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| PMID |
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| TITLE |
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| The Effect of Genetic Predisposition to Alzheimer's Disease and Related Traits on Recruitment Bias in a Study of Cognitive Aging. |
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| ABSTRACT |
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| The recruitment of participants for research studies may be subject to bias. The Prospective Imaging Study of Ageing (PISA) aims to characterize the phenotype and natural history of healthy adult Australians at high future risk of Alzheimer's disease (AD). Participants approached to take part in PISA were selected from existing cohort studies with available genomewide genetic data for both successfully and unsuccessfully recruited participants, allowing us to investigate the genetic contribution to voluntary recruitment, including the genetic predisposition to AD. We use a polygenic risk score (PRS) approach to test to what extent the genetic risk for AD, and related risk factors predict participation in PISA. We did not identify a significant association of genetic risk for AD with study participation, but we did identify significant associations with PRS for key causal risk factors for AD, IQ, household income and years of education. We also found that older and female participants were more likely to take part in the study. Our findings highlight the importance of considering bias in key risk factors for AD in the recruitment of individuals for cohort studies. |
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| DATE PUBLISHED |
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| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| medline |
2023/07/21 06:44 |
| pubmed |
2023/07/21 06:44 |
| entrez |
2023/07/21 05:26 |
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| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Gomez LM |
|
Gomez |
Lina M |
LM |
|
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
| Mitchell BL |
|
Mitchell |
Brittany L |
BL |
|
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
| McAloney K |
|
McAloney |
Kerrie |
K |
|
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
| Adsett J |
|
Adsett |
Jessica |
J |
|
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
| Garden N |
|
Garden |
Natalie |
N |
|
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
| Wood M |
|
Wood |
Madeline |
M |
|
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
| Diaz-Torres S |
|
Diaz-Torres |
Santiago |
S |
|
School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia. |
| Garcia-Marin LM |
|
Garcia-Marin |
Luis M |
LM |
|
School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia. |
| Breakspear M |
|
Breakspear |
Michael |
M |
|
School of Psychological Sciences, The University of Newcastle, Newcastle, New South Wales, Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
| Lupton MK |
|
Lupton |
Michelle K |
MK |
|
School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Queensland, Australia. |
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| INVESTIGATORS |
|
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| JOURNAL |
|
| VOLUME: |
| ISSUE: |
| TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies |
| ISOABBREVIATION: Twin Res Hum Genet |
| YEAR: 2023 |
| MONTH: Jul |
| DAY: 21 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1832-4274 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
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| MEDLINETA: Twin Res Hum Genet |
| COUNTRY: England |
| ISSNLINKING: 1832-4274 |
| NLMUNIQUEID: 101244624 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| Alzheimer’s disease |
| PRS |
| bias |
| genetics |
| polygenic |
| recruitment |
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| MESH HEADINGS |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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