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| PMID |
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| TITLE |
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| Normative modelling of brain morphometry across the lifespan with CentileBrain: algorithm benchmarking and model optimisation. |
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| ABSTRACT |
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| The value of normative models in research and clinical practice relies on their robustness and a systematic comparison of different modelling algorithms and parameters; however, this has not been done to date. We aimed to identify the optimal approach for normative modelling of brain morphometric data through systematic empirical benchmarking, by quantifying the accuracy of different algorithms and identifying parameters that optimised model performance. We developed this framework with regional morphometric data from 37 407 healthy individuals (53% female and 47% male; aged 3-90 years) from 87 datasets from Europe, Australia, the USA, South Africa, and east Asia following a comparative evaluation of eight algorithms and multiple covariate combinations pertaining to image acquisition and quality, parcellation software versions, global neuroimaging measures, and longitudinal stability. The multivariate fractional polynomial regression (MFPR) emerged as the preferred algorithm, optimised with non-linear polynomials for age and linear effects of global measures as covariates. The MFPR models showed excellent accuracy across the lifespan and within distinct age-bins and longitudinal stability over a 2-year period. The performance of all MFPR models plateaued at sample sizes exceeding 3000 study participants. This model can inform about the biological and behavioural implications of deviations from typical age-related neuroanatomical changes and support future study designs. The model and scripts described here are freely available through CentileBrain. |
| Copyright © 2024 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2023/03/20 |
| revised |
2023/10/04 |
| accepted |
2023/12/01 |
| medline |
2024/02/26 06:42 |
| pubmed |
2024/02/24 11:42 |
| entrez |
2024/02/23 21:02 |
| pmc-release |
2024/03/12 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Ge R |
|
Ge |
Ruiyang |
R |
|
Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada. |
| Yu Y |
|
Yu |
Yuetong |
Y |
|
Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada. |
| Qi YX |
|
Qi |
Yi Xuan |
YX |
|
Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada. |
| Fan YN |
|
Fan |
Yu-Nan |
YN |
|
Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada. |
| Chen S |
|
Chen |
Shiyu |
S |
|
Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada. |
| Gao C |
|
Gao |
Chuntong |
C |
|
Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada. |
| Haas SS |
|
Haas |
Shalaila S |
SS |
|
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. |
| New F |
|
New |
Faye |
F |
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Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. |
| Boomsma DI |
|
Boomsma |
Dorret I |
DI |
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Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, Netherlands. |
| Brodaty H |
|
Brodaty |
Henry |
H |
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Centre for Healthy Brain Ageing, University of New South Wales, Sydney, NSW, Australia. |
| Brouwer RM |
|
Brouwer |
Rachel M |
RM |
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Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit, Amsterdam, Netherlands. |
| Buckner R |
|
Buckner |
Randy |
R |
|
Center for Brain Science, Harvard University, Cambridge, MA, USA. |
| Caseras X |
|
Caseras |
Xavier |
X |
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Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, Wales, UK. |
| Crivello F |
|
Crivello |
Fabrice |
F |
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Groupe d'Imagerie Neurofonctionnelle-Institut des Maladies Neurodégénératives, Université de Bordeaux, CNRS UMR 5293, Bordeaux, France. |
| Crone EA |
|
Crone |
Eveline A |
EA |
|
Erasmus School of Social and Behavioural Sciences, Erasmus University Rotterdam, Rotterdam, Netherlands. |
| Erk S |
|
Erk |
Susanne |
S |
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Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, Germany. |
| Fisher SE |
|
Fisher |
Simon E |
SE |
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Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, Netherlands. |
| Franke B |
|
Franke |
Barbara |
B |
|
Departments of Human Genetics, Psychiatry and Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, Netherlands. |
| Glahn DC |
|
Glahn |
David C |
DC |
|
Department of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Boston, MA, USA. |
| Dannlowski U |
|
Dannlowski |
Udo |
U |
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Department of Psychiatry and Psychotherapy, University of Münster, Münster, Germany. |
| Grotegerd D |
|
Grotegerd |
Dominik |
D |
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Department of Psychiatry and Psychotherapy, University of Münster, Münster, Germany. |
| Gruber O |
|
Gruber |
Oliver |
O |
|
Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany. |
| Hulshoff Pol HE |
|
Hulshoff Pol |
Hilleke E |
HE |
|
Department of Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, Netherlands. |
| Schumann G |
|
Schumann |
Gunter |
G |
|
Centre for Population Neuroscience and Stratified Medicine, Institute for Science and Technology of Brain-inspired Intelligence, Fudan University, Shanghai, China; PONS Centre, Department of Psychiatry and Clinical Neuroscience, CCM, Charite Universitätsmedizin Berlin, Berlin, Germany. |
| Tamnes CK |
|
Tamnes |
Christian K |
CK |
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Department of Psychology, University of Oslo, Oslo, Norway. |
| Walter H |
|
Walter |
Henrik |
H |
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Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, Germany. |
| Wierenga LM |
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Wierenga |
Lara M |
LM |
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Brain and Development Research Center, Leiden University, Leiden, Netherlands. |
| Jahanshad N |
|
Jahanshad |
Neda |
N |
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Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA. |
| Thompson PM |
|
Thompson |
Paul M |
PM |
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Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA. |
| Frangou S |
|
Frangou |
Sophia |
S |
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Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: sophia.frangou@gmail.com. |
|
ENIGMA Lifespan Working Group |
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| INVESTIGATORS |
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| LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
| Agartz |
Ingrid |
I |
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| Asherson |
Philip |
P |
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| Ayesa-Arriola |
Rosa |
R |
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| Banaj |
Nerisa |
N |
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| Banaschewski |
Tobias |
T |
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| Baumeister |
Sarah |
S |
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| Bertolino |
Alessandro |
A |
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| Borgwardt |
Stefan |
S |
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| Bourque |
Josiane |
J |
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| Brandeis |
Daniel |
D |
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| Breier |
Alan |
A |
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| Buitelaar |
Jan K |
JK |
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| Cannon |
Dara M |
DM |
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| Cervenka |
Simon |
S |
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| Conrod |
Patricia J |
PJ |
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| Crespo-Facorro |
Benedicto |
B |
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| Davey |
Christopher G |
CG |
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| de Haan |
Lieuwe |
L |
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| de Zubicaray |
Greig I |
GI |
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| Di Giorgio |
Annabella |
A |
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| Frodl |
Thomas |
T |
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| Gruner |
Patricia |
P |
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| Gur |
Raquel E |
RE |
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| Gur |
Ruben C |
RC |
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| Harrison |
Ben J |
BJ |
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| Hatton |
Sean N |
SN |
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| Hickie |
Ian |
I |
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| Howells |
Fleur M |
FM |
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| Huyser |
Chaim |
C |
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| Jernigan |
Terry L |
TL |
|
| Jiang |
Jiyang |
J |
|
| Joska |
John A |
JA |
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| Kahn |
René S |
RS |
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| Kalnin |
Andrew J |
AJ |
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| Kochan |
Nicole A |
NA |
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| Koops |
Sanne |
S |
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| Kuntsi |
Jonna |
J |
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| Lagopoulos |
Jim |
J |
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| Lazaro |
Luisa |
L |
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| Lebedeva |
Irina S |
IS |
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| Lochner |
Christine |
C |
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| Martin |
Nicholas G |
NG |
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| Mazoyer |
Bernard |
B |
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| McDonald |
Brenna C |
BC |
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| McDonald |
Colm |
C |
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| McMahon |
Katie L |
KL |
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| Medland |
Sarah |
S |
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| Modabbernia |
Amirhossein |
A |
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| Mwangi |
Benson |
B |
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| Nakao |
Tomohiro |
T |
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| Nyberg |
Lars |
L |
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| Piras |
Fabrizio |
F |
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| Portella |
Maria J |
MJ |
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| Qiu |
Jiang |
J |
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| Roffman |
Joshua L |
JL |
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| Sachdev |
Perminder S |
PS |
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| Sanford |
Nicole |
N |
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| Satterthwaite |
Theodore D |
TD |
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| Saykin |
Andrew J |
AJ |
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| Sellgren |
Carl M |
CM |
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| Sim |
Kang |
K |
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| Smoller |
Jordan W |
JW |
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| Soares |
Jair C |
JC |
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| Sommer |
Iris E |
IE |
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| Spalletta |
Gianfranco |
G |
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| Stein |
Dan J |
DJ |
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| Thomopoulos |
Sophia I |
SI |
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| Tomyshev |
Alexander S |
AS |
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| Tordesillas-Gutiérrez |
Diana |
D |
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| Trollor |
Julian N |
JN |
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| van 't Ent |
Dennis |
D |
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| van den Heuvel |
Odile A |
OA |
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| van Erp |
Theo Gm |
TG |
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| van Haren |
Neeltje Em |
NE |
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| Vecchio |
Daniela |
D |
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| Veltman |
Dick J |
DJ |
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| Wang |
Yang |
Y |
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| Weber |
Bernd |
B |
|
| Wei |
Dongtao |
D |
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| Wen |
Wei |
W |
|
| Westlye |
Lars T |
LT |
|
| Williams |
Steven Cr |
SC |
|
| Wright |
Margaret J |
MJ |
|
| Wu |
Mon-Ju |
MJ |
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| Yu |
Kevin |
K |
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| JOURNAL |
|
| VOLUME: 6 |
| ISSUE: 3 |
| TITLE: The Lancet. Digital health |
| ISOABBREVIATION: Lancet Digit Health |
| YEAR: 2024 |
| MONTH: Mar |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 2589-7500 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Lancet Digit Health |
| COUNTRY: England |
| ISSNLINKING: 2589-7500 |
| NLMUNIQUEID: 101751302 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
| Review |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
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| COMMENTS AND CORRECTIONS |
|
| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
| UpdateOf |
bioRxiv. 2023 Dec 02:2023.01.30.523509. doi: 10.1101/2023.01.30.523509. |
38076938 |
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|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| P30 AG010133 |
NIA NIH HHS |
United States |
| R01 AG067420 |
NIA NIH HHS |
United States |
| R01 MH104284 |
NIMH NIH HHS |
United States |
| R01 MH116147 |
NIMH NIH HHS |
United States |
| R01 MH113619 |
NIMH NIH HHS |
United States |
| T32 MH122394 |
NIMH NIH HHS |
United States |
| U54 EB020403 |
NIBIB NIH HHS |
United States |
| R01 HD050735 |
NICHD NIH HHS |
United States |
| UL1 TR004419 |
NCATS NIH HHS |
United States |
| UL1 TR000153 |
NCATS NIH HHS |
United States |
| R01 CA101318 |
NCI NIH HHS |
United States |
| U24 RR025736 |
NCRR NIH HHS |
United States |
| R01 AG019771 |
NIA NIH HHS |
United States |
| UL1 RR025761 |
NCRR NIH HHS |
United States |
| P50 HD105351 |
NICHD NIH HHS |
United States |
| R01 MH117014 |
NIMH NIH HHS |
United States |
| R01 MH042191 |
NIMH NIH HHS |
United States |
| U24 RR021992 |
NCRR NIH HHS |
United States |
| R01 MH090553 |
NIMH NIH HHS |
United States |
| RC2 DA029475 |
NIDA NIH HHS |
United States |
|
| GENERAL NOTE |
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| KEYWORDS |
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| MESH HEADINGS |
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| DESCRIPTORNAME |
QUALIFIERNAME |
| Humans |
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| Male |
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| Female |
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| Longevity |
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| Benchmarking |
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| Brain |
diagnostic imaging |
| Models, Statistical |
diagnostic imaging |
| Algorithms |
diagnostic imaging |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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