Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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39433889
TITLE
Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries.
ABSTRACT
Subcortical brain structures are involved in developmental, psychiatric and neurological disorders. Here we performed genome-wide association studies meta-analyses of intracranial and nine subcortical brain volumes (brainstem, caudate nucleus, putamen, hippocampus, globus pallidus, thalamus, nucleus accumbens, amygdala and the ventral diencephalon) in 74,898 participants of European ancestry. We identified 254 independent loci associated with these brain volumes, explaining up to 35% of phenotypic variance. We observed gene expression in specific neural cell types across differentiation time points, including genes involved in intracellular signaling and brain aging-related processes. Polygenic scores for brain volumes showed predictive ability when applied to individuals of diverse ancestries. We observed causal genetic effects of brain volumes with Parkinson's disease and attention-deficit/hyperactivity disorder. Findings implicate specific gene expression patterns in brain development and genetic variants in comorbid neuropsychiatric disorders, which could point to a brain substrate and region of action for risk genes implicated in brain diseases.
© 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.
DATE PUBLISHED
2024 Nov
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2023/08/09
accepted 2024/09/18
medline 2024/11/13 13:53
pubmed 2024/10/22 00:21
entrez 2024/10/21 23:38
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
García-Marín LM García-Marín Luis M LM School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.
Campos AI Campos Adrian I AI Institute for Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.
Diaz-Torres S Diaz-Torres Santiago S Population Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Rabinowitz JA Rabinowitz Jill A JA Department of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, USA.
Ceja Z Ceja Zuriel Z School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.
Mitchell BL Mitchell Brittany L BL School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.
Grasby KL Grasby Katrina L KL School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.
Thorp JG Thorp Jackson G JG Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Agartz I Agartz Ingrid I Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Services, Stockholm, Sweden.
Alhusaini S Alhusaini Saud S Molecular and Cellular Therapeutics Department, Royal College of Surgeons in Ireland, Dublin, Ireland.
Ames D Ames David D National Ageing Research Institute, Parkville, Victoria, Australia.
Amouyel P Amouyel Philippe P Institut Pasteur de Lille UMR1167, Lille, France.
Andreassen OA Andreassen Ole A OA KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway.
Arfanakis K Arfanakis Konstantinos K Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA.
Arias-Vasquez A Arias-Vasquez Alejandro A Departments of Psychiatry and Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
Armstrong NJ Armstrong Nicola J NJ Department of Mathematics and Statistics, Curtin University, Perth, Western Australia, Australia.
Athanasiu L Athanasiu Lavinia L CoE NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Bastin ME Bastin Mark E ME Centre for Clinical Brain Sciences and Edinburgh Imaging, University of Edinburgh, Edinburgh, UK.
Beiser AS Beiser Alexa S AS Framingham Heart Study, Chobanian and Avedisian Boston University School of Medicine, Boston, MA, USA.
Bennett DA Bennett David A DA Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
Bis JC Bis Joshua C JC Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Boks MPM Boks Marco P M MPM Brain Center University Medical Center Utrecht, Utrecht, The Netherlands.
Boomsma DI Boomsma Dorret I DI Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU Amsterdam, Amsterdam, The Netherlands.
Brodaty H Brodaty Henry H Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia.
Brouwer RM Brouwer Rachel M RM Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU Amsterdam, Amsterdam, The Netherlands.
Buitelaar JK Buitelaar Jan K JK Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
Burkhardt R Burkhardt Ralph R LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Cahn W Cahn Wiepke W Altrecht Mental Health Institute, Utrecht, The Netherlands.
Calhoun VD Calhoun Vince D VD Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS)-Georgia State, Georgia Tech and Emory University, Atlanta, GA, USA.
Carmichael OT Carmichael Owen T OT Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Chakravarty M Chakravarty Mallar M Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
Chen Q Chen Qiang Q Lieber Institute for Brain Development, Baltimore, MD, USA.
Ching CRK Ching Christopher R K CRK Laboratory of Neuro Imaging, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Cichon S Cichon Sven S Medical Genetics, Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.
Crespo-Facorro B Crespo-Facorro Benedicto B HU Virgen del Rocio, Instituto de Investigacion Biomedica IBIS-CSIC, Universidad de Sevilla, CIBERSAM, Sevilla, Spain.
Crivello F Crivello Fabrice F CNRS, IMN, UMR 5293, University of Bordeaux, Bordeaux, France.
Dale AM Dale Anders M AM Center for Multimodal Imaging and Genetics, La Jolla, CA, USA.
Smith GD Smith George Davey GD Population Health Sciences, University of Bristol, Bristol, UK.
de Geus EJC de Geus Eco J C EJC Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
De Jager PL De Jager Philip L PL Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York City, NY, USA.
de Zubicaray GI de Zubicaray Greig I GI School of Psychology and Counselling, Queensland University of Technology, Brisbane, Queensland, Australia.
Debette S Debette Stéphanie S Department of Neurology, Institute of Neurodegenerative Diseases, Bordeaux University Hospital, Bordeaux, France.
DeCarli C DeCarli Charles C Imaging of Dementia and Aging Laboratory, Department of Neurology, University of California, Davis, Sacramento, CA, USA.
Depondt C Depondt Chantal C Department of Neurology, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Brussels, Belgium.
Desrivières S Desrivières Sylvane S Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Djurovic S Djurovic Srdjan S Department of Clinical Science, University of Bergen, Bergen, Norway.
Ehrlich S Ehrlich Stefan S Translational Developmental Neuroscience Section, Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, Dresden, Germany.
Erk S Erk Susanne S Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Espeseth T Espeseth Thomas T Department of Psychology, Oslo New University College, Oslo, Norway.
Fernández G Fernández Guillén G Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
Filippi I Filippi Irina I INSERM U1299, Paris Saclay University, Gif-sur-Yvette, France.
Fisher SE Fisher Simon E SE Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
Fleischman DA Fleischman Debra A DA Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA.
Fletcher E Fletcher Evan E Department of Neurology, University of California, Davis, Davis, CA, USA.
Fornage M Fornage Myriam M Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Forstner AJ Forstner Andreas J AJ Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.
Francks C Francks Clyde C Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands.
Franke B Franke Barbara B Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
Ge T Ge Tian T Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Goldman AL Goldman Aaron L AL Lieber Institute for Brain Development, Baltimore, MD, USA.
Grabe HJ Grabe Hans J HJ Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Green RC Green Robert C RC Department of Medicine (Genetics), Mass General Brigham and Harvard Medical School, Boston, MA, USA.
Grimm O Grimm Oliver O Goethe-University Frankfurt, Frankfurt, Germany.
Groenewold NA Groenewold Nynke A NA Department of Psychiatry and Mental Health, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Gruber O Gruber Oliver O Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany.
Gudnason V Gudnason Vilmundur V Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Håberg AK Håberg Asta K AK MiDT National Research Center, Department of Research, St Olavs Hospital, Trondheim, Norway.
Haukvik UK Haukvik Unn K UK Centre for Forensic Psychiatry Research, Oslo University Hospital, Oslo, Norway.
Heinz A Heinz Andreas A Centre for Forensic Psychiatry Research, Oslo University Hospital, Oslo, Norway.
Hibar DP Hibar Derrek P DP Product Development, Genentech, Inc., South San Francisco, CA, USA.
Hilal S Hilal Saima S Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore City, Singapore.
Himali JJ Himali Jayandra J JJ Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
Ho BC Ho Beng-Choon BC Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Hoehn DF Hoehn David F DF Max Planck Institute of Psychiatry, Munich, Germany.
Hoekstra PJ Hoekstra Pieter J PJ Accare Child Study Center, Groningen, The Netherlands.
Hofer E Hofer Edith E Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria.
Hoffmann W Hoffmann Wolfgang W Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Holmes AJ Holmes Avram J AJ Department of Psychiatry, Brain Health Institute, Rutgers University, Piscataway, NJ, USA.
Homuth G Homuth Georg G Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Hosten N Hosten Norbert N Department of Radiology, University Clinic Greifswald, Greifswald, Germany.
Ikram MK Ikram M Kamran MK Departments of Epidemiology and Neurology, Erasmus MC, Rotterdam, The Netherlands.
Ipser JC Ipser Jonathan C JC Department of Psychiatry and Mental Health, Neuroscience Institute, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.
Jack CR Jr Jack Clifford R CR Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Jahanshad N Jahanshad Neda N Laboratory of Neuro Imaging, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Jönsson EG Jönsson Erik G EG Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Sciences, Stockholm Region, Stockholm, Sweden.
Kahn RS Kahn Rene S RS Altrecht Mental Health Institute, Utrecht, The Netherlands.
Kanai R Kanai Ryota R Araya, Inc, Tokyo, Japan.
Klein M Klein Marieke M Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
Knol MJ Knol Maria J MJ Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Launer LJ Launer Lenore J LJ Intramural Research Program, National Institute on Aging, Baltimore, MD, USA.
Lawrie SM Lawrie Stephen M SM Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
Hellard SL Hellard Stephanie Le SL Department of Clinical Science, University of Bergen, Bergen, Norway.
Lee PH Lee Phil H PH Stanley Center for Psychiatry, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Lemaître H Lemaître Hervé H Groupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives, UMR 5293, CNRS, Université de Bordeaux, Bordeaux, France.
Li S Li Shuo S Framingham Heart Study, Chobanian and Avedisian Boston University School of Medicine, Boston, MA, USA.
Liewald DCM Liewald David C M DCM PPLS, University of Edinburgh, Edinburgh, UK.
Lin H Lin Honghuang H Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Longstreth WT Jr Longstreth W T WT Department of Epidemiology, University of Washington, Seattle, WA, USA.
Lopez OL Lopez Oscar L OL Departments of Neurology and Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Luciano M Luciano Michelle M Department of Psychology, University of Edinburgh, Edinburgh, UK.
Maillard P Maillard Pauline P Department of Neurology, University of California, Davis, Davis, CA, USA.
Marquand AF Marquand Andre F AF Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
Martin NG Martin Nicholas G NG Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Martinot JL Martinot Jean-Luc JL Université Paris-Saclay, Institut National de la Santé et de la Recherche Médicale, INSERM U1299 'Trajectoires développementales Psychiatrie', Ecole Normale Supérieure Paris-Saclay, CNRS UMR 9010, Université Paris Cité, Centre Borelli, Gif sur Yvette, France.
Mather KA Mather Karen A KA Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia.
Mattay VS Mattay Venkata S VS Lieber Institute for Brain Development, Baltimore, MD, USA.
McMahon KL McMahon Katie L KL School of Clinical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia.
Mecocci P Mecocci Patrizia P Clinical Geriatrics, NVS Department, Karolinska Institute, Huddinge, Sweden.
Melle I Melle Ingrid I Centre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Meyer-Lindenberg A Meyer-Lindenberg Andreas A Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Mirza-Schreiber N Mirza-Schreiber Nazanin N Neurogenetic Systems Analysis Group, Institute of Neurogenomics, Helmholtz Munich, Neuherberg, Germany.
Milaneschi Y Milaneschi Yuri Y Amsterdam Neuroscience, Complex Trait Genetics Program, Amsterdam, The Netherlands.
Mosley TH Mosley Thomas H TH MIND Center, Jackson, MS, USA.
Mühleisen TW Mühleisen Thomas W TW Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland.
Müller-Myhsok B Müller-Myhsok Bertram B Statistics Genetics Group, Max Planck Institute of Psychiatry, Munich, Germany.
Maniega SM Maniega Susana Muñoz SM Centre for Clinical Brain Sciences and Edinburgh Imaging, University of Edinburgh, Edinburgh, UK.
Nauck M Nauck Matthias M German Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, Germany.
Nho K Nho Kwangsik K Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, USA.
Niessen WJ Niessen Wiro J WJ University Medical Center Groningen, Groningen, The Netherlands.
Nöthen MM Nöthen Markus M MM Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.
Nyquist PA Nyquist Paul A PA General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Oosterlaan J Oosterlaan Jaap J Amsterdam Reproduction and Development Research Institute, Amsterdam, The Netherlands.
Pandolfo M Pandolfo Massimo M Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
Paus T Paus Tomas T Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal, Quebec, Canada.
Pausova Z Pausova Zdenka Z Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
Penninx BWJH Penninx Brenda W J H BWJH Department of Psychiatry, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Pike GB Pike G Bruce GB Departments of Radiology and Clinical Neurosciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Psaty BM Psaty Bruce M BM Department of Health Systems and Population Health, Seattle, WA, USA.
Pütz B Pütz Benno B Translational Psychiatry, Munich, Germany.
Reppermund S Reppermund Simone S Department of Developmental Disability Neuropsychiatry, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia.
Rietschel MD Rietschel Marcella D MD Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany.
Risacher SL Risacher Shannon L SL Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, USA.
Romanczuk-Seiferth N Romanczuk-Seiferth Nina N Department of Psychology, Clinical Psychology and Psychotherapy, MSB Medical School Berlin, Berlin, Germany.
Romero-Garcia R Romero-Garcia Rafael R Department of Psychiatry, University of Cambridge, Cambridge, UK.
Roshchupkin GV Roshchupkin Gennady V GV Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Rotter JI Rotter Jerome I JI The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Sachdev PS Sachdev Perminder S PS Neuropsychiatric Institute, The Prince of Wales Hospital, Randwick, New South Wales, Australia.
Sämann PG Sämann Philipp G PG Max Planck Institute of Psychiatry, Munich, Germany.
Saremi A Saremi Arvin A Laboratory of Neuro Imaging, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Sargurupremraj M Sargurupremraj Muralidharan M Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA.
Saykin AJ Saykin Andrew J AJ Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, USA.
Schmaal L Schmaal Lianne L Orygen, Parkville, Victoria, Australia.
Schmidt H Schmidt Helena H Institute of Molecular Biology and Biochemistry, Gottfried Schatz Center for Signaling, Metabolism and Aging, Medical University Graz, Graz, Austria.
Schmidt R Schmidt Reinhold R Department of Neurology, Medical University Graz Austria, Graz, Austria.
Schofield PR Schofield Peter R PR School of Biomedical Sciences, University of New South Wales, Sydney, New South Wales, Australia.
Scholz M Scholz Markus M Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
Schumann G Schumann Gunter G PONS Centre, Department of Psychiatry, CCM, Charite Unversitaetsmedizin Berlin, Berlin, Germany.
Schwarz E Schwarz Emanuel E Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Shen L Shen Li L Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Shin J Shin Jean J The Hospital for Sick Children, Departments of Physiology and Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada.
Sisodiya SM Sisodiya Sanjay M SM Chalfont Centre for Epilepsy, Chalfont St Peter, UK.
Smith AV Smith Albert V AV Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Smoller JW Smoller Jordan W JW Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Soininen HS Soininen Hilkka S HS Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
Steen VM Steen Vidar M VM Dr. Einar Martens Research Group for Biological Psychiatry, Department of Medical Genetics, Haukeland University Hospital, Bergen, Norway.
Stein DJ Stein Dan J DJ SAMRC Research Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Stein JL Stein Jason L JL Department of Genetics and UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Thomopoulos SI Thomopoulos Sophia I SI Laboratory of Neuro Imaging, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Toga AW Toga Arthur W AW Laboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.
Tordesillas-Gutiérrez D Tordesillas-Gutiérrez Diana D Department of Radiology, Marqués de Valdecilla University Hospital, Valdecilla Biomedical Research Institute IDIVAL, Santander, Spain.
Trollor JN Trollor Julian N JN The National Centre of Excellence in Intellectual Disability Health, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia.
Valdes-Hernandez MC Valdes-Hernandez Maria C MC Centre for Clinical Brain Sciences and Edinburgh Imaging, University of Edinburgh, Edinburgh, UK.
van T Ent D van T Ent Dennis D Department of Biological Psychology and Netherlands Twin Register, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
van Bokhoven H van Bokhoven Hans H Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
van der Meer D van der Meer Dennis D School of Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.
van der Wee NJA van der Wee Nic J A NJA Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.
Vázquez-Bourgon J Vázquez-Bourgon Javier J Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM), Sevilla, Spain.
Veltman DJ Veltman Dick J DJ Department of Psychiatry, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Vernooij MW Vernooij Meike W MW Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Villringer A Villringer Arno A Cognitive Neurology, University of Leipzig Medical Center, Leipzig, Germany.
Vinke LN Vinke Louis N LN Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Völzke H Völzke Henry H Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Walter H Walter Henrik H Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Wardlaw JM Wardlaw Joanna M JM UK Dementia Research Institute Centre, University of Edinburgh, Edinburgh, UK.
Weinberger DR Weinberger Daniel R DR Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Weiner MW Weiner Michael W MW Veterans Administration Medical Center, San Francisco, CA, USA.
Wen W Wen Wei W Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia.
Westlye LT Westlye Lars T LT Department of Psychology, University of Oslo, Oslo, Norway.
Westman E Westman Eric E Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Huddinge, Sweden.
White T White Tonya T Section on Social and Cognitive Developmental Neuroscience, National Institute of Mental Health, Bethesda, MD, USA.
Witte AV Witte A Veronica AV Cognitive Neurology, University of Leipzig Medical Center, Leipzig, Germany.
Wolf C Wolf Christiane C Max Planck Institute of Psychiatry, Munich, Germany.
Yang J Yang Jingyun J Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
Zwiers MP Zwiers Marcel P MP Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
Ikram MA Ikram M Arfan MA Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Seshadri S Seshadri Sudha S Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA.
Thompson PM Thompson Paul M PM Laboratory of Neuro Imaging, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Satizabal CL Satizabal Claudia L CL Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.
Medland SE Medland Sarah E SE School of Psychology, The University of Queensland, Brisbane, Queensland, Australia.
Rentería ME Rentería Miguel E ME School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia. miguel.renteria@qimrberghofer.edu.au.
INVESTIGATORS
JOURNAL
VOLUME: 56
ISSUE: 11
TITLE: Nature genetics
ISOABBREVIATION: Nat Genet
YEAR: 2024
MONTH: Nov
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1546-1718
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Genet
COUNTRY: United States
ISSNLINKING: 1061-4036
NLMUNIQUEID: 9216904
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
UpdateOf medRxiv. 2024 Aug 15:2024.08.13.24311922. doi: 10.1101/2024.08.13.24311922 39371125
GRANTS
GRANTID AGENCY COUNTRY
U01 AG068221 NIA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Humans
Genome-Wide Association Study
Multifactorial Inheritance genetics
Brain pathology
Female pathology
Male pathology
Organ Size genetics
Attention Deficit Disorder with Hyperactivity pathology
Parkinson Disease pathology
Polymorphism, Single Nucleotide pathology
Genomics methods
Adult methods
Genetic Predisposition to Disease methods
Middle Aged methods
White People genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
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