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| PMID |
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| TITLE |
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| Financial strain moderates genetic influences on self-rated health: support for diathesis-stress model of gene-environment interplay. |
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| ABSTRACT |
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| Data from the Interplay of Genes and Environment across Multiple Studies (IGEMS) consortium were used to examine predictions of different models of gene-by-environment interaction to understand how genetic variance in self-rated health (SRH) varies at different levels of financial strain. A total of 11,359 individuals from 10 twin studies in Australia, Sweden, and the United States contributed relevant data, including 2,074 monozygotic and 2,623 dizygotic twin pairs. Age ranged from 22 to 98 years, with a mean age of 61.05 (SD = 13.24). A factor model was used to create a harmonized measure of financial strain across studies and items. Twin analyses of genetic and environmental variance for SRH incorporating age, age , sex, and financial strain moderators indicated significant financial strain moderation of genetic influences on self-rated health. Moderation results did not differ across sex or country. Genetic variance for SRH increased as financial strain increased, matching the predictions of the diathesis-stress and social comparison models for components of variance. Under these models, environmental improvements would be expected to reduce genetically based health disparities. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| pmc-release |
2023/02/14 |
| pubmed |
2022/02/15 06:00 |
| medline |
2022/04/28 06:00 |
| entrez |
2022/02/14 12:14 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Finkel D |
|
Finkel |
Deborah |
D |
|
Institute of Gerontology and Aging Research Network-Jönköping (ARN-J), Jönköping University, Jönköping, Sweden. |
| Zavala C |
|
Zavala |
Catalina |
C |
|
Department of Psychology, University of Southern California, Los Angeles, California. |
| Franz CE |
|
Franz |
Carol E |
CE |
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Department of Psychology, University of California, San Diego, California. |
| Pahlen S |
|
Pahlen |
Shandell |
S |
|
Department of Psychology, University of California, Riverside, California. |
| Gatz M |
|
Gatz |
Margaret |
M |
|
Center for Economic and Social Research, University of Southern California, Los Angeles, California. |
| Pedersen NL |
|
Pedersen |
Nancy L |
NL |
|
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden. |
| Finch BK |
|
Finch |
Brian K |
BK |
|
Department of Sociology and Spatial Sciences, University of Southern California, Los Angeles, California. |
| Dahl Aslan A |
|
Dahl Aslan |
Anna |
A |
|
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden. |
| Catts VS |
|
Catts |
Vibeke S |
VS |
|
Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, UNSW Sydney, Kensington, Australia. |
| Ericsson M |
|
Ericsson |
Malin |
M |
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Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden. |
| Krueger RF |
|
Krueger |
Robert F |
RF |
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Department of Psychology, University of Minnesota, Minneapolis, Minnesota. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Mohan A |
|
Mohan |
Adith |
A |
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Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, UNSW Sydney, Kensington, Australia. |
| Mosing MA |
|
Mosing |
Miriam A |
MA |
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Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Australia. |
| Prescott CA |
|
Prescott |
Carol A |
CA |
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Department of Psychology, University of Southern California, Los Angeles, California. |
| Whitfield KE |
|
Whitfield |
Keith E |
KE |
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Department of Psychology, University of Nevada Las Vegas, Las Vegas, Nevada. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 67 |
| ISSUE: 1 |
| TITLE: Biodemography and social biology |
| ISOABBREVIATION: Biodemography Soc Biol |
| YEAR: |
| MONTH: |
| DAY: |
| MEDLINEDATE: 2022 Jan-Mar |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1948-5573 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Biodemography Soc Biol |
| COUNTRY: United States |
| ISSNLINKING: 1948-5565 |
| NLMUNIQUEID: 101500303 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GRANTID |
AGENCY |
COUNTRY |
| R01 AG037985 |
NIA NIH HHS |
United States |
| R01 AG059329 |
NIA NIH HHS |
United States |
| R01 AG060470 |
NIA NIH HHS |
United States |
| R56 AG037985 |
NIA NIH HHS |
United States |
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| GENERAL NOTE |
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| KEYWORDS |
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| MESH HEADINGS |
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| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
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| Aged |
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| Aged, 80 and over |
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| Disease Susceptibility |
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| Humans |
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| Middle Aged |
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| Sweden |
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| Twins, Dizygotic |
genetics |
| United States |
genetics |
| Young Adult |
genetics |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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