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| PMID |
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| TITLE |
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| Examining sex differences in neurodevelopmental and psychiatric genetic risk in anxiety and depression. |
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| ABSTRACT |
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| Anxiety and depression are common mental health disorders and have a higher prevalence in females. They are modestly heritable, share genetic liability with other psychiatric disorders, and are highly heterogeneous. There is evidence that genetic liability to neurodevelopmental disorders, such as attention deficit hyperactivity disorder (ADHD) is associated with anxiety and depression, particularly in females. We investigated sex differences in family history for neurodevelopmental and psychiatric disorders and neurodevelopmental genetic risk burden (indexed by ADHD polygenic risk scores (PRS) and rare copy number variants; CNVs) in individuals with anxiety and depression, also taking into account age at onset. We used two complementary datasets: 1) participants with a self-reported diagnosis of anxiety or depression (N = 4,178, 65.5% female; mean age = 41.5 years; N = 1,315 with genetic data) from the National Centre for Mental Health (NCMH) cohort and 2) a clinical sample of 13,273 (67.6% female; mean age = 45.2 years) patients with major depressive disorder (MDD) from the Psychiatric Genomics Consortium (PGC). We tested for sex differences in family history of psychiatric problems and presence of rare CNVs (neurodevelopmental and >500kb loci) in NCMH only and for sex differences in ADHD PRS in both datasets. In the NCMH cohort, females were more likely to report family history of neurodevelopmental and psychiatric disorders, but there were no robust sex differences in ADHD PRS or presence of rare CNVs. There was weak evidence of higher ADHD PRS in females compared to males in the PGC MDD sample, particularly in those with an early onset of MDD. These results do not provide strong evidence of sex differences in neurodevelopmental genetic risk burden in adults with anxiety and depression. This indicates that sex may not be a major index of neurodevelopmental genetic heterogeneity, that is captured by ADHD PRS and rare CNV burden, in adults with anxiety and depression. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2021/03/08 |
| accepted |
2021/07/21 |
| entrez |
2021/09/02 17:40 |
| pubmed |
2021/09/03 06:00 |
| medline |
2021/09/03 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Martin J |
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Martin |
Joanna |
J |
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MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, United Kingdom. |
| Asjadi K |
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Asjadi |
Kimiya |
K |
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MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, United Kingdom. |
| Hubbard L |
|
Hubbard |
Leon |
L |
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MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, United Kingdom. |
| Kendall K |
|
Kendall |
Kimberley |
K |
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MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, United Kingdom. |
| Pardiñas AF |
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Pardiñas |
Antonio F |
AF |
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MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, United Kingdom. |
| Jermy B |
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Jermy |
Bradley |
B |
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Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom. |
| Lewis CM |
|
Lewis |
Cathryn M |
CM |
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Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom. |
| Baune BT |
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Baune |
Bernhard T |
BT |
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Florey Institute for Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia. |
| Boomsma DI |
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Boomsma |
Dorret I |
DI |
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Dept. of Biological Psychology & EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, Netherland. |
| Hamilton SP |
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Hamilton |
Steven P |
SP |
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Psychiatry, Kaiser Permanente Northern California, San Francisco, California, United States of America. |
| Lucae S |
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Lucae |
Susanne |
S |
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Max Planck Institute of Psychiatry, Munich, Germany. |
| Magnusson PK |
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Magnusson |
Patrik K |
PK |
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Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
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Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
| McIntosh AM |
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McIntosh |
Andrew M |
AM |
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Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom. |
| Mehta D |
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Mehta |
Divya |
D |
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Centre for Genomics and Personalised Health, Faculty of Health, Queensland University of Technology (QUT), Kelvin Grove, Queensland, Australia. |
| Mors O |
|
Mors |
Ole |
O |
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Psychosis Research Unit, Aarhus University Hospital, Risskov, Aarhus, Denmark. |
| Mullins N |
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Mullins |
Niamh |
N |
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Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America. |
| Penninx BWJH |
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Penninx |
Brenda W J H |
BWJH |
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Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, Netherland. |
| Preisig M |
|
Preisig |
Martin |
M |
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Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. |
| Rietschel M |
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Rietschel |
Marcella |
M |
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Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Baden-Württemberg, Germany. |
| Jones I |
|
Jones |
Ian |
I |
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National Centre for Mental Health, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, United Kingdom. |
| Walters JTR |
|
Walters |
James T R |
JTR |
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National Centre for Mental Health, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, United Kingdom. |
| Rice F |
|
Rice |
Frances |
F |
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MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, United Kingdom. |
| Thapar A |
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Thapar |
Anita |
A |
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National Centre for Mental Health, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, United Kingdom. |
| O'Donovan M |
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O'Donovan |
Michael |
M |
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National Centre for Mental Health, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, United Kingdom. |
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Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium |
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| JOURNAL |
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| VOLUME: 16 |
| ISSUE: 9 |
| TITLE: PloS one |
| ISOABBREVIATION: PLoS One |
| YEAR: 2021 |
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| DAY: |
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| CITEDMEDIUM: Internet |
| ISSN: 1932-6203 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: PLoS One |
| COUNTRY: United States |
| ISSNLINKING: 1932-6203 |
| NLMUNIQUEID: 101285081 |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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