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| PMID |
|
|
| TITLE |
|
| Potential causal association between gut microbiome and posttraumatic stress disorder. |
|
| ABSTRACT |
|
| BACKGROUND |
NlmCategory: BACKGROUND |
| The causal effects of gut microbiome and the development of posttraumatic stress disorder (PTSD) are still unknown. This study aimed to clarify their potential causal association using mendelian randomization (MR). |
| METHODS |
NlmCategory: METHODS |
| The causal effects of gut microbiome and the development of posttraumatic stress disorder (PTSD) are still unknown. This study aimed to clarify their potential causal association using mendelian randomization (MR). The summary-level statistics for gut microbiome were retrieved from a genome-wide association study (GWAS) of the MiBioGen consortium. As to PTSD, the Freeze 2 datasets were originated from the Psychiatric Genomics Consortium Posttraumatic Stress Disorder Working Group (PGC-PTSD), and the replicated datasets were obtained from FinnGen consortium. Single nucleotide polymorphisms meeting MR assumptions were selected as instrumental variables. The inverse variance weighting (IVW) method was employed as the main approach, supplemented by sensitivity analyses to evaluate potential pleiotropy and heterogeneity and ensure the robustness of the MR results. We also performed reverse MR analyses to explore PTSD's causal effects on the relative abundances of specific features of the gut microbiome. |
| RESULTS |
NlmCategory: RESULTS |
| The causal effects of gut microbiome and the development of posttraumatic stress disorder (PTSD) are still unknown. This study aimed to clarify their potential causal association using mendelian randomization (MR). The summary-level statistics for gut microbiome were retrieved from a genome-wide association study (GWAS) of the MiBioGen consortium. As to PTSD, the Freeze 2 datasets were originated from the Psychiatric Genomics Consortium Posttraumatic Stress Disorder Working Group (PGC-PTSD), and the replicated datasets were obtained from FinnGen consortium. Single nucleotide polymorphisms meeting MR assumptions were selected as instrumental variables. The inverse variance weighting (IVW) method was employed as the main approach, supplemented by sensitivity analyses to evaluate potential pleiotropy and heterogeneity and ensure the robustness of the MR results. We also performed reverse MR analyses to explore PTSD's causal effects on the relative abundances of specific features of the gut microbiome. In Freeze 2 datasets from PGC-PTSD, eight bacterial traits revealed a potential causal association between gut microbiome and PTSD (IVW, all P < 0.05). In addition, Genus.Dorea and genus.Sellimonas were replicated in FinnGen datasets, in which eight bacterial traits revealed a potential causal association between gut microbiome and the occurrence of PTSD. The heterogeneity and pleiotropy analyses further supported the robustness of the IVW findings, providing additional evidence for their reliability. |
| CONCLUSION |
NlmCategory: CONCLUSIONS |
| The causal effects of gut microbiome and the development of posttraumatic stress disorder (PTSD) are still unknown. This study aimed to clarify their potential causal association using mendelian randomization (MR). The summary-level statistics for gut microbiome were retrieved from a genome-wide association study (GWAS) of the MiBioGen consortium. As to PTSD, the Freeze 2 datasets were originated from the Psychiatric Genomics Consortium Posttraumatic Stress Disorder Working Group (PGC-PTSD), and the replicated datasets were obtained from FinnGen consortium. Single nucleotide polymorphisms meeting MR assumptions were selected as instrumental variables. The inverse variance weighting (IVW) method was employed as the main approach, supplemented by sensitivity analyses to evaluate potential pleiotropy and heterogeneity and ensure the robustness of the MR results. We also performed reverse MR analyses to explore PTSD's causal effects on the relative abundances of specific features of the gut microbiome. In Freeze 2 datasets from PGC-PTSD, eight bacterial traits revealed a potential causal association between gut microbiome and PTSD (IVW, all P < 0.05). In addition, Genus.Dorea and genus.Sellimonas were replicated in FinnGen datasets, in which eight bacterial traits revealed a potential causal association between gut microbiome and the occurrence of PTSD. The heterogeneity and pleiotropy analyses further supported the robustness of the IVW findings, providing additional evidence for their reliability. Our study provides the potential causal impact of gut microbiomes on the development of PTSD, shedding new light on the understanding of the dysfunctional gut-brain axis in this disorder. Our findings present novel evidence and call for investigations to confirm the association between their links, as well as to illuminate the underlying mechanisms. |
| © 2024. The Author(s). |
|
| DATE PUBLISHED |
|
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| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| received |
2023/08/01 |
| accepted |
2024/01/10 |
| revised |
2024/01/05 |
| medline |
2024/02/02 06:43 |
| pubmed |
2024/02/01 00:42 |
| entrez |
2024/01/31 23:24 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| He Q |
|
He |
Qiang |
Q |
|
Department of Neurosurgery, West China Hospital, Sichuan University, 37 Guoxue Lane, Wuhou District, Chengdu, 610041, Sichuan, China. |
| Wang W |
|
Wang |
Wenjing |
W |
|
Department of Pharmacy, Institute of Metabolic Diseases and Pharmacotherapy, West China Hospital, Sichuan University, 37 Guoxue Lane, Wuhou District, Chengdu, China. |
| Xu D |
|
Xu |
Dingkang |
D |
|
Department of Neurosurgery, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China. |
| Xiong Y |
|
Xiong |
Yang |
Y |
|
Department of Urology, West China Hospital, Sichuan University, Chengdu, China. |
| Tao C |
|
Tao |
Chuanyuan |
C |
|
Department of Neurosurgery, West China Hospital, Sichuan University, 37 Guoxue Lane, Wuhou District, Chengdu, 610041, Sichuan, China. |
| You C |
|
You |
Chao |
C |
|
Department of Neurosurgery, West China Hospital, Sichuan University, 37 Guoxue Lane, Wuhou District, Chengdu, 610041, Sichuan, China. |
| Ma L |
|
Ma |
Lu |
L |
|
Department of Neurosurgery, West China Hospital, Sichuan University, 37 Guoxue Lane, Wuhou District, Chengdu, 610041, Sichuan, China. |
| Ma J |
|
Ma |
Junpeng |
J |
|
Department of Neurosurgery, West China Hospital, Sichuan University, 37 Guoxue Lane, Wuhou District, Chengdu, 610041, Sichuan, China. junpengma6@163.com. |
|
Psychiatric Genomics Consortium Posttraumatic Stress Disorder Working Group |
|
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| INVESTIGATORS |
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| LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
| Nievergelt |
Caroline M |
CM |
|
| Maihofer |
Adam X |
AX |
|
| Klengel |
Torsten |
T |
|
| Atkinson |
Elizabeth G |
EG |
|
| Chen |
Chia-Yen |
CY |
|
| Choi |
Karmel W |
KW |
|
| Coleman |
Jonathan R I |
JRI |
|
| Dalvie |
Shareefa |
S |
|
| Duncan |
Laramie E |
LE |
|
| Logue |
Mark W |
MW |
|
| Provost |
Allison C |
AC |
|
| Ratanatharathorn |
Andrew |
A |
|
| Stein |
Murray B |
MB |
|
| Torres |
Katy |
K |
|
| Aiello |
Allison E |
AE |
|
| Almli |
Lynn M |
LM |
|
| Amstadter |
Ananda B |
AB |
|
| Andersen |
Søren B |
SB |
|
| Andreassen |
Ole A |
OA |
|
| Arbisi |
Paul A |
PA |
|
| Ashley-Koch |
Allison E |
AE |
|
| Austin |
S Bryn |
SB |
|
| Avdibegovic |
Esmina |
E |
|
| Babić |
Dragan |
D |
|
| Bækvad-Hansen |
Marie |
M |
|
| Baker |
Dewleen G |
DG |
|
| Beckham |
Jean C |
JC |
|
| Bierut |
Laura J |
LJ |
|
| Bisson |
Jonathan I |
JI |
|
| Boks |
Marco P |
MP |
|
| Bolger |
Elizabeth A |
EA |
|
| Børglum |
Anders D |
AD |
|
| Bradley |
Bekh |
B |
|
| Brashear |
Megan |
M |
|
| Breen |
Gerome |
G |
|
| Bryant |
Richard A |
RA |
|
| Bustamante |
Angela C |
AC |
|
| Bybjerg-Grauholm |
Jonas |
J |
|
| Calabrese |
Joseph R |
JR |
|
| Caldas-de-Almeida |
José M |
JM |
|
| Dale |
Anders M |
AM |
|
| Daly |
Mark J |
MJ |
|
| Daskalakis |
Nikolaos P |
NP |
|
| Deckert |
Jürgen |
J |
|
| Delahanty |
Douglas L |
DL |
|
| Dennis |
Michelle F |
MF |
|
| Disner |
Seth G |
SG |
|
| Domschke |
Katharina |
K |
|
| Dzubur-Kulenovic |
Alma |
A |
|
| Erbes |
Christopher R |
CR |
|
| Evans |
Alexandra |
A |
|
| Farrer |
Lindsay A |
LA |
|
| Feeny |
Norah C |
NC |
|
| Flory |
Janine D |
JD |
|
| Forbes |
David |
D |
|
| Franz |
Carol E |
CE |
|
| Galea |
Sandro |
S |
|
| Garrett |
Melanie E |
ME |
|
| Gelaye |
Bizu |
B |
|
| Gelernter |
Joel |
J |
|
| Geuze |
Elbert |
E |
|
| Gillespie |
Charles |
C |
|
| Uka |
Aferdita Goci |
AG |
|
| Gordon |
Scott D |
SD |
|
| Guffanti |
Guia |
G |
|
| Hammamieh |
Rasha |
R |
|
| Harnal |
Supriya |
S |
|
| Hauser |
Michael A |
MA |
|
| Heath |
Andrew C |
AC |
|
| Hemmings |
Sian M J |
SMJ |
|
| Hougaard |
David Michael |
DM |
|
| Jakovljevic |
Miro |
M |
|
| Jett |
Marti |
M |
|
| Johnson |
Eric Otto |
EO |
|
| Jones |
Ian |
I |
|
| Jovanovic |
Tanja |
T |
|
| Qin |
Xue-Jun |
XJ |
|
| Junglen |
Angela G |
AG |
|
| Karstoft |
Karen-Inge |
KI |
|
| Kaufman |
Milissa L |
ML |
|
| Kessler |
Ronald C |
RC |
|
| Khan |
Alaptagin |
A |
|
| Kimbrel |
Nathan A |
NA |
|
| King |
Anthony P |
AP |
|
| Koen |
Nastassja |
N |
|
| Kranzler |
Henry R |
HR |
|
| Kremen |
William S |
WS |
|
| Lawford |
Bruce R |
BR |
|
| Lebois |
Lauren A M |
LAM |
|
| Lewis |
Catrin E |
CE |
|
| Linnstaedt |
Sarah D |
SD |
|
| Lori |
Adriana |
A |
|
| Lugonja |
Bozo |
B |
|
| Luykx |
Jurjen J |
JJ |
|
| Lyons |
Michael J |
MJ |
|
| Maples-Keller |
Jessica |
J |
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| Marmar |
Charles |
C |
|
| Martin |
Alicia R |
AR |
|
| Martin |
Nicholas G |
NG |
|
| Maurer |
Douglas |
D |
|
| Mavissakalian |
Matig R |
MR |
|
| McFarlane |
Alexander |
A |
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| McGlinchey |
Regina E |
RE |
|
| McLaughlin |
Katie A |
KA |
|
| McLean |
Samuel A |
SA |
|
| McLeay |
Sarah |
S |
|
| Mehta |
Divya |
D |
|
| Milberg |
William P |
WP |
|
| Miller |
Mark W |
MW |
|
| Morey |
Rajendra A |
RA |
|
| Morris |
Charles Phillip |
CP |
|
| Mors |
Ole |
O |
|
| Mortensen |
Preben B |
PB |
|
| Neale |
Benjamin M |
BM |
|
| Nelson |
Elliot C |
EC |
|
| Nordentoft |
Merete |
M |
|
| Norman |
Sonya B |
SB |
|
| O'Donnell |
Meaghan |
M |
|
| Orcutt |
Holly K |
HK |
|
| Panizzon |
Matthew S |
MS |
|
| Peters |
Edward S |
ES |
|
| Peterson |
Alan L |
AL |
|
| Peverill |
Matthew |
M |
|
| Pietrzak |
Robert H |
RH |
|
| Polusny |
Melissa A |
MA |
|
| Rice |
John P |
JP |
|
| Ripke |
Stephan |
S |
|
| Risbrough |
Victoria B |
VB |
|
| Roberts |
Andrea L |
AL |
|
| Rothbaum |
Alex O |
AO |
|
| Rothbaum |
Barbara O |
BO |
|
| Roy-Byrne |
Peter |
P |
|
| Ruggiero |
Ken |
K |
|
| Rung |
Ariane |
A |
|
| Rutten |
Bart P F |
BPF |
|
| Saccone |
Nancy L |
NL |
|
| Sanchez |
Sixto E |
SE |
|
| Schijven |
Dick |
D |
|
| Seedat |
Soraya |
S |
|
| Seligowski |
Antonia V |
AV |
|
| Seng |
Julia S |
JS |
|
| Sheerin |
Christina M |
CM |
|
| Silove |
Derrick |
D |
|
| Smith |
Alicia K |
AK |
|
| Smoller |
Jordan W |
JW |
|
| Solovieff |
Nadia |
N |
|
| Sponheim |
Scott R |
SR |
|
| Stein |
Dan J |
DJ |
|
| Sumner |
Jennifer A |
JA |
|
| Teicher |
Martin H |
MH |
|
| Thompson |
Wesley K |
WK |
|
| Trapido |
Edward |
E |
|
| Uddin |
Monica |
M |
|
| Ursano |
Robert J |
RJ |
|
| van den Heuvel |
Leigh Luella |
LL |
|
| van Hooff |
Miranda |
M |
|
| Vermetten |
Eric |
E |
|
| Vinkers |
Christiaan H |
CH |
|
| Voisey |
Joanne |
J |
|
| Wang |
Yunpeng |
Y |
|
| Wang |
Zhewu |
Z |
|
| Werge |
Thomas |
T |
|
| Williams |
Michelle A |
MA |
|
| Williamson |
Douglas E |
DE |
|
| Winternitz |
Sherry |
S |
|
| Wolf |
Christiane |
C |
|
| Wolf |
Erika J |
EJ |
|
| Wolff |
Jonathan D |
JD |
|
| Yehuda |
Rachel |
R |
|
| Young |
Keith A |
KA |
|
| Young |
Ross McD |
RM |
|
| Zhao |
Hongyu |
H |
|
| Zoellner |
Lori A |
LA |
|
| Liberzon |
Israel |
I |
|
| Ressler |
Kerry J |
KJ |
|
| Haas |
Magali |
M |
|
| Koenen |
Karestan C |
KC |
|
|
| JOURNAL |
|
| VOLUME: 14 |
| ISSUE: 1 |
| TITLE: Translational psychiatry |
| ISOABBREVIATION: Transl Psychiatry |
| YEAR: 2024 |
| MONTH: Jan |
| DAY: 31 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 2158-3188 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
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| MEDLINETA: Transl Psychiatry |
| COUNTRY: United States |
| ISSNLINKING: 2158-3188 |
| NLMUNIQUEID: 101562664 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| MESH HEADINGS |
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| DESCRIPTORNAME |
QUALIFIERNAME |
| Humans |
|
| Gastrointestinal Microbiome |
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| Stress Disorders, Post-Traumatic |
genetics |
| Genome-Wide Association Study |
genetics |
| Reproducibility of Results |
genetics |
| Dietary Supplements |
genetics |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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