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| PMID |
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| TITLE |
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| Uncovering the complex relationship between balding, testosterone and skin cancers in men. |
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| ABSTRACT |
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| Male-pattern baldness (MPB) is related to dysregulation of androgens such as testosterone. A previously observed relationship between MPB and skin cancer may be due to greater exposure to ultraviolet radiation or indicate a role for androgenic pathways in the pathogenesis of skin cancers. We dissected this relationship via Mendelian randomization (MR) analyses, using genetic data from recent male-only meta-analyses of cutaneous melanoma (12,232 cases; 20,566 controls) and keratinocyte cancers (KCs) (up to 17,512 cases; >100,000 controls), followed by stratified MR analysis by body-sites. We found strong associations between MPB and the risk of KC, but not with androgens, and multivariable models revealed that this relationship was heavily confounded by MPB single nucleotide polymorphisms involved in pigmentation pathways. Site-stratified MR analyses revealed strong associations between MPB with head and neck squamous cell carcinoma and melanoma, suggesting that sun exposure on the scalp, rather than androgens, is the main driver. Men with less hair covering likely explains, at least in part, the higher incidence of melanoma in men residing in countries with high ambient UV. |
| © 2023. Springer Nature Limited. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2022/09/28 |
| accepted |
2023/08/24 |
| medline |
2023/10/04 00:42 |
| pubmed |
2023/10/04 00:42 |
| entrez |
2023/10/03 23:19 |
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| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Ong JS |
|
Ong |
Jue-Sheng |
JS |
|
Population Health Department, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia. JueSheng.Ong@qimrberghofer.edu.au. |
| Seviiri M |
|
Seviiri |
Mathias |
M |
|
School of Biomedical Sciences, Faculty of Health, and Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia. |
| Dusingize JC |
|
Dusingize |
Jean Claude |
JC |
|
Population Health Department, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia. |
| Wu Y |
|
Wu |
Yeda |
Y |
|
Population Health Department, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia. |
| Han X |
|
Han |
Xikun |
X |
|
Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. |
| Shi J |
|
Shi |
Jianxin |
J |
|
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. |
| Olsen CM |
|
Olsen |
Catherine M |
CM |
|
Faculty of Medicine, University of Queensland, Herston, QLD, Australia. |
| Neale RE |
|
Neale |
Rachel E |
RE |
|
Population Health Department, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia. |
| Thompson JF |
|
Thompson |
John F |
JF |
|
Department of Melanoma and Surgical Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia. |
| Saw RPM |
|
Saw |
Robyn P M |
RPM |
|
Department of Melanoma and Surgical Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia. |
| Shannon KF |
|
Shannon |
Kerwin F |
KF |
|
Department of Melanoma and Surgical Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia. |
| Mann GJ |
|
Mann |
Graham J |
GJ |
|
John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
Department of Mental Health & Neuroscience, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia. |
| Medland SE |
|
Medland |
Sarah E |
SE |
|
Department of Mental Health & Neuroscience, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia. |
| Gordon SD |
|
Gordon |
Scott D |
SD |
|
Department of Mental Health & Neuroscience, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia. |
| Scolyer RA |
|
Scolyer |
Richard A |
RA |
|
Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia. |
| Long GV |
|
Long |
Georgina V |
GV |
|
Department of Medical Oncology, Royal North Shore Hospital, St Leonards, NSW, Australia. |
| Iles MM |
|
Iles |
Mark M |
MM |
|
NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK. |
| Landi MT |
|
Landi |
Maria Teresa |
MT |
|
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. |
| Whiteman DC |
|
Whiteman |
David C |
DC |
|
Population Health Department, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia. |
| MacGregor S |
|
MacGregor |
Stuart |
S |
|
Population Health Department, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia. |
| Law MH |
|
Law |
Matthew H |
MH |
|
School of Biomedical Sciences, Faculty of Health, and Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia. matthew.law@qimrberghofer.edu.au. |
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| INVESTIGATORS |
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| JOURNAL |
|
| VOLUME: 14 |
| ISSUE: 1 |
| TITLE: Nature communications |
| ISOABBREVIATION: Nat Commun |
| YEAR: 2023 |
| MONTH: Oct |
| DAY: 03 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 2041-1723 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Nat Commun |
| COUNTRY: England |
| ISSNLINKING: 2041-1723 |
| NLMUNIQUEID: 101528555 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GRANTID |
AGENCY |
COUNTRY |
| 1073898 |
Department of Health | National Health and Medical Research Council (NHMRC) |
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