Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
35909142
TITLE
Smoking remains associated with education after controlling for social background and genetic factors in a study of 18 twin cohorts.
ABSTRACT
We tested the causality between education and smoking using the natural experiment of discordant twin pairs allowing to optimally control for background genetic and childhood social factors. Data from 18 cohorts including 10,527 monozygotic (MZ) and same-sex dizygotic (DZ) twin pairs discordant for education and smoking were analyzed by linear fixed effects regression models. Within twin pairs, education levels were lower among the currently smoking than among the never smoking co-twins and this education difference was larger within DZ than MZ pairs. Similarly, education levels were higher among former smoking than among currently smoking co-twins, and this difference was larger within DZ pairs. Our results support the hypothesis of a causal effect of education on both current smoking status and smoking cessation. However, the even greater intra-pair differences within DZ pairs, who share only 50% of their segregating genes, provide evidence that shared genetic factors also contribute to these associations.
© 2022. The Author(s).
DATE PUBLISHED
2022 Jul 31
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2021/10/27
accepted 2022/07/27
entrez 2022/07/31 23:14
pubmed 2022/08/01 06:00
medline 2022/08/03 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Silventoinen K Silventoinen Karri K Center for Twin Research, Osaka University Graduate School of Medicine, Osaka, Japan. karri.silventoinen@helsinki.fi.
Piirtola M Piirtola Maarit M Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland.
Jelenkovic A Jelenkovic Aline A Department of Public Health, University of Helsinki, Helsinki, Finland.
Sund R Sund Reijo R Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
Tarnoki AD Tarnoki Adam D AD Hungarian Twin Registry, Budapest, Hungary.
Tarnoki DL Tarnoki David L DL Hungarian Twin Registry, Budapest, Hungary.
Medda E Medda Emanuela E Istituto Superiore di Sanità - Centre for Behavioural Sciences and Mental Health, Rome, Italy.
Nisticò L Nisticò Lorenza L Istituto Superiore di Sanità - Centre for Behavioural Sciences and Mental Health, Rome, Italy.
Toccaceli V Toccaceli Virgilia V Istituto Superiore di Sanità - Centre for Behavioural Sciences and Mental Health, Rome, Italy.
Honda C Honda Chika C School of Nursing, Shiga University of Medical Science, Osaka, Japan.
Inui F Inui Fujio F Faculty of Health Science, Kio University, Nara, Japan.
Tomizawa R Tomizawa Rie R Center for Twin Research, Osaka University Graduate School of Medicine, Osaka, Japan.
Watanabe M Watanabe Mikio M Center for Twin Research, Osaka University Graduate School of Medicine, Osaka, Japan.
Sakai N Sakai Norio N Center for Twin Research, Osaka University Graduate School of Medicine, Osaka, Japan.
Gatz M Gatz Margaret M Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Butler DA Butler David A DA The National Academies of Sciences, Engineering, and Medicine, Washington, DC, USA.
Lee J Lee Jooyeon J Department of Epidemiology, School of Public Health, Seoul National University, Seoul, South Korea.
Lee SJ Lee Soo Ji SJ Institute of Health and Environment, Seoul National University, Seoul, South Korea.
Sung J Sung Joohon J Institute of Health and Environment, Seoul National University, Seoul, South Korea.
Franz CE Franz Carol E CE Department of Psychiatry, University of California, San Diego, CA, USA.
Kremen WS Kremen William S WS VA San Diego Center of Excellence for Stress and Mental Health, La Jolla, CA, USA.
Lyons MJ Lyons Michael J MJ Department of Psychological and Brain Sciences, Boston University, Boston, MA, USA.
Derom CA Derom Catherine A CA Department of Obstetrics and Gynaecology, Ghent University Hospitals, Ghent, Belgium.
Vlietinck RF Vlietinck Robert F RF Centre of Human Genetics, University Hospitals Leuven, Leuven, Belgium.
Loos RJF Loos Ruth J F RJF The Charles Bronfman Institute for Personalized Medicine, The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Tynelius P Tynelius Per P Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden.
Rasmussen F Rasmussen Finn F Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden.
Martin NG Martin Nicholas G NG Genetic Epidemiology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Medland SE Medland Sarah E SE Genetic Epidemiology Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Montgomery GW Montgomery Grant W GW Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
Brandt I Brandt Ingunn I Division of Health Data and Digitalization, Norwegian Institute of Public Health, Oslo, Norway.
Nilsen TS Nilsen Thomas S TS Division of Health Data and Digitalization, Norwegian Institute of Public Health, Oslo, Norway.
Harris JR Harris Jennifer R JR Center for Fertility and Health, The Norwegian Institute of Public Health, Oslo, Norway.
Tyler J Tyler Jessica J Centre for Epidemiology and Biostatistics, Twins Research Australia, The University of Melbourne, Melbourne, VIC, Australia.
Hopper JL Hopper John L JL Centre for Epidemiology and Biostatistics, Twins Research Australia, The University of Melbourne, Melbourne, VIC, Australia.
Magnusson PKE Magnusson Patrik K E PKE Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Pedersen NL Pedersen Nancy L NL Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Dahl Aslan AK Dahl Aslan Anna K AK School of Health Sciences, University of Skövde, Skövde, Sweden.
Ordoñana JR Ordoñana Juan R JR IMIB-Arrixaca, Murcia, Spain.
Sánchez-Romera JF Sánchez-Romera Juan F JF IMIB-Arrixaca, Murcia, Spain.
Colodro-Conde L Colodro-Conde Lucia L Department of Human Anatomy and Psychobiology, University of Murcia, Murcia, Spain.
Rebato E Rebato Esther E Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country UPV/EHU, Leioa, Spain.
Zhang D Zhang Dongfeng D Department of Public Health, Qingdao University Medical College, Qingdao, China.
Pang Z Pang Zengchang Z Department of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, China.
Tan Q Tan Qihua Q Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark.
Silberg JL Silberg Judy L JL Department of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Maes HH Maes Hermine H HH Department of Human and Molecular Genetics, Psychiatry and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
Boomsma DI Boomsma Dorret I DI Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, Amsterdam, The Netherlands.
Sørensen TIA Sørensen Thorkild I A TIA Department of Public Health (Section of Epidemiology), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Korhonen T Korhonen Tellervo T Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland.
Kaprio J Kaprio Jaakko J Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland.
INVESTIGATORS
JOURNAL
VOLUME: 12
ISSUE: 1
TITLE: Scientific reports
ISOABBREVIATION: Sci Rep
YEAR: 2022
MONTH: Jul
DAY: 31
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2045-2322
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Sci Rep
COUNTRY: England
ISSNLINKING: 2045-2322
NLMUNIQUEID: 101563288
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
R01 AG022982 NIA NIH HHS United States
R01 AG018386 NIA NIH HHS United States
R21 AG039572 NIA NIH HHS United States
K05 AA000145 NIAAA NIH HHS United States
R01 AA012502 NIAAA NIH HHS United States
R01 AA009203 NIAAA NIH HHS United States
R01 AG018384 NIA NIH HHS United States
R01 AG022381 NIA NIH HHS United States
R37 AA012502 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Child
Educational Status
Humans
Smoking genetics
Smoking Cessation genetics
Twins, Dizygotic genetics
Twins, Monozygotic genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
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