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| PMID |
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| TITLE |
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| Identical twins carry a persistent epigenetic signature of early genome programming. |
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| ABSTRACT |
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| Monozygotic (MZ) twins and higher-order multiples arise when a zygote splits during pre-implantation stages of development. The mechanisms underpinning this event have remained a mystery. Because MZ twinning rarely runs in families, the leading hypothesis is that it occurs at random. Here, we show that MZ twinning is strongly associated with a stable DNA methylation signature in adult somatic tissues. This signature spans regions near telomeres and centromeres, Polycomb-repressed regions and heterochromatin, genes involved in cell-adhesion, WNT signaling, cell fate, and putative human metastable epialleles. Our study also demonstrates a never-anticipated corollary: because identical twins keep a lifelong molecular signature, we can retrospectively diagnose if a person was conceived as monozygotic twin. |
| © 2021. The Author(s). |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2021/02/27 |
| accepted |
2021/07/19 |
| entrez |
2021/09/29 06:05 |
| pubmed |
2021/09/30 06:00 |
| medline |
2021/09/30 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| van Dongen J |
|
van Dongen |
Jenny |
J |
|
Amsterdam Public Health Research Institute, Amsterdam, The Netherlands. j.van.dongen@vu.nl. |
| Gordon SD |
|
Gordon |
Scott D |
SD |
|
Queensland Institute of Medical Research Berghofer, Brisbane, QLD, Australia. |
| McRae AF |
|
McRae |
Allan F |
AF |
|
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia. |
| Odintsova VV |
|
Odintsova |
Veronika V |
VV |
|
Amsterdam Public Health Research Institute, Amsterdam, The Netherlands. |
| Mbarek H |
|
Mbarek |
Hamdi |
H |
|
Amsterdam Public Health Research Institute, Amsterdam, The Netherlands. |
| Breeze CE |
|
Breeze |
Charles E |
CE |
|
Altius Institute for Biomedical Sciences, Seattle, WA, USA. |
| Sugden K |
|
Sugden |
Karen |
K |
|
Department of Psychology and Neuroscience and Center for Genomic and Computational Biology, Duke University, Durham, NC, USA. |
| Lundgren S |
|
Lundgren |
Sara |
S |
|
Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland. |
| Castillo-Fernandez JE |
|
Castillo-Fernandez |
Juan E |
JE |
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Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK. |
| Hannon E |
|
Hannon |
Eilis |
E |
|
University of Exeter Medical School, University of Exeter, Exeter, UK. |
| Moffitt TE |
|
Moffitt |
Terrie E |
TE |
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Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. |
| Hagenbeek FA |
|
Hagenbeek |
Fiona A |
FA |
|
Amsterdam Public Health Research Institute, Amsterdam, The Netherlands. |
| van Beijsterveldt CEM |
|
van Beijsterveldt |
Catharina E M |
CEM |
|
Amsterdam Public Health Research Institute, Amsterdam, The Netherlands. |
| Jan Hottenga J |
|
Jan Hottenga |
Jouke |
J |
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Amsterdam Public Health Research Institute, Amsterdam, The Netherlands. |
| Tsai PC |
|
Tsai |
Pei-Chien |
PC |
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Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK. |
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BIOS Consortium |
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Genetics of DNA Methylation Consortium |
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| Min JL |
|
Min |
Josine L |
JL |
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Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK. |
| Hemani G |
|
Hemani |
Gibran |
G |
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Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK. |
| Ehli EA |
|
Ehli |
Erik A |
EA |
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Avera Institute for Human Genetics, Sioux Falls, SD, USA. |
| Paul F |
|
Paul |
Franziska |
F |
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Institute of Molecular and Cellular Biology, A*STAR, Singapore, Singapore. |
| Stern CD |
|
Stern |
Claudio D |
CD |
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Department of Cell and Developmental Biology, University College London, London, UK. |
| Heijmans BT |
|
Heijmans |
Bastiaan T |
BT |
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Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands. |
| Slagboom PE |
|
Slagboom |
P Eline |
PE |
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Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands. |
| Daxinger L |
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Daxinger |
Lucia |
L |
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Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands. |
| van der Maarel SM |
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van der Maarel |
Silvère M |
SM |
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Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands. |
| de Geus EJC |
|
de Geus |
Eco J C |
EJC |
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Amsterdam Public Health Research Institute, Amsterdam, The Netherlands. |
| Willemsen G |
|
Willemsen |
Gonneke |
G |
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Amsterdam Public Health Research Institute, Amsterdam, The Netherlands. |
| Montgomery GW |
|
Montgomery |
Grant W |
GW |
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Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia. |
| Reversade B |
|
Reversade |
Bruno |
B |
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Medical Genetics Department, KOC University, School of Medicine, Istanbul, Turkey. |
| Ollikainen M |
|
Ollikainen |
Miina |
M |
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Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland. |
| Kaprio J |
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Kaprio |
Jaakko |
J |
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Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland. |
| Spector TD |
|
Spector |
Tim D |
TD |
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Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK. |
| Bell JT |
|
Bell |
Jordana T |
JT |
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Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK. |
| Mill J |
|
Mill |
Jonathan |
J |
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University of Exeter Medical School, University of Exeter, Exeter, UK. |
| Caspi A |
|
Caspi |
Avshalom |
A |
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Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
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Queensland Institute of Medical Research Berghofer, Brisbane, QLD, Australia. |
| Boomsma DI |
|
Boomsma |
Dorret I |
DI |
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Amsterdam Public Health Research Institute, Amsterdam, The Netherlands. |
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| INVESTIGATORS |
|
| LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
| van Dongen |
Jenny |
J |
|
| Hottenga |
Jouke-Jan |
JJ |
|
| McRae |
Allan F |
AF |
|
| Sugden |
Karen |
K |
|
| Castillo-Fernandez |
Juan E |
JE |
|
| Hannon |
Eilis |
E |
|
| Moffitt |
Terrie E |
TE |
|
| Hottenga |
Jouke-Jan |
JJ |
|
| de Geus |
Eco J C |
EJC |
|
| Spector |
Timothy D |
TD |
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| JOURNAL |
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| VOLUME: 12 |
| ISSUE: 1 |
| TITLE: Nature communications |
| ISOABBREVIATION: Nat Commun |
| YEAR: 2021 |
| MONTH: Sep |
| DAY: 28 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 2041-1723 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Nat Commun |
| COUNTRY: England |
| ISSNLINKING: 2041-1723 |
| NLMUNIQUEID: 101528555 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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