|
|
| PMID |
|
|
| TITLE |
|
| Dynamic networks of psychological symptoms, impairment, substance use, and social support: The evolution of psychopathology among emerging adults. |
|
| ABSTRACT |
|
| BACKGROUND |
NlmCategory: BACKGROUND |
| Subthreshold/attenuated syndromes are established precursors of full-threshold mood and psychotic disorders. Less is known about the individual symptoms that may precede the development of subthreshold syndromes and associated social/functional outcomes among emerging adults. |
| METHODS |
NlmCategory: METHODS |
| Subthreshold/attenuated syndromes are established precursors of full-threshold mood and psychotic disorders. Less is known about the individual symptoms that may precede the development of subthreshold syndromes and associated social/functional outcomes among emerging adults. We modeled two dynamic Bayesian networks (DBN) to investigate associations among self-rated phenomenology and personal/lifestyle factors (role impairment, low social support, and alcohol and substance use) across the 19Up and 25Up waves of the Brisbane Longitudinal Twin Study. We examined whether symptoms and personal/lifestyle factors at 19Up were associated with (a) themselves or different items at 25Up, and (b) onset of a depression-like, hypo-manic-like, or psychotic-like subthreshold syndrome (STS) at 25Up. |
| RESULTS |
NlmCategory: RESULTS |
| Subthreshold/attenuated syndromes are established precursors of full-threshold mood and psychotic disorders. Less is known about the individual symptoms that may precede the development of subthreshold syndromes and associated social/functional outcomes among emerging adults. We modeled two dynamic Bayesian networks (DBN) to investigate associations among self-rated phenomenology and personal/lifestyle factors (role impairment, low social support, and alcohol and substance use) across the 19Up and 25Up waves of the Brisbane Longitudinal Twin Study. We examined whether symptoms and personal/lifestyle factors at 19Up were associated with (a) themselves or different items at 25Up, and (b) onset of a depression-like, hypo-manic-like, or psychotic-like subthreshold syndrome (STS) at 25Up. The first DBN identified 11 items that when endorsed at 19Up were more likely to be reendorsed at 25Up (e.g., hypersomnia, impaired concentration, impaired sleep quality) and seven items that when endorsed at 19Up were associated with different items being endorsed at 25Up (e.g., earlier fatigue and later role impairment; earlier anergia and later somatic pain). In the second DBN, no arcs met our a priori threshold for inclusion. In an exploratory model with no threshold, >20 items at 19Up were associated with progression to an STS at 25Up (with lower statistical confidence); the top five arcs were: feeling threatened by others and a later psychotic-like STS; increased activity and a later hypo-manic-like STS; and anergia, impaired sleep quality, and/or hypersomnia and a later depression-like STS. |
| CONCLUSIONS |
NlmCategory: CONCLUSIONS |
| Subthreshold/attenuated syndromes are established precursors of full-threshold mood and psychotic disorders. Less is known about the individual symptoms that may precede the development of subthreshold syndromes and associated social/functional outcomes among emerging adults. We modeled two dynamic Bayesian networks (DBN) to investigate associations among self-rated phenomenology and personal/lifestyle factors (role impairment, low social support, and alcohol and substance use) across the 19Up and 25Up waves of the Brisbane Longitudinal Twin Study. We examined whether symptoms and personal/lifestyle factors at 19Up were associated with (a) themselves or different items at 25Up, and (b) onset of a depression-like, hypo-manic-like, or psychotic-like subthreshold syndrome (STS) at 25Up. The first DBN identified 11 items that when endorsed at 19Up were more likely to be reendorsed at 25Up (e.g., hypersomnia, impaired concentration, impaired sleep quality) and seven items that when endorsed at 19Up were associated with different items being endorsed at 25Up (e.g., earlier fatigue and later role impairment; earlier anergia and later somatic pain). In the second DBN, no arcs met our a priori threshold for inclusion. In an exploratory model with no threshold, >20 items at 19Up were associated with progression to an STS at 25Up (with lower statistical confidence); the top five arcs were: feeling threatened by others and a later psychotic-like STS; increased activity and a later hypo-manic-like STS; and anergia, impaired sleep quality, and/or hypersomnia and a later depression-like STS. These probabilistic models identify symptoms and personal/lifestyle factors that might prove useful targets for indicated preventative strategies. |
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| DATE PUBLISHED |
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| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
2022/06/14 06:00 |
| medline |
2022/06/30 06:00 |
| entrez |
2022/06/13 03:55 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Crouse JJ |
|
Crouse |
Jacob J |
JJ |
|
Youth Mental Health & Technology Team, Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia. |
| Ho N |
|
Ho |
Nicholas |
N |
|
Youth Mental Health & Technology Team, Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia. |
| Scott J |
|
Scott |
Jan |
J |
|
Department of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway. |
| Parker R |
|
Parker |
Richard |
R |
|
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
| Park SH |
|
Park |
Shin Ho |
SH |
|
Youth Mental Health & Technology Team, Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia. |
| Couvy-Duchesne B |
|
Couvy-Duchesne |
Baptiste |
B |
|
Paris Brain Institute (ICM), INSERM U 1127, CNRS UMR 7225, Sorbonne University, Inria, Aramis Project-Team, 75013Paris, France. |
| Mitchell BL |
|
Mitchell |
Brittany L |
BL |
|
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
| Byrne EM |
|
Byrne |
Enda M |
EM |
|
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
| Hermens DF |
|
Hermens |
Daniel F |
DF |
|
Thompson Institute, University of the Sunshine Coast, Birtinya, Queensland, Australia. |
| Medland SE |
|
Medland |
Sarah E |
SE |
|
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
| Gillespie NA |
|
Gillespie |
Nathan A |
NA |
|
Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, Virginia, USA. |
| Hickie IB |
|
Hickie |
Ian B |
IB |
|
Youth Mental Health & Technology Team, Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia. |
|
| INVESTIGATORS |
|
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| JOURNAL |
|
| VOLUME: 65 |
| ISSUE: 1 |
| TITLE: European psychiatry : the journal of the Association of European Psychiatrists |
| ISOABBREVIATION: Eur Psychiatry |
| YEAR: 2022 |
| MONTH: Jun |
| DAY: 13 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1778-3585 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
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| MEDLINETA: Eur Psychiatry |
| COUNTRY: England |
| ISSNLINKING: 0924-9338 |
| NLMUNIQUEID: 9111820 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| Cohort |
| network analysis |
| prospective |
| psychopathology |
| youth mental health |
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| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
|
| Bayes Theorem |
|
| Humans |
|
| Mental Disorders |
epidemiology |
| Risk Factors |
epidemiology |
| Social Support |
epidemiology |
| Substance-Related Disorders |
epidemiology |
| Twin Studies as Topic |
epidemiology |
| Young Adult |
epidemiology |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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