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| PMID |
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| TITLE |
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| Genetic Specificity of Hippocampal Subfield Volumes, Relative to Hippocampal Formation, Identified in 2148 Young Adult Twins and Siblings. |
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| ABSTRACT |
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| The hippocampus is a complex brain structure with key roles in cognitive and emotional processing and with subregion abnormalities associated with a range of disorders and psychopathologies. Here we combine data from two large independent young adult twin/sibling cohorts to obtain the most accurate estimates to date of genetic covariation between hippocampal subfield volumes and the hippocampus as a single volume. The combined sample included 2148 individuals, comprising 1073 individuals from 627 families (mean age = 22.3 years) from the Queensland Twin IMaging (QTIM) Study, and 1075 individuals from 454 families (mean age = 28.8 years) from the Human Connectome Project (HCP). Hippocampal subfields were segmented using FreeSurfer version 6.0 (CA4 and dentate gyrus were phenotypically and genetically indistinguishable and were summed to a single volume). Multivariate twin modeling was conducted in OpenMx to decompose variance into genetic and environmental sources. Bivariate analyses of hippocampal formation and each subfield volume showed that 10%-72% of subfield genetic variance was independent of the hippocampal formation, with greatest specificity found for the smaller volumes; for example, CA2/3 with 42% of genetic variance being independent of the hippocampus; fissure (63%); fimbria (72%); hippocampus-amygdala transition area (41%); parasubiculum (62%). In terms of genetic influence, whole hippocampal volume is a good proxy for the largest hippocampal subfields, but a poor substitute for the smaller subfields. Additive genetic sources accounted for 49%-77% of total variance for each of the subfields in the combined sample multivariate analysis. In addition, the multivariate analyses were sufficiently powered to identify common environmental influences (replicated in QTIM and HCP for the molecular layer and CA4/dentate gyrus, and accounting for 7%-16% of total variance for 8 of 10 subfields in the combined sample). This provides the clearest indication yet from a twin study that factors such as home environment may influence hippocampal volumes (albeit, with caveats). |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| entrez |
2022/07/06 05:23 |
| pubmed |
2022/07/07 06:00 |
| medline |
2022/07/07 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Hansell NK |
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Hansell |
Narelle K |
NK |
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Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia. |
| Strike LT |
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Strike |
Lachlan T |
LT |
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Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia. |
| van Eijk L |
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van Eijk |
Liza |
L |
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Department of Psychology, Division of Tropical Health and Medicine, James Cook University, Townsville, QLD, Australia. |
| O'Callaghan V |
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O'Callaghan |
Victoria |
V |
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Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
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Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
| de Zubicaray GI |
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de Zubicaray |
Greig I |
GI |
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School of Psychology and Counselling, Queensland University of Technology, Brisbane, QLD, Australia. |
| Thompson PM |
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Thompson |
Paul M |
PM |
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Imaging Genetics Center, Mark & Mary Stevens Institute for Neuroimaging & Informatics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. |
| McMahon KL |
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McMahon |
Katie L |
KL |
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Herston Imaging Research Facility & School of Clinical Sciences, Queensland University of Technology, Brisbane, QLD, Australia. |
| Wright MJ |
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Wright |
Margaret J |
MJ |
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Centre for Advanced Imaging, University of Queensland, Brisbane, QLD, Australia. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: |
| ISSUE: |
| TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies |
| ISOABBREVIATION: Twin Res Hum Genet |
| YEAR: 2022 |
| MONTH: Jul |
| DAY: 06 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1832-4274 |
| ISSNTYPE: Print |
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| MEDLINE JOURNAL |
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| MEDLINETA: Twin Res Hum Genet |
| COUNTRY: England |
| ISSNLINKING: 1832-4274 |
| NLMUNIQUEID: 101244624 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| Hippocampus |
| MRI |
| human genetics |
| subfields |
| twin study |
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| MESH HEADINGS |
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| SUPPLEMENTARY MESH |
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| CHEMICALS |
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