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| PMID |
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| TITLE |
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| Perinatal depression is associated with a higher polygenic risk for major depressive disorder than non-perinatal depression. |
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| ABSTRACT |
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| BACKGROUND |
NlmCategory: BACKGROUND |
| Distinctions between major depressive disorder (MDD) and perinatal depression (PND) reflect varying views of PND, from a unique etiological subtype of MDD to an MDD episode that happens to coincide with childbirth. This case-control study investigated genetic differences between PND and MDD outside the perinatal period (non-perinatal depression or NPD). |
| METHODS |
NlmCategory: METHODS |
| Distinctions between major depressive disorder (MDD) and perinatal depression (PND) reflect varying views of PND, from a unique etiological subtype of MDD to an MDD episode that happens to coincide with childbirth. This case-control study investigated genetic differences between PND and MDD outside the perinatal period (non-perinatal depression or NPD). We conducted a genome-wide association study using PND cases (Edinburgh Postnatal Depression Scale score ≥ 13) from the Australian Genetics of Depression Study 2018 data (n = 3804) and screened controls (n = 6134). Results of gene-set enrichment analysis were compared with those of women with non-PND. For six psychiatric disorders/traits, genetic correlations with PND were evaluated, and logistic regression analysis reported polygenic score (PGS) association with both PND and NPD. |
| RESULTS |
NlmCategory: RESULTS |
| Distinctions between major depressive disorder (MDD) and perinatal depression (PND) reflect varying views of PND, from a unique etiological subtype of MDD to an MDD episode that happens to coincide with childbirth. This case-control study investigated genetic differences between PND and MDD outside the perinatal period (non-perinatal depression or NPD). We conducted a genome-wide association study using PND cases (Edinburgh Postnatal Depression Scale score ≥ 13) from the Australian Genetics of Depression Study 2018 data (n = 3804) and screened controls (n = 6134). Results of gene-set enrichment analysis were compared with those of women with non-PND. For six psychiatric disorders/traits, genetic correlations with PND were evaluated, and logistic regression analysis reported polygenic score (PGS) association with both PND and NPD. Genes differentially expressed in ovarian tissue were significantly enriched (stdBeta = 0.07, p = 3.3e-04), but were not found to be associated with NPD. The genetic correlation between PND and MDD was 0.93 (SE = 0.07; p = 3.5e-38). Compared with controls, PGS for MDD are higher for PND cases (odds ratio [OR] = 1.8, confidence interval [CI] = [1.7-1.8], p = 9.5e-140) than for NPD cases (OR = 1.6, CI = [1.5-1.7], p = 1.2e-49). Highest risk is for those reporting both antenatal and postnatal depression, irrespective of prior MDD history. |
| CONCLUSIONS |
NlmCategory: CONCLUSIONS |
| Distinctions between major depressive disorder (MDD) and perinatal depression (PND) reflect varying views of PND, from a unique etiological subtype of MDD to an MDD episode that happens to coincide with childbirth. This case-control study investigated genetic differences between PND and MDD outside the perinatal period (non-perinatal depression or NPD). We conducted a genome-wide association study using PND cases (Edinburgh Postnatal Depression Scale score ≥ 13) from the Australian Genetics of Depression Study 2018 data (n = 3804) and screened controls (n = 6134). Results of gene-set enrichment analysis were compared with those of women with non-PND. For six psychiatric disorders/traits, genetic correlations with PND were evaluated, and logistic regression analysis reported polygenic score (PGS) association with both PND and NPD. Genes differentially expressed in ovarian tissue were significantly enriched (stdBeta = 0.07, p = 3.3e-04), but were not found to be associated with NPD. The genetic correlation between PND and MDD was 0.93 (SE = 0.07; p = 3.5e-38). Compared with controls, PGS for MDD are higher for PND cases (odds ratio [OR] = 1.8, confidence interval [CI] = [1.7-1.8], p = 9.5e-140) than for NPD cases (OR = 1.6, CI = [1.5-1.7], p = 1.2e-49). Highest risk is for those reporting both antenatal and postnatal depression, irrespective of prior MDD history. PND has a high genetic overlap with MDD, but points of distinction focus on differential expression in ovarian tissue and higher MDD PGS, particularly for women experiencing both antenatal and postpartum PND. |
| © 2022 Wiley Periodicals LLC. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| revised |
2021/11/19 |
| received |
2021/06/18 |
| accepted |
2021/12/12 |
| entrez |
2022/01/05 12:33 |
| pubmed |
2022/01/06 06:00 |
| medline |
2022/01/06 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Kiewa J |
|
Kiewa |
Jacqueline |
J |
|
Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia. |
| Meltzer-Brody S |
|
Meltzer-Brody |
Samantha |
S |
|
Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina, USA. |
| Milgrom J |
|
Milgrom |
Jeanette |
J |
|
Melbourne School of Psychological Sciences, The University of Melbourne, Melbourne, Victoria, Australia. |
| Guintivano J |
|
Guintivano |
Jerry |
J |
|
Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina, USA. |
| Hickie IB |
|
Hickie |
Ian B |
IB |
|
Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia. |
| Whiteman DC |
|
Whiteman |
David C |
DC |
|
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
| Olsen CM |
|
Olsen |
Catherine M |
CM |
|
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
| Colodro-Conde L |
|
Colodro-Conde |
Lucía |
L |
|
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
| Medland SE |
|
Medland |
Sarah E |
SE |
|
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
| Wray NR |
|
Wray |
Naomi R |
NR |
|
Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia. |
| Byrne EM |
|
Byrne |
Enda M |
EM |
|
Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia. |
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| INVESTIGATORS |
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| JOURNAL |
|
| VOLUME: |
| ISSUE: |
| TITLE: Depression and anxiety |
| ISOABBREVIATION: Depress Anxiety |
| YEAR: 2022 |
| MONTH: Jan |
| DAY: 05 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1520-6394 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Depress Anxiety |
| COUNTRY: United States |
| ISSNLINKING: 1091-4269 |
| NLMUNIQUEID: 9708816 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GRANTID |
AGENCY |
COUNTRY |
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QIMR Berghofer Institute fellowship |
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University of Queensland Research Training Program Scholarship |
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| 1078901 |
National Health and Medical Research Council |
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| 1086683 |
National Health and Medical Research Council |
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| 1087889 |
National Health and Medical Research Council |
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| 1145645 |
National Health and Medical Research Council |
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| APP1058522 |
National Health and Medical Research Council |
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| APP1073898 |
National Health and Medical Research Council |
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| APP1155413 |
National Health and Medical Research Council |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| depression |
| genetics |
| personality/disorder |
| pregnancy and postpartum |
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| MESH HEADINGS |
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| SUPPLEMENTARY MESH |
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| CHEMICALS |
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