Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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36071172
TITLE
Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention.
ABSTRACT
Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type II muscle fibers, and possibly protection from exercise-induced muscle damage. Finally, Mendelian randomization analyses show that beneficial effects of lower LST and higher MVPA on several risk factors and diseases are mediated or confounded by body mass index (BMI). Our results provide insights into physical activity mechanisms and its role in disease prevention.
© 2022. The Author(s).
DATE PUBLISHED
2022 Sep
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2021/11/30
accepted 2022/07/18
pubmed 2022/09/08 06:00
medline 2022/09/16 06:00
entrez 2022/09/07 23:27
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Wang Z Wang Zhe Z The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. zhe.wang@mssm.edu.
Emmerich A Emmerich Andrew A Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.
Pillon NJ Pillon Nicolas J NJ Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Moore T Moore Tim T Division of Cardiology, Department of Medicine, University of California, Los Angeles, CA, USA.
Hemerich D Hemerich Daiane D The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Cornelis MC Cornelis Marilyn C MC Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Mazzaferro E Mazzaferro Eugenia E The Beijer Laboratory and Department of Immunology, Genetics and Pathology, Uppsala University and SciLifeLab, Uppsala, Sweden.
Broos S Broos Siacia S Faculty of Movement and Rehabilitation Sciences, Department of Movement Sciences - Physical Activity, Sports & Health Research Group, KU Leuven, Leuven, Belgium.
Ahluwalia TS Ahluwalia Tarunveer S TS The Bioinformatics Center, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Bartz TM Bartz Traci M TM Department of Biostatistics, University of Washington, Seattle, WA, USA.
Bentley AR Bentley Amy R AR Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Bielak LF Bielak Lawrence F LF Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Chong M Chong Mike M Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
Chu AY Chu Audrey Y AY GlaxoSmithKline, Cambridge, MA, USA.
Berry D Berry Diane D Division of Population, Policy and Practice, Great Ormond Street Hospital Institute for Child Health, University College London, London, UK.
Dorajoo R Dorajoo Rajkumar R Health Services and Systems Research, Duke-NUS Medical School, Singapore, Singapore.
Dueker ND Dueker Nicole D ND Department of Epidemiology & Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Kasbohm E Kasbohm Elisa E Institute of Mathematics and Computer Science, University of Greifswald, Greifswald, Germany.
Feenstra B Feenstra Bjarke B Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Feitosa MF Feitosa Mary F MF Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Gieger C Gieger Christian C Research Unit of Molecular Epidemiology, Helmholtz Zentrum München -Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Munich, Germany.
Graff M Graff Mariaelisa M Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
Hall LM Hall Leanne M LM NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Haller T Haller Toomas T Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Hartwig FP Hartwig Fernando P FP MRC Integrative Epidemiology Unit, NIHR Bristol Biomedical Research Center, University of Bristol, Bristol, UK.
Hillis DA Hillis David A DA Genetics, Genomics, and Bioinformatics Graduate Program, University of California, Riverside, CA, USA.
Huikari V Huikari Ville V Institute of Health Sciences, University of Oulu, Oulu, Finland.
Heard-Costa N Heard-Costa Nancy N Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
Holzapfel C Holzapfel Christina C Institute for Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany.
Jackson AU Jackson Anne U AU Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Johansson Å Johansson Åsa Å Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Jørgensen AM Jørgensen Anja Moltke AM Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Kaakinen MA Kaakinen Marika A MA Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Karlsson R Karlsson Robert R Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Kerr KF Kerr Kathleen F KF Department of Biostatistics, University of Washington, Seattle, WA, USA.
Kim B Kim Boram B Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, South Korea.
Koolhaas CM Koolhaas Chantal M CM Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Kutalik Z Kutalik Zoltan Z Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Lagou V Lagou Vasiliki V Wellcome Sanger Institute, Cambridge, UK.
Lind PA Lind Penelope A PA School of Biomedical Science, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.
Lorentzon M Lorentzon Mattias M Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Victoria, Australia.
Lyytikäinen LP Lyytikäinen Leo-Pekka LP Finnish Cardiovascular Research Center - Tampere, Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Mangino M Mangino Massimo M NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, UK.
Metzendorf C Metzendorf Christoph C The Beijer Laboratory and Department of Immunology, Genetics and Pathology, Uppsala University and SciLifeLab, Uppsala, Sweden.
Monroe KR Monroe Kristine R KR Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Pacolet A Pacolet Alexander A Faculty of Movement and Rehabilitation Sciences, Department of Movement Sciences - Exercise Physiology Research Group, KU Leuven, Leuven, Belgium.
Pérusse L Pérusse Louis L Centre Nutrition Santé et Société (NUTRISS), Institute of Nutrition and Functional Foods (INAF), Université Laval, Quebec, Quebec, Canada.
Pool R Pool Rene R Amsterdam Public Health Research Institute, Amsterdam UMC, Amsterdam, the Netherlands.
Richmond RC Richmond Rebecca C RC MRC Integrative Epidemiology Unit and Avon Longitudinal Study of Parents and Children, University of Bristol Medical School, Population Health Sciences and Avon Longitudinal Study of Parents and Children, University of Bristol, Bristol, UK.
Rivera NV Rivera Natalia V NV Center of Molecular Medicine (CMM), Karolinska Institutet, Stockholm, Sweden.
Robiou-du-Pont S Robiou-du-Pont Sebastien S Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
Schraut KE Schraut Katharina E KE Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
Schulz CA Schulz Christina-Alexandra CA Department of Nutrition and Food Sciences, Nutritional Epidemiology, University of Bonn, Bonn, Germany.
Stringham HM Stringham Heather M HM Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Tanaka T Tanaka Toshiko T Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
Teumer A Teumer Alexander A German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany.
Turman C Turman Constance C Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
van der Most PJ van der Most Peter J PJ Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Vanmunster M Vanmunster Mathias M Faculty of Movement and Rehabilitation Sciences, Department of Movement Sciences - Exercise Physiology Research Group, KU Leuven, Leuven, Belgium.
van Rooij FJA van Rooij Frank J A FJA Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
van Vliet-Ostaptchouk JV van Vliet-Ostaptchouk Jana V JV Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Zhang X Zhang Xiaoshuai X School of Public Health, Department of Biostatistics, Shandong University, Jinan, China.
Zhao JH Zhao Jing-Hua JH Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Zhao W Zhao Wei W Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Balkhiyarova Z Balkhiyarova Zhanna Z People-Centred Artificial Intelligence Institute, University of Surrey, Guilford, UK.
Balslev-Harder MN Balslev-Harder Marie N MN Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Baumeister SE Baumeister Sebastian E SE University of Münster, Münster, Germany.
Beilby J Beilby John J Diagnostic Genomics, PathWest Laboratory Medicine WA, Perth, Western Australia, Australia.
Blangero J Blangero John J South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, TX, USA.
Boomsma DI Boomsma Dorret I DI Amsterdam Public Health Research Institute, Amsterdam UMC, Amsterdam, the Netherlands.
Brage S Brage Soren S MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Braund PS Braund Peter S PS NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Brody JA Brody Jennifer A JA Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Bruinenberg M Bruinenberg Marcel M Lifelines Cohort Study, Groningen, the Netherlands.
Ekelund U Ekelund Ulf U Department of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway.
Liu CT Liu Ching-Ti CT Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Cole JW Cole John W JW Vascular Neurology, Department of Neurology, University of Maryland School of Medicine and the Baltimore VAMC, Baltimore, MD, USA.
Collins FS Collins Francis S FS Center for Precision Health Research, National Human Genome Research Institute, NIH, Bethesda, MD, USA.
Cupples LA Cupples L Adrienne LA Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Esko T Esko Tõnu T Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Enroth S Enroth Stefan S Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Faul JD Faul Jessica D JD Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Fernandez-Rhodes L Fernandez-Rhodes Lindsay L Department of Biobehavioral Health, College of Health and Human Development, Pennsylvania State University, University Park, PA, USA.
Fohner AE Fohner Alison E AE Department of Epidemiology, Institute of Public Health Genetics, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.
Franco OH Franco Oscar H OH Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland.
Galesloot TE Galesloot Tessel E TE Radboud Institute for Health Sciences, Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands.
Gordon SD Gordon Scott D SD Mental Health and Neuroscience Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Grarup N Grarup Niels N Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Hartman CA Hartman Catharina A CA Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Heiss G Heiss Gerardo G Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
Hui J Hui Jennie J Busselton Population Medical Research Institute, Busselton, Western Australia, Australia.
Illig T Illig Thomas T Department of Human Genetics, Hannover Medical School, Hannover, Germany.
Jago R Jago Russell R Centre for Exercise Nutrition & Health Sciences, School for Policy Studies, University of Bristol, Bristol, UK.
James A James Alan A Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Western Australia, Perth, Australia.
Joshi PK Joshi Peter K PK Humanity Inc, Boston, MA, USA.
Jung T Jung Taeyeong T Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, South Korea.
Kähönen M Kähönen Mika M Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.
Kilpeläinen TO Kilpeläinen Tuomas O TO Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Koh WP Koh Woon-Puay WP Singapore Institute for Clinical Sciences, Agency for Science, Technology, and Research, Singapore, Singapore.
Kolcic I Kolcic Ivana I Department of Public Health, University of Split School of Medicine, Split, Croatia.
Kraft PP Kraft Peter P PP Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Kuusisto J Kuusisto Johanna J Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Launer LJ Launer Lenore J LJ Laboratory of Epidemiology and Population Sciences, National Institutes of Health, Baltimore, MD, USA.
Li A Li Aihua A Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
Linneberg A Linneberg Allan A Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Luan J Luan Jian'an J MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Vidal PM Vidal Pedro Marques PM Division of Internal Medicine, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Medland SE Medland Sarah E SE School of Psychology and Faculty of Medicine, University of Queensland, St Lucia, Queensland, Australia.
Milaneschi Y Milaneschi Yuri Y Department of Psychiatry, Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands.
Moscati A Moscati Arden A The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Musk B Musk Bill B Busselton Population Medical Research Institute, Busselton, Western Australia, Australia.
Nelson CP Nelson Christopher P CP NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Nolte IM Nolte Ilja M IM Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Pedersen NL Pedersen Nancy L NL Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Peters A Peters Annette A Institute of Epidemiology, Helmholtz Zentrum München -Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Munich, Germany.
Peyser PA Peyser Patricia A PA Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Power C Power Christine C Division of Population, Policy and Practice, Great Ormond Street Hospital Institute for Child Health, University College London, London, UK.
Raitakari OT Raitakari Olli T OT Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
Reedik M Reedik Mägi M Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Reiner AP Reiner Alex P AP Department of Epidemiology, University of Washington, Seattle, WA, USA.
Ridker PM Ridker Paul M PM Harvard Medical School, Boston, MA, USA.
Rudan I Rudan Igor I Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
Ryan K Ryan Kathy K Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Sarzynski MA Sarzynski Mark A MA Department of Exercise Science, University of South Carolina, Columbia, SC, USA.
Scott LJ Scott Laura J LJ Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Scott RA Scott Robert A RA MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Sidney S Sidney Stephen S Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Siggeirsdottir K Siggeirsdottir Kristin K Icelandic Heart Association, Kópavogur, Iceland.
Smith AV Smith Albert V AV Icelandic Heart Association, Kópavogur, Iceland.
Smith JA Smith Jennifer A JA Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Sonestedt E Sonestedt Emily E Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
Strøm M Strøm Marin M Faculty of Health Sciences, University of the Faroe Islands, Tórshavn, Faroe Islands.
Tai ES Tai E Shyong ES Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Teo KK Teo Koon K KK Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Thorand B Thorand Barbara B Institute of Epidemiology, Helmholtz Zentrum München -Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Munich, Germany.
Tönjes A Tönjes Anke A Department of Medicine, University of Leipzig, Leipzig, Germany.
Tremblay A Tremblay Angelo A Centre Nutrition Santé et Société (NUTRISS), Institute of Nutrition and Functional Foods (INAF), Université Laval, Quebec, Quebec, Canada.
Uitterlinden AG Uitterlinden Andre G AG Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
Vangipurapu J Vangipurapu Jagadish J Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
van Schoor N van Schoor Natasja N Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, the Netherlands.
Völker U Völker Uwe U Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Willemsen G Willemsen Gonneke G Amsterdam Public Health Research Institute, Amsterdam UMC, Amsterdam, the Netherlands.
Williams K Williams Kayleen K Department of Biostatistics, University of Washington, Seattle, WA, USA.
Wong Q Wong Quenna Q Department of Biostatistics, University of Washington, Seattle, WA, USA.
Xu H Xu Huichun H Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Young KL Young Kristin L KL Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
Yuan JM Yuan Jian Min JM Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Zillikens MC Zillikens M Carola MC Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
Zonderman AB Zonderman Alan B AB Laboratory of Epidemiology and Population Science, National Instiute on Aging, National Institutes of Health, Bethesda, MD, USA.
Ameur A Ameur Adam A Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Bandinelli S Bandinelli Stefania S Geriatric Unit, Azienda USL Toscana Centro, Florence, Italy.
Bis JC Bis Joshua C JC Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Boehnke M Boehnke Michael M Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Bouchard C Bouchard Claude C Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Chasman DI Chasman Daniel I DI Harvard Medical School, Boston, MA, USA.
Smith GD Smith George Davey GD Population Health Science, Bristol Medical School, NIHR Bristol Biomedical Research Center, University of Bristol, Bristol, UK.
de Geus EJC de Geus Eco J C EJC Amsterdam Public Health Research Institute, Amsterdam UMC, Amsterdam, the Netherlands.
Deldicque L Deldicque Louise L Faculty of Movement and Rehabilitation Sciences, Institute of Neuroscience, UC Louvain, Louvain-la-Neuve, Belgium.
Dörr M Dörr Marcus M Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
Evans MK Evans Michele K MK Laboratory of Epidemiology and Population Science, National Instiute on Aging, National Institutes of Health, Bethesda, MD, USA.
Ferrucci L Ferrucci Luigi L Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
Fornage M Fornage Myriam M Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Fox C Fox Caroline C Genetics and Pharmacogenomics (GpGx), Merck Research Labs, Boston, MA, USA.
Garland T Jr Garland Theodore T Department of Evolution, Ecology, and Organismal Biology, University of California, Riverside, Riverside, CA, USA.
Gudnason V Gudnason Vilmundur V Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Gyllensten U Gyllensten Ulf U Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Hansen T Hansen Torben T Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Hayward C Hayward Caroline C MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Horta BL Horta Bernardo L BL Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.
Hyppönen E Hyppönen Elina E Population, Policy and Practice, Great Ormond Street Hospital Institute for Child Health, University College London, London, UK.
Jarvelin MR Jarvelin Marjo-Riitta MR Department of Epidemiology and Biostatistics and HPA-MRC Center, School of Public Health, Imperial College London, London, UK.
Johnson WC Johnson W Craig WC Department of Biostatistics, University of Washington, Seattle, WA, USA.
Kardia SLR Kardia Sharon L R SLR Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Kiemeney LA Kiemeney Lambertus A LA Radboud Institute for Health Sciences, Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands.
Laakso M Laakso Markku M Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Langenberg C Langenberg Claudia C Computational Medicine, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.
Lehtimäki T Lehtimäki Terho T Finnish Cardiovascular Research Center - Tampere, Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Marchand LL Marchand Loic Le LL Epidemiology Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, HI, USA.
Lifelines Cohort Study
Magnusson PKE Magnusson Patrik K E PKE Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Martin NG Martin Nicholas G NG Mental Health and Neuroscience Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Melbye M Melbye Mads M Center for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Metspalu A Metspalu Andres A Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Meyre D Meyre David D Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
North KE North Kari E KE Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
Ohlsson C Ohlsson Claes C Department of Drug Treatment, Sahlgrenska University Hospital, Gothenburg, Sweden.
Oldehinkel AJ Oldehinkel Albertine J AJ Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Orho-Melander M Orho-Melander Marju M Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
Pare G Pare Guillaume G Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
Park T Park Taesung T Department of Statistics, Seoul National University, Seoul, South Korea.
Pedersen O Pedersen Oluf O Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Penninx BWJH Penninx Brenda W J H BWJH Department of Psychiatry, Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands.
Pers TH Pers Tune H TH Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Polasek O Polasek Ozren O University of Split School of Medicine, Split, Croatia.
Prokopenko I Prokopenko Inga I UMR 8199 - EGID, Institut Pasteur de Lille, CNRS, University of Lille, Lille, France.
Rotimi CN Rotimi Charles N CN Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Samani NJ Samani Nilesh J NJ NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Sim X Sim Xueling X Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Snieder H Snieder Harold H Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Sørensen TIA Sørensen Thorkild I A TIA Department of Public Health, Section of Epidemiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Spector TD Spector Tim D TD Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK.
Timpson NJ Timpson Nicholas J NJ MRC Integrative Epidemiology Unit, University of Bristol Medical School, University of Bristol, Bristol, UK.
van Dam RM van Dam Rob M RM Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, George Washington University, Washington, DC, USA.
van der Velde N van der Velde Nathalie N Amsterdam Public Health, Aging and Later Life, Amsterdam, the Netherlands.
van Duijn CM van Duijn Cornelia M CM Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Vollenweider P Vollenweider Peter P Division of Internal Medicine, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Völzke H Völzke Henry H German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany.
Voortman T Voortman Trudy T Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Waeber G Waeber Gérard G Division of Internal Medicine, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Wareham NJ Wareham Nicholas J NJ MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Weir DR Weir David R DR Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Wichmann HE Wichmann Heinz-Erich HE Institute of Epidemiology, Helmholtz Zentrum München -Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Munich, Germany.
Wilson JF Wilson James F JF MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Hevener AL Hevener Andrea L AL Division of Endocrinology, Department of Medicine, University of California, Los Angeles, CA, USA.
Krook A Krook Anna A Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Zierath JR Zierath Juleen R JR Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Thomis MAI Thomis Martine A I MAI Faculty of Movement and Rehabilitation Sciences, Department of Movement Sciences - Physical Activity, Sports & Health Research Group, KU Leuven, Leuven, Belgium.
Loos RJF Loos Ruth J F RJF The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hoed MD Hoed Marcel den MD The Beijer Laboratory and Department of Immunology, Genetics and Pathology, Uppsala University and SciLifeLab, Uppsala, Sweden. marcel.den_hoed@igp.uu.se.
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
Alizadeh Behrooz Z BZ
Boezen H Marike HM
Franke Lude L
Swertz Morris M
Wijmenga Cisca C
van der Harst Pim P
Navis Gerjan G
Rots Marianne M
Wolffenbuttel Bruce H R BHR
JOURNAL
VOLUME: 54
ISSUE: 9
TITLE: Nature genetics
ISOABBREVIATION: Nat Genet
YEAR: 2022
MONTH: Sep
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1546-1718
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Genet
COUNTRY: United States
ISSNLINKING: 1061-4036
NLMUNIQUEID: 9216904
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Meta-Analysis
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
R01 HL143885 NHLBI NIH HHS United States
2019-01417 Vetenskapsrådet (Swedish Research Council)
R01 DK107786 NIDDK NIH HHS United States
R01 DK075787 NIDDK NIH HHS United States
R01 NS100178 NINDS NIH HHS United States
R01 DK101855 NIDDK NIH HHS United States
R01 HL151152 NHLBI NIH HHS United States
R01 NS114045 NINDS NIH HHS United States
R01 HG010297 NHGRI NIH HHS United States
R01 DK122503 NIDDK NIH HHS United States
R01 HG009974 NHGRI NIH HHS United States
U01 AG070959 NIA NIH HHS United States
R01 HL142302 NHLBI NIH HHS United States
R01 DK110113 NIDDK NIH HHS United States
R01 DK124097 NIDDK NIH HHS United States
R01 NS105150 NINDS NIH HHS United States
R01 DK089256 NIDDK NIH HHS United States
Wellcome Trust United Kingdom
R01 HD057194 NICHD NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Actinin genetics
Cross-Sectional Studies genetics
Exercise physiology
Genome-Wide Association Study physiology
Humans physiology
Leisure Activities physiology
Sedentary Behavior physiology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 ACTN3 protein, human
11003-00-2 Actinin
OTHER ID's
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Last Modified: Oct 15 2007