Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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36477530
TITLE
Genetic diversity fuels gene discovery for tobacco and alcohol use.
ABSTRACT
Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease and injury . These substances are used across the globe, yet genome-wide association studies have focused largely on individuals of European ancestries . Here we leveraged global genetic diversity across 3.4 million individuals from four major clines of global ancestry (approximately 21% non-European) to power the discovery and fine-mapping of genomic loci associated with tobacco and alcohol use, to inform function of these loci via ancestry-aware transcriptome-wide association studies, and to evaluate the genetic architecture and predictive power of polygenic risk within and across populations. We found that increases in sample size and genetic diversity improved locus identification and fine-mapping resolution, and that a large majority of the 3,823 associated variants (from 2,143 loci) showed consistent effect sizes across ancestry dimensions. However, polygenic risk scores developed in one ancestry performed poorly in others, highlighting the continued need to increase sample sizes of diverse ancestries to realize any potential benefit of polygenic prediction.
© 2022. The Author(s).
DATE PUBLISHED
2022 Dec
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2022/03/09
accepted 2022/10/25
pubmed 2022/12/09 06:00
medline 2022/12/24 06:00
entrez 2022/12/08 11:54
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Saunders GRB Saunders Gretchen R B GRB Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
Wang X Wang Xingyan X Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA.
Chen F Chen Fang F Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA.
Jang SK Jang Seon-Kyeong SK Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
Liu M Liu Mengzhen M Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
Wang C Wang Chen C Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA.
Gao S Gao Shuang S Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA.
Jiang Y Jiang Yu Y Department of Epidemiology & Population Health at Stanford University, Stanford, CA, USA.
Khunsriraksakul C Khunsriraksakul Chachrit C Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA.
Otto JM Otto Jacqueline M JM Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
Addison C Addison Clifton C Jackson Heart Study (JHS) Graduate Training and Education Center (GTEC), Department of Epidemiology and Biostatistics, School of Public Health, Jackson State University, Jackson, MS, USA.
Akiyama M Akiyama Masato M Department of Ocular Pathology and Imaging Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Albert CM Albert Christine M CM Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Aliev F Aliev Fazil F Department of Psychiatry, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Alonso A Alonso Alvaro A Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Arnett DK Arnett Donna K DK Dean's Office and Department of Epidemiology, College of Public Health, University of Kentucky, Lexington, KY, USA.
Ashley-Koch AE Ashley-Koch Allison E AE Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
Ashrani AA Ashrani Aneel A AA Division of Hematology, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
Barnes KC Barnes Kathleen C KC Tempus, Chicago, IL, USA.
Barr RG Barr R Graham RG Department of Medicine, Columbia University Medical Center, New York, NY, USA.
Bartz TM Bartz Traci M TM Department of Biostatistics, University of Washington, Seattle, WA, USA.
Becker DM Becker Diane M DM Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Bielak LF Bielak Lawrence F LF Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Benjamin EJ Benjamin Emelia J EJ Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
Bis JC Bis Joshua C JC Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Bjornsdottir G Bjornsdottir Gyda G deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Blangero J Blangero John J Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.
Bleecker ER Bleecker Eugene R ER Department of Medicine, University of Arizona, Tucson, AZ, USA.
Boardman JD Boardman Jason D JD Institute of Behavioral Science, University of Colorado Boulder, Boulder, CO, USA.
Boerwinkle E Boerwinkle Eric E Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Boomsma DI Boomsma Dorret I DI Netherlands Twin Register, Dept Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Boorgula MP Boorgula Meher Preethi MP Division of Biomedical Informatics & Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Bowden DW Bowden Donald W DW Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Brody JA Brody Jennifer A JA Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Cade BE Cade Brian E BE Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
Chasman DI Chasman Daniel I DI Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Chavan S Chavan Sameer S Division of Biomedical Informatics & Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Chen YI Chen Yii-Der Ida YI Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Chen Z Chen Zhengming Z MRC Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Cheng I Cheng Iona I UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Cho MH Cho Michael H MH Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Choquet H Choquet Hélène H Kaiser Permanente Northern California (KPNC), Division of Research, Oakland, CA, USA.
Cole JW Cole John W JW Division of Vascular Neurology, Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA.
Cornelis MC Cornelis Marilyn C MC Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Cucca F Cucca Francesco F University of Sassari, Sassari SS, Italy.
Curran JE Curran Joanne E JE Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.
de Andrade M de Andrade Mariza M Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
Dick DM Dick Danielle M DM Department of Psychiatry, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Docherty AR Docherty Anna R AR Huntsman Mental Health Institute, Salt Lake City, UT, USA.
Duggirala R Duggirala Ravindranath R Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.
Eaton CB Eaton Charles B CB Department of Family Medicine, Brown University, Providence, RI, USA.
Ehringer MA Ehringer Marissa A MA Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
Esko T Esko Tõnu T Institute of Genomics, University of Tartu, Tartu, Estonia.
Faul JD Faul Jessica D JD Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Fernandes Silva L Fernandes Silva Lilian L Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
Fiorillo E Fiorillo Edoardo E Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy.
Fornage M Fornage Myriam M Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Freedman BI Freedman Barry I BI Department of Internal Medicine-Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Gabrielsen ME Gabrielsen Maiken E ME K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Garrett ME Garrett Melanie E ME Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
Gharib SA Gharib Sina A SA Center for Lung Biology, Department of Medicine, University of Washington, Seattle, WA, USA.
Gieger C Gieger Christian C Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Gillespie N Gillespie Nathan N Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Virginia, USA.
Glahn DC Glahn David C DC Department of Psychiatry & Behavioral Sciences, Boston Children's Hospital & Harvard Medical School, Boston, MA, USA.
Gordon SD Gordon Scott D SD Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Gu CC Gu Charles C CC Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.
Gu D Gu Dongfeng D Department of Epidemiology and Key Laboratory of Cardiovascular Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Gudbjartsson DF Gudbjartsson Daniel F DF School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland.
Guo X Guo Xiuqing X The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Haessler J Haessler Jeffrey J Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Hall ME Hall Michael E ME Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Haller T Haller Toomas T Institute of Genomics, University of Tartu, Tartu, Estonia.
Harris KM Harris Kathleen Mullan KM Department of Sociology and the Carolina Population Center, University of North Carolina, Chapel Hill, NC, USA.
He J He Jiang J Translational Sciences Institute, Tulane University, New Orleans, LA, USA.
Herd P Herd Pamela P McCourt School of Public Policy, Georgetown University, Washington, DC, USA.
Hewitt JK Hewitt John K JK Department Of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Hickie I Hickie Ian I Youth Mental Health & Technology Team, Brain and Mind Centre, University of Sydney, Sydney, Australia.
Hidalgo B Hidalgo Bertha B Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
Hokanson JE Hokanson John E JE Department of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Hopfer C Hopfer Christian C Department of Psychiatry, University of Colorado Anschutz Medical Center, Denver, CO, USA.
Hottenga J Hottenga JoukeJan J Netherlands Twin Register, Dept Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Hou L Hou Lifang L Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Huang H Huang Hongyan H Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Hung YJ Hung Yi-Jen YJ Institute of Preventive Medicine, National Defense Medical Center, New Taipei City, Taiwan.
Hunter DJ Hunter David J DJ Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Hveem K Hveem Kristian K Department of Research, Innovation and Education, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Hwang SJ Hwang Shih-Jen SJ Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Hwu CM Hwu Chii-Min CM Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Iacono W Iacono William W Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
Irvin MR Irvin Marguerite R MR Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
Jee YH Jee Yon Ho YH Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Johnson EO Johnson Eric O EO Fellow Program, RTI International, Research Triangle Park, NC, USA.
Joo YY Joo Yoonjung Y YY Institute of Data Science, Korea University, Seoul, South Korea.
Jorgenson E Jorgenson Eric E Regeneron Genetics Center, Tarrytown, NY, USA.
Justice AE Justice Anne E AE Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Kamatani Y Kamatani Yoichiro Y Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
Kaplan RC Kaplan Robert C RC Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Kaprio J Kaprio Jaakko J Institute for Molecular Medicine Finland - FIMM, University of Helsinki, Helsinki, Finland.
Kardia SLR Kardia Sharon L R SLR Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Keller MC Keller Matthew C MC Department Of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Kelly TN Kelly Tanika N TN Translational Sciences Institute, Tulane University, New Orleans, LA, USA.
Kooperberg C Kooperberg Charles C Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Korhonen T Korhonen Tellervo T Institute for Molecular Medicine Finland - FIMM, University of Helsinki, Helsinki, Finland.
Kraft P Kraft Peter P Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Krauter K Krauter Kenneth K Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO, USA.
Kuusisto J Kuusisto Johanna J Center for Medicine and Clinical Research, Kuopio University Hospital, Kuopio, Finland.
Laakso M Laakso Markku M Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Lasky-Su J Lasky-Su Jessica J Brigham and Women's Hospital, Department of Medicine, Channing Division of Network Medicine, Boston, MA, USA.
Lee WJ Lee Wen-Jane WJ Department of Medical Research, Taichung Veterans General Hospital, Taichung City, Taiwan.
Lee JJ Lee James J JJ Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
Levy D Levy Daniel D Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Li L Li Liming L Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China.
Li K Li Kevin K Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Li Y Li Yuqing Y Department of Epidemiology & Biostatistics, University of California, San Francisco, CA, USA.
Lin K Lin Kuang K Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Lind PA Lind Penelope A PA School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia.
Liu C Liu Chunyu C Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Lloyd-Jones DM Lloyd-Jones Donald M DM Departments of Preventive Medicine, Medicine, and Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Lutz SM Lutz Sharon M SM Department of Biostatics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Ma J Ma Jiantao J Division of Nutrition Epidemiology and Data Science, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA.
Mägi R Mägi Reedik R Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
Manichaikul A Manichaikul Ani A Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, USA.
Martin NG Martin Nicholas G NG Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Mathur R Mathur Ravi R GenOmics, Bioinformatics, and Translational Research Center, RTI International, Research Triangle Park, NC, USA.
Matoba N Matoba Nana N Department of Genetics, UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
McArdle PF McArdle Patrick F PF Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
McGue M McGue Matt M Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
McQueen MB McQueen Matthew B MB Department of Integrative Physiology, University of Colorado, Boulder, CO, USA.
Medland SE Medland Sarah E SE Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Metspalu A Metspalu Andres A Institute of Genomics, University of Tartu, Tartu, Estonia.
Meyers DA Meyers Deborah A DA Department of Medicine, University of Arizona, Tucson, AZ, USA.
Millwood IY Millwood Iona Y IY MRC Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Mitchell BD Mitchell Braxton D BD Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA.
Mohlke KL Mohlke Karen L KL Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Moll M Moll Matthew M Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Montasser ME Montasser May E ME Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Morrison AC Morrison Alanna C AC Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Mulas A Mulas Antonella A Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy.
Nielsen JB Nielsen Jonas B JB Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.
North KE North Kari E KE Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Oelsner EC Oelsner Elizabeth C EC Department of Medicine, Columbia University Medical Center, New York, NY, USA.
Okada Y Okada Yukinori Y Department of Genome Informatics, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.
Orrù V Orrù Valeria V Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy.
Palmer ND Palmer Nicholette D ND Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Palviainen T Palviainen Teemu T Institute for Molecular Medicine Finland - FIMM, University of Helsinki, Helsinki, Finland.
Pandit A Pandit Anita A Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Park SL Park S Lani SL Population Sciences of the Pacific Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Peters U Peters Ulrike U Department of Epidemiology, University of Washington, Seattle, WA, USA.
Peters A Peters Annette A German Centre for Cardiovascular Research, DZHK, Partner Site Munich, Munich, Germany.
Peyser PA Peyser Patricia A PA Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Polderman TJC Polderman Tinca J C TJC Department of Child and Adolescent Psychiatry, Amsterdam UMC, Amsterdam, The Netherlands.
Rafaels N Rafaels Nicholas N Division of Biomedical Informatics & Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Redline S Redline Susan S Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Reed RM Reed Robert M RM Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Reiner AP Reiner Alex P AP Department of Epidemiology, University of Washington, Seattle, WA, USA.
Rice JP Rice John P JP Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Rich SS Rich Stephen S SS Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, USA.
Richmond NE Richmond Nicole E NE Department of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Roan C Roan Carol C Center for Demography of Health and Aging, University of Wisconsin-Madison, Madison, WI, USA.
Rotter JI Rotter Jerome I JI The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Rueschman MN Rueschman Michael N MN Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.
Runarsdottir V Runarsdottir Valgerdur V SAA-National Center of Addiction Medicine, Vogur Hospital, Reykjavik, Iceland.
Saccone NL Saccone Nancy L NL Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Schwartz DA Schwartz David A DA Division of Pulmonary Sciences and Critical Care Medicine; Department of Medicine and Immunology, University of Colorado, Aurora, CO, USA.
Shadyab AH Shadyab Aladdin H AH Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, CA, USA.
Shi J Shi Jingchunzi J 23andMe, Inc, Sunnyvale, CA, USA.
Shringarpure SS Shringarpure Suyash S SS 23andMe, Inc, Sunnyvale, CA, USA.
Sicinski K Sicinski Kamil K Center for Demography of Health and Aging, University of Wisconsin-Madison, Madison, WI, USA.
Skogholt AH Skogholt Anne Heidi AH K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Smith JA Smith Jennifer A JA Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Smith NL Smith Nicholas L NL Seattle Epidemiologic Research and Information Center, Department of Veterans Affairs Office of Research and Development, Seattle, WA, USA.
Sotoodehnia N Sotoodehnia Nona N Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA.
Stallings MC Stallings Michael C MC Department Of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Stefansson H Stefansson Hreinn H deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Stefansson K Stefansson Kari K Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Stitzel JA Stitzel Jerry A JA Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.
Sun X Sun Xiao X Department of Epidemiology, Tulane University, New Orleans, LA, USA.
Syed M Syed Moin M Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
Tal-Singer R Tal-Singer Ruth R COPD Foundation, Washington, DC, USA.
Taylor AE Taylor Amy E AE Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Taylor KD Taylor Kent D KD The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Telen MJ Telen Marilyn J MJ Department of Medicine and Duke Comprehensive Sickle Cell Center, Duke University School of Medicine, Durham, NC, USA.
Thai KK Thai Khanh K KK Kaiser Permanente Northern California (KPNC), Division of Research, Oakland, CA, USA.
Tiwari H Tiwari Hemant H Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
Turman C Turman Constance C Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Tyrfingsson T Tyrfingsson Thorarinn T SAA-National Center of Addiction Medicine, Vogur Hospital, Reykjavik, Iceland.
Wall TL Wall Tamara L TL Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
Walters RG Walters Robin G RG MRC Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Weir DR Weir David R DR Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Weiss ST Weiss Scott T ST Brigham and Women's Hospital, Department of Medicine, Channing Division of Network Medicine, Boston, MA, USA.
White WB White Wendy B WB Jackson Heart Study Undergraduate Training and Education Center, Tougaloo College, Tougaloo, MS, USA.
Whitfield JB Whitfield John B JB Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Wiggins KL Wiggins Kerri L KL Department of Medicine, University of Washington, Seattle, WA, USA.
Willemsen G Willemsen Gonneke G Netherlands Twin Register, Dept Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Willer CJ Willer Cristen J CJ Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Winsvold BS Winsvold Bendik S BS Department of Neurology, Oslo University Hospital, Oslo, Norway.
Xu H Xu Huichun H Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Yanek LR Yanek Lisa R LR Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Yin J Yin Jie J Kaiser Permanente Northern California (KPNC), Division of Research, Oakland, CA, USA.
Young KL Young Kristin L KL Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Young KA Young Kendra A KA Department of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Yu B Yu Bing B Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Zhao W Zhao Wei W Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Zhou W Zhou Wei W Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Zöllner S Zöllner Sebastian S Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Zuccolo L Zuccolo Luisa L Health Data Science Centre, Fondazione Human Technopole, Milan, Italy.
23andMe Research Team
Biobank Japan Project
Batini C Batini Chiara C Department of Population Health Sciences, University of Leicester, Leicester, UK.
Bergen AW Bergen Andrew W AW BioRealm, LLC, Walnut, CA, USA.
Bierut LJ Bierut Laura J LJ Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
David SP David Sean P SP Department of Family Medicine, University of Chicago, Chicago, IL, USA.
Gagliano Taliun SA Gagliano Taliun Sarah A SA Research Centre, Montréal Heart Institute, Montréal, Québec, Canada.
Hancock DB Hancock Dana B DB GenOmics, Bioinformatics, and Translational Research Center, RTI International, Research Triangle Park, NC, USA.
Jiang B Jiang Bibo B Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA.
Munafò MR Munafò Marcus R MR School of Psychological Science, University of Bristol, Bristol, UK.
Thorgeirsson TE Thorgeirsson Thorgeir E TE deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Liu DJ Liu Dajiang J DJ Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA. dajiang.liu@psu.edu.
Vrieze S Vrieze Scott S Department of Psychology, University of Minnesota, Minneapolis, MN, USA. vrieze@umn.edu.
INVESTIGATORS
JOURNAL
VOLUME: 612
ISSUE: 7941
TITLE: Nature
ISOABBREVIATION: Nature
YEAR: 2022
MONTH: Dec
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1476-4687
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nature
COUNTRY: England
ISSNLINKING: 0028-0836
NLMUNIQUEID: 0410462
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
R01 DK093757 NIDDK NIH HHS United States
MC_PC_17228 Medical Research Council United Kingdom
R56 HG012358 NHGRI NIH HHS United States
MC_UU_12026/2 Medical Research Council United Kingdom
R21 DA040177 NIDA NIH HHS United States
R44 AA027675 NIAAA NIH HHS United States
R56 HG011035 NHGRI NIH HHS United States
R01 HL105756 NHLBI NIH HHS United States
R01 HG008983 NHGRI NIH HHS United States
MC_UU_00017/1 Medical Research Council United Kingdom
K24 HL148521 NHLBI NIH HHS United States
MC_U137686851 Medical Research Council United Kingdom
R03 HL154284 NHLBI NIH HHS United States
T32 DA050560 NIDA NIH HHS United States
R01 HG011035 NHGRI NIH HHS United States
MC_QA137853 Medical Research Council United Kingdom
R01 HL153805 NHLBI NIH HHS United States
R01 DK072193 NIDDK NIH HHS United States
R01 HL149683 NHLBI NIH HHS United States
R01 DA044283 NIDA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Humans
Genetic Predisposition to Disease genetics
Genetic Variation genetics
Genome-Wide Association Study methods
Multifactorial Inheritance genetics
Risk Factors genetics
Tobacco Use genetics
Alcohol Drinking genetics
Transcriptome genetics
Sample Size genetics
Genetic Loci genetics
Internationality genetics
Europe ethnology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
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Last Modified: Oct 15 2007