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| PMID |
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| Patterns of stressful life events and polygenic scores for five mental disorders and neuroticism among adults with depression. |
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| ABSTRACT |
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| The dominant ('general') version of the diathesis-stress theory of depression views stressors and genetic vulnerability as independent risks. In the Australian Genetics of Depression Study (N = 14,146; 75% female), we tested whether polygenic scores (PGS) for major depression, bipolar disorder, schizophrenia, anxiety, ADHD, and neuroticism were associated with reported exposure to 32 childhood, past-year, lifetime, and accumulated stressful life events (SLEs). In false discovery rate-corrected models, the clearest PGS-SLE relationships were for the ADHD- and depression-PGSs, and to a lesser extent, the anxiety- and schizophrenia-PGSs. We describe the associations for childhood and accumulated SLEs, and the 2-3 strongest past-year/lifetime SLE associations. Higher ADHD-PGS was associated with all childhood SLEs (emotional abuse, emotional neglect, physical neglect; ORs = 1.09-1.14; p's < 1.3 × 10 ), more accumulated SLEs, and reported exposure to sudden violent death (OR = 1.23; p = 3.6 × 10 ), legal troubles (OR = 1.15; p = 0.003), and sudden accidental death (OR = 1.14; p = 0.006). Higher depression-PGS was associated with all childhood SLEs (ORs = 1.07-1.12; p's < 0.013), more accumulated SLEs, and severe human suffering (OR = 1.17; p = 0.003), assault with a weapon (OR = 1.12; p = 0.003), and living in unpleasant surroundings (OR = 1.11; p = 0.001). Higher anxiety-PGS was associated with childhood emotional abuse (OR = 1.08; p = 1.6 × 10 ), more accumulated SLEs, and serious accident (OR = 1.23; p = 0.004), physical assault (OR = 1.08; p = 2.2 × 10 ), and transportation accident (OR = 1.07; p = 0.001). Higher schizophrenia-PGS was associated with all childhood SLEs (ORs = 1.12-1.19; p's < 9.3 ), more accumulated SLEs, and severe human suffering (OR = 1.16; p = 0.003). Higher neuroticism-PGS was associated with living in unpleasant surroundings (OR = 1.09; p = 0.007) and major financial troubles (OR = 1.06; p = 0.014). A reversed pattern was seen for the bipolar-PGS, with lower odds of reported physical assault (OR = 0.95; p = 0.014), major financial troubles (OR = 0.93; p = 0.004), and living in unpleasant surroundings (OR = 0.92; p = 0.007). Genetic risk for several mental disorders influences reported exposure to SLEs among adults with moderately severe, recurrent depression. Our findings emphasise that stressors and diatheses are inter-dependent and challenge diagnosis and subtyping (e.g., reactive/endogenous) based on life events. |
| © 2024. The Author(s). |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2023/06/06 |
| accepted |
2024/02/20 |
| revised |
2024/02/08 |
| medline |
2024/04/05 00:42 |
| pubmed |
2024/04/05 00:42 |
| entrez |
2024/04/04 23:29 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Crouse JJ |
|
Crouse |
Jacob J |
JJ |
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Brain and Mind Centre, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia. |
| Park SH |
|
Park |
Shin Ho |
SH |
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Brain and Mind Centre, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia. |
| Byrne EM |
|
Byrne |
Enda M |
EM |
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Child Health Research Centre, The University of Queensland, Brisbane, QLD, Australia. |
| Mitchell BL |
|
Mitchell |
Brittany L |
BL |
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Mental Health and Neuroscience Program, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
| Scott J |
|
Scott |
Jan |
J |
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Université de Paris, Paris, France. |
| Medland SE |
|
Medland |
Sarah E |
SE |
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Mental Health and Neuroscience Program, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
| Lin T |
|
Lin |
Tian |
T |
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Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia. |
| Wray NR |
|
Wray |
Naomi R |
NR |
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Oxford Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
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Mental Health and Neuroscience Program, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
| Hickie IB |
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Hickie |
Ian B |
IB |
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Brain and Mind Centre, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia. ian.hickie@sydney.edu.au. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: |
| ISSUE: |
| TITLE: Molecular psychiatry |
| ISOABBREVIATION: Mol Psychiatry |
| YEAR: 2024 |
| MONTH: Apr |
| DAY: 04 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1476-5578 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Mol Psychiatry |
| COUNTRY: England |
| ISSNLINKING: 1359-4184 |
| NLMUNIQUEID: 9607835 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GRANTID |
AGENCY |
COUNTRY |
| GNT2016346 |
Department of Health | National Health and Medical Research Council (NHMRC) |
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| 1086683 |
Department of Health | National Health and Medical Research Council (NHMRC) |
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| GNT2008196 |
Department of Health | National Health and Medical Research Council (NHMRC) |
|
| 1086683 |
Department of Health | National Health and Medical Research Council (NHMRC) |
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| 1086683 |
Department of Health | National Health and Medical Research Council (NHMRC) |
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| 1086683 |
Department of Health | National Health and Medical Research Council (NHMRC) |
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| 1086683 |
Department of Health | National Health and Medical Research Council (NHMRC) |
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