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| PMID |
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| TITLE |
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| Shared molecular genetic factors influence subcortical brain morphometry and Parkinson's disease risk. |
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| ABSTRACT |
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| Parkinson's disease (PD) is a late-onset and genetically complex neurodegenerative disorder. Here we sought to identify genes and molecular pathways underlying the associations between PD and the volume of ten brain structures measured through magnetic resonance imaging (MRI) scans. We leveraged genome-wide genetic data from several cohorts, including the International Parkinson's Disease Genomics Consortium (IPDG), the UK Biobank, the Adolescent Brain Cognitive Development (ABCD) study, the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE), the Enhancing Neuroimaging Genetics through Meta-Analyses (ENIGMA), and 23andMe. We observed significant positive genetic correlations between PD and intracranial and subcortical brain volumes. Genome-wide association studies (GWAS) - pairwise analyses identified 210 genomic segments with shared aetiology between PD and at least one of these brain structures. Pathway enrichment results highlight potential links with chronic inflammation, the hypothalamic-pituitary-adrenal pathway, mitophagy, disrupted vesicle-trafficking, calcium-dependent, and autophagic pathways. Investigations for putative causal genetic effects suggest that a larger putamen volume could influence PD risk, independently of the potential causal genetic effects of intracranial volume (ICV) on PD. Our findings suggest that genetic variants influencing larger intracranial and subcortical brain volumes, possibly during earlier stages of life, influence the risk of developing PD later in life. |
| © 2023. The Author(s). |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2023/02/19 |
| accepted |
2023/04/28 |
| medline |
2023/05/11 00:42 |
| pubmed |
2023/05/11 00:41 |
| entrez |
2023/05/10 23:14 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| García-Marín LM |
|
García-Marín |
Luis M |
LM |
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Laboratorio Internacional de Investigación del Genoma Humano, Universidad Nacional Autónoma de México, Juriquilla, Querétaro, México. luis.garciamarin@qimrberghofer.edu.au. |
| Reyes-Pérez P |
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Reyes-Pérez |
Paula |
P |
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Laboratorio Internacional de Investigación del Genoma Humano, Universidad Nacional Autónoma de México, Juriquilla, Querétaro, México. |
| Diaz-Torres S |
|
Diaz-Torres |
Santiago |
S |
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School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia. |
| Medina-Rivera A |
|
Medina-Rivera |
Alejandra |
A |
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Laboratorio Internacional de Investigación del Genoma Humano, Universidad Nacional Autónoma de México, Juriquilla, Querétaro, México. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
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Mental Health and Neuroscience Program, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
| Mitchell BL |
|
Mitchell |
Brittany L |
BL |
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School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia. |
| Rentería ME |
|
Rentería |
Miguel E |
ME |
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School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 9 |
| ISSUE: 1 |
| TITLE: NPJ Parkinson's disease |
| ISOABBREVIATION: NPJ Parkinsons Dis |
| YEAR: 2023 |
| MONTH: May |
| DAY: 10 |
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| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 2373-8057 |
| ISSNTYPE: Print |
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| MEDLINE JOURNAL |
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| MEDLINETA: NPJ Parkinsons Dis |
| COUNTRY: United States |
| ISSNLINKING: 2373-8057 |
| NLMUNIQUEID: 101675390 |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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