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| TITLE |
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| Potential Genetic Overlap Between Insomnia and Sleep Symptoms in Major Depressive Disorder: A Polygenic Risk Score Analysis. |
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| ABSTRACT |
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| The prevalence of insomnia and hypersomnia in depressed individuals is substantially higher than that found in the general population. Unfortunately, these concurrent sleep problems can have profound effects on the disease course. Although the full biology of sleep remains to be elucidated, a recent genome-wide association (GWAS) of insomnia, and other sleep traits in over 1 million individuals was recently published and provides many promising hits for genetics of insomnia in a population-based sample. Using data from the largest available GWAS of insomnia and other sleep traits, we sought to test if sleep variable PRS scores derived from population-based studies predicted sleep variables in samples of depressed cases [Psychiatric Genomics Consortium - Major Depressive Disorder subjects (PGC MDD)]. A leave-one-out analysis was performed to determine the effects that each individual study had on our results. The only significant finding was for insomnia, where -value threshold, = 0.05 was associated with insomnia in our PGC MDD sample ( = 1.75 , = 0.006). Our results reveal that <1% of variance is explained by the variants that cover the two significant -value thresholds, which is in line with the fact that depression and insomnia are both polygenic disorders. To the best of our knowledge, this is the first study to investigate genetic overlap between the general population and a depression sample for insomnia, which has important treatment implications, such as leading to novel drug targets in future research efforts. |
| Copyright © 2021 Melhuish Beaupre, Tiwari, Gonçalves, Zai, Marshe, Lewis, Martin, McIntosh, Adams, Baune, Levinson, Boomsma, Penninx, Breen, Hamilton, Awasthi, Ripke, Jones, Jones, Byrne, Hickie, Potash, Shi, Weissman, Milaneschi, Shyn, Geus, Willemsen, Brown, Kennedy and Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2021/07/22 |
| accepted |
2021/11/01 |
| entrez |
2021/12/20 06:05 |
| pubmed |
2021/12/21 06:00 |
| medline |
2021/12/21 06:01 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Melhuish Beaupre LM |
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Melhuish Beaupre |
Lindsay M |
LM |
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Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada. |
| Tiwari AK |
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Tiwari |
Arun K |
AK |
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Department of Psychiatry, University of Toronto, Toronto, ON, Canada. |
| Gonçalves VF |
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Gonçalves |
Vanessa F |
VF |
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Department of Psychiatry, University of Toronto, Toronto, ON, Canada. |
| Zai CC |
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Zai |
Clement C |
CC |
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Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. |
| Marshe VS |
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Marshe |
Victoria S |
VS |
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Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada. |
| Lewis CM |
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Lewis |
Cathryn M |
CM |
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Department of Medical and Molecular Genetics, King's College London, London, United Kingdom. |
| Martin NG |
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Martin |
Nicholas G |
NG |
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Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
| McIntosh AM |
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McIntosh |
Andrew M |
AM |
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Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom. |
| Adams MJ |
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Adams |
Mark J |
MJ |
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Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom. |
| Baune BT |
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Baune |
Bernhard T |
BT |
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Melbourne Medical School, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, Australia. |
| Levinson DF |
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Levinson |
Doug F |
DF |
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Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, United States. |
| Boomsma DI |
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Boomsma |
Dorret I |
DI |
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Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, Netherlands. |
| Penninx BWJH |
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Penninx |
Brenda W J H |
BWJH |
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Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC/Vrije Universiteit, Amsterdam, Netherlands. |
| Breen G |
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Breen |
Gerome |
G |
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National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre, King's College London, London, United Kingdom. |
| Hamilton S |
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Hamilton |
Steve |
S |
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The Permanente Medical Group, San Francisco, CA, United States. |
| Awasthi S |
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Awasthi |
Swapnil |
S |
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Department of Psychiatry and Psychotherapy, Universitäts Medizin Berlin Campus Charité Mitte, Berlin, Germany. |
| Ripke S |
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Ripke |
Stephan |
S |
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Department of Psychiatry, Charité, Berlin, Germany. |
| Jones L |
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Jones |
Lisa |
L |
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Psychological Medicine, University of Worcester, Worcester, United Kingdom. |
| Jones I |
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Jones |
Ian |
I |
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Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, United Kingdom. |
| Byrne EM |
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Byrne |
Enda M |
EM |
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Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia. |
| Hickie IB |
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Hickie |
Ian B |
IB |
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Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia. |
| Potash JP |
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Potash |
James P |
JP |
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Psychiatry Department, University of Iowa, Iowa City, IA, United States. |
| Shi J |
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Shi |
Jianxin |
J |
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Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States. |
| Weissman MM |
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Weissman |
Myrna M |
MM |
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Division of Epidemiology, New York State Psychiatric Institute, New York, NY, United States. |
| Milaneschi Y |
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Milaneschi |
Yuri |
Y |
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Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC/Vrije Universiteit, Amsterdam, Netherlands. |
| Shyn SI |
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Shyn |
Stanley I |
SI |
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Washington Permanente Medical Group, Kaiser Permanente Washington Health Research Institute, Seattle, WA, United States. |
| de Geus EJC |
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de Geus |
Eco J C |
EJC |
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Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC/Vrije Universiteit, Amsterdam, Netherlands. |
| Willemsen G |
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Willemsen |
Gonneke |
G |
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Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC/Vrije Universiteit, Amsterdam, Netherlands. |
| Brown GM |
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Brown |
Gregory M |
GM |
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Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada. |
| Kennedy JL |
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Kennedy |
James L |
JL |
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Department of Psychiatry, University of Toronto, Toronto, ON, Canada. |
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Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium |
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| JOURNAL |
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| VOLUME: 12 |
| ISSUE: |
| TITLE: Frontiers in psychiatry |
| ISOABBREVIATION: Front Psychiatry |
| YEAR: 2021 |
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| DAY: |
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| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 1664-0640 |
| ISSNTYPE: Print |
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| MEDLINE JOURNAL |
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| MEDLINETA: Front Psychiatry |
| COUNTRY: Switzerland |
| ISSNLINKING: 1664-0640 |
| NLMUNIQUEID: 101545006 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| hypersomnia |
| insomnia |
| major depressive disorder |
| polygenic risk |
| sleep |
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| MESH HEADINGS |
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