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| PMID |
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| TITLE |
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| Clinical, demographic, and genetic risk factors of treatment-attributed suicidality in >10,000 Australian adults taking antidepressants. |
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| ABSTRACT |
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| Emergence of suicidal symptoms has been reported as a potential antidepressant adverse drug reaction. Identifying risk factors associated could increase our understanding of this phenomenon and stratify individuals at higher risk. Logistic regressions were used to identify risk factors of self-reported treatment-attributed suicidal ideation (TASI). We then employed classifiers to test the predictive ability of the variables identified. A TASI GWAS, as well as SNP-based heritability estimation, were performed. GWAS replication was sought from an independent study. Significant associations were found for age and comorbid conditions, including bipolar and personality disorders. Participants reporting TASI from one antidepressant were more likely to report TASI from other antidepressants. No genetic loci associated with TAS I (p < 5e-8) were identified. Of 32 independent variants with suggestive association (p < 1e-5), 27 lead SNPs were available in a replication dataset from the GENDEP study. Only one variant showed a consistent effect and nominal association in the independent replication sample. Classifiers were able to stratify non-TASI from TASI participants (AUC = 0.77) and those reporting treatment-attributed suicide attempts (AUC = 0.85). The pattern of TASI co-occurrence across participants suggest nonspecific factors underlying its etiology. These findings provide insights into the underpinnings of TASI and serve as a proof-of-concept of the use of classifiers for risk stratification. |
| © 2022 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics published by Wiley Periodicals LLC. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| revised |
2022/04/07 |
| received |
2021/07/14 |
| accepted |
2022/06/28 |
| entrez |
2022/07/14 06:53 |
| pubmed |
2022/07/15 06:00 |
| medline |
2022/07/15 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Campos AI |
|
Campos |
Adrian I |
AI |
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Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia. |
| Byrne EM |
|
Byrne |
Enda M |
EM |
|
Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia. |
| Iorfino F |
|
Iorfino |
Frank |
F |
|
Brain and Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia. |
| Fabbri C |
|
Fabbri |
Chiara |
C |
|
Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy. |
| Hickie IB |
|
Hickie |
Ian B |
IB |
|
Brain and Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia. |
| Lewis CM |
|
Lewis |
Cathryn M |
CM |
|
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. |
| Wray NR |
|
Wray |
Naomi R |
NR |
|
Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia. |
| Medland SE |
|
Medland |
Sarah E |
SE |
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Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
| Rentería ME |
|
Rentería |
Miguel E |
ME |
|
School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: |
| ISSUE: |
| TITLE: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics |
| ISOABBREVIATION: Am J Med Genet B Neuropsychiatr Genet |
| YEAR: 2022 |
| MONTH: Jul |
| DAY: 14 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1552-485X |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Am J Med Genet B Neuropsychiatr Genet |
| COUNTRY: United States |
| ISSNLINKING: 1552-4841 |
| NLMUNIQUEID: 101235742 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GRANTID |
AGENCY |
COUNTRY |
| GNT1086683 |
National Health and Medical Research Council |
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| GNT1102821 |
National Health and Medical Research Council |
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| GNT1103623 |
National Health and Medical Research Council |
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| GNT1138514 |
National Health and Medical Research Council |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| antidepressants |
| genetics |
| suicide |
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| MESH HEADINGS |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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