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PMID |
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TITLE |
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Genetic diversity fuels gene discovery for tobacco and alcohol use. |
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ABSTRACT |
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Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease and injury . These substances are used across the globe, yet genome-wide association studies have focused largely on individuals of European ancestries . Here we leveraged global genetic diversity across 3.4 million individuals from four major clines of global ancestry (approximately 21% non-European) to power the discovery and fine-mapping of genomic loci associated with tobacco and alcohol use, to inform function of these loci via ancestry-aware transcriptome-wide association studies, and to evaluate the genetic architecture and predictive power of polygenic risk within and across populations. We found that increases in sample size and genetic diversity improved locus identification and fine-mapping resolution, and that a large majority of the 3,823 associated variants (from 2,143 loci) showed consistent effect sizes across ancestry dimensions. However, polygenic risk scores developed in one ancestry performed poorly in others, highlighting the continued need to increase sample sizes of diverse ancestries to realize any potential benefit of polygenic prediction. |
© 2022. The Author(s). |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
received |
2022/03/09 |
accepted |
2022/10/25 |
pubmed |
2022/12/09 06:00 |
medline |
2022/12/24 06:00 |
entrez |
2022/12/08 11:54 |
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AUTHORS |
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NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Saunders GRB |
|
Saunders |
Gretchen R B |
GRB |
|
Department of Psychology, University of Minnesota, Minneapolis, MN, USA. |
Wang X |
|
Wang |
Xingyan |
X |
|
Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA. |
Chen F |
|
Chen |
Fang |
F |
|
Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA. |
Jang SK |
|
Jang |
Seon-Kyeong |
SK |
|
Department of Psychology, University of Minnesota, Minneapolis, MN, USA. |
Liu M |
|
Liu |
Mengzhen |
M |
|
Department of Psychology, University of Minnesota, Minneapolis, MN, USA. |
Wang C |
|
Wang |
Chen |
C |
|
Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA. |
Gao S |
|
Gao |
Shuang |
S |
|
Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA. |
Jiang Y |
|
Jiang |
Yu |
Y |
|
Department of Epidemiology & Population Health at Stanford University, Stanford, CA, USA. |
Khunsriraksakul C |
|
Khunsriraksakul |
Chachrit |
C |
|
Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA. |
Otto JM |
|
Otto |
Jacqueline M |
JM |
|
Department of Psychology, University of Minnesota, Minneapolis, MN, USA. |
Addison C |
|
Addison |
Clifton |
C |
|
Jackson Heart Study (JHS) Graduate Training and Education Center (GTEC), Department of Epidemiology and Biostatistics, School of Public Health, Jackson State University, Jackson, MS, USA. |
Akiyama M |
|
Akiyama |
Masato |
M |
|
Department of Ocular Pathology and Imaging Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan. |
Albert CM |
|
Albert |
Christine M |
CM |
|
Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. |
Aliev F |
|
Aliev |
Fazil |
F |
|
Department of Psychiatry, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA. |
Alonso A |
|
Alonso |
Alvaro |
A |
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Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA. |
Arnett DK |
|
Arnett |
Donna K |
DK |
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Dean's Office and Department of Epidemiology, College of Public Health, University of Kentucky, Lexington, KY, USA. |
Ashley-Koch AE |
|
Ashley-Koch |
Allison E |
AE |
|
Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA. |
Ashrani AA |
|
Ashrani |
Aneel A |
AA |
|
Division of Hematology, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA. |
Barnes KC |
|
Barnes |
Kathleen C |
KC |
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Tempus, Chicago, IL, USA. |
Barr RG |
|
Barr |
R Graham |
RG |
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Department of Medicine, Columbia University Medical Center, New York, NY, USA. |
Bartz TM |
|
Bartz |
Traci M |
TM |
|
Department of Biostatistics, University of Washington, Seattle, WA, USA. |
Becker DM |
|
Becker |
Diane M |
DM |
|
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. |
Bielak LF |
|
Bielak |
Lawrence F |
LF |
|
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA. |
Benjamin EJ |
|
Benjamin |
Emelia J |
EJ |
|
Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA. |
Bis JC |
|
Bis |
Joshua C |
JC |
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Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA. |
Bjornsdottir G |
|
Bjornsdottir |
Gyda |
G |
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deCODE Genetics/Amgen, Inc., Reykjavik, Iceland. |
Blangero J |
|
Blangero |
John |
J |
|
Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA. |
Bleecker ER |
|
Bleecker |
Eugene R |
ER |
|
Department of Medicine, University of Arizona, Tucson, AZ, USA. |
Boardman JD |
|
Boardman |
Jason D |
JD |
|
Institute of Behavioral Science, University of Colorado Boulder, Boulder, CO, USA. |
Boerwinkle E |
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Boerwinkle |
Eric |
E |
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Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA. |
Boomsma DI |
|
Boomsma |
Dorret I |
DI |
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Netherlands Twin Register, Dept Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. |
Boorgula MP |
|
Boorgula |
Meher Preethi |
MP |
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Division of Biomedical Informatics & Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. |
Bowden DW |
|
Bowden |
Donald W |
DW |
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Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA. |
Brody JA |
|
Brody |
Jennifer A |
JA |
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Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA. |
Cade BE |
|
Cade |
Brian E |
BE |
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Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA. |
Chasman DI |
|
Chasman |
Daniel I |
DI |
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Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. |
Chavan S |
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Chavan |
Sameer |
S |
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Division of Biomedical Informatics & Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. |
Chen YI |
|
Chen |
Yii-Der Ida |
YI |
|
Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA. |
Chen Z |
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Chen |
Zhengming |
Z |
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MRC Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK. |
Cheng I |
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Cheng |
Iona |
I |
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UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA. |
Cho MH |
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Cho |
Michael H |
MH |
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Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. |
Choquet H |
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Choquet |
Hélène |
H |
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Kaiser Permanente Northern California (KPNC), Division of Research, Oakland, CA, USA. |
Cole JW |
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Cole |
John W |
JW |
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Division of Vascular Neurology, Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA. |
Cornelis MC |
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Cornelis |
Marilyn C |
MC |
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Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. |
Cucca F |
|
Cucca |
Francesco |
F |
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University of Sassari, Sassari SS, Italy. |
Curran JE |
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Curran |
Joanne E |
JE |
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Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA. |
de Andrade M |
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de Andrade |
Mariza |
M |
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Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic College of Medicine and Science, Rochester, MN, USA. |
Dick DM |
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Dick |
Danielle M |
DM |
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Department of Psychiatry, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA. |
Docherty AR |
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Docherty |
Anna R |
AR |
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Huntsman Mental Health Institute, Salt Lake City, UT, USA. |
Duggirala R |
|
Duggirala |
Ravindranath |
R |
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Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA. |
Eaton CB |
|
Eaton |
Charles B |
CB |
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Department of Family Medicine, Brown University, Providence, RI, USA. |
Ehringer MA |
|
Ehringer |
Marissa A |
MA |
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Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA. |
Esko T |
|
Esko |
Tõnu |
T |
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Institute of Genomics, University of Tartu, Tartu, Estonia. |
Faul JD |
|
Faul |
Jessica D |
JD |
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Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA. |
Fernandes Silva L |
|
Fernandes Silva |
Lilian |
L |
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Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland. |
Fiorillo E |
|
Fiorillo |
Edoardo |
E |
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Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy. |
Fornage M |
|
Fornage |
Myriam |
M |
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Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA. |
Freedman BI |
|
Freedman |
Barry I |
BI |
|
Department of Internal Medicine-Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, USA. |
Gabrielsen ME |
|
Gabrielsen |
Maiken E |
ME |
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K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway. |
Garrett ME |
|
Garrett |
Melanie E |
ME |
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Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA. |
Gharib SA |
|
Gharib |
Sina A |
SA |
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Center for Lung Biology, Department of Medicine, University of Washington, Seattle, WA, USA. |
Gieger C |
|
Gieger |
Christian |
C |
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Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. |
Gillespie N |
|
Gillespie |
Nathan |
N |
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Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Virginia, USA. |
Glahn DC |
|
Glahn |
David C |
DC |
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Department of Psychiatry & Behavioral Sciences, Boston Children's Hospital & Harvard Medical School, Boston, MA, USA. |
Gordon SD |
|
Gordon |
Scott D |
SD |
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Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
Gu CC |
|
Gu |
Charles C |
CC |
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Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA. |
Gu D |
|
Gu |
Dongfeng |
D |
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Department of Epidemiology and Key Laboratory of Cardiovascular Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. |
Gudbjartsson DF |
|
Gudbjartsson |
Daniel F |
DF |
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School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland. |
Guo X |
|
Guo |
Xiuqing |
X |
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The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA. |
Haessler J |
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Haessler |
Jeffrey |
J |
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Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. |
Hall ME |
|
Hall |
Michael E |
ME |
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Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA. |
Haller T |
|
Haller |
Toomas |
T |
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Institute of Genomics, University of Tartu, Tartu, Estonia. |
Harris KM |
|
Harris |
Kathleen Mullan |
KM |
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Department of Sociology and the Carolina Population Center, University of North Carolina, Chapel Hill, NC, USA. |
He J |
|
He |
Jiang |
J |
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Translational Sciences Institute, Tulane University, New Orleans, LA, USA. |
Herd P |
|
Herd |
Pamela |
P |
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McCourt School of Public Policy, Georgetown University, Washington, DC, USA. |
Hewitt JK |
|
Hewitt |
John K |
JK |
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Department Of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA. |
Hickie I |
|
Hickie |
Ian |
I |
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Youth Mental Health & Technology Team, Brain and Mind Centre, University of Sydney, Sydney, Australia. |
Hidalgo B |
|
Hidalgo |
Bertha |
B |
|
Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA. |
Hokanson JE |
|
Hokanson |
John E |
JE |
|
Department of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. |
Hopfer C |
|
Hopfer |
Christian |
C |
|
Department of Psychiatry, University of Colorado Anschutz Medical Center, Denver, CO, USA. |
Hottenga J |
|
Hottenga |
JoukeJan |
J |
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Netherlands Twin Register, Dept Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. |
Hou L |
|
Hou |
Lifang |
L |
|
Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. |
Huang H |
|
Huang |
Hongyan |
H |
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Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA. |
Hung YJ |
|
Hung |
Yi-Jen |
YJ |
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Institute of Preventive Medicine, National Defense Medical Center, New Taipei City, Taiwan. |
Hunter DJ |
|
Hunter |
David J |
DJ |
|
Nuffield Department of Population Health, University of Oxford, Oxford, UK. |
Hveem K |
|
Hveem |
Kristian |
K |
|
Department of Research, Innovation and Education, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. |
Hwang SJ |
|
Hwang |
Shih-Jen |
SJ |
|
Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. |
Hwu CM |
|
Hwu |
Chii-Min |
CM |
|
Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan. |
Iacono W |
|
Iacono |
William |
W |
|
Department of Psychology, University of Minnesota, Minneapolis, MN, USA. |
Irvin MR |
|
Irvin |
Marguerite R |
MR |
|
Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA. |
Jee YH |
|
Jee |
Yon Ho |
YH |
|
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. |
Johnson EO |
|
Johnson |
Eric O |
EO |
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Fellow Program, RTI International, Research Triangle Park, NC, USA. |
Joo YY |
|
Joo |
Yoonjung Y |
YY |
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Institute of Data Science, Korea University, Seoul, South Korea. |
Jorgenson E |
|
Jorgenson |
Eric |
E |
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Regeneron Genetics Center, Tarrytown, NY, USA. |
Justice AE |
|
Justice |
Anne E |
AE |
|
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. |
Kamatani Y |
|
Kamatani |
Yoichiro |
Y |
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Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan. |
Kaplan RC |
|
Kaplan |
Robert C |
RC |
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Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA. |
Kaprio J |
|
Kaprio |
Jaakko |
J |
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Institute for Molecular Medicine Finland - FIMM, University of Helsinki, Helsinki, Finland. |
Kardia SLR |
|
Kardia |
Sharon L R |
SLR |
|
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA. |
Keller MC |
|
Keller |
Matthew C |
MC |
|
Department Of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA. |
Kelly TN |
|
Kelly |
Tanika N |
TN |
|
Translational Sciences Institute, Tulane University, New Orleans, LA, USA. |
Kooperberg C |
|
Kooperberg |
Charles |
C |
|
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. |
Korhonen T |
|
Korhonen |
Tellervo |
T |
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Institute for Molecular Medicine Finland - FIMM, University of Helsinki, Helsinki, Finland. |
Kraft P |
|
Kraft |
Peter |
P |
|
Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA. |
Krauter K |
|
Krauter |
Kenneth |
K |
|
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO, USA. |
Kuusisto J |
|
Kuusisto |
Johanna |
J |
|
Center for Medicine and Clinical Research, Kuopio University Hospital, Kuopio, Finland. |
Laakso M |
|
Laakso |
Markku |
M |
|
Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland. |
Lasky-Su J |
|
Lasky-Su |
Jessica |
J |
|
Brigham and Women's Hospital, Department of Medicine, Channing Division of Network Medicine, Boston, MA, USA. |
Lee WJ |
|
Lee |
Wen-Jane |
WJ |
|
Department of Medical Research, Taichung Veterans General Hospital, Taichung City, Taiwan. |
Lee JJ |
|
Lee |
James J |
JJ |
|
Department of Psychology, University of Minnesota, Minneapolis, MN, USA. |
Levy D |
|
Levy |
Daniel |
D |
|
Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. |
Li L |
|
Li |
Liming |
L |
|
Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China. |
Li K |
|
Li |
Kevin |
K |
|
Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA. |
Li Y |
|
Li |
Yuqing |
Y |
|
Department of Epidemiology & Biostatistics, University of California, San Francisco, CA, USA. |
Lin K |
|
Lin |
Kuang |
K |
|
Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK. |
Lind PA |
|
Lind |
Penelope A |
PA |
|
School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia. |
Liu C |
|
Liu |
Chunyu |
C |
|
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. |
Lloyd-Jones DM |
|
Lloyd-Jones |
Donald M |
DM |
|
Departments of Preventive Medicine, Medicine, and Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. |
Lutz SM |
|
Lutz |
Sharon M |
SM |
|
Department of Biostatics, Harvard T.H. Chan School of Public Health, Boston, MA, USA. |
Ma J |
|
Ma |
Jiantao |
J |
|
Division of Nutrition Epidemiology and Data Science, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA. |
Mägi R |
|
Mägi |
Reedik |
R |
|
Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA. |
Manichaikul A |
|
Manichaikul |
Ani |
A |
|
Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, USA. |
Martin NG |
|
Martin |
Nicholas G |
NG |
|
Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
Mathur R |
|
Mathur |
Ravi |
R |
|
GenOmics, Bioinformatics, and Translational Research Center, RTI International, Research Triangle Park, NC, USA. |
Matoba N |
|
Matoba |
Nana |
N |
|
Department of Genetics, UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. |
McArdle PF |
|
McArdle |
Patrick F |
PF |
|
Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. |
McGue M |
|
McGue |
Matt |
M |
|
Department of Psychology, University of Minnesota, Minneapolis, MN, USA. |
McQueen MB |
|
McQueen |
Matthew B |
MB |
|
Department of Integrative Physiology, University of Colorado, Boulder, CO, USA. |
Medland SE |
|
Medland |
Sarah E |
SE |
|
Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
Metspalu A |
|
Metspalu |
Andres |
A |
|
Institute of Genomics, University of Tartu, Tartu, Estonia. |
Meyers DA |
|
Meyers |
Deborah A |
DA |
|
Department of Medicine, University of Arizona, Tucson, AZ, USA. |
Millwood IY |
|
Millwood |
Iona Y |
IY |
|
MRC Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK. |
Mitchell BD |
|
Mitchell |
Braxton D |
BD |
|
Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA. |
Mohlke KL |
|
Mohlke |
Karen L |
KL |
|
Department of Genetics, University of North Carolina, Chapel Hill, NC, USA. |
Moll M |
|
Moll |
Matthew |
M |
|
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. |
Montasser ME |
|
Montasser |
May E |
ME |
|
Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. |
Morrison AC |
|
Morrison |
Alanna C |
AC |
|
Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA. |
Mulas A |
|
Mulas |
Antonella |
A |
|
Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy. |
Nielsen JB |
|
Nielsen |
Jonas B |
JB |
|
Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA. |
North KE |
|
North |
Kari E |
KE |
|
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. |
Oelsner EC |
|
Oelsner |
Elizabeth C |
EC |
|
Department of Medicine, Columbia University Medical Center, New York, NY, USA. |
Okada Y |
|
Okada |
Yukinori |
Y |
|
Department of Genome Informatics, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan. |
Orrù V |
|
Orrù |
Valeria |
V |
|
Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy. |
Palmer ND |
|
Palmer |
Nicholette D |
ND |
|
Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA. |
Palviainen T |
|
Palviainen |
Teemu |
T |
|
Institute for Molecular Medicine Finland - FIMM, University of Helsinki, Helsinki, Finland. |
Pandit A |
|
Pandit |
Anita |
A |
|
Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA. |
Park SL |
|
Park |
S Lani |
SL |
|
Population Sciences of the Pacific Program, University of Hawaii Cancer Center, Honolulu, HI, USA. |
Peters U |
|
Peters |
Ulrike |
U |
|
Department of Epidemiology, University of Washington, Seattle, WA, USA. |
Peters A |
|
Peters |
Annette |
A |
|
German Centre for Cardiovascular Research, DZHK, Partner Site Munich, Munich, Germany. |
Peyser PA |
|
Peyser |
Patricia A |
PA |
|
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA. |
Polderman TJC |
|
Polderman |
Tinca J C |
TJC |
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Department of Child and Adolescent Psychiatry, Amsterdam UMC, Amsterdam, The Netherlands. |
Rafaels N |
|
Rafaels |
Nicholas |
N |
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Division of Biomedical Informatics & Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. |
Redline S |
|
Redline |
Susan |
S |
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Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA. |
Reed RM |
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Reed |
Robert M |
RM |
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Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. |
Reiner AP |
|
Reiner |
Alex P |
AP |
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Department of Epidemiology, University of Washington, Seattle, WA, USA. |
Rice JP |
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Rice |
John P |
JP |
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Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. |
Rich SS |
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Rich |
Stephen S |
SS |
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Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, USA. |
Richmond NE |
|
Richmond |
Nicole E |
NE |
|
Department of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. |
Roan C |
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Roan |
Carol |
C |
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Center for Demography of Health and Aging, University of Wisconsin-Madison, Madison, WI, USA. |
Rotter JI |
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Rotter |
Jerome I |
JI |
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The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA. |
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|
Rueschman |
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MN |
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Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA. |
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Runarsdottir |
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V |
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SAA-National Center of Addiction Medicine, Vogur Hospital, Reykjavik, Iceland. |
Saccone NL |
|
Saccone |
Nancy L |
NL |
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Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA. |
Schwartz DA |
|
Schwartz |
David A |
DA |
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Division of Pulmonary Sciences and Critical Care Medicine; Department of Medicine and Immunology, University of Colorado, Aurora, CO, USA. |
Shadyab AH |
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Shadyab |
Aladdin H |
AH |
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Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, CA, USA. |
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J |
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23andMe, Inc, Sunnyvale, CA, USA. |
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Shringarpure |
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SS |
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23andMe, Inc, Sunnyvale, CA, USA. |
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Sicinski |
Kamil |
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Center for Demography of Health and Aging, University of Wisconsin-Madison, Madison, WI, USA. |
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Skogholt |
Anne Heidi |
AH |
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K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway. |
Smith JA |
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Smith |
Jennifer A |
JA |
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Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA. |
Smith NL |
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Smith |
Nicholas L |
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Seattle Epidemiologic Research and Information Center, Department of Veterans Affairs Office of Research and Development, Seattle, WA, USA. |
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Sotoodehnia |
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N |
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Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA. |
Stallings MC |
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Stallings |
Michael C |
MC |
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Department Of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA. |
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Stefansson |
Hreinn |
H |
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deCODE Genetics/Amgen, Inc., Reykjavik, Iceland. |
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Stefansson |
Kari |
K |
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Faculty of Medicine, University of Iceland, Reykjavik, Iceland. |
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|
Stitzel |
Jerry A |
JA |
|
Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA. |
Sun X |
|
Sun |
Xiao |
X |
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Department of Epidemiology, Tulane University, New Orleans, LA, USA. |
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Syed |
Moin |
M |
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Department of Psychology, University of Minnesota, Minneapolis, MN, USA. |
Tal-Singer R |
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Tal-Singer |
Ruth |
R |
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COPD Foundation, Washington, DC, USA. |
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Taylor |
Amy E |
AE |
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Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. |
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Taylor |
Kent D |
KD |
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The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA. |
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Telen |
Marilyn J |
MJ |
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Department of Medicine and Duke Comprehensive Sickle Cell Center, Duke University School of Medicine, Durham, NC, USA. |
Thai KK |
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Thai |
Khanh K |
KK |
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Kaiser Permanente Northern California (KPNC), Division of Research, Oakland, CA, USA. |
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Tiwari |
Hemant |
H |
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Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA. |
Turman C |
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Turman |
Constance |
C |
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Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA. |
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T |
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SAA-National Center of Addiction Medicine, Vogur Hospital, Reykjavik, Iceland. |
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Wall |
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TL |
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Department of Psychiatry, University of California San Diego, San Diego, CA, USA. |
Walters RG |
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Walters |
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RG |
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MRC Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK. |
Weir DR |
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Weir |
David R |
DR |
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Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA. |
Weiss ST |
|
Weiss |
Scott T |
ST |
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Brigham and Women's Hospital, Department of Medicine, Channing Division of Network Medicine, Boston, MA, USA. |
White WB |
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White |
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WB |
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Jackson Heart Study Undergraduate Training and Education Center, Tougaloo College, Tougaloo, MS, USA. |
Whitfield JB |
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Whitfield |
John B |
JB |
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Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
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Wiggins |
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KL |
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Department of Medicine, University of Washington, Seattle, WA, USA. |
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G |
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Netherlands Twin Register, Dept Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. |
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Willer |
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CJ |
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Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA. |
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Winsvold |
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Department of Neurology, Oslo University Hospital, Oslo, Norway. |
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Huichun |
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Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. |
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Lisa R |
LR |
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Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. |
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Kaiser Permanente Northern California (KPNC), Division of Research, Oakland, CA, USA. |
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Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. |
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Department of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. |
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Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA. |
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W |
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Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA. |
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W |
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Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA. |
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Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA. |
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Health Data Science Centre, Fondazione Human Technopole, Milan, Italy. |
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Biobank Japan Project |
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Department of Population Health Sciences, University of Leicester, Leicester, UK. |
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Bergen |
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AW |
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BioRealm, LLC, Walnut, CA, USA. |
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Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. |
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Department of Family Medicine, University of Chicago, Chicago, IL, USA. |
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Gagliano Taliun |
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SA |
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Research Centre, Montréal Heart Institute, Montréal, Québec, Canada. |
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GenOmics, Bioinformatics, and Translational Research Center, RTI International, Research Triangle Park, NC, USA. |
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Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA. |
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School of Psychological Science, University of Bristol, Bristol, UK. |
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deCODE Genetics/Amgen, Inc., Reykjavik, Iceland. |
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Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA. dajiang.liu@psu.edu. |
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Department of Psychology, University of Minnesota, Minneapolis, MN, USA. vrieze@umn.edu. |
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INVESTIGATORS |
|
|
JOURNAL |
|
VOLUME: 612 |
ISSUE: 7941 |
TITLE: Nature |
ISOABBREVIATION: Nature |
YEAR: 2022 |
MONTH: Dec |
DAY: |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Internet |
ISSN: 1476-4687 |
ISSNTYPE: Electronic |
|
MEDLINE JOURNAL |
|
MEDLINETA: Nature |
COUNTRY: England |
ISSNLINKING: 0028-0836 |
NLMUNIQUEID: 0410462 |
|
PUBLICATION TYPE |
|
PUBLICATIONTYPE TEXT |
Journal Article |
Research Support, Non-U.S. Gov't |
Research Support, N.I.H., Extramural |
|
COMMENTS AND CORRECTIONS |
|
|
GRANTS |
|
GRANTID |
AGENCY |
COUNTRY |
R01 DK093757 |
NIDDK NIH HHS |
United States |
MC_PC_17228 |
Medical Research Council |
United Kingdom |
R56 HG012358 |
NHGRI NIH HHS |
United States |
MC_UU_12026/2 |
Medical Research Council |
United Kingdom |
R21 DA040177 |
NIDA NIH HHS |
United States |
R44 AA027675 |
NIAAA NIH HHS |
United States |
R56 HG011035 |
NHGRI NIH HHS |
United States |
R01 HL105756 |
NHLBI NIH HHS |
United States |
R01 HG008983 |
NHGRI NIH HHS |
United States |
MC_UU_00017/1 |
Medical Research Council |
United Kingdom |
K24 HL148521 |
NHLBI NIH HHS |
United States |
MC_U137686851 |
Medical Research Council |
United Kingdom |
R03 HL154284 |
NHLBI NIH HHS |
United States |
T32 DA050560 |
NIDA NIH HHS |
United States |
R01 HG011035 |
NHGRI NIH HHS |
United States |
MC_QA137853 |
Medical Research Council |
United Kingdom |
R01 HL153805 |
NHLBI NIH HHS |
United States |
R01 DK072193 |
NIDDK NIH HHS |
United States |
R01 HL149683 |
NHLBI NIH HHS |
United States |
R01 DA044283 |
NIDA NIH HHS |
United States |
|
GENERAL NOTE |
|
|
KEYWORDS |
|
|
MESH HEADINGS |
|
DESCRIPTORNAME |
QUALIFIERNAME |
Humans |
|
Genetic Predisposition to Disease |
genetics |
Genetic Variation |
genetics |
Genome-Wide Association Study |
methods |
Multifactorial Inheritance |
genetics |
Risk Factors |
genetics |
Tobacco Use |
genetics |
Alcohol Drinking |
genetics |
Transcriptome |
genetics |
Sample Size |
genetics |
Genetic Loci |
genetics |
Internationality |
genetics |
Europe |
ethnology |
|
SUPPLEMENTARY MESH |
|
|
GENE SYMBOLS |
|
|
CHEMICALS |
|
|
OTHER ID's |
|
|
|