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| PMID |
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| TITLE |
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| Phenotypic and genetic factors associated with donation of DNA and consent to record linkage for prescription history in the Australian Genetics of Depression Study. |
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| ABSTRACT |
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| Samples can be prone to ascertainment and attrition biases. The Australian Genetics of Depression Study is a large publicly recruited cohort (n = 20,689) established to increase the understanding of depression and antidepressant treatment response. This study investigates differences between participants who donated a saliva sample or agreed to linkage of their records compared to those who did not. We observed that older, male participants with higher education were more likely to donate a saliva sample. Self-reported bipolar disorder, ADHD, panic disorder, PTSD, substance use disorder, and social anxiety disorder were associated with lower odds of donating a saliva sample, whereas anorexia was associated with higher odds of donation. Male and younger participants showed higher odds of agreeing to record linkage. Participants with higher neuroticism scores and those with a history of bipolar disorder were also more likely to agree to record linkage whereas participants with a diagnosis of anorexia were less likely to agree. Increased likelihood of consent was associated with increased genetic susceptibility to anorexia and reduced genetic risk for depression, and schizophrenia. Overall, our results show moderate differences among these subsamples. Most current epidemiological studies do not search for attrition biases at the genetic level. The possibility to do so is a strength of samples such as the AGDS. Our results suggest that analyses can be made more robust by identifying attrition biases both on the phenotypic and genetic level, and either contextualising them as a potential limitation or performing sensitivity analyses adjusting for them. |
| © 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2021/12/10 |
| accepted |
2022/11/15 |
| entrez |
2022/11/24 11:24 |
| pubmed |
2022/11/25 06:00 |
| medline |
2022/11/25 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Gomez L |
|
Gomez |
Lina |
L |
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Genetic Epidemiology Lab, Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
| Díaz-Torres S |
|
Díaz-Torres |
Santiago |
S |
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Statistical Genetics Lab, Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
| Colodro-Conde L |
|
Colodro-Conde |
Lucía |
L |
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Psychiatric Genetics Lab, Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
| Garcia-Marin LM |
|
Garcia-Marin |
Luis M |
LM |
|
School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia. |
| Yap CX |
|
Yap |
Chloe X |
CX |
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Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia. |
| Byrne EM |
|
Byrne |
Enda M |
EM |
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Child Health Research Centre, The University of Queensland, Brisbane, QLD, Australia. |
| Yengo L |
|
Yengo |
Loic |
L |
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Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia. |
| Lind PA |
|
Lind |
Penelope A |
PA |
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School of Biomedical Sciences, Queensland Institute of Technology, Brisbane, QLD, Australia. |
| Wray NR |
|
Wray |
Naomi R |
NR |
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Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia. |
| Medland SE |
|
Medland |
Sarah E |
SE |
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Psychiatric Genetics Lab, Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
| Hickie IB |
|
Hickie |
Ian B |
IB |
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Brain and Mind Centre, University of Sydney, Camperdown, NSW, Australia. |
| Lupton MK |
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Lupton |
Michelle K |
MK |
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Genetic Epidemiology Lab, Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
| Rentería ME |
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Rentería |
Miguel E |
ME |
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School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
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Genetic Epidemiology Lab, Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
| Campos AI |
|
Campos |
Adrian I |
AI |
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Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia. adrianisaac.camposgonzalez@uq.edu.au. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: |
| ISSUE: |
| TITLE: European archives of psychiatry and clinical neuroscience |
| ISOABBREVIATION: Eur Arch Psychiatry Clin Neurosci |
| YEAR: 2022 |
| MONTH: Nov |
| DAY: 24 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1433-8491 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Eur Arch Psychiatry Clin Neurosci |
| COUNTRY: Germany |
| ISSNLINKING: 0940-1334 |
| NLMUNIQUEID: 9103030 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| Attrition |
| Bias |
| Cohort study |
| Depression |
| Epidemiology |
| Genetics |
| PRS |
| Polygenic |
| Recruitment |
| Selection bias |
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