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| PMID |
|
|
| TITLE |
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| Educational Attainment Polygenic Scores: Examining Evidence for Gene-Environment Interplay with Adolescent Alcohol, Tobacco and Cannabis Use. |
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| ABSTRACT |
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| Genes associated with educational attainment may be related to or interact with adolescent alcohol, tobacco and cannabis use. Potential gene-environment interplay between educational attainment polygenic scores (EA-PGS) and adolescent alcohol, tobacco, and cannabis use was evaluated with a series of regression models fitted to data from a sample of 1871 adult Australian twins. All models controlled for age, age<sup>2</sup>, cohort, sex and genetic ancestry as fixed effects, and a genetic relatedness matrix was included as a random effect. Although there was no evidence that adolescent alcohol, tobacco or cannabis use interacted with EA-PGS to influence educational attainment, there was a significant, positive gene-environment correlation with adolescent alcohol use at all PGS thresholds (<i>p</i>s <.02). Higher EA-PGS were associated with an increased likelihood of using alcohol as an adolescent (Δ<i>R</i><sup>2</sup> ranged from 0.5% to 1.1%). The positive gene-environment correlation suggests a complex relationship between educational attainment and alcohol use that is due to common genetic factors. |
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| DATE PUBLISHED |
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| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
2022/10/04 06:00 |
| medline |
2022/11/10 06:00 |
| entrez |
2022/10/03 06:14 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Davis CN |
|
Davis |
Christal N |
CN |
|
Department of Psychological Sciences, University of Missouri, Columbia, MO65211, USA. |
| Gizer IR |
|
Gizer |
Ian R |
IR |
|
Department of Psychological Sciences, University of Missouri, Columbia, MO65211, USA. |
| Colodro-Conde L |
|
Colodro-Conde |
Lucía |
L |
|
QIMR Berghofer Medical Research Institute, Brisbane, Queensland4006, Australia. |
| Statham DJ |
|
Statham |
Dixie J |
DJ |
|
Federation University, Ballarat, Victoria3350, Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
QIMR Berghofer Medical Research Institute, Brisbane, Queensland4006, Australia. |
| Slutske WS |
|
Slutske |
Wendy S |
WS |
|
Center for Tobacco Research and Intervention and Department of Family Medicine and Community Health, University of Wisconsin School of Medicine and Public Health, Madison, WI53711, USA. |
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| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 25 |
| ISSUE: 4-5 |
| TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies |
| ISOABBREVIATION: Twin Res Hum Genet |
| YEAR: 2022 |
| MONTH: 10 |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1832-4274 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
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| MEDLINETA: Twin Res Hum Genet |
| COUNTRY: England |
| ISSNLINKING: 1832-4274 |
| NLMUNIQUEID: 101244624 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
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| COMMENTS AND CORRECTIONS |
|
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| GRANTS |
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| GENERAL NOTE |
|
|
| KEYWORDS |
|
| KEYWORD |
| alcohol |
| cannabis |
| educational attainment |
| polygenic scores |
| tobacco |
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| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
|
| Adolescent |
|
| Humans |
|
| Cannabis |
|
| Tobacco |
|
| Australia |
epidemiology |
| Multifactorial Inheritance |
genetics |
| Educational Status |
genetics |
| Ethanol |
genetics |
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| SUPPLEMENTARY MESH |
|
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| GENE SYMBOLS |
|
|
| CHEMICALS |
|
| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| 3K9958V90M |
Ethanol |
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| OTHER ID's |
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