Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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36575460
TITLE
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
ABSTRACT
BACKGROUND
Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery.
RESULTS
Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3-5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism.
CONCLUSIONS
Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3-5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism. Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.
© 2022. The Author(s).
DATE PUBLISHED
2022 Dec 27
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2022/04/05
accepted 2022/12/06
entrez 2022/12/27 23:45
pubmed 2022/12/28 06:00
medline 2022/12/30 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Kanoni S Kanoni Stavroula S William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Graham SE Graham Sarah E SE Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, 48109, USA.
Wang Y Wang Yuxuan Y Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Ave, Boston, MA, 02118, USA.
Surakka I Surakka Ida I Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, 48109, USA.
Ramdas S Ramdas Shweta S Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Zhu X Zhu Xiang X Department of Statistics, Stanford University, Stanford, CA, USA.
Clarke SL Clarke Shoa L SL Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Bhatti KF Bhatti Konain Fatima KF William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Vedantam S Vedantam Sailaja S Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Winkler TW Winkler Thomas W TW Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Locke AE Locke Adam E AE McDonnell Genome Institute and Department of Medicine, Washington University, St. Louis, MO, 63108, USA.
Marouli E Marouli Eirini E William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Zajac GJM Zajac Greg J M GJM Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Wu KH Wu Kuan-Han H KH Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA.
Ntalla I Ntalla Ioanna I Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
Hui Q Hui Qin Q Atlanta VA Health Care System, Decatur, GA, USA.
Klarin D Klarin Derek D Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Hilliard AT Hilliard Austin T AT VA Palo Alto Health Care Systems, Palo Alto, CA, USA.
Wang Z Wang Zeyuan Z Atlanta VA Health Care System, Decatur, GA, USA.
Xue C Xue Chao C Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, 48109, USA.
Thorleifsson G Thorleifsson Gudmar G deCODE Genetics/Amgen, Inc. Sturlugata 8, Reykjavik, 102, Iceland.
Helgadottir A Helgadottir Anna A deCODE Genetics/Amgen, Inc. Sturlugata 8, Reykjavik, 102, Iceland.
Gudbjartsson DF Gudbjartsson Daniel F DF School of Engineering and Natural Sciences, University of Iceland, Sæmundargötu 2, Reykjavik, 102, Iceland.
Holm H Holm Hilma H deCODE Genetics/Amgen, Inc. Sturlugata 8, Reykjavik, 102, Iceland.
Olafsson I Olafsson Isleifur I Department of Clinical Biochemistry, Landspitali - National University Hospital of Iceland, Hringbraut, Reykjavik, 101, Iceland.
Hwang MY Hwang Mi Yeong MY Division of Genome Science, Department of Precision Medicine, National Institute of Health, Chungcheongbuk-Do, South Korea.
Han S Han Sohee S Division of Genome Science, Department of Precision Medicine, National Institute of Health, Chungcheongbuk-Do, South Korea.
Akiyama M Akiyama Masato M Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Sakaue S Sakaue Saori S Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Terao C Terao Chikashi C Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Kanai M Kanai Masahiro M Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Zhou W Zhou Wei W Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Brumpton BM Brumpton Ben M BM Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Rasheed H Rasheed Humaira H Division of Medicine and Laboratory Sciences, University of Oslo, Oslo, Norway.
Havulinna AS Havulinna Aki S AS Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
Veturi Y Veturi Yogasudha Y Department of Genetics, Institute for Biomedical Informatics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Pacheco JA Pacheco Jennifer Allen JA Center for Genetic Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, 60618, USA.
Rosenthal EA Rosenthal Elisabeth A EA Department of Medicine (Medical Genetics), University of Washington, Seattle, WA, USA.
Lingren T Lingren Todd T Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Feng Q Feng QiPing Q Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Kullo IJ Kullo Iftikhar J IJ Department of Cardiovascular Medicine and the Gonda Vascular Center, Mayo Clinic, Rochester, MN, USA.
Narita A Narita Akira A Tohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan.
Takayama J Takayama Jun J Tohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan.
Martin HC Martin Hilary C HC Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK.
Hunt KA Hunt Karen A KA Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Trivedi B Trivedi Bhavi B Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Haessler J Haessler Jeffrey J Fred Hutchinson Cancer Center, Division of Public Health Sciences, Seattle, WA, 9810, USA.
Giulianini F Giulianini Franco F Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.
Bradford Y Bradford Yuki Y Department of Genetics, Institute for Biomedical Informatics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Miller JE Miller Jason E JE Department of Genetics, Institute for Biomedical Informatics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Campbell A Campbell Archie A Usher Institute, The University of Edinburgh, Nine, Edinburgh Bioquarter, 9 Little France Road, Edinburgh, EH16 4UX, UK.
Lin K Lin Kuang K Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
Millwood IY Millwood Iona Y IY Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
Rasheed A Rasheed Asif A Center for Non-Communicable Diseases, Karachi, Sindh, Pakistan.
Hindy G Hindy George G Department of Population Medicine, Qatar University College of Medicine, QU Health, Doha, Qatar.
Faul JD Faul Jessica D JD Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA.
Zhao W Zhao Wei W Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
Weir DR Weir David R DR Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA.
Turman C Turman Constance C Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA.
Huang H Huang Hongyan H Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA.
Graff M Graff Mariaelisa M Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Choudhury A Choudhury Ananyo A Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Sengupta D Sengupta Dhriti D Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Mahajan A Mahajan Anubha A Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.
Brown MR Brown Michael R MR Human Genetics Center, Department of Epidemiology, School of Public Health, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Zhang W Zhang Weihua W Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, Middlesex, UB1 3HW, UK.
Yu K Yu Ketian K Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Schmidt EM Schmidt Ellen M EM Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Pandit A Pandit Anita A Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Gustafsson S Gustafsson Stefan S Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Yin X Yin Xianyong X Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Luan J Luan Jian'an J MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
Zhao JH Zhao Jing-Hua JH Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort's Causeway, Cambridge, CB1 8RN, UK.
Matsuda F Matsuda Fumihiko F Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Jang HM Jang Hye-Mi HM Division of Genome Science, Department of Precision Medicine, National Institute of Health, Chungcheongbuk-Do, South Korea.
Yoon K Yoon Kyungheon K Division of Genome Science, Department of Precision Medicine, National Institute of Health, Chungcheongbuk-Do, South Korea.
Medina-Gomez C Medina-Gomez Carolina C Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Pitsillides A Pitsillides Achilleas A Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Ave, Boston, MA, 02118, USA.
Hottenga JJ Hottenga Jouke Jan JJ Amsterdam Public Health Research Institute, Amsterdam UMC, the Netherlands.
Wood AR Wood Andrew R AR Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK.
Ji Y Ji Yingji Y Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK.
Gao Z Gao Zishan Z Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Haworth S Haworth Simon S Bristol Dental School, University of Bristol, Lower Maudlin Street, Bristol, BS1 2LY, UK.
Yousri NA Yousri Noha A NA Department of Computer and Systems Engineering, Alexandria University, Alexandria, Egypt.
Mitchell RE Mitchell Ruth E RE Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield Grove, Bristol, BS8 2BN, UK.
Chai JF Chai Jin Fang JF Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore.
Aadahl M Aadahl Mette M Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Bjerregaard AA Bjerregaard Anne A AA Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
Yao J Yao Jie J The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Manichaikul A Manichaikul Ani A Center for Public Health Genomics, University of Virginia, Charlottesville, VA, 22903, USA.
Hwu CM Hwu Chii-Min CM Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Hung YJ Hung Yi-Jen YJ Institute of Preventive Medicine, National Defense Medical Center, Postbox 90048~700, Sanhsia Dist, New Taipei City, 237101, Taiwan.
Warren HR Warren Helen R HR NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
Ramirez J Ramirez Julia J Aragon Institute of Engineering Research, University of Zaragoza and Centro de Investigación Biomédica en Red - Bioingeniería, Biomateriales Y Nanomedicina, Spain.
Bork-Jensen J Bork-Jensen Jette J Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Kårhus LL Kårhus Line L LL Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
Goel A Goel Anuj A Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK.
Sabater-Lleal M Sabater-Lleal Maria M Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Noordam R Noordam Raymond R Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.
Mauro P Mauro Pala P Istituto Di Ricerca Genetica E Biomedica, Consiglio Nazionale Delle Ricerche, Rome, Italy.
Matteo F Matteo Floris F Dipartimento Di Scienze Biomediche, Università Degli Studi Di Sassari, Sardinia, Italy.
McDaid AF McDaid Aaron F AF Swiss Institute of Bioinformatics, 1015, Lausanne, Switzerland.
Marques-Vidal P Marques-Vidal Pedro P Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 46, 1011, Lausanne, Switzerland.
Wielscher M Wielscher Matthias M Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
Trompet S Trompet Stella S Dept of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.
Sattar N Sattar Naveed N BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, Glasgow, UK.
Møllehave LT Møllehave Line T LT Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
Munz M Munz Matthias M Institute for Cardiogenetics, University of Lübeck, DZHK (German Research Centre for Cardiovascular Research), Partner Site Hamburg/Lübeck/Kiel, University Heart Center Lübeck, Lübeck and Charité - University Medicine Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Zu Berlin and Berlin Institute of Health, Institute for Dental and Craniofacial Sciences, Department of Periodontology and Synoptic Dentistry, Berlin, Germany.
Zeng L Zeng Lingyao L Deutsches Zentrum Für Herz-Kreislauf-Forschung (DZHK) E.V., Partner Site Munich Heart Alliance, Munich, Germany.
Huang J Huang Jianfeng J Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Yang B Yang Bin B Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Poveda A Poveda Alaitz A Lund University Diabetes Center, Lund University, Malmö, Sweden.
Kurbasic A Kurbasic Azra A Lund University Diabetes Center, Lund University, Malmö, Sweden.
Lamina C Lamina Claudia C German Chronic Kidney Disease Study, Berlin, Germany.
Forer L Forer Lukas L German Chronic Kidney Disease Study, Berlin, Germany.
Scholz M Scholz Markus M LIFE Research Centre for Civilization Diseases, University of Leipzig, Philipp-Rosenthal-Straße 27, 04103, Leipzig, Germany.
Galesloot TE Galesloot Tessel E TE Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.
Bradfield JP Bradfield Jonathan P JP Quantinuum Research LLC, Wayne, PA, 19087, USA.
Ruotsalainen SE Ruotsalainen Sanni E SE Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014, Helsinki, Finland.
Daw E Daw EWarwick E Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Zmuda JM Zmuda Joseph M JM Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.
Mitchell JS Mitchell Jonathan S JS Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Via Galvani 31, 39100, Bolzano, Italy.
Fuchsberger C Fuchsberger Christian C Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Via Galvani 31, 39100, Bolzano, Italy.
Christensen H Christensen Henry H Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark.
Brody JA Brody Jennifer A JA Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, 98101, USA.
Vazquez-Moreno M Vazquez-Moreno Miguel M Unidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Feitosa MF Feitosa Mary F MF Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Wojczynski MK Wojczynski Mary K MK Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Wang Z Wang Zhe Z The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Preuss MH Preuss Michael H MH The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mangino M Mangino Massimo M NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, SE1 9RT, UK.
Christofidou P Christofidou Paraskevi P Department of Twin Research and Genetic Epidemiology, King's College London, London, SE1 7EH, UK.
Verweij N Verweij Niek N Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Benjamins JW Benjamins Jan W JW Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Engmann J Engmann Jorgen J Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London, WC1E 6BT, UK.
Tsao NL Tsao Noah L NL Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA.
Verma A Verma Anurag A Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Slieker RC Slieker Roderick C RC Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, 2333ZA, The Netherlands.
Lo KS Lo Ken Sin KS Montreal Heart Institute, Université de Montréal, 5000 Belanger Street, Montreal, PQ, H1T1C8, Canada.
Zilhao NR Zilhao Nuno R NR Icelandic Heart Association, 201, Kopavogur, Iceland.
Le P Le Phuong P Department of Anthropology, University of Toronto at Mississauga, Mississauga, ON, L5L 1C6, Canada.
Kleber ME Kleber Marcus E ME SYNLAB MVZ Humangenetik Mannheim GmbH, 68163, Mannheim, Germany.
Delgado GE Delgado Graciela E GE Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, 68167, Mannheim, Germany.
Huo S Huo Shaofeng S Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Ikeda DD Ikeda Daisuke D DD Biomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, Tokushima, Japan.
Iha H Iha Hiroyuki H Biomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, Tokushima, Japan.
Yang J Yang Jian J Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.
Liu J Liu Jun J Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Demirkan A Demirkan Ayşe A Section of Statistical Multi-Omics, Department of Clinical and Experimental Research, University of Surrey, Guildford, Surrey, UK.
Leonard HL Leonard Hampton L HL Data Tecnica International, Glen Echo, MD, USA.
Marten J Marten Jonathan J MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, Scotland.
Frank M Frank Mirjam M Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany.
Schmidt B Schmidt Börge B Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany.
Smyth LJ Smyth Laura J LJ Centre for Public Health, Queen's University of Belfast, Belfast, Northern Ireland.
Cañadas-Garre M Cañadas-Garre Marisa M Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), Granada, Spain.
Wang C Wang Chaolong C Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.
Nakatochi M Nakatochi Masahiro M Public Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, 461-8673, Japan.
Wong A Wong Andrew A MRC Unit for Lifelong Health and Ageing at UCL, 1-19 Torrington Place, London, WC1E 7HB, UK.
Hutri-Kähönen N Hutri-Kähönen Nina N Tampere Centre for Skills Training and Simulation, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Sim X Sim Xueling X Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore.
Xia R Xia Rui R Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Huerta-Chagoya A Huerta-Chagoya Alicia A Departamento de Medicina Genómica Y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Coyoacán, 04510, Mexico City, Mexico.
Fernandez-Lopez JC Fernandez-Lopez Juan Carlos JC Departamento de Genómica Computacional, Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
Lyssenko V Lyssenko Valeriya V Center for Diabetes Research, University of Bergen, Bergen, Norway.
Nongmaithem SS Nongmaithem Suraj S SS Academy of Scientific and Innovative Research (AcSIR), New Delhi, India.
Bayyana S Bayyana Swati S Academy of Scientific and Innovative Research (AcSIR), New Delhi, India.
Stringham HM Stringham Heather M HM Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Irvin MR Irvin Marguerite R MR Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
Oldmeadow C Oldmeadow Christopher C Hunter Medical Research Institute, Newcastle, Australia.
Kim HN Kim Han-Na HN Department of Clinical Research Design & Evaluation, SAIHST, Sungkyunkwan University, Seoul, 06355, Korea.
Ryu S Ryu Seungho S Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, 03181, Korea.
Timmers PRHJ Timmers Paul R H J PRHJ Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.
Arbeeva L Arbeeva Liubov L Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA.
Dorajoo R Dorajoo Rajkumar R Duke-NUS Medical School, Health Services and Systems Research, Singapore, 169857, Singapore.
Lange LA Lange Leslie A LA Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, Anschutz Medical Campus, University of Colorado, Denver, Aurora, CO, 80045, USA.
Prasad G Prasad Gauri G Academy of Scientific and Innovative Research, CSIR-Human Resource Development Centre, Ghaziabad, Uttar Pradesh, India.
Lorés-Motta L Lorés-Motta Laura L Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Philips Van Leydenlaan 15, Nijmegen, 6525 EX, the Netherlands.
Pauper M Pauper Marc M Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Philips Van Leydenlaan 15, Nijmegen, 6525 EX, the Netherlands.
Long J Long Jirong J Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, USA.
Li X Li Xiaohui X The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Theusch E Theusch Elizabeth E Department of Pediatrics, University of California San Francisco, Oakland, CA, 94609, USA.
Takeuchi F Takeuchi Fumihiko F National Center for Global Health and Medicine, Tokyo, 1628655, Japan.
Spracklen CN Spracklen Cassandra N CN Department of Biostatistics and Epidemiology, University of Massachusetts-Amherst, Amherst, MA, 01003, USA.
Loukola A Loukola Anu A Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014, Helsinki, Finland.
Bollepalli S Bollepalli Sailalitha S Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014, Helsinki, Finland.
Warner SC Warner Sophie C SC NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Wang YX Wang Ya Xing YX Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 17 Hougou Lane, Chong Wen Men, Beijing, 100005, China.
Wei WB Wei Wen B WB Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 1 Dong Jiao Min Xiang, Beijing, 100730, Dong Cheng District, China.
Nutile T Nutile Teresa T Institute of Genetics and Biophysics "Adriano Buzzati-Traverso" - CNR, Naples, Italy.
Ruggiero D Ruggiero Daniela D IRCCS Neuromed, Pozzilli, Isernia, Italy.
Sung YJ Sung Yun Ju YJ Division of Biostatistics, Washington University, St. Louis, MO, 63110, USA.
Chen S Chen Shufeng S Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Liu F Liu Fangchao F Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Yang J Yang Jingyun J Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
Kentistou KA Kentistou Katherine A KA Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.
Banas B Banas Bernhard B Dept of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Nardone GG Nardone Giuseppe Giovanni GG Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.
Meidtner K Meidtner Karina K German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany.
Bielak LF Bielak Lawrence F LF Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
Smith JA Smith Jennifer A JA Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
Hebbar P Hebbar Prashantha P Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait.
Farmaki AE Farmaki Aliki-Eleni AE Department of Clinical Epidemiology, Institute of Health Informatics, University College London, London, UK.
Hofer E Hofer Edith E Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria.
Lin M Lin Maoxuan M Massachusetts General Hospital Cancer Center, Charlestown, MA, 02129, USA.
Concas MP Concas Maria Pina MP Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.
Vaccargiu S Vaccargiu Simona S Institute of Genetic and Biomedical Research, National Research Council of Italy, UOS of Sassari, Sassari, Italy.
van der Most PJ van der Most Peter J PJ Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, the Netherlands.
Pitkänen N Pitkänen Niina N Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.
Cade BE Cade Brian E BE Division of Sleep Medicine, Harvard Medical School, Boston, MA, 02115, USA.
van der Laan SW van der Laan Sander W SW Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Chitrala KN Chitrala Kumaraswamy Naidu KN Department of Engineering Technology, University of Houston-Sugarland, Houston, TX, USA.
Weiss S Weiss Stefan S Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University of Greifswald and University Medicine Greifswald, Greifswald, Germany.
Bentley AR Bentley Amy R AR Center for Research On Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, Room 1025, Bethesda, MD, 20892, USA.
Doumatey AP Doumatey Ayo P AP Center for Research On Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, Room 1025, Bethesda, MD, 20892, USA.
Adeyemo AA Adeyemo Adebowale A AA Center for Research On Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, Room 1025, Bethesda, MD, 20892, USA.
Lee JY Lee Jong Young JY , Oneomics. Co. Ltd. 2F, Soonchunhyang Mirai Medical Center 173, Buheuyng-Ro, Bucheon-Si Gyeonggi-Do, 14585, Korea.
Petersen ERB Petersen Eva R B ERB Department of Clinical Biochemistry and Immunology, Hospital of Southern Jutland, Kresten Philipsens Vej 15, 6200, Aabenraa, Denmark.
Nielsen AA Nielsen Aneta A AA Department of Clinical Biochemistry, Lillebaelt Hospital, Kolding, Denmark.
Choi HS Choi Hyeok Sun HS Department of Biomedical Science, Hallym University, Chuncheon, 24252, Gangwon-Do, Korea.
Nethander M Nethander Maria M Bioinformatics Core Facility, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Freitag-Wolf S Freitag-Wolf Sandra S Institute of Medical Informatics and Statistics, Kiel University, Kiel, Germany.
Southam L Southam Lorraine L Institute of Translational Genomics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Rayner NW Rayner Nigel W NW Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Wang CA Wang Carol A CA School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, NSW, 2308, Australia.
Lin SY Lin Shih-Yi SY School of Medicine, National Defense Medical Center, Taipei, Taiwan.
Wang JS Wang Jun-Sing JS Department of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Couture C Couture Christian C Department of Kinesiology, Université Laval, Québec, Canada.
Lyytikäinen LP Lyytikäinen Leo-Pekka LP Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, 33014, Tampere, Finland.
Nikus K Nikus Kjell K Department of Cardiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, 33014, Tampere, Finland.
Cuellar-Partida G Cuellar-Partida Gabriel G University of Queensland Diamantina Institute, Translational Research Institute, Kent St, Woolloongabba, Brisbane, QLD, 4102, Australia.
Vestergaard H Vestergaard Henrik H Department of Medicine, Bornholms Hospital, Rønne, Denmark.
Hidalgo B Hidalgo Bertha B Department of Epidemiology, Ryals School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
Giannakopoulou O Giannakopoulou Olga O William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Cai Q Cai Qiuyin Q Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, USA.
Obura MO Obura Morgan O MO Amsterdam UMC, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam, 1081HV, the Netherlands.
van Setten J van Setten Jessica J Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Li X Li Xiaoyin X Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA.
Liang J Liang Jingjing J Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA.
Tang H Tang Hua H Department of Genetics, Stanford University School of Medicine Stanford, Palo Alto, CA, 94305, USA.
Terzikhan N Terzikhan Natalie N Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Shin JH Shin Jae Hun JH Department of Biomedical Science, Hallym University, Chuncheon, 24252, Gangwon-Do, Korea.
Jackson RD Jackson Rebecca D RD Division of Endocrinology, Ohio State University, Columbus, OH, 43210, USA.
Reiner AP Reiner Alexander P AP Department of Epidemiology, University of Washington, Seattle, WA, 98195, USA.
Martin LW Martin Lisa Warsinger LW School of Medicine and Health Sciences, George Washington University, Washington, DC, 20037, USA.
Chen Z Chen Zhengming Z Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
Li L Li Liming L Department of Epidemiology, School of Public Health, Peking University Health Science Center, Beijing, China.
Kawaguchi T Kawaguchi Takahisa T Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Thiery J Thiery Joachim J Institute for Laboratory Medicine, University Hospital Leipzig, Paul-List-Strasse 13/15, 04103, Leipzig, Germany.
Bis JC Bis Joshua C JC Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, 98101, USA.
Launer LJ Launer Lenore J LJ Laboratory of Epidemiology and Population Sciences, National Institute On Aging, NIH, Baltimore, MD, 20892-9205, USA.
Li H Li Huaixing H Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Nalls MA Nalls Mike A MA Data Tecnica International, Washington, DC, USA.
Raitakari OT Raitakari Olli T OT Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
Ichihara S Ichihara Sahoko S Department of Environmental and Preventive Medicine, Jichi Medical University School of Medicine, Shimotsuke, 329-0498, Japan.
Wild SH Wild Sarah H SH Centre for Population Health Sciences, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.
Nelson CP Nelson Christopher P CP NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Campbell H Campbell Harry H Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.
Jäger S Jäger Susanne S German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany.
Nabika T Nabika Toru T Department of Functional Pathology, Shimane University School of Medicine, Izumo, 6938501, Japan.
Al-Mulla F Al-Mulla Fahd F Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait.
Niinikoski H Niinikoski Harri H Department of Physiology, University of Turku, Turku, Finland.
Braund PS Braund Peter S PS NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Kolcic I Kolcic Ivana I University of Split School of Medicine, Šoltanska 2, HR-21000, Split, Croatia.
Kovacs P Kovacs Peter P University of Leipzig Medical Center, Liebigstr. 18, 04103, Medical Department III - Endocrinology, Nephrology, RheumatologyLeipzig, Germany.
Giardoglou T Giardoglou Tota T Department of Nutrition-Dietetics, Harokopio University, Eleftheriou Venizelou, 17676, Athens, Greece.
Katsuya T Katsuya Tomohiro T Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, 5650871, Japan.
de Kleijn D de Kleijn Dominique D Department of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
de Borst GJ de Borst Gert J GJ Department of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Kim EK Kim Eung Kweon EK Corneal Dystrophy Research Institute, Yonsei University College of Medicine, Saevit Eye Hospital, SeoulIlsan, 03722, Korea.
Adams HHH Adams Hieab H H HHH Latin American Brain Health (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile.
Ikram MA Ikram M Arfan MA Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Zhu X Zhu Xiaofeng X Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA.
Asselbergs FW Asselbergs Folkert W FW Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Kraaijeveld AO Kraaijeveld Adriaan O AO Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Beulens JWJ Beulens Joline W J JWJ Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, 3584CG, Utrecht, the Netherlands.
Shu XO Shu Xiao-Ou XO Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, USA.
Rallidis LS Rallidis Loukianos S LS Second Department of Cardiology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece.
Pedersen O Pedersen Oluf O Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Hansen T Hansen Torben T Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Mitchell P Mitchell Paul P Center for Vision Research, Department of Ophthalmology and The Westmead Institute, University of Sydney, Hawkesbury Rd, Sydney, NSW, 2145, Australia.
Hewitt AW Hewitt Alex W AW Centre for Eye Research Australia, University of Melbourne, Melbourne, VIC, 3002, Australia.
Kähönen M Kähönen Mika M Department of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, 33014, Tampere, Finland.
Pérusse L Pérusse Louis L Centre Nutrition, Santé Et Société (NUTRISS), Institute of Nutrition and Functional Foods (INAF), Québec, Canada.
Bouchard C Bouchard Claude C Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA.
Tönjes A Tönjes Anke A University of Leipzig Medical Center, Liebigstr. 18, 04103, Medical Department III - Endocrinology, Nephrology, RheumatologyLeipzig, Germany.
Chen YI Chen Yii-Der Ida YI The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Pennell CE Pennell Craig E CE School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, NSW, 2308, Australia.
Mori TA Mori Trevor A TA Discipline of Internal Medicine, Medical School, The University of Western Australia, Perth, WA, Australia.
Lieb W Lieb Wolfgang W Institute of Epidemiology, Kiel University, Kiel, Germany.
Franke A Franke Andre A Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
Ohlsson C Ohlsson Claes C Department of Drug Treatment, Sahlgrenska University Hospital, Gothenburg, Sweden.
Mellström D Mellström Dan D Geriatric Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Cho YS Cho Yoon Shin YS Department of Biomedical Science, Hallym University, Chuncheon, 24252, Gangwon-Do, Korea.
Lee H Lee Hyejin H Department of Internal Medicine, EwhaWomans University School of Medicine, Seoul, Korea.
Yuan JM Yuan Jian-Min JM Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15232, USA.
Koh WP Koh Woon-Puay WP Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore, 117609, Singapore.
Rhee SY Rhee Sang Youl SY Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, 02447, Korea.
Woo JT Woo Jeong-Taek JT Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, 02447, Korea.
Heid IM Heid Iris M IM Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Stark KJ Stark Klaus J KJ Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Zimmermann ME Zimmermann Martina E ME Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Völzke H Völzke Henry H Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Homuth G Homuth Georg G Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University of Greifswald and University Medicine Greifswald, Greifswald, Germany.
Evans MK Evans Michele K MK Laboratory of Epidemiology and Population Science, National Institute On Aging Intramural Research Program, NIH Biomedical Research Center, NIH 251 Bayview Blvd, Baltimore, MD, 21224, USA.
Zonderman AB Zonderman Alan B AB Laboratory of Epidemiology and Population Science, National Institute On Aging Intramural Research Program, NIH Biomedical Research Center, NIH 251 Bayview Blvd, Baltimore, MD, 21224, USA.
Polasek O Polasek Ozren O Algebra University College, Ilica 242, Zagreb, Croatia.
Pasterkamp G Pasterkamp Gerard G Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Hoefer IE Hoefer Imo E IE Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Redline S Redline Susan S Division of Sleep Medicine, Harvard Medical School, Boston, MA, 02115, USA.
Pahkala K Pahkala Katja K Department of Physical Activity and Health, Paavo Nurmi Centre, Sports and Exercise Medicine Unit, University of Turku, Turku, Finland.
Oldehinkel AJ Oldehinkel Albertine J AJ Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, the Netherlands.
Snieder H Snieder Harold H Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, the Netherlands.
Biino G Biino Ginevra G Institute of Molecular Genetics, National Research Council of Italy, Pavia, Italy.
Schmidt R Schmidt Reinhold R Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.
Schmidt H Schmidt Helena H Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria.
Bandinelli S Bandinelli Stefania S Local Health Unit Toscana Centro, Florence, Italy.
Dedoussis G Dedoussis George G Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, Athens, Greece.
Thanaraj TA Thanaraj Thangavel Alphonse TA Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait.
Kardia SLR Kardia Sharon L R SLR Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
Peyser PA Peyser Patricia A PA Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
Kato N Kato Norihiro N National Center for Global Health and Medicine, Tokyo, 1628655, Japan.
Schulze MB Schulze Matthias B MB Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany.
Girotto G Girotto Giorgia G Department of Medicine, Surgery and Health Sciences, University of Trieste, Strada Di Fiume 447, 34149, Trieste, Italy.
Böger CA Böger Carsten A CA KfH Kidney Center Traunstein, Traunstein, Germany.
Jung B Jung Bettina B KfH Kidney Center Traunstein, Traunstein, Germany.
Joshi PK Joshi Peter K PK Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.
Bennett DA Bennett David A DA Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
De Jager PL De Jager Philip L PL Department of Neurology, Center for Translational and Systems Neuroimmunology, Columbia University Medical Center, New York, NY, USA.
Lu X Lu Xiangfeng X Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Mamakou V Mamakou Vasiliki V Dromokaiteio Psychiatric Hospital, 124 61, Athens, Greece.
Brown M Brown Morris M Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK.
Caulfield MJ Caulfield Mark J MJ NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
Munroe PB Munroe Patricia B PB NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
Guo X Guo Xiuqing X The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Ciullo M Ciullo Marina M IRCCS Neuromed, Pozzilli, Isernia, Italy.
Jonas JB Jonas Jost B JB Privatpraxis Prof Jonas Und Dr Panda-Jonas, Heidelberg, Germany.
Samani NJ Samani Nilesh J NJ NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Kaprio J Kaprio Jaakko J Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014, Helsinki, Finland.
Pajukanta P Pajukanta Päivi P Department of Human Genetics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA, USA.
Tusié-Luna T Tusié-Luna Teresa T Unidad de Biología Molecular Y Medicina Genómica, Instituto de Investigaciones Biomédicas UNAM/ Instituto Nacional de Ciencias Médicas Y Nutrición Salvador Zubirán, Mexico City, Mexico.
Aguilar-Salinas CA Aguilar-Salinas Carlos A CA Departamento de Endocrinología Y Metabolismo, Instituto Nacional de Ciencias Médicas Y Nutrición Salvador Zubirán, 14080, Mexico, Mexico.
Adair LS Adair Linda S LS Carolina Population Center, University of North Carolina, Chapel Hill, NC, 27516, USA.
Bechayda SA Bechayda Sonny Augustin SA Department of Anthropology, Sociology, and History, University of San Carlos, 6000, Cebu City, Philippines.
de Silva HJ de Silva H Janaka HJ Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, 11010, Sri Lanka.
Wickremasinghe AR Wickremasinghe Ananda R AR Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, 11010, Sri Lanka.
Krauss RM Krauss Ronald M RM Children's Hospital Oakland Research Institute, Oakland, CA, 94609, USA.
Wu JY Wu Jer-Yuarn JY Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Zheng W Zheng Wei W Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, USA.
Hollander AI Hollander Anneke Iden AI Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Philips Van Leydenlaan 15, Nijmegen, 6525 EX, the Netherlands.
Bharadwaj D Bharadwaj Dwaipayan D Systems Genomics Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi, 110067, India.
Correa A Correa Adolfo A Department of Medicine, University of Mississippi Medical Center, Jackson, MS, 39216, USA.
Wilson JG Wilson James G JG Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, 39216, USA.
Lind L Lind Lars L Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Heng CK Heng Chew-Kiat CK Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore and Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore, Singapore.
Nelson AE Nelson Amanda E AE Department of Medicine, University of North Carolina, Chapel Hill, NC, USA.
Golightly YM Golightly Yvonne M YM Division of Physical Therapy, University of North Carolina, Chapel Hill, NC, USA.
Wilson JF Wilson James F JF Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.
Penninx B Penninx Brenda B Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Kim HL Kim Hyung-Lae HL Department of Biochemistry, College of Medicine, Ewha Womans University, Seoul, 07804, Korea.
Attia J Attia John J Faculty of Health and Medicine, University of Newcastle, Callaghan, Australia.
Scott RJ Scott Rodney J RJ Faculty of Health and Medicine, University of Newcastle, Callaghan, Australia.
Rao DC Rao D C DC Division of Biostatistics, Washington University School of Medicine, St. Louis, USA.
Arnett DK Arnett Donna K DK Office of the Provost, University of South Carolina, Columbia, SC, USA.
Hunt SC Hunt Steven C SC Department of Internal Medicine, University of Utah, Salt Lake City, Utah, 84132, USA.
Walker M Walker Mark M Institute of Cellular Medicine (Diabetes), The Medical School, Newcastle University, Framlington Place, Newcastle Upon Tyne, NE2 4HH, UK.
Koistinen HA Koistinen Heikki A HA Minerva Foundation Institute for Medical Research, Biomedicum 2U, Tukholmankatu 8, 00290, Helsinki, Finland.
Chandak GR Chandak Giriraj R GR JSS Academy of Higher Education and Research, Mysuru, India.
Mercader JM Mercader Josep M JM Harvard Medical School, Boston, MA, 02115, USA.
Costanzo MC Costanzo Maria C MC Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Jang D Jang Dongkeun D Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Burtt NP Burtt Noël P NP Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Villalpando CG Villalpando Clicerio Gonzalez CG InstitutoNacional de Salud Publica Y Centro de Estudios en Diabetes, Cuernavaca, Mexico.
Orozco L Orozco Lorena L Laboratorio de Inmunogenómica Y Enfermedades Metabólicas, Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
Fornage M Fornage Myriam M Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Tai E Tai EShyong E Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, 119228, Singapore.
van Dam RM van Dam Rob M RM Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, George Washington University, Washington, DC, 20052, USA.
Lehtimäki T Lehtimäki Terho T Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, 33014, Tampere, Finland.
Chaturvedi N Chaturvedi Nish N MRC Unit for Lifelong Health and Ageing at UCL, 1-19 Torrington Place, London, WC1E 7HB, UK.
Yokota M Yokota Mitsuhiro M Kurume University School of Medicine, Kurume, 830-0011, Japan.
Liu J Liu Jianjun J Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.
Reilly DF Reilly Dermot F DF Genetics, Merck Sharp & Dohme Corp., Kenilworth, NJ, 07033, USA.
McKnight AJ McKnight Amy Jayne AJ Centre for Public Health, Queen's University of Belfast, Belfast, Northern Ireland.
Kee F Kee Frank F Centre for Public Health, Queen's University of Belfast, Belfast, Northern Ireland.
Jöckel KH Jöckel Karl-Heinz KH Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany.
McCarthy MI McCarthy Mark I MI Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Palmer CNA Palmer Colin N A CNA Population Health and Genomics, University of Dundee, Ninwells Hospital and Medical School, Dundee, DD1 9SY, UK.
Vitart V Vitart Veronique V MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, Scotland.
Hayward C Hayward Caroline C MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, Scotland.
Simonsick E Simonsick Eleanor E Intramural Research Program, National Institute On Aging, 3001 S. Hanover St., Baltimore, MD, 21225, USA.
van Duijn CM van Duijn Cornelia M CM Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Jin ZB Jin Zi-Bing ZB The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 325027, Zhejiang, China.
Qu J Qu Jia J The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 325027, Zhejiang, China.
Hishigaki H Hishigaki Haretsugu H Biomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, Tokushima, Japan.
Lin X Lin Xu X Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
März W März Winfried W Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
Gudnason V Gudnason Vilmundur V Faculty of Medicine, University of Iceland, 101, Reykjavik, Iceland.
Tardif JC Tardif Jean-Claude JC Montreal Heart Institute, Université de Montréal, 5000 Belanger Street, Montreal, PQ, H1T1C8, Canada.
Lettre G Lettre Guillaume G Montreal Heart Institute, Université de Montréal, 5000 Belanger Street, Montreal, PQ, H1T1C8, Canada.
Hart LM' Hart Leen M 't LM' Amsterdam Public Health Research Institute, Amsterdam Cardiovascular Sciences, Amsterdam, 1081HV, the Netherlands.
Elders PJM Elders Petra J M PJM Amsterdam Public Health Research Institute, Health Behaviours and Chronic Diseases, Amsterdam, 1081HV, the Netherlands.
Damrauer SM Damrauer Scott M SM Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, 19104, USA.
Kumari M Kumari Meena M Institute of Social and Economic Research, University of Essex, Wivenhoe Park, Colchester, CO4 3SQ, UK.
Kivimaki M Kivimaki Mika M Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London, WC1E 6BT, UK.
van der Harst P van der Harst Pim P Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Spector TD Spector Tim D TD Department of Twin Research and Genetic Epidemiology, King's College London, London, SE1 7EH, UK.
Loos RJF Loos Ruth J F RJF Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Province MA Province Michael A MA Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Parra EJ Parra Esteban J EJ Department of Anthropology, University of Toronto at Mississauga, Mississauga, ON, L5L 1C6, Canada.
Cruz M Cruz Miguel M Unidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Psaty BM Psaty Bruce M BM Department of Health Systems and Population Health, University of Washington, Seattle, WA, USA.
Brandslund I Brandslund Ivan I Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark.
Pramstaller PP Pramstaller Peter P PP Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Via Galvani 31, 39100, Bolzano, Italy.
Rotimi CN Rotimi Charles N CN Center for Research On Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, Room 1025, Bethesda, MD, 20892, USA.
Christensen K Christensen Kaare K Danish Aging Research Center, University of Southern Denmark, Odense C, Denmark.
Ripatti S Ripatti Samuli S Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Widén E Widén Elisabeth E Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014, Helsinki, Finland.
Hakonarson H Hakonarson Hakon H Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Grant SFA Grant Struan F A SFA Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Kiemeney LALM Kiemeney Lambertus A L M LALM Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.
de Graaf J de Graaf Jacqueline J Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.
Loeffler M Loeffler Markus M LIFE Research Centre for Civilization Diseases, University of Leipzig, Philipp-Rosenthal-Straße 27, 04103, Leipzig, Germany.
Kronenberg F Kronenberg Florian F German Chronic Kidney Disease Study, Berlin, Germany.
Gu D Gu Dongfeng D School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Erdmann J Erdmann Jeanette J Institute for Cardiogenetics, University of Lübeck, DZHK (German Research Centre for Cardiovascular Research), Partner Site Hamburg/Lübeck/Kiel, and University Heart Center Lübeck, Lübeck, Germany.
Schunkert H Schunkert Heribert H Deutsches Zentrum Für Herz-Kreislauf-Forschung (DZHK) E.V., Partner Site Munich Heart Alliance, Munich, Germany.
Franks PW Franks Paul W PW Lund University Diabetes Center, Lund University, Malmö, Sweden.
Linneberg A Linneberg Allan A Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jukema JW Jukema J Wouter JW Netherlands Heart Institute, Utrecht, the Netherlands.
Khera AV Khera Amit V AV Verve Therapeutics, Cambridge, MA, USA.
Männikkö M Männikkö Minna M Northern Finland Birth Cohorts, Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, Oulu, Finland.
Jarvelin MR Jarvelin Marjo-Riitta MR Biocenter of Oulu, University of Oulu, Oulu, Finland.
Kutalik Z Kutalik Zoltan Z Swiss Institute of Bioinformatics, 1015, Lausanne, Switzerland.
Francesco C Francesco Cucca C University of Sassari, Sassari, Italy.
Mook-Kanamori DO Mook-Kanamori Dennis O DO Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands.
van Dijk KW van Dijk Ko Willems KW Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Watkins H Watkins Hugh H Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK.
Strachan DP Strachan David P DP Population Health Research Institute, St George's, University of London, London, SW17 0RE, UK.
Grarup N Grarup Niels N Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Sever P Sever Peter P National Heart and Lung Institute, Imperial College London, London, W12 0NN, UK.
Poulter N Poulter Neil N School of Public Health, Imperial College London, London, W12 7RH, UK.
Chuang LM Chuang Lee-Ming LM Department of Internal Medicine, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei, Taiwan.
Rotter JI Rotter Jerome I JI The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Dantoft TM Dantoft Thomas M TM Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
Karpe F Karpe Fredrik F NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, UK.
Neville MJ Neville Matt J MJ NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, UK.
Timpson NJ Timpson Nicholas J NJ Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield Grove, Bristol, BS8 2BN, UK.
Cheng CY Cheng Ching-Yu CY Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, 169857, Singapore.
Wong TY Wong Tien-Yin TY Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, 169857, Singapore.
Khor CC Khor Chiea Chuen CC Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.
Li H Li Hengtong H Data Science, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 168751, Singapore.
Sabanayagam C Sabanayagam Charumathi C Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, 169857, Singapore.
Peters A Peters Annette A German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany.
Gieger C Gieger Christian C German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany.
Hattersley AT Hattersley Andrew T AT Medical School, University of Exeter, University of Exeter, Exeter, EX2 5DW, UK.
Pedersen NL Pedersen Nancy L NL Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Magnusson PKE Magnusson Patrik K E PKE Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Boomsma DI Boomsma Dorret I DI Amsterdam Public Health Research Institute, Amsterdam UMC, the Netherlands.
Willemsen AHM Willemsen Allegonda H M AHM Amsterdam Public Health Research Institute, Amsterdam UMC, the Netherlands.
Cupples L Cupples LAdrienne L Framingham Heart Study, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, MD, USA.
van Meurs JBJ van Meurs Joyce B J JBJ Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Ghanbari M Ghanbari Mohsen M Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Gordon-Larsen P Gordon-Larsen Penny P Carolina Population Center, University of North Carolina, Chapel Hill, NC, 27516, USA.
Huang W Huang Wei W Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, 201203, China.
Kim YJ Kim Young Jin YJ Division of Genome Science, Department of Precision Medicine, National Institute of Health, Chungcheongbuk-Do, South Korea.
Tabara Y Tabara Yasuharu Y Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Wareham NJ Wareham Nicholas J NJ MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
Langenberg C Langenberg Claudia C Computational Medicine, Berlin Institute of Health at Charité - Universitätsmedizin, Berlin, Germany.
Zeggini E Zeggini Eleftheria E Technical University of Munich (TUM) and Klinikum Rechts Der Isar, TUM School of Medicine, Munich, Germany.
Kuusisto J Kuusisto Johanna J Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Laakso M Laakso Markku M Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Ingelsson E Ingelsson Erik E Stanford Diabetes Research Center, Stanford University, Stanford, CA, 94305, USA.
Abecasis G Abecasis Goncalo G Regeneron Pharmaceuticals, Tarrytown, NY, USA.
Chambers JC Chambers John C JC Imperial College Healthcare NHS Trust, Imperial College London, London, W12 0HS, UK.
Kooner JS Kooner Jaspal S JS MRC-PHE Centre for Environment and Health, Imperial College London, London, W2 1PG, UK.
de Vries PS de Vries Paul S PS Human Genetics Center, Department of Epidemiology, School of Public Health, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Morrison AC Morrison Alanna C AC Human Genetics Center, Department of Epidemiology, School of Public Health, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Hazelhurst S Hazelhurst Scott S School of Electrical and Information Engineering, University of the Witwatersrand, Johannesburg, South Africa.
Ramsay M Ramsay Michèle M Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
North KE North Kari E KE Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Daviglus M Daviglus Martha M Institute for Minority Health Research, University of Illinois College of Medicine, Chicago, IL, USA.
Kraft P Kraft Peter P Department of Biostatistics, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, 300 Herston Road, Brisbane, QLD, 4006, Australia.
Whitfield JB Whitfield John B JB QIMR Berghofer Medical Research Institute, 300 Herston Road, Brisbane, QLD, 4006, Australia.
Abbas S Abbas Shahid S Faisalabad Institute of Cardiology, Faislabad, Pakistan.
Saleheen D Saleheen Danish D Department of Cardiology, Columbia University Irving Medical Center, New York, NY, USA.
Walters RG Walters Robin G RG Big Data Institute, University of Oxford, Oxford, OX3 7LF, UK.
Holmes MV Holmes Michael V MV National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospitals, Oxford, UK.
Black C Black Corri C Aberdeen Centre for Health Data Science,1:042 Polwarth Building School of Medicine, Medical Science and Nutrition University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK.
Smith BH Smith Blair H BH Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK.
Baras A Baras Aris A Regeneron Pharmaceuticals, Tarrytown, NY, USA.
Justice AE Justice Anne E AE Department of Population Health Sciences, Geisinger Health, Danville, PA, 17822, USA.
Buring JE Buring Julie E JE Harvard Medical School, Boston, MA, 02115, USA.
Ridker PM Ridker Paul M PM Harvard Medical School, Boston, MA, 02115, USA.
Chasman DI Chasman Daniel I DI Harvard Medical School, Boston, MA, 02115, USA.
Kooperberg C Kooperberg Charles C Fred Hutchinson Cancer Center, Division of Public Health Sciences, Seattle, WA, 9810, USA.
Tamiya G Tamiya Gen G Tohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan.
Yamamoto M Yamamoto Masayuki M Tohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan.
van Heel DA van Heel David A DA Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Trembath RC Trembath Richard C RC School of Basic and Medical Biosciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Wei WQ Wei Wei-Qi WQ Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Jarvik GP Jarvik Gail P GP Departments of Medicine (Medical Genetics) and Genome Sciences, University of Washington, Washington, USA.
Namjou B Namjou Bahram B Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH, USA.
Hayes MG Hayes M Geoffrey MG Department of Anthropology, Northwestern University, Evanston, IL, 60208, USA.
Ritchie MD Ritchie Marylyn D MD Department of Genetics, Institute for Biomedical Informatics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Jousilahti P Jousilahti Pekka P Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
Salomaa V Salomaa Veikko V Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
Hveem K Hveem Kristian K Department of Research, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Åsvold BO Åsvold Bjørn Olav BO Department of Endocrinology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Kubo M Kubo Michiaki M RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.
Kamatani Y Kamatani Yoichiro Y Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
Okada Y Okada Yukinori Y Department of Genome Informatics, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.
Murakami Y Murakami Yoshinori Y Division of Molecular Pathology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Kim BJ Kim Bong-Jo BJ Division of Genome Science, Department of Precision Medicine, National Institute of Health, Chungcheongbuk-Do, South Korea.
Thorsteinsdottir U Thorsteinsdottir Unnur U Faculty of Medicine, University of Iceland, Sæmundargötu 2, Reykjavik, 102, Iceland.
Stefansson K Stefansson Kari K Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, The University of Manchester, Manchester, UK.
Zhang J Zhang Jifeng J Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, 48109, USA.
Chen Y Chen YEugene Y Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, 48109, USA.
Ho YL Ho Yuk-Lam YL VA Boston Healthcare System, Boston, MA, USA.
Lynch JA Lynch Julie A JA University of Massachusetts, Boston, MA, USA.
Rader DJ Rader Daniel J DJ Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Tsao PS Tsao Philip S PS Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.
Chang KM Chang Kyong-Mi KM Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Cho K Cho Kelly K Department of Medicine, Brigham Women's Hospital, Boston, MA, USA.
O'Donnell CJ O'Donnell Christopher J CJ Department of Medicine, Brigham Women's Hospital, Boston, MA, USA.
Gaziano JM Gaziano John M JM Department of Medicine, Brigham Women's Hospital, Boston, MA, USA.
Wilson PWF Wilson Peter W F PWF Division of Cardiology, Emory University School of Medicine, Atlanta, GA, USA.
Frayling TM Frayling Timothy M TM Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK.
Hirschhorn JN Hirschhorn Joel N JN Departments of Pediatrics and Genetics, Harvard Medical School, Boston, MA, USA.
Kathiresan S Kathiresan Sekar S Department of Medicine, Harvard Medical School, Boston, MA, USA.
Mohlke KL Mohlke Karen L KL Department of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA.
Sun YV Sun Yan V YV Atlanta VA Health Care System, Decatur, GA, USA.
Morris AP Morris Andrew P AP Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, The University of Manchester, Manchester, UK.
Boehnke M Boehnke Michael M Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Brown CD Brown Christopher D CD Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Natarajan P Natarajan Pradeep P Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Deloukas P Deloukas Panos P Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia.
Willer CJ Willer Cristen J CJ Department of Human Genetics, University of Michigan, Ann Arbor, MI, 48109, USA. cristen@umich.edu.
Assimes TL Assimes Themistocles L TL Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.
Peloso GM Peloso Gina M GM Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Ave, Boston, MA, 02118, USA. gpeloso@bu.edu.
INVESTIGATORS
JOURNAL
VOLUME: 23
ISSUE: 1
TITLE: Genome biology
ISOABBREVIATION: Genome Biol
YEAR: 2022
MONTH: Dec
DAY: 27
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1474-760X
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Genome Biol
COUNTRY: England
ISSNLINKING: 1474-7596
NLMUNIQUEID: 100960660
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Meta-Analysis
Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
U01 HG011172 NHGRI NIH HHS United States
R01 HD030880 NICHD NIH HHS United States
G0601463 Medical Research Council United Kingdom
R01 HL142302 NHLBI NIH HHS United States
FS/14/66/3129 British Heart Foundation United Kingdom
R01 DK075787 NIDDK NIH HHS United States
U01 HG011723 NHGRI NIH HHS United States
201543/B/16/Z Wellcome Trust United Kingdom
R03 HL154284 NHLBI NIH HHS United States
R01 DK093757 NIDDK NIH HHS United States
R01 HL142711 NHLBI NIH HHS United States
217065/Z/19/Z Wellcome Trust United Kingdom
MC_UU_00006/1 Medical Research Council United Kingdom
MC_UU_00011 Medical Research Council United Kingdom
R01 HL153805 NHLBI NIH HHS United States
R01 DK072193 NIDDK NIH HHS United States
R01 HL127564 NHLBI NIH HHS United States
C18281/A19169 Cancer Research UK United Kingdom
Z01 HG200362 Intramural NIH HHS United States
R01 HL105756 NHLBI NIH HHS United States
BRC-1215-2001 Department of Health United Kingdom
202802/Z/16/Z Wellcome Trust United Kingdom
R01 AG015819 NIA NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
Cholesterol
GWAS
Genetics
Genome-wide association study
Lipids
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Humans
Genome-Wide Association Study
Genetic Predisposition to Disease
Sex Characteristics
Phenotype
Lipids genetics
Polymorphism, Single Nucleotide genetics
Genetic Pleiotropy genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Lipids
OTHER ID's
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