|
|
| PMID |
|
|
| TITLE |
|
| Self-reported impact of developmental stuttering across the lifespan. |
|
| ABSTRACT |
|
| AIM |
NlmCategory: OBJECTIVE |
| To examine the phenomenology of stuttering across the lifespan in the largest prospective cohort to date. |
| METHOD |
NlmCategory: METHODS |
| To examine the phenomenology of stuttering across the lifespan in the largest prospective cohort to date. Participants aged 7 years and older with a history of developmental stuttering were recruited. Self-reported phenotypic data were collected online including stuttering symptomatology, co-occurring phenotypes, genetic predisposition, factors associated with stuttering severity, and impact on anxiety, education, and employment. |
| RESULTS |
NlmCategory: RESULTS |
| To examine the phenomenology of stuttering across the lifespan in the largest prospective cohort to date. Participants aged 7 years and older with a history of developmental stuttering were recruited. Self-reported phenotypic data were collected online including stuttering symptomatology, co-occurring phenotypes, genetic predisposition, factors associated with stuttering severity, and impact on anxiety, education, and employment. A total of 987 participants (852 adults: 590 males, 262 females, mean age 49 years [SD = 17 years 10 months; range = 18-93 years] and 135 children: 97 males, 38 females, mean age 11 years 4 months [SD = 3 years; range = 7-17 years]) were recruited. Stuttering onset occurred at age 3 to 6 years in 64.0%. Blocking (73.2%) was the most frequent phenotype; 75.9% had sought stuttering therapy and 15.5% identified as having recovered. Half (49.9%) reported a family history. There was a significant negative correlation with age for both stuttering frequency and severity in adults. Most were anxious due to stuttering (90.4%) and perceived stuttering as a barrier to education and employment outcomes (80.7%). |
| INTERPRETATION |
NlmCategory: CONCLUSIONS |
| To examine the phenomenology of stuttering across the lifespan in the largest prospective cohort to date. Participants aged 7 years and older with a history of developmental stuttering were recruited. Self-reported phenotypic data were collected online including stuttering symptomatology, co-occurring phenotypes, genetic predisposition, factors associated with stuttering severity, and impact on anxiety, education, and employment. A total of 987 participants (852 adults: 590 males, 262 females, mean age 49 years [SD = 17 years 10 months; range = 18-93 years] and 135 children: 97 males, 38 females, mean age 11 years 4 months [SD = 3 years; range = 7-17 years]) were recruited. Stuttering onset occurred at age 3 to 6 years in 64.0%. Blocking (73.2%) was the most frequent phenotype; 75.9% had sought stuttering therapy and 15.5% identified as having recovered. Half (49.9%) reported a family history. There was a significant negative correlation with age for both stuttering frequency and severity in adults. Most were anxious due to stuttering (90.4%) and perceived stuttering as a barrier to education and employment outcomes (80.7%). The frequent persistence of stuttering and the high proportion with a family history suggest that stuttering is a complex trait that does not often resolve, even with therapy. These data provide new insights into the phenotype and prognosis of stuttering, information that is critically needed to encourage the development of more effective speech therapies. |
| © 2022 Mac Keith Press. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| revised |
2022/02/24 |
| received |
2021/08/06 |
| accepted |
2022/02/28 |
| entrez |
2022/03/21 05:45 |
| pubmed |
2022/03/22 06:00 |
| medline |
2022/03/22 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Boyce JO |
|
Boyce |
Jessica O |
JO |
|
Department of Audiology and Speech Pathology, University of Melbourne, Parkville, VIC, Australia. |
| Jackson VE |
|
Jackson |
Victoria E |
VE |
|
Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia. |
| van Reyk O |
|
van Reyk |
Olivia |
O |
|
Speech and Language, Murdoch Children's Research Institute, Melbourne, VIC, Australia. |
| Parker R |
|
Parker |
Richard |
R |
|
Queensland Institute for Medical Research, Berghofer Medical Research Institute, Brisbane, Australia. |
| Vogel AP |
|
Vogel |
Adam P |
AP |
|
Redenlab Inc, Melbourne, VIC, Australia. |
| Eising E |
|
Eising |
Else |
E |
|
Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, the Netherlands. |
| Horton SE |
|
Horton |
Sarah E |
SE |
|
Department of Audiology and Speech Pathology, University of Melbourne, Parkville, VIC, Australia. |
| Gillespie NA |
|
Gillespie |
Nathan A |
NA |
|
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, VA, USA. |
| Scheffer IE |
|
Scheffer |
Ingrid E |
IE |
|
Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia. |
| Amor DJ |
|
Amor |
David J |
DJ |
|
Royal Children's Hospital. |
| Hildebrand MS |
|
Hildebrand |
Michael S |
MS |
|
Epilepsy Research Centre, Department of Medicine, University of Melbourne, Heidelberg, VIC, Australia. |
| Fisher SE |
|
Fisher |
Simon E |
SE |
|
Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
Queensland Institute for Medical Research, Berghofer Medical Research Institute, Brisbane, Australia. |
| Reilly S |
|
Reilly |
Sheena |
S |
|
Menzies Health Institute Queensland, Griffith University, Southport, Australia. |
| Bahlo M |
|
Bahlo |
Melanie |
M |
|
Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia. |
| Morgan AT |
|
Morgan |
Angela T |
AT |
|
Royal Children's Hospital. |
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: |
| ISSUE: |
| TITLE: Developmental medicine and child neurology |
| ISOABBREVIATION: Dev Med Child Neurol |
| YEAR: 2022 |
| MONTH: Mar |
| DAY: 21 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1469-8749 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Dev Med Child Neurol |
| COUNTRY: England |
| ISSNLINKING: 0012-1622 |
| NLMUNIQUEID: 0006761 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
|
Victorian Government |
|
|
Max Planck Society |
|
| 1104831 |
National Health and Medical Research Council |
|
| 1105008 |
National Health and Medical Research Council |
|
| 1116976 |
National Health and Medical Research Council |
|
| 1135683 |
National Health and Medical Research Council |
|
| 1160893 |
National Health and Medical Research Council |
|
| 1195236 |
National Health and Medical Research Council |
|
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
|
|
