|
|
| PMID |
|
|
| TITLE |
|
| Changing genetic architecture of body mass index from infancy to early adulthood: an individual based pooled analysis of 25 twin cohorts. |
|
| ABSTRACT |
|
| BACKGROUND |
|
| Body mass index (BMI) shows strong continuity over childhood and adolescence and high childhood BMI is the strongest predictor of adult obesity. Genetic factors strongly contribute to this continuity, but it is still poorly known how their contribution changes over childhood and adolescence. Thus, we used the genetic twin design to estimate the genetic correlations of BMI from infancy to adulthood and compared them to the genetic correlations of height. |
| METHODS |
|
| Body mass index (BMI) shows strong continuity over childhood and adolescence and high childhood BMI is the strongest predictor of adult obesity. Genetic factors strongly contribute to this continuity, but it is still poorly known how their contribution changes over childhood and adolescence. Thus, we used the genetic twin design to estimate the genetic correlations of BMI from infancy to adulthood and compared them to the genetic correlations of height. We pooled individual level data from 25 longitudinal twin cohorts including 38,530 complete twin pairs and having 283,766 longitudinal height and weight measures. The data were analyzed using Cholesky decomposition offering genetic and environmental correlations of BMI and height between all age combinations from 1 to 19 years of age. |
| RESULTS |
|
| Body mass index (BMI) shows strong continuity over childhood and adolescence and high childhood BMI is the strongest predictor of adult obesity. Genetic factors strongly contribute to this continuity, but it is still poorly known how their contribution changes over childhood and adolescence. Thus, we used the genetic twin design to estimate the genetic correlations of BMI from infancy to adulthood and compared them to the genetic correlations of height. We pooled individual level data from 25 longitudinal twin cohorts including 38,530 complete twin pairs and having 283,766 longitudinal height and weight measures. The data were analyzed using Cholesky decomposition offering genetic and environmental correlations of BMI and height between all age combinations from 1 to 19 years of age. The genetic correlations of BMI and height were stronger than the trait correlations. For BMI, we found that genetic correlations decreased as the age between the assessments increased, a trend that was especially visible from early to middle childhood. In contrast, for height, the genetic correlations were strong between all ages. Age-to-age correlations between environmental factors shared by co-twins were found for BMI in early childhood but disappeared altogether by middle childhood. For height, shared environmental correlations persisted from infancy to adulthood. |
| CONCLUSIONS |
|
| Body mass index (BMI) shows strong continuity over childhood and adolescence and high childhood BMI is the strongest predictor of adult obesity. Genetic factors strongly contribute to this continuity, but it is still poorly known how their contribution changes over childhood and adolescence. Thus, we used the genetic twin design to estimate the genetic correlations of BMI from infancy to adulthood and compared them to the genetic correlations of height. We pooled individual level data from 25 longitudinal twin cohorts including 38,530 complete twin pairs and having 283,766 longitudinal height and weight measures. The data were analyzed using Cholesky decomposition offering genetic and environmental correlations of BMI and height between all age combinations from 1 to 19 years of age. The genetic correlations of BMI and height were stronger than the trait correlations. For BMI, we found that genetic correlations decreased as the age between the assessments increased, a trend that was especially visible from early to middle childhood. In contrast, for height, the genetic correlations were strong between all ages. Age-to-age correlations between environmental factors shared by co-twins were found for BMI in early childhood but disappeared altogether by middle childhood. For height, shared environmental correlations persisted from infancy to adulthood. Our results suggest that the genes affecting BMI change over childhood and adolescence leading to decreasing age-to-age genetic correlations. This change is especially visible from early to middle childhood indicating that new genetic factors start to affect BMI in middle childhood. Identifying mediating pathways of these genetic factors can open possibilities for interventions, especially for those children with high genetic predisposition to adult obesity. |
| © 2022. The Author(s). |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| received |
2022/03/31 |
| accepted |
2022/07/25 |
| revised |
2022/07/22 |
| pubmed |
2022/08/10 06:00 |
| medline |
2022/09/24 06:00 |
| entrez |
2022/08/09 23:20 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Silventoinen K |
|
Silventoinen |
Karri |
K |
|
Center for Twin Research, Osaka University Graduate School of Medicine, Osaka, Japan. karri.silventoinen@helsinki.fi. |
| Li W |
|
Li |
Weilong |
W |
|
Population Research Unit, Faculty of Social Sciences, University of Helsinki, Helsinki, Finland. |
| Jelenkovic A |
|
Jelenkovic |
Aline |
A |
|
Department of Public Health, University of Helsinki, Helsinki, Finland. |
| Sund R |
|
Sund |
Reijo |
R |
|
Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland. |
| Yokoyama Y |
|
Yokoyama |
Yoshie |
Y |
|
Department of Public Health Nursing, Osaka Metropolitan University, Osaka, Japan. |
| Aaltonen S |
|
Aaltonen |
Sari |
S |
|
Institute for Molecular Medicine Finland FIMM, Helsinki, Finland. |
| Piirtola M |
|
Piirtola |
Maarit |
M |
|
UKK Institute - Centre for Health Promotion Research, Tampere, Finland. |
| Sugawara M |
|
Sugawara |
Masumi |
M |
|
Faculty of Human Studies, Shirayuri University, Tokyo, Japan. |
| Tanaka M |
|
Tanaka |
Mami |
M |
|
Center for Forensic Mental Health, Chiba University, Chiba, Japan. |
| Matsumoto S |
|
Matsumoto |
Satoko |
S |
|
Institute for Education and Human Development, Ochanomizu University, Tokyo, Japan. |
| Baker LA |
|
Baker |
Laura A |
LA |
|
Department of Psychology, University of Southern California, Los Angeles, CA, USA. |
| Tuvblad C |
|
Tuvblad |
Catherine |
C |
|
School of Law, Psychology and Social Work, Örebro University, Örebro, Sweden. |
| Tynelius P |
|
Tynelius |
Per |
P |
|
Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden. |
| Rasmussen F |
|
Rasmussen |
Finn |
F |
|
Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden. |
| Craig JM |
|
Craig |
Jeffrey M |
JM |
|
Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia. |
| Saffery R |
|
Saffery |
Richard |
R |
|
Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia. |
| Willemsen G |
|
Willemsen |
Gonneke |
G |
|
Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, Amsterdam, Netherlands. |
| Bartels M |
|
Bartels |
Meike |
M |
|
Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, Amsterdam, Netherlands. |
| van Beijsterveldt CEM |
|
van Beijsterveldt |
Catharina E M |
CEM |
|
Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, Amsterdam, Netherlands. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
Genetic Epidemiology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Medland SE |
|
Medland |
Sarah E |
SE |
|
Genetic Epidemiology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Montgomery GW |
|
Montgomery |
Grant W |
GW |
|
Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia. |
| Lichtenstein P |
|
Lichtenstein |
Paul |
P |
|
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. |
| Krueger RF |
|
Krueger |
Robert F |
RF |
|
Department of Psychology, University of Minnesota, Minneapolis, MN, USA. |
| McGue M |
|
McGue |
Matt |
M |
|
Department of Psychology, University of Minnesota, Minneapolis, MN, USA. |
| Pahlen S |
|
Pahlen |
Shandell |
S |
|
Department of Psychology, University of California, Riverside, Riverside, CA, 92521, USA. |
| Christensen K |
|
Christensen |
Kaare |
K |
|
Department of Clinical Biochemistry and Pharmacology and Department of Clinical Genetics, Odense University Hospital, Odense, Denmark. |
| Skytthe A |
|
Skytthe |
Axel |
A |
|
The Danish Twin Registry, Department of Public Health, Epidemiology, Biostatistics & Biodemography, University of Southern Denmark Odense, Odense, Denmark. |
| Kyvik KO |
|
Kyvik |
Kirsten O |
KO |
|
Odense Patient data Explorative Network (OPEN), Odense University Hospital, Odense, Denmark. |
| Saudino KJ |
|
Saudino |
Kimberly J |
KJ |
|
Boston University, Department of Psychological and Brain Sciencies, Boston, MA, USA. |
| Dubois L |
|
Dubois |
Lise |
L |
|
School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada. |
| Boivin M |
|
Boivin |
Michel |
M |
|
École de psychologie, Université Laval, Québec, Canada. |
| Brendgen M |
|
Brendgen |
Mara |
M |
|
Département de psychologie, Université du Québec à Montréal, Montréal, Québec, Canada. |
| Dionne G |
|
Dionne |
Ginette |
G |
|
École de psychologie, Université Laval, Québec, Canada. |
| Vitaro F |
|
Vitaro |
Frank |
F |
|
École de psychoéducation, Université de Montréal, Montréal, Québec, Canada. |
| Ullemar V |
|
Ullemar |
Vilhelmina |
V |
|
Theme Women's Health, Karolinska University Hospital, Karolinska University Hospital, Stockholm, Sweden. |
| Almqvist C |
|
Almqvist |
Catarina |
C |
|
Pediatric Allergy and Pulmonology Unit at Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden. |
| Magnusson PKE |
|
Magnusson |
Patrik K E |
PKE |
|
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. |
| Corley RP |
|
Corley |
Robin P |
RP |
|
Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado, USA. |
| Huibregtse BM |
|
Huibregtse |
Brooke M |
BM |
|
Department of Psychology and Neuroscience, University of Colorado, Boulder, Colorado, USA. |
| Knafo-Noam A |
|
Knafo-Noam |
Ariel |
A |
|
The Hebrew University of Jerusalem, Jerusalem, Israel. |
| Mankuta D |
|
Mankuta |
David |
D |
|
Hadassah Hospital Obstetrics and Gynecology Department, Hebrew University Medical School, Jerusalem, Israel. |
| Abramson L |
|
Abramson |
Lior |
L |
|
The Hebrew University of Jerusalem, Jerusalem, Israel. |
| Haworth CMA |
|
Haworth |
Claire M A |
CMA |
|
School of Psychological Science, University of Bristol, Bristol, UK. |
| Plomin R |
|
Plomin |
Robert |
R |
|
Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. |
| Bjerregaard-Andersen M |
|
Bjerregaard-Andersen |
Morten |
M |
|
Department of Endocrinology, Odense University Hospital, Odense, Denmark. |
| Beck-Nielsen H |
|
Beck-Nielsen |
Henning |
H |
|
Department of Endocrinology, Odense University Hospital, Odense, Denmark. |
| Sodemann M |
|
Sodemann |
Morten |
M |
|
Department of Infectious Diseases, Odense University Hospital, Odense, Denmark. |
| Duncan GE |
|
Duncan |
Glen E |
GE |
|
Washington State Twin Registry, Washington State University - Health Sciences Spokane, Spokane, WA, USA. |
| Buchwald D |
|
Buchwald |
Dedra |
D |
|
Washington State Twin Registry, Washington State University - Health Sciences Spokane, Spokane, WA, USA. |
| Burt SA |
|
Burt |
S Alexandra |
SA |
|
Department of Psychology, Michigan State University, East Lansing, Michigan, USA. |
| Klump KL |
|
Klump |
Kelly L |
KL |
|
Department of Psychology, Michigan State University, East Lansing, Michigan, USA. |
| Llewellyn CH |
|
Llewellyn |
Clare H |
CH |
|
Department of Behavioural Science and Health, Institute of Epidemiology and Health Care, University College London, London, UK. |
| Fisher A |
|
Fisher |
Abigail |
A |
|
Department of Behavioural Science and Health, Institute of Epidemiology and Health Care, University College London, London, UK. |
| Boomsma DI |
|
Boomsma |
Dorret I |
DI |
|
Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, Amsterdam, Netherlands. |
| Sørensen TIA |
|
Sørensen |
Thorkild I A |
TIA |
|
Department of Public Health (Section of Epidemiology), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. |
| Kaprio J |
|
Kaprio |
Jaakko |
J |
|
Institute for Molecular Medicine Finland FIMM, Helsinki, Finland. |
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 46 |
| ISSUE: 10 |
| TITLE: International journal of obesity (2005) |
| ISOABBREVIATION: Int J Obes (Lond) |
| YEAR: 2022 |
| MONTH: Oct |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1476-5497 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Int J Obes (Lond) |
| COUNTRY: England |
| ISSNLINKING: 0307-0565 |
| NLMUNIQUEID: 101256108 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Twin Study |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| R01 MH081813 |
NIMH NIH HHS |
United States |
| R01 HD066040 |
NICHD NIH HHS |
United States |
| R01 MH092377 |
NIMH NIH HHS |
United States |
| T32 AG052371 |
NIA NIH HHS |
United States |
| T32 DA017637 |
NIDA NIH HHS |
United States |
| MR/M021475/1 |
Medical Research Council |
United Kingdom |
| G0901245 |
Medical Research Council |
United Kingdom |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adolescent |
|
| Adult |
|
| Body Height |
genetics |
| Body Mass Index |
genetics |
| Child |
genetics |
| Child, Preschool |
genetics |
| Humans |
genetics |
| Infant |
genetics |
| Obesity |
genetics |
| Twins, Dizygotic |
genetics |
| Twins, Monozygotic |
genetics |
| Young Adult |
genetics |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
|
|
