimensions and help-seeking and diagnostic subgroup using analyses of co-variance (ANCOVA) adjusted for variables of influence (such as age, sex, twin status). Almost 30 % (409 of 1473) of study participants met CIDI criteria for ≥ 1 mood or psychotic disorder. Overall, 60 % (n = 245) of CIDI cases sought help, ranging from 35 % for psychosis to 77 % for mania. Furthermore, 143 help-seekers did not have a CIDI diagnosis of mood or psychotic disorders. The BD-SCZ dimension showed associations with help-seeking behaviour and diagnostic groups, but the MDD-NEU dimension only showed associations with help-seeking. |
| LIMITATIONS |
NlmCategory: CONCLUSIONS |
| We examined associations between polygenic risk scores (PRS) for depression (PRS-MDD), psychosis (PRS-SCZ), bipolar disorders (PRS-BD) and neuroticism (PRS-NEU) and (i) help-seeking, and (ii) new onset cases of full-threshold mood or psychotic disorders in youth. Help-seeking for mental health problems was assessed by self-report and mood and psychotic disorders were identified using the Composite International Diagnostic Interview. A principal component analysis of the four selected PRS identified two dimensions (BD-SCZ; MDD-NEU) that accounted for 69.9 % of the explained variance. We explored the associations between these PRS dimensions and help-seeking and diagnostic subgroup using analyses of co-variance (ANCOVA) adjusted for variables of influence (such as age, sex, twin status). Almost 30 % (409 of 1473) of study participants met CIDI criteria for ≥ 1 mood or psychotic disorder. Overall, 60 % (n = 245) of CIDI cases sought help, ranging from 35 % for psychosis to 77 % for mania. Furthermore, 143 help-seekers did not have a CIDI diagnosis of mood or psychotic disorders. The BD-SCZ dimension showed associations with help-seeking behaviour and diagnostic groups, but the MDD-NEU dimension only showed associations with help-seeking. Some diagnoses could not be studied in detail (i.e., schizophreniform disorders) due to the small size of subgroups and planned analyses needed to be adjusted for the presence of twins and non-twin siblings. |
| CONCLUSIONS |
NlmCategory: CONCLUSIONS |
| We examined associations between polygenic risk scores (PRS) for depression (PRS-MDD), psychosis (PRS-SCZ), bipolar disorders (PRS-BD) and neuroticism (PRS-NEU) and (i) help-seeking, and (ii) new onset cases of full-threshold mood or psychotic disorders in youth. Help-seeking for mental health problems was assessed by self-report and mood and psychotic disorders were identified using the Composite International Diagnostic Interview. A principal component analysis of the four selected PRS identified two dimensions (BD-SCZ; MDD-NEU) that accounted for 69.9 % of the explained variance. We explored the associations between these PRS dimensions and help-seeking and diagnostic subgroup using analyses of co-variance (ANCOVA) adjusted for variables of influence (such as age, sex, twin status). Almost 30 % (409 of 1473) of study participants met CIDI criteria for ≥ 1 mood or psychotic disorder. Overall, 60 % (n = 245) of CIDI cases sought help, ranging from 35 % for psychosis to 77 % for mania. Furthermore, 143 help-seekers did not have a CIDI diagnosis of mood or psychotic disorders. The BD-SCZ dimension showed associations with help-seeking behaviour and diagnostic groups, but the MDD-NEU dimension only showed associations with help-seeking. Some diagnoses could not be studied in detail (i.e., schizophreniform disorders) due to the small size of subgroups and planned analyses needed to be adjusted for the presence of twins and non-twin siblings. Signals of genetic liability are higher in young people who seek help from health services whether or not the problem they are seeking help for meets full-threshold diagnostic criteria for a major mental disorder. |
| Copyright © 2024 Elsevier B.V. All rights reserved. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2024/09/16 |
| revised |
2024/11/18 |
| accepted |
2024/11/21 |
| medline |
2025/01/14 00:20 |
| pubmed |
2024/12/01 15:22 |
| entrez |
2024/11/30 19:29 |
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| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Scott J |
|
Scott |
Jan |
J |
|
Brain and Mind Centre, The University of Sydney, Sydney, Australia; Institute of Neuroscience, Newcastle University, Newcastle, United Kingdom. Electronic address: jan.scott@newcastle.ac.uk. |
| Crouse JJ |
|
Crouse |
Jacob J |
JJ |
|
Brain and Mind Centre, The University of Sydney, Sydney, Australia. |
| Medland SE |
|
Medland |
Sarah E |
SE |
|
Brain and Mental Health Program, QIMR Berghofer Institute of Medical Research, Brisbane, Australia; Institute of Molecular Bioscience, The University of Queensland, Brisbane, Australia; School of Psychology, The University of Queensland, Brisbane, Queensland, Australia; School of Psychology and Counselling, Queensland University of Techonology, Brisbane, Queensland, Australia. |
| Mitchell BL |
|
Mitchell |
Brittany L |
BL |
|
Brain and Mental Health Program, QIMR Berghofer Institute of Medical Research, Brisbane, Australia; Institute of Molecular Bioscience, The University of Queensland, Brisbane, Australia. |
| Gillespie NA |
|
Gillespie |
Nathan A |
NA |
|
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
Brain and Mental Health Program, QIMR Berghofer Institute of Medical Research, Brisbane, Australia. |
| Hickie IB |
|
Hickie |
Ian B |
IB |
|
Brain and Mind Centre, The University of Sydney, Sydney, Australia. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 372 |
| ISSUE: |
| TITLE: Journal of affective disorders |
| ISOABBREVIATION: J Affect Disord |
| YEAR: 2025 |
| MONTH: Mar |
| DAY: 01 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1573-2517 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: J Affect Disord |
| COUNTRY: Netherlands |
| ISSNLINKING: 0165-0327 |
| NLMUNIQUEID: 7906073 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| Bipolar |
| Help seeking |
| Psychosis polygenic risk scores |
| Unipolar |
| Youth |
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| MESH HEADINGS |
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| DESCRIPTORNAME |
QUALIFIERNAME |
| Humans |
|
| Male |
|
| Female |
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| Psychotic Disorders |
psychology |
| Adolescent |
psychology |
| Multifactorial Inheritance |
genetics |
| Bipolar Disorder |
genetics |
| Young Adult |
genetics |
| Help-Seeking Behavior |
genetics |
| Neuroticism |
genetics |
| Mood Disorders |
genetics |
| Adult |
genetics |
| Genetic Predisposition to Disease |
genetics |
| Patient Acceptance of Health Care |
statistics & numerical data |
| Risk Factors |
statistics & numerical data |
| Depressive Disorder, Major |
genetics |
| Genetic Risk Score |
genetics |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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