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| PMID |
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| TITLE |
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| Models for the joint effect of genotype and environment on liability to psychiatric illness. |
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| ABSTRACT |
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| The authors present three major models for the joint effect of genes and environment on liability to psychiatric illness: additive effects of genotype and environment, genetic control of sensitivity to the environment, and genetic control of exposure to the environment. Each model is illustrated by several examples, including a quantitative one. The authors attempt to demonstrate that genes and the environment can interact in several interesting and potentially subtle ways, that these interactions can be expressed in simple models from which clear empirical predictions can be generated, and that elucidation of the etiology of psychiatric disorders will require the consideration of both genetic and environmental risk factors. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
1986/03/01 |
| medline |
1986/03/01 00:01 |
| entrez |
1986/03/01 00:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Kendler KS |
|
Kendler |
K S |
KS |
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| Eaves LJ |
|
Eaves |
L J |
LJ |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 143 |
| ISSUE: 3 |
| TITLE: The American journal of psychiatry |
| ISOABBREVIATION: Am J Psychiatry |
| YEAR: 1986 |
| MONTH: Mar |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 0002-953X |
| ISSNTYPE: Print |
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| MEDLINE JOURNAL |
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| MEDLINETA: Am J Psychiatry |
| COUNTRY: United States |
| ISSNLINKING: 0002-953X |
| NLMUNIQUEID: 0370512 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, Non-U.S. Gov't |
| Research Support, U.S. Gov't, P.H.S. |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GRANTID |
AGENCY |
COUNTRY |
| GM-30520 |
NIGMS NIH HHS |
United States |
| GM-32732 |
NIGMS NIH HHS |
United States |
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| GENERAL NOTE |
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| KEYWORDS |
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| MESH HEADINGS |
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| DESCRIPTORNAME |
QUALIFIERNAME |
| Depressive Disorder |
genetics |
| Diseases in Twins |
genetics |
| Genes |
genetics |
| Genotype |
genetics |
| Humans |
genetics |
| Mental Disorders |
genetics |
| Models, Genetic |
genetics |
| Models, Theoretical |
genetics |
| Research Design |
genetics |
| Risk |
genetics |
| Schizophrenia |
genetics |
| Smoking |
genetics |
| Social Environment |
genetics |
| Twins, Dizygotic |
genetics |
| Twins, Monozygotic |
genetics |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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