Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
38746362
TITLE
Genetics of environmental sensitivity to psychiatric and neurodevelopmental phenotypes: evidence from GWAS of monozygotic twins.
ABSTRACT
Individual sensitivity to environmental exposures may be genetically influenced. This genotype-by-environment interplay implies differences in phenotypic variance across genotypes. However, environmental sensitivity genetic variants have proven challenging to detect. GWAS of monozygotic twin differences is a family-based variance analysis method, which is more robust to systemic biases that impact population-based methods. We combined data from up to 21,792 monozygotic twins (10,896 pairs) from 11 studies to conduct the largest GWAS meta-analysis of monozygotic phenotypic differences in children and adolescents/adults for seven psychiatric and neurodevelopmental phenotypes: attention deficit hyperactivity disorder (ADHD) symptoms, autistic traits, anxiety and depression symptoms, psychotic-like experiences, neuroticism, and wellbeing. The SNP-heritability of variance in these phenotypes were estimated (h2: 0% to 18%), but were imprecise. We identified a total of 13 genome-wide significant associations (SNP, gene, and gene-set), including genes related to stress-reactivity for depression, growth factor-related genes for autistic traits and catecholamine uptake-related genes for psychotic-like experiences. Monozygotic twins are an important new source of evidence about the genetics of environmental sensitivity.
DATE PUBLISHED
2024 May 02
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2024/05/15 11:43
medline 2024/05/15 11:44
entrez 2024/05/15 03:58
pmc-release 2024/05/14
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Assary E Assary Elham E Kings College London.
Coleman J Coleman Jonathan J Institute of Psychiatry, Psychology, and Neuroscience, King's College London.
Hemani G Hemani Gibran G University of Bristol.
van Der Veijer M van Der Veijer Margot M Vrije Universiteit Amsterdam.
Howe L Howe Laurence L University of Bristol.
Palviainen T Palviainen Teemu T Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki.
Grasby K Grasby Katrina K QIMR Berghofer Medical Research Institute.
Ahlskog R Ahlskog Rafael R Uppsala University.
Nygaard M Nygaard Marianne M Danish Twin Registry.
Cheesman R Cheesman Rosa R University of Oslo.
Lim K Lim Kai K King's College London.
Reynolds C Reynolds Chandra C University of Colorado Boulder.
Ordoñana J Ordoñana Juan J University of Murcia.
Colodro-Conde L Colodro-Conde Lucia L QIMR Berghofer Medical Research Institute.
Gordon S Gordon Scott S QIMR Berghofer Medical Research Institute.
Madrid-Valero J Madrid-Valero Juan J University of Murcia.
Thalamuthu A Thalamuthu Anbupalam A University of New South Wales.
Hottenga JJ Hottenga Jouke-Jan JJ Vrije Universiteit.
Mengel-From J Mengel-From Jonas J University of Southern Denmark.
Armstrong NJ Armstrong Nicola J NJ Curtin University.
Sachdev P Sachdev Perminder P University of New South Wales.
Lee T Lee Teresa T University of New South Wales.
Brodaty H Brodaty Henry H Centre for Healthy Brain Ageing.
Trollor J Trollor Julian J University of New South Wales.
Wright M Wright Margaret M The University of Queensland.
Ames D Ames David D University of Melbourne.
Catts V Catts Vibeke V University of New South Wales.
Latvala A Latvala Antti A University of Helsinki.
Vuoksimaa E Vuoksimaa Eero E University of Helsinki.
Mallard T Mallard Travis T Massachusetts General Hospital.
Harden K Harden K K University of Texas at Austin.
Tucker-Drob E Tucker-Drob Elliot E The University of Texas at Austin.
Oskarsson S Oskarsson Sven S Uppsala University.
Hammond C Hammond Christopher C King's College London.
Christensen K Christensen Kaare K University of Southern Denmark.
Taylor M Taylor Mark M Karolinska Institutet.
Lundström S Lundström Sebastian S University of Gothenburg.
Larsson H Larsson Henrik H Dummy.
Karlsson R Karlsson Robert R Karolinska Institutet.
Pedersen N Pedersen Nancy N Karolinska Institute.
Mather K Mather Karen K Centre for Healthy Brain Ageing, Psychiatry, University of New South Wales (UNSW).
Medland S Medland Sarah S QIMR Berghofer Medical Research Institute.
Boomsma D Boomsma D D Vrije Universiteit Amsterdam, The Netherlands.
Martin N Martin Nicholas N QIMR Berghofer Medical Research Institute.
Plomin R Plomin Robert R Institute of Psychiatry, Psychology and Neuroscience, King's College London, London.
Bartels M Bartels Meike M VU University Amsterdam.
Lichtenstein P Lichtenstein Paul P Karolinska Institute.
Kaprio J Kaprio Jaakko J University of Helsinki.
Eley T Eley Thalia T King's College London.
Davies N Davies Neil N University College London.
Munroe P Munroe Patricia P Queen Mary University of London.
Keers R Keers Robert R Queen Mary University of London.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Research square
ISOABBREVIATION: Res Sq
YEAR: 2024
MONTH: May
DAY: 02
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2693-5015
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Res Sq
COUNTRY: United States
ISSNLINKING: 2693-5015
NLMUNIQUEID: 101768035
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Preprint
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
EP-C-15-001 EPA United States
R01 AG059329 NIA NIH HHS United States
R01 AG008724 NIA NIH HHS United States
R01 AG037985 NIA NIH HHS United States
R01 AG017561 NIA NIH HHS United States
R01 AG060470 NIA NIH HHS United States
K05 AA000145 NIAAA NIH HHS United States
R01 AA012502 NIAAA NIH HHS United States
R01 AG010175 NIA NIH HHS United States
R01 AG046938 NIA NIH HHS United States
R01 AA009203 NIAAA NIH HHS United States
R01 MH130448 NIMH NIH HHS United States
R01 AG028555 NIA NIH HHS United States
K02 AA018755 NIAAA NIH HHS United States
P01 AG008761 NIA NIH HHS United States
Wellcome Trust United Kingdom
R01 AA015416 NIAAA NIH HHS United States
R37 AA012502 NIAAA NIH HHS United States
R01 AG050595 NIA NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
environmental sensitivity
gene-environmental interaction
vQTLs
variance effects
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
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