Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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35697829
TITLE
Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals.
ABSTRACT
Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without DM (n  = 178,691, n  = 1,296,113). Our genome-wide searches identified (i) seven eGFR loci with significant DM/noDM-difference, (ii) four additional novel loci with suggestive difference and (iii) 28 further novel loci (including CUBN) by allowing for potential difference. GWAS on eGFR among DM individuals identified 2 known and 27 potentially responsible loci for diabetic kidney disease. Gene prioritization highlighted 18 genes that may inform reno-protective drug development. We highlight the existence of DM-only and noDM-only effects, which can inform about the target group, if respective genes are advanced as drug targets. Largely shared effects suggest that most drug interventions to alter eGFR should be effective in DM and noDM.
© 2022. The Author(s).
DATE PUBLISHED
2022 Jun 13
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2021/12/16
accepted 2022/05/04
entrez 2022/06/13 23:25
pubmed 2022/06/14 06:00
medline 2022/06/16 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Winkler TW Winkler Thomas W TW Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany. thomas.winkler@ukr.de.
Rasheed H Rasheed Humaira H Division of Medicine and Laboratory Sciences, University of Oslo, Oslo, Norway.
Teumer A Teumer Alexander A Department of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, Bialystok, Poland.
Gorski M Gorski Mathias M Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Rowan BX Rowan Bryce X BX Department of Veteran's Affairs, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.
Stanzick KJ Stanzick Kira J KJ Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Thomas LF Thomas Laurent F LF BioCore-Bioinformatics Core Facility, Norwegian University of Science and Technology, Trondheim, Norway.
Tin A Tin Adrienne A Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Hoppmann A Hoppmann Anselm A Institute of Genetic Epidemiology, Department of Data Driven Medicine, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.
Chu AY Chu Audrey Y AY Genetics, Merck & Co., Inc, Kenilworth, NJ, USA.
Tayo B Tayo Bamidele B Department of Public Health Sciences, Loyola University Chicago, Maywood, IL, USA.
Thio CHL Thio Chris H L CHL Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Cusi D Cusi Daniele D Bio4Dreams-Business Nursery for Life Sciences, Milan, Italy.
Chai JF Chai Jin-Fang JF Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Sieber KB Sieber Karsten B KB Target Sciences-Genetics, GlaxoSmithKline, Collegeville, PA, USA.
Horn K Horn Katrin K LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Li M Li Man M Division of Nephrology and Hypertension, Department of Medicine, University of Utah, Salt Lake City, UT, USA.
Scholz M Scholz Markus M LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Cocca M Cocca Massimiliano M Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
Wuttke M Wuttke Matthias M Renal Division, Department of Medicine IV, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.
van der Most PJ van der Most Peter J PJ Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Yang Q Yang Qiong Q Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Ghasemi S Ghasemi Sahar S Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Nutile T Nutile Teresa T Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso'-CNR, Naples, Italy.
Li Y Li Yong Y Institute of Genetic Epidemiology, Department of Data Driven Medicine, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.
Pontali G Pontali Giulia G University of Trento, Department of Cellular, Computational and Integrative Biology-CIBIO, Trento, Italy.
Günther F Günther Felix F Statistical Consulting Unit StaBLab, Department of Statistics, LMU Munich, Munich, Germany.
Dehghan A Dehghan Abbas A Dementia Research Institute, Imperial College London, London, UK.
Correa A Correa Adolfo A Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Parsa A Parsa Afshin A University of Maryland School of Medicine, Baltimore, MD, USA.
Feresin A Feresin Agnese A Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
de Vries APJ de Vries Aiko P J APJ Section of Nephrology, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands.
Zonderman AB Zonderman Alan B AB Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Baltimore, MD, USA.
Smith AV Smith Albert V AV CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.
Oldehinkel AJ Oldehinkel Albertine J AJ Interdisciplinary Center of Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
De Grandi A De Grandi Alessandro A Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
Rosenkranz AR Rosenkranz Alexander R AR Department of Internal Medicine, Division of Nephrology, Medical University Graz, Graz, Austria.
Franke A Franke Andre A Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
Teren A Teren Andrej A Heart Center Leipzig, Leipzig, Germany.
Metspalu A Metspalu Andres A Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Hicks AA Hicks Andrew A AA Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
Morris AP Morris Andrew P AP Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK.
Tönjes A Tönjes Anke A Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.
Morgan A Morgan Anna A Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
Podgornaia AI Podgornaia Anna I AI Genetics, Merck & Co., Inc, Kenilworth, NJ, USA.
Peters A Peters Annette A Chair of Epidemiology, IBE, Faculty of Medicine, Ludwig-Maximilians-Universität München, München, Germany.
Körner A Körner Antje A Center for Pediatric Research, University of Leipzig, Leipzig, Germany.
Mahajan A Mahajan Anubha A Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.
Campbell A Campbell Archie A Center for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Freedman BI Freedman Barry I BI Section on Nephrology, Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Spedicati B Spedicati Beatrice B Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Ponte B Ponte Belen B Service de Néphrologie et Hypertension, Medicine Department, Geneva University Hospitals, Geneva, Switzerland.
Schöttker B Schöttker Ben B Network Aging Research, University of Heidelberg, Heidelberg, Germany.
Brumpton B Brumpton Ben B HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, 7600, Norway.
Banas B Banas Bernhard B Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Krämer BK Krämer Bernhard K BK Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology, Pneumology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Jung B Jung Bettina B Department of Nephrology and Rheumatology, Kliniken Südostbayern, Traunstein, Germany.
Åsvold BO Åsvold Bjørn Olav BO Department of Endocrinology, Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Smith BH Smith Blair H BH Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
Ning B Ning Boting B Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Penninx BWJH Penninx Brenda W J H BWJH Department of Psychiatry, VU University Medical Centre, Amsterdam, The Netherlands.
Vanderwerff BR Vanderwerff Brett R BR Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, 48109, USA.
Psaty BM Psaty Bruce M BM Department of Health Systems and Population Health, University of Washington, Seattle, WA, USA.
Kammerer CM Kammerer Candace M CM Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Langefeld CD Langefeld Carl D CD Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Hayward C Hayward Caroline C Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Spracklen CN Spracklen Cassandra N CN Department of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst, MA, USA.
Robinson-Cohen C Robinson-Cohen Cassianne C Vanderbilt University Medical Center, Division of Nephrology and Hypertension, Vanderbilt Center for Kidney Disease and Integrated Program for Acute Kidney Injury Research, and Vanderbilt Precision Nephrology Program Nashville, Nashville, TN, USA.
Hartman CA Hartman Catharina A CA Interdisciplinary Center of Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Lindgren CM Lindgren Cecilia M CM Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, OX3 7LF, UK.
Wang C Wang Chaolong C School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Sabanayagam C Sabanayagam Charumathi C Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.
Heng CK Heng Chew-Kiat CK Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore, Singapore.
Lanzani C Lanzani Chiara C Nephrology and Dialysis Unit, Genomics of Renal Diseases and Hypertension Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Khor CC Khor Chiea-Chuen CC Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
Cheng CY Cheng Ching-Yu CY Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.
Fuchsberger C Fuchsberger Christian C Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
Gieger C Gieger Christian C Research Unit Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Shaffer CM Shaffer Christian M CM Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Schulz CA Schulz Christina-Alexandra CA Department of Clincial Sciences in Malmö, Lund University, Malmö, Sweden.
Willer CJ Willer Cristen J CJ Department of Human Genetics, University of Michigan, Ann Arbor, MI, 48109, USA.
Chasman DI Chasman Daniel I DI Harvard Medical School, Boston, MA, USA.
Gudbjartsson DF Gudbjartsson Daniel F DF Iceland School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland.
Ruggiero D Ruggiero Daniela D IRCCS Neuromed, Pozzilli, Italy.
Toniolo D Toniolo Daniela D San Raffaele Research Institute, Milan, Italy.
Czamara D Czamara Darina D Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.
Porteous DJ Porteous David J DJ Center for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Waterworth DM Waterworth Dawn M DM Target Sciences-Genetics, GlaxoSmithKline, Collegeville, PA, USA.
Mascalzoni D Mascalzoni Deborah D Centre for Research Ethics & Bioethics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
Mook-Kanamori DO Mook-Kanamori Dennis O DO Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Reilly DF Reilly Dermot F DF Genetics, Merck & Co., Inc, Kenilworth, NJ, USA.
Daw EW Daw E Warwick EW Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Hofer E Hofer Edith E Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria.
Boerwinkle E Boerwinkle Eric E Human Genetics Center, University of Texas Health Science Center, Houston, TX, USA.
Salvi E Salvi Erika E Neuroalgology Unit, Fondazione IRCCS Istituto Neurologico 'Carlo Besta', Milan, Italy.
Bottinger EP Bottinger Erwin P EP Digital Health Center, Hasso Plattner Institute and University of Potsdam, Potsdam, Germany.
Tai ES Tai E-Shyong ES Duke - NUS Medical School, Singapore, Singapore.
Catamo E Catamo Eulalia E Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
Rizzi F Rizzi Federica F ePhood Scientific Unit, ePhood SRL, Milano, Italy.
Guo F Guo Feng F Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Rivadeneira F Rivadeneira Fernando F Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Guilianini F Guilianini Franco F Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Sveinbjornsson G Sveinbjornsson Gardar G deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Ehret G Ehret Georg G Cardiology, Geneva University Hospitals, Geneva, Switzerland.
Waeber G Waeber Gerard G Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Biino G Biino Ginevra G Institute of Molecular Genetics "Luigi Luca Cavalli-Sforza", National Research Council of Italy, Pavia, Italy.
Girotto G Girotto Giorgia G Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Pistis G Pistis Giorgio G Department of Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland.
Nadkarni GN Nadkarni Girish N GN Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Delgado GE Delgado Graciela E GE Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Montgomery GW Montgomery Grant W GW Institute for Molecular Bioscience, University of Queensland, St Lucia, QLD, Australia.
Snieder H Snieder Harold H Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Campbell H Campbell Harry H Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK.
White HD White Harvey D HD Green Lane Cardiovascular Service, Auckland City Hospital and University of Auckland, Auckland, New Zealand.
Gao H Gao He H MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, UK.
Stringham HM Stringham Heather M HM Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Schmidt H Schmidt Helena H Research Unit Genetic Epidemiology, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria.
Li H Li Hengtong H Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
Brenner H Brenner Hermann H Network Aging Research, University of Heidelberg, Heidelberg, Germany.
Holm H Holm Hilma H deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Kirsten H Kirsten Holgen H LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Kramer H Kramer Holly H Division of Nephrology and Hypertension, Loyola University Chicago, Chicago, IL, USA.
Rudan I Rudan Igor I Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK.
Nolte IM Nolte Ilja M IM Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Tzoulaki I Tzoulaki Ioanna I Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
Olafsson I Olafsson Isleifur I Department of Clinical Biochemistry, Landspitali University Hospital, Reykjavik, Iceland.
Martins J Martins Jade J Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.
Cook JP Cook James P JP Department of Health Data Science, University of Liverpool, Liverpool, UK.
Wilson JF Wilson James F JF Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK.
Halbritter J Halbritter Jan J Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Felix JF Felix Janine F JF Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Divers J Divers Jasmin J Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Kooner JS Kooner Jaspal S JS National Heart and Lung Institute, Imperial College London, London, UK.
Lee JJ Lee Jeannette Jen-Mai JJ Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
O'Connell J O'Connell Jeffrey J University of Maryland School of Medicine, Baltimore, MD, USA.
Rotter JI Rotter Jerome I JI The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institutefor Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Liu J Liu Jianjun J Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.
Xu J Xu Jie J Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Thiery J Thiery Joachim J Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany.
Ärnlöv J Ärnlöv Johan J School of Health and Social Studies, Dalarna University, Stockholm, Sweden.
Kuusisto J Kuusisto Johanna J Kuopio University Hospital, Kuopio, Finland.
Jakobsdottir J Jakobsdottir Johanna J The Center of Public Health Sciences, University of Iceland, Reykjavík, Iceland.
Tremblay J Tremblay Johanne J CRCHUM, Montreal, QC, Canada.
Chambers JC Chambers John C JC Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Whitfield JB Whitfield John B JB QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Gaziano JM Gaziano John M JM VA Cooperative Studies Program, VA Boston Healthcare System, Boston, MA, USA.
Marten J Marten Jonathan J Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Coresh J Coresh Josef J Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Jonas JB Jonas Jost B JB Privatpraxis Prof Jonas und Dr Panda-Jonas, Heidelberg, Germany.
Mychaleckyj JC Mychaleckyj Josyf C JC Center for Public Health Genomics, University of Virginia, Charlottesville, Charlottesville, VA, USA.
Christensen K Christensen Kaare K Danish Aging Research Center, University of Southern Denmark, Odense C, Denmark.
Eckardt KU Eckardt Kai-Uwe KU Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.
Mohlke KL Mohlke Karen L KL Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Endlich K Endlich Karlhans K Department of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany.
Dittrich K Dittrich Katalin K Center for Pediatric Research, University of Leipzig, Leipzig, Germany.
Ryan KA Ryan Kathleen A KA Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.
Rice KM Rice Kenneth M KM Department of Biostatistics, University of Washington, Seattle, WA, USA.
Taylor KD Taylor Kent D KD The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institutefor Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Ho K Ho Kevin K Department of Nephrology, Geisinger, Danville, PA, USA.
Nikus K Nikus Kjell K Department of Cardiology, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Matsuda K Matsuda Koichi K Laboratory of Clinical Genome Sequencing, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
Strauch K Strauch Konstantin K Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany.
Miliku K Miliku Kozeta K Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Hveem K Hveem Kristian K K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Lind L Lind Lars L Cardiovascular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Wallentin L Wallentin Lars L Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.
Yerges-Armstrong LM Yerges-Armstrong Laura M LM Target Sciences-Genetics, GlaxoSmithKline, Collegeville, PA, USA.
Raffield LM Raffield Laura M LM Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Phillips LS Phillips Lawrence S LS Division of Endocrinology and Metabolism, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Launer LJ Launer Lenore J LJ Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Bethesda, MD, USA.
Lyytikäinen LP Lyytikäinen Leo-Pekka LP Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Lange LA Lange Leslie A LA Division of Biomedical Informatics and Personalized Medicine, School of Medicine, University of Colorado Denver-Anschutz Medical Campus, Aurora, CO, USA.
Citterio L Citterio Lorena L Nephrology and Dialysis Unit, Genomics of Renal Diseases and Hypertension Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Klaric L Klaric Lucija L Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Ikram MA Ikram M Arfan MA Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Ising M Ising Marcus M Max Planck Institute of Psychiatry, Munich, Germany.
Kleber ME Kleber Marcus E ME SYNLAB MVZ Humangenetik Mannheim, Mannheim, Germany.
Francescatto M Francescatto Margherita M Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Concas MP Concas Maria Pina MP Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
Ciullo M Ciullo Marina M IRCCS Neuromed, Pozzilli, Italy.
Piratsu M Piratsu Mario M Institute of Genetic and Biomedical Research, National Research Council of Italy, Cagliari, Italy.
Orho-Melander M Orho-Melander Marju M Department of Clincial Sciences in Malmö, Lund University, Malmö, Sweden.
Laakso M Laakso Markku M Kuopio University Hospital, Kuopio, Finland.
Loeffler M Loeffler Markus M LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Perola M Perola Markus M Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
de Borst MH de Borst Martin H MH Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Gögele M Gögele Martin M Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
Bianca M Bianca Martina La M Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
Lukas MA Lukas Mary Ann MA Target Sciences-Genetics, GlaxoSmithKline, Albuquerque, NM, USA.
Feitosa MF Feitosa Mary F MF Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Biggs ML Biggs Mary L ML Department of Biostatistics, University of Washington, Seattle, WA, USA.
Wojczynski MK Wojczynski Mary K MK Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Kavousi M Kavousi Maryam M Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Kanai M Kanai Masahiro M Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Akiyama M Akiyama Masato M Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Yasuda M Yasuda Masayuki M Department of Ophthalmology, Tohoku University Graduate School of Medicine, Miyagi, Japan.
Nauck M Nauck Matthias M Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
Waldenberger M Waldenberger Melanie M DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
Chee ML Chee Miao-Li ML Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
Chee ML Chee Miao-Ling ML Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
Boehnke M Boehnke Michael M Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Preuss MH Preuss Michael H MH Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Stumvoll M Stumvoll Michael M Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.
Province MA Province Michael A MA Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Evans MK Evans Michele K MK Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Baltimore, MD, USA.
O'Donoghue ML O'Donoghue Michelle L ML TIMI Study Group, Boston, MA, USA.
Kubo M Kubo Michiaki M RIKEN Center for Integrative Medical Sciences (IMS), Yokohama (Kanagawa), Japan.
Kähönen M Kähönen Mika M Department of Clinical Physiology, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Kastarinen M Kastarinen Mika M Kuopio University Hospital, Kuopio, Finland.
Nalls MA Nalls Mike A MA Data Tecnica International, Glen Echo, MD, USA.
Kuokkanen M Kuokkanen Mikko M South Texas Diabetes and Obesity Institute and Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.
Ghanbari M Ghanbari Mohsen M Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Bochud M Bochud Murielle M Center for Primary Care and Public Health (Unisanté), University of Lausanne, 1010, Lausanne, Switzerland.
Josyula NS Josyula Navya Shilpa NS Department of Population Health Sciences, Geisinger Health, 100 N. Academy Ave., Danville, PA, USA.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Tan NYQ Tan Nicholas Y Q NYQ Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
Palmer ND Palmer Nicholette D ND Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Pirastu N Pirastu Nicola N Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK.
Schupf N Schupf Nicole N Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA.
Verweij N Verweij Niek N Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Hutri-Kähönen N Hutri-Kähönen Nina N Tampere Centre for Skills Training and Simulation, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Mononen N Mononen Nina N Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Bansal N Bansal Nisha N Kidney Research Institute, University of Washington, Seattle, WA, USA.
Devuyst O Devuyst Olivier O Institute of Physiology, University of Zurich, Zurich, Switzerland.
Melander O Melander Olle O Department of Clincial Sciences in Malmö, Lund University, Malmö, Sweden.
Raitakari OT Raitakari Olli T OT Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.
Polasek O Polasek Ozren O Algebra University College, Ilica 242, Zagreb, Croatia.
Manunta P Manunta Paolo P Nephrology and Dialysis Unit, Genomics of Renal Diseases and Hypertension Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Gasparini P Gasparini Paolo P Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Mishra PP Mishra Pashupati P PP Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Sulem P Sulem Patrick P deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Magnusson PKE Magnusson Patrik K E PKE Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Elliott P Elliott Paul P Health Data Research UK-London, London, UK.
Ridker PM Ridker Paul M PM Harvard Medical School, Boston, MA, USA.
Hamet P Hamet Pavel P Medpharmgene, Montreal, QC, Canada.
Svensson PO Svensson Per O PO Department of Cardiology, Södersjukhuset, Stockholm, Sweden.
Joshi PK Joshi Peter K PK Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK.
Kovacs P Kovacs Peter P Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Leipzig, Germany.
Pramstaller PP Pramstaller Peter P PP Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
Rossing P Rossing Peter P Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Vollenweider P Vollenweider Peter P Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
van der Harst P van der Harst Pim P Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Dorajoo R Dorajoo Rajkumar R Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore.
Sim RZH Sim Ralene Z H RZH Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
Burkhardt R Burkhardt Ralph R Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany.
Tao R Tao Ran R Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
Noordam R Noordam Raymond R Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands.
Mägi R Mägi Reedik R Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Schmidt R Schmidt Reinhold R Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.
de Mutsert R de Mutsert Renée R Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Rueedi R Rueedi Rico R Swiss Institute of Bioinformatics, Lausanne, Switzerland.
van Dam RM van Dam Rob M RM Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, The George Washington University, Washington, DC, USA.
Carroll RJ Carroll Robert J RJ Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Gansevoort RT Gansevoort Ron T RT Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Loos RJF Loos Ruth J F RJF Novo Nordisk Foundation Center for Basic Metabolic Research, Department of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Felicita SC Felicita Sala Cinzia SC San Raffaele Research Institute, Milan, Italy.
Sedaghat S Sedaghat Sanaz S Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Padmanabhan S Padmanabhan Sandosh S Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Freitag-Wolf S Freitag-Wolf Sandra S Institute of Medical Informatics and Statistics, Kiel University, University Hospital Schleswig-Holstein, Kiel, Germany.
Pendergrass SA Pendergrass Sarah A SA Geisinger Research, Biomedical and Translational Informatics Institute, Danville, PA, USA.
Graham SE Graham Sarah E SE Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, 48109, USA.
Gordon SD Gordon Scott D SD QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Hwang SJ Hwang Shih-Jen SJ The Center for Population Studies, NHLBI, Framingham, MA, USA.
Kerr SM Kerr Shona M SM Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Vaccargiu S Vaccargiu Simona S Institute of Genetic and Biomedical Research, National Research Council of Italy, Cagliari, Italy.
Patil SB Patil Snehal B SB Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA.
Hallan S Hallan Stein S Department of Nephrology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Bakker SJL Bakker Stephan J L SJL Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Lim SC Lim Su-Chi SC Diabetes Center, Khoo Teck Puat Hospital, Singapore, Singapore.
Lucae S Lucae Susanne S Max Planck Institute of Psychiatry, Munich, Germany.
Vogelezang S Vogelezang Suzanne S Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Bergmann S Bergmann Sven S Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Corre T Corre Tanguy T Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Ahluwalia TS Ahluwalia Tarunveer S TS The Bioinformatics Center, Department of Biology, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
Lehtimäki T Lehtimäki Terho T Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Boutin TS Boutin Thibaud S TS Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Meitinger T Meitinger Thomas T Institute of Human Genetics, Technische Universität München, Munich, Germany.
Wong TY Wong Tien-Yin TY Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.
Bergler T Bergler Tobias T Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Rabelink TJ Rabelink Ton J TJ Einthoven Laboratory of Experimental Vascular Research, Leiden University Medical Center, Leiden, The Netherlands.
Esko T Esko Tõnu T Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
Haller T Haller Toomas T Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Thorsteinsdottir U Thorsteinsdottir Unnur U deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Völker U Völker Uwe U Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Foo VHX Foo Valencia Hui Xian VHX Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
Salomaa V Salomaa Veikko V Finnish Institute for Health and Welfare, Helsinki, Finland.
Vitart V Vitart Veronique V Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Giedraitis V Giedraitis Vilmantas V Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
Gudnason V Gudnason Vilmundur V Icelandic Heart Association, Kopavogur, Iceland.
Jaddoe VWV Jaddoe Vincent W V VWV Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Huang W Huang Wei W Shanghai Industrial Technology Institute, Shanghai, China.
Zhang W Zhang Weihua W Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, Middlesex, UK.
Wei WB Wei Wen Bin WB Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Kiess W Kiess Wieland W Center for Pediatric Research, University of Leipzig, Leipzig, Germany.
März W März Winfried W Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
Koenig W Koenig Wolfgang W Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany.
Lieb W Lieb Wolfgang W Institute of Epidemiology and Biobank Popgen, Kiel University, Kiel, Germany.
Gao X Gao Xin X Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Sim X Sim Xueling X Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Wang YX Wang Ya Xing YX Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Friedlander Y Friedlander Yechiel Y School of Public Health and Community Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Tham YC Tham Yih-Chung YC Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
Kamatani Y Kamatani Yoichiro Y Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
Okada Y Okada Yukinori Y Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.
Milaneschi Y Milaneschi Yuri Y Department of Psychiatry, VU University Medical Centre, Amsterdam, The Netherlands.
Yu Z Yu Zhi Z Massachusetts General Hospital, Boston, MA, USA.
Lifelines cohort study
DiscovEHR/MyCode study
VA Million Veteran Program
Stark KJ Stark Klaus J KJ Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
Stefansson K Stefansson Kari K deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Böger CA Böger Carsten A CA Department of Nephrology and Rheumatology, Kliniken Südostbayern, Traunstein, Germany.
Hung AM Hung Adriana M AM Vanderbilt University Medical Center, Division of Nephrology and Hypertension, Vanderbilt Center for Kidney Disease and Integrated Program for Acute Kidney Injury Research, and Vanderbilt Precision Nephrology Program Nashville, Nashville, TN, USA.
Kronenberg F Kronenberg Florian F Department of Genetics and Pharmacology, Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.
Köttgen A Köttgen Anna A Institute of Genetic Epidemiology, Department of Data Driven Medicine, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.
Pattaro C Pattaro Cristian C Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
Heid IM Heid Iris M IM Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany. iris.heid@ukr.de.
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
Thio Chris H L CHL
van der Most Peter J PJ
de Borst Martin H MH
Ho Kevin K
Josyula Navya Shilpa NS
Pendergrass Sarah A SA
Rowan Bryce X BX
Robinson-Cohen Cassianne C
Gaziano John M JM
Phillips Lawrence S LS
Tao Ran R
Hung Adriana M AM
JOURNAL
VOLUME: 5
ISSUE: 1
TITLE: Communications biology
ISOABBREVIATION: Commun Biol
YEAR: 2022
MONTH: Jun
DAY: 13
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2399-3642
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Commun Biol
COUNTRY: England
ISSNLINKING: 2399-3642
NLMUNIQUEID: 101719179
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Meta-Analysis
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Creatinine
Diabetes Mellitus
Diabetic Nephropathies genetics
Genome-Wide Association Study genetics
Glomerular Filtration Rate genetics
Humans genetics
Kidney genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
AYI8EX34EU Creatinine
OTHER ID's
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