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| PMID |
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| TITLE |
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| Genetic control of DNA methylation is largely shared across European and East Asian populations. |
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| ABSTRACT |
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| DNA methylation is an ideal trait to study the extent of the shared genetic control across ancestries, effectively providing hundreds of thousands of model molecular traits with large QTL effect sizes. We investigate cis DNAm QTLs in three European (n = 3701) and two East Asian (n = 2099) cohorts to quantify the similarities and differences in the genetic architecture across populations. We observe 80,394 associated mQTLs (62.2% of DNAm probes with significant mQTL) to be significant in both ancestries, while 28,925 mQTLs (22.4%) are identified in only a single ancestry. mQTL effect sizes are highly conserved across populations, with differences in mQTL discovery likely due to differences in allele frequency of associated variants and differing linkage disequilibrium between causal variants and assayed SNPs. This study highlights the overall similarity of genetic control across ancestries and the value of ancestral diversity in increasing the power to detect associations and enhancing fine mapping resolution. |
| © 2024. The Author(s). |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2023/05/29 |
| accepted |
2024/03/15 |
| medline |
2024/04/01 06:43 |
| pubmed |
2024/03/29 06:45 |
| entrez |
2024/03/29 00:15 |
| pmc-release |
2024/03/28 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Hatton AA |
|
Hatton |
Alesha A |
AA |
|
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia. |
| Cheng FF |
|
Cheng |
Fei-Fei |
FF |
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School of Life Sciences, Westlake University, Hangzhou, 310030, Zhejiang, China. |
| Lin T |
|
Lin |
Tian |
T |
|
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia. |
| Shen RJ |
|
Shen |
Ren-Juan |
RJ |
|
School of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou, 325027, China. |
| Chen J |
|
Chen |
Jie |
J |
|
School of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou, 325027, China. |
| Zheng Z |
|
Zheng |
Zhili |
Z |
|
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia. |
| Qu J |
|
Qu |
Jia |
J |
|
School of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou, 325027, China. |
| Lyu F |
|
Lyu |
Fan |
F |
|
School of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou, 325027, China. |
| Harris SE |
|
Harris |
Sarah E |
SE |
|
Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK. |
| Cox SR |
|
Cox |
Simon R |
SR |
|
Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK. |
| Jin ZB |
|
Jin |
Zi-Bing |
ZB |
|
School of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou, 325027, China. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
Queensland Institute of Medical Research Berghofer, Brisbane, QLD, 4006, Australia. |
| Fan D |
|
Fan |
Dongsheng |
D |
|
Department of Neurology, Peking University Third Hospital, 100191, Beijing, China. |
| Montgomery GW |
|
Montgomery |
Grant W |
GW |
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Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia. |
| Yang J |
|
Yang |
Jian |
J |
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Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, 310024, Zhejiang, China. |
| Wray NR |
|
Wray |
Naomi R |
NR |
|
Queensland Brain Institute, The University of Queensland, Brisbane, QLD, 4072, Australia. |
| Marioni RE |
|
Marioni |
Riccardo E |
RE |
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Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, UK. |
| Visscher PM |
|
Visscher |
Peter M |
PM |
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Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia. |
| McRae AF |
|
McRae |
Allan F |
AF |
|
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia. a.mcrae@uq.edu.au. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 15 |
| ISSUE: 1 |
| TITLE: Nature communications |
| ISOABBREVIATION: Nat Commun |
| YEAR: 2024 |
| MONTH: Mar |
| DAY: 28 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 2041-1723 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Nat Commun |
| COUNTRY: England |
| ISSNLINKING: 2041-1723 |
| NLMUNIQUEID: 101528555 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| MESH HEADINGS |
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| DESCRIPTORNAME |
QUALIFIERNAME |
| Humans |
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| DNA Methylation |
genetics |
| East Asian People |
genetics |
| Quantitative Trait Loci |
genetics |
| Gene Expression Regulation |
genetics |
| Linkage Disequilibrium |
genetics |
| Polymorphism, Single Nucleotide |
genetics |
| Genome-Wide Association Study |
genetics |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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