Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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38951643
TITLE
Understanding the genetic complexity of puberty timing across the allele frequency spectrum.
ABSTRACT
Pubertal timing varies considerably and is associated with later health outcomes. We performed multi-ancestry genetic analyses on ~800,000 women, identifying 1,080 signals for age at menarche. Collectively, these explained 11% of trait variance in an independent sample. Women at the top and bottom 1% of polygenic risk exhibited ~11 and ~14-fold higher risks of delayed and precocious puberty, respectively. We identified several genes harboring rare loss-of-function variants in ~200,000 women, including variants in ZNF483, which abolished the impact of polygenic risk. Variant-to-gene mapping approaches and mouse gonadotropin-releasing hormone neuron RNA sequencing implicated 665 genes, including an uncharacterized G-protein-coupled receptor, GPR83, which amplified the signaling of MC3R, a key nutritional sensor. Shared signals with menopause timing at genes involved in DNA damage response suggest that the ovarian reserve might signal centrally to trigger puberty. We also highlight body size-dependent and independent mechanisms that potentially link reproductive timing to later life disease.
© 2024. The Author(s).
DATE PUBLISHED
2024 Jul 01
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2023/06/12
accepted 2024/05/13
medline 2024/07/02 00:42
pubmed 2024/07/02 00:42
entrez 2024/07/01 23:44
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Kentistou KA Kentistou Katherine A KA MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Kaisinger LR Kaisinger Lena R LR MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Stankovic S Stankovic Stasa S MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Vaudel M Vaudel Marc M Department of Genetics and Bioinformatics, Health Data and Digitalization, Norwegian Institute of Public Health, Oslo, Norway.
Mendes de Oliveira E Mendes de Oliveira Edson E University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
Messina A Messina Andrea A Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
Walters RG Walters Robin G RG Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Liu X Liu Xiaoxi X Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Busch AS Busch Alexander S AS Department of Growth and Reproduction, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
Helgason H Helgason Hannes H School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland.
Thompson DJ Thompson Deborah J DJ Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Santoni F Santoni Federico F Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
Petricek KM Petricek Konstantin M KM Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Pharmacology, Berlin, Germany.
Zouaghi Y Zouaghi Yassine Y Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
Huang-Doran I Huang-Doran Isabel I University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
Gudbjartsson DF Gudbjartsson Daniel F DF School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland.
Bratland E Bratland Eirik E Department of Medical Genetics, Haukeland University Hospital, Bergen, Norway.
Lin K Lin Kuang K Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Gardner EJ Gardner Eugene J EJ MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Zhao Y Zhao Yajie Y MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Jia RY Jia Raina Y RY MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Terao C Terao Chikashi C Department of Applied Genetics, The School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
Riggan MJ Riggan Marjorie J MJ Department of Gynecology, Duke University Medical Center, Durham, NC, USA.
Bolla MK Bolla Manjeet K MK Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Yazdanpanah M Yazdanpanah Mojgan M Research Center of the Sainte-Justine University Hospital, University of Montreal, Montreal, Quebec, Canada.
Yazdanpanah N Yazdanpanah Nahid N Research Center of the Sainte-Justine University Hospital, University of Montreal, Montreal, Quebec, Canada.
Bradfield JP Bradfield Jonathan P JP Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Broer L Broer Linda L Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
Campbell A Campbell Archie A Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Chasman DI Chasman Daniel I DI Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Cousminer DL Cousminer Diana L DL Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Franceschini N Franceschini Nora N Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
Franke LH Franke Lude H LH Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Girotto G Girotto Giorgia G Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
He C He Chunyan C Cancer Prevention and Control Research Program, Markey Cancer Center, University of Kentucky, Lexington, KY, USA.
Järvelin MR Järvelin Marjo-Riitta MR Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland.
Joshi PK Joshi Peter K PK Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland.
Kamatani Y Kamatani Yoichiro Y Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
Karlsson R Karlsson Robert R Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Luan J Luan Jian'an J MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Lunetta KL Lunetta Kathryn L KL NHLBI's and Boston University's Framingham Heart Study, Framingham, MA, USA.
Mägi R Mägi Reedik R Institute of Genomics, University of Tartu, Tartu, Estonia.
Mangino M Mangino Massimo M NIHR Biomedical Research Centre at Guy's and St. Thomas' Foundation Trust, London, UK.
Medland SE Medland Sarah E SE Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.
Meisinger C Meisinger Christa C Epidemiology, Medical Faculty, University of Augsburg, University Hospital of Augsburg, Augsburg, Germany.
Noordam R Noordam Raymond R Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
Nutile T Nutile Teresa T Institute of Genetics and Biophysics 'A. Buzzati-Traverso', CNR, Naples, Italy.
Concas MP Concas Maria Pina MP Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, Italy.
Polašek O Polašek Ozren O Algebra University College, Zagreb, Croatia.
Porcu E Porcu Eleonora E Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
Ring SM Ring Susan M SM Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK.
Sala C Sala Cinzia C Division of Genetics and Cell Biology, San Raffele Hospital, Milano, Italy.
Smith AV Smith Albert V AV Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Tanaka T Tanaka Toshiko T National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
van der Most PJ van der Most Peter J PJ Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Vitart V Vitart Veronique V MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Wang CA Wang Carol A CA Hunter Medical Research Institute, Newcastle, New South Wales, Australia.
Willemsen G Willemsen Gonneke G Department of Biological Psychology, Vrije Universiteit Amsterdam; Amsterdam Public Health (APH) Research Institute, Amsterdam, The Netherlands.
Zygmunt M Zygmunt Marek M Clinic of Gynaecology and Obstetrics, University Medicine Greifswald, Greifswald, Germany.
Ahearn TU Ahearn Thomas U TU Division of Cancer Epidemiology and Genetics National Cancer Institute, National Institutes of Health, Department of Health and Human Services Bethesda, Bethesda, MD, USA.
Andrulis IL Andrulis Irene L IL Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Anton-Culver H Anton-Culver Hoda H Department of Medicine, Genetic Epidemiology Research Institute, University of California Irvine, Irvine, CA, USA.
Antoniou AC Antoniou Antonis C AC Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Auer PL Auer Paul L PL Division of Biostatistics, Institute for Health and Equity and Cancer Center, Medical College of Wisconsin, Milwaukee, WI, USA.
Barnes CLK Barnes Catriona L K CLK Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland.
Beckmann MW Beckmann Matthias W MW Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany.
Berrington de Gonzalez A Berrington de Gonzalez Amy A Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Bogdanova NV Bogdanova Natalia V NV N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus.
Bojesen SE Bojesen Stig E SE Department of Clinical Biochemistry, Herlev and Gentofte Hospital Copenhagen University Hospital, Herlev, Denmark.
Brenner H Brenner Hermann H German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Buring JE Buring Julie E JE Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Canzian F Canzian Federico F Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Chang-Claude J Chang-Claude Jenny J Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Couch FJ Couch Fergus J FJ Department of Laboratory Medicine and Pathology, Mayo Clinic Rochester, Rochester, MN, USA.
Cox A Cox Angela A Sheffield Institute for Nucleic Acids (SInFoNiA), Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
Crisponi L Crisponi Laura L Institute of Genetics and Biomedical Research, National Research Council, Sardinia, Italy.
Czene K Czene Kamila K Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Daly MB Daly Mary B MB Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA, USA.
Demerath EW Demerath Ellen W EW Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Dennis J Dennis Joe J Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Devilee P Devilee Peter P Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
De Vivo I De Vivo Immaculata I Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Dörk T Dörk Thilo T Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.
Dunning AM Dunning Alison M AM Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Dwek M Dwek Miriam M School of Life Sciences, University of Westminster, London, UK.
Eriksson JG Eriksson Johan G JG Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore City, Singapore.
Fasching PA Fasching Peter A PA Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany.
Fernandez-Rhodes L Fernandez-Rhodes Lindsay L Department of Biobehavioral Health, Pennsylvania State University, University Park, PA, USA.
Ferreli L Ferreli Liana L Institute of Genetics and Biomedical Research, National Research Council, Sardinia, Italy.
Fletcher O Fletcher Olivia O The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
Gago-Dominguez M Gago-Dominguez Manuela M Genomic Medicine Group, International Cancer Genetics and Epidemiology Group Fundación Pública Galega de Medicina Xenómica, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS Santiago de Compostela, Coruña, Spain.
García-Closas M García-Closas Montserrat M Division of Cancer Epidemiology and Genetics National Cancer Institute, National Institutes of Health, Department of Health and Human Services Bethesda, Bethesda, MD, USA.
García-Sáenz JA García-Sáenz José A JA Medical Oncology Department, Hospital Clínico San Carlos Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.
González-Neira A González-Neira Anna A Human Genotyping Unit-CeGen, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Grallert H Grallert Harald H Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Guénel P Guénel Pascal P Team 'Exposome and Heredity', CESP, Gustave Roussy INSERM, University Paris-Saclay, UVSQ, Orsay, France.
Haiman CA Haiman Christopher A CA Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Hall P Hall Per P Department of Oncology, Södersjukhuset, Stockholm, Sweden.
Hamann U Hamann Ute U Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Hakonarson H Hakonarson Hakon H Division of Pulmonary Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Hart RJ Hart Roger J RJ Division of Obstetrics and Gynaecology, University of Western Australia, Crawley, Western Australia, Australia.
Hickey M Hickey Martha M Department of Obstetrics and Gynaecology, University of Melbourne and The Royal Women's Hospital, Parkville, Victoria, Australia.
Hooning MJ Hooning Maartje J MJ Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Hoppe R Hoppe Reiner R University of Tübingen, Tübingen, Germany.
Hopper JL Hopper John L JL Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Hottenga JJ Hottenga Jouke-Jan JJ Department of Biological Psychology, Vrije Universiteit Amsterdam; Amsterdam Public Health (APH) Research Institute, Amsterdam, The Netherlands.
Hu FB Hu Frank B FB Department of Nutrition, Harvard T.H. Chan School of Public Health School of Public Health, Boston, MA, USA.
Huebner H Huebner Hanna H Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany.
Hunter DJ Hunter David J DJ Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
ABCTB Investigators
Jernström H Jernström Helena H Oncology, Department of Clinical Sciences in Lund, Lund University, Lund, Sweden.
John EM John Esther M EM Department of Medicine, Division of Oncology Stanford Cancer Institute, Stanford University School of Medicine Stanford, Stanford, CA, USA.
Karasik D Karasik David D Harvard Medical School, Boston, MA, USA.
Khusnutdinova EK Khusnutdinova Elza K EK Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russia.
Kristensen VN Kristensen Vessela N VN Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Lacey JV Lacey James V JV City of Hope Comprehensive Cancer Center, City of Hope, Duarte, CA, USA.
Lambrechts D Lambrechts Diether D VIB Center for Cancer Biology, VIB, Leuven, Belgium.
Launer LJ Launer Lenore J LJ Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.
Lind PA Lind Penelope A PA School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia.
Lindblom A Lindblom Annika A Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.
Magnusson PKE Magnusson Patrik K E PKE Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Mannermaa A Mannermaa Arto A Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland.
McCarthy MI McCarthy Mark I MI NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, UK.
Meitinger T Meitinger Thomas T Institute of Human Genetics, Klinikum rechts der Isar, Technical University of Munich, School of Medicine, Munich, Germany.
Menni C Menni Cristina C Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Michailidou K Michailidou Kyriaki K Biostatistics Unit, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.
Millwood IY Millwood Iona Y IY Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Milne RL Milne Roger L RL Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
Montgomery GW Montgomery Grant W GW Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Nevanlinna H Nevanlinna Heli H Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Nolte IM Nolte Ilja M IM Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Nyholt DR Nyholt Dale R DR School of Biomedical Sciences, Faculty of Health, Centre for Genomics and Personalised Health, Queensland University of Technology, Brisbane, Queensland, Australia.
Obi N Obi Nadia N Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
O'Brien KM O'Brien Katie M KM Epidemiology Branch, National Institute of Environmental Health Sciences, NIH Research Triangle Park, Durham, NC, USA.
Offit K Offit Kenneth K Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York City, NY, USA.
Oldehinkel AJ Oldehinkel Albertine J AJ Interdisciplinary Center Psychopathology and Emotion Regulation, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Ostrowski SR Ostrowski Sisse R SR Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Palotie A Palotie Aarno A Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Pedersen OB Pedersen Ole B OB Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark.
Peters A Peters Annette A Institute for Medical Information Processing, Biometry and Epidemiology-IBE, Ludwig-Maximilians-Universität München, Munich, Germany.
Pianigiani G Pianigiani Giulia G Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, Italy.
Plaseska-Karanfilska D Plaseska-Karanfilska Dijana D Research Centre for Genetic Engineering and Biotechnology 'Georgi D. Efremov', MASA, Skopje, Republic of North Macedonia.
Pouta A Pouta Anneli A National Institute for Health and Welfare, Helsinki, Finland.
Pozarickij A Pozarickij Alfred A Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Radice P Radice Paolo P Unit of Preventive Medicine: Molecular Bases of Genetic Risk, Department of Experimental Oncology, Fondazione IRCCS, Istituto Nazionale dei Tumori (INT), Milan, Italy.
Rennert G Rennert Gad G Faculty of Medicine, Clalit National Cancer Control Center, Carmel Medical Center and Technion, Haifa, Israel.
Rosendaal FR Rosendaal Frits R FR Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Ruggiero D Ruggiero Daniela D IRCCS Neuromed, Isernia, Italy.
Saloustros E Saloustros Emmanouil E Division of Oncology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
Sandler DP Sandler Dale P DP Epidemiology Branch, National Institute of Environmental Health Sciences, NIH Research Triangle Park, Durham, NC, USA.
Schipf S Schipf Sabine S Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Schmidt CO Schmidt Carsten O CO Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Schmidt MK Schmidt Marjanka K MK Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Small K Small Kerrin K Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Spedicati B Spedicati Beatrice B Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Stampfer M Stampfer Meir M Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Stone J Stone Jennifer J Genetic Epidemiology Group, School of Population and Global Health, University of Western Australia Perth, Perth, Western Australia, Australia.
Tamimi RM Tamimi Rulla M RM Department of Population Health Sciences, Weill Cornell Medicine, New York City, NY, USA.
Teras LR Teras Lauren R LR Department of Population Science, American Cancer Society, Atlanta, GA, USA.
Tikkanen E Tikkanen Emmi E Public Health Genomics Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.
Turman C Turman Constance C Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Vachon CM Vachon Celine M CM Department of Quantitative Health Sciences, Division of Epidemiology, Mayo Clinic Rochester, Rochester, MN, USA.
Wang Q Wang Qin Q Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Winqvist R Winqvist Robert R Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre, Oulu, Finland.
Wolk A Wolk Alicja A Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Zemel BS Zemel Babette S BS Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Zheng W Zheng Wei W Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
van Dijk KW van Dijk Ko W KW Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands.
Alizadeh BZ Alizadeh Behrooz Z BZ Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Bandinelli S Bandinelli Stefania S Geriatric Unit, Local Health Toscana Centro, Florence, Italy.
Boerwinkle E Boerwinkle Eric E Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.
Boomsma DI Boomsma Dorret I DI Amsterdam Reproduction and Development Research Institute, Amsterdam, The Netherlands.
Ciullo M Ciullo Marina M IRCCS Neuromed, Isernia, Italy.
Chenevix-Trench G Chenevix-Trench Georgia G QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Cucca F Cucca Francesco F Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
Esko T Esko Tõnu T Institute of Genomics, University of Tartu, Tartu, Estonia.
Gieger C Gieger Christian C German Center for Diabetes Research (DZD), Neuherberg, Germany.
Grant SFA Grant Struan F A SFA Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Gudnason V Gudnason Vilmundur V Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Hayward C Hayward Caroline C MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Kolčić I Kolčić Ivana I Algebra University College, Zagreb, Croatia.
Kraft P Kraft Peter P Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Lawlor DA Lawlor Deborah A DA Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Nøhr EA Nøhr Ellen A EA Institute of Clinical Research, University of Southern Denmark, Department of Obstetrics and Gynecology, Odense University Hospital, Odense, Denmark.
Pedersen NL Pedersen Nancy L NL Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Pennell CE Pennell Craig E CE Department of Maternity and Gynaecology, John Hunter Hospital, Newcastle, New South Wales, Australia.
Ridker PM Ridker Paul M PM Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Robino A Robino Antonietta A Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, Italy.
Snieder H Snieder Harold H Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Sovio U Sovio Ulla U Department of Obstetrics and Gynaecology, University of Cambridge, Cambridge, UK.
Spector TD Spector Tim D TD Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Stöckl D Stöckl Doris D State Institute of Health, Bavarian Health and Food Safety Authority (LGL), Oberschleissheim, Germany.
Sudlow C Sudlow Cathie C Centre for Medical Informatics, Usher Institute, University of Edinburgh, Edinburgh, UK.
Timpson NJ Timpson Nic J NJ Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK.
Toniolo D Toniolo Daniela D Division of Genetics and Cell Biology, San Raffele Hospital, Milano, Italy.
Uitterlinden A Uitterlinden André A Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
Ulivi S Ulivi Sheila S Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, Italy.
Völzke H Völzke Henry H Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Wareham NJ Wareham Nicholas J NJ MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Widen E Widen Elisabeth E Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Wilson JF Wilson James F JF Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland.
Lifelines Cohort Study
Danish Blood Donor Study
Ovarian Cancer Association Consortium
Breast Cancer Association Consortium
Biobank Japan Project
China Kadoorie Biobank Collaborative Group
Pharoah PDP Pharoah Paul D P PDP Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Li L Li Liming L Center for Public Health and Epidemic Preparedness and Response, Peking University, Beijing, China.
Easton DF Easton Douglas F DF Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Njølstad PR Njølstad Pål R PR Children and Adolescent Clinic, Haukeland University Hospital, Bergen, Norway.
Sulem P Sulem Patrick P deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Murabito JM Murabito Joanne M JM Boston University Chobanian and Avedisian School of Medicine, Department of Medicine, Section of General Internal Medicine, Boston, MA, USA.
Murray A Murray Anna A Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, RILD Level 3, Royal Devon and Exeter Hospital, Exeter, UK.
Manousaki D Manousaki Despoina D Department of Biochemistry and Molecular Medicine, University of Montreal, Montreal, Quebec, Canada.
Juul A Juul Anders A Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Erikstrup C Erikstrup Christian C Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Stefansson K Stefansson Kari K Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Horikoshi M Horikoshi Momoko M Laboratory for Genomics of Diabetes and Metabolism, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Chen Z Chen Zhengming Z Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Farooqi IS Farooqi I Sadaf IS University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
Pitteloud N Pitteloud Nelly N Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
Johansson S Johansson Stefan S Department of Medical Genetics, Haukeland University Hospital, Bergen, Norway.
Day FR Day Felix R FR MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Perry JRB Perry John R B JRB Metabolic Research Laboratory, Wellcome-MRC Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK. john.perry@mrc-epid.cam.ac.uk.
Ong KK Ong Ken K KK Department of Paediatrics, University of Cambridge, Cambridge, UK.
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
John Esther M EM
Hall Per P
Winqvis Robert R
JOURNAL
VOLUME:
ISSUE:
TITLE: Nature genetics
ISOABBREVIATION: Nat Genet
YEAR: 2024
MONTH: Jul
DAY: 01
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1546-1718
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Genet
COUNTRY: United States
ISSNLINKING: 1061-4036
NLMUNIQUEID: 9216904
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
MC_UU_00006/2 RCUK | MRC | Medical Research Foundation
MC_UU_00006/2 RCUK | MRC | Medical Research Foundation
MC_UU_00006/2 RCUK | MRC | Medical Research Foundation
MC_UU_00006/2 RCUK | MRC | Medical Research Foundation
MC_UU_00006/2 RCUK | MRC | Medical Research Foundation
GENERAL NOTE
KEYWORDS
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
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