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| PMID |
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| TITLE |
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| Continuity of Genetic Risk for Aggressive Behavior Across the Life-Course. |
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| ABSTRACT |
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| We test whether genetic influences that explain individual differences in aggression in early life also explain individual differences across the life-course. In two cohorts from The Netherlands (N = 13,471) and Australia (N = 5628), polygenic scores (PGSs) were computed based on a genome-wide meta-analysis of childhood/adolescence aggression. In a novel analytic approach, we ran a mixed effects model for each age (Netherlands: 12-70 years, Australia: 16-73 years), with observations at the focus age weighted as 1, and decaying weights for ages further away. We call this approach a 'rolling weights' model. In The Netherlands, the estimated effect of the PGS was relatively similar from age 12 to age 41, and decreased from age 41-70. In Australia, there was a peak in the effect of the PGS around age 40 years. These results are a first indication from a molecular genetics perspective that genetic influences on aggressive behavior that are expressed in childhood continue to play a role later in life. |
| © 2021. The Author(s). |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2021/01/31 |
| accepted |
2021/06/23 |
| pubmed |
2021/08/15 06:00 |
| medline |
2021/12/15 06:00 |
| entrez |
2021/08/14 12:10 |
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| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| van der Laan CM |
|
van der Laan |
Camiel M |
CM |
|
The Netherlands Institute for the Study of Crime and Law Enforcement, Amsterdam, The Netherlands. C.M.vander.Laan@vu.nl. |
| Morosoli-García JJ |
|
Morosoli-García |
José J |
JJ |
|
QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
| van de Weijer SGA |
|
van de Weijer |
Steve G A |
SGA |
|
The Netherlands Institute for the Study of Crime and Law Enforcement, Amsterdam, The Netherlands. |
| Colodro-Conde L |
|
Colodro-Conde |
Lucía |
L |
|
QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
|
ACTION Consortium |
|
|
|
|
|
| Lupton MK |
|
Lupton |
Michelle K |
MK |
|
QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
| Mitchell BL |
|
Mitchell |
Brittany L |
BL |
|
QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
| McAloney K |
|
McAloney |
Kerrie |
K |
|
QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
| Parker R |
|
Parker |
Richard |
R |
|
QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
| Burns JM |
|
Burns |
Jane M |
JM |
|
Faculty of Health Sciences, The University of Sydney, Sydney, Australia. |
| Hickie IB |
|
Hickie |
Ian B |
IB |
|
Brain and Mind Centre, University of Sydney, Camperdown, Australia. |
| Pool R |
|
Pool |
René |
R |
|
Biological Psychology, Vrije Universiteit, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands. |
| Hottenga JJ |
|
Hottenga |
Jouke-Jan |
JJ |
|
Biological Psychology, Vrije Universiteit, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
| Medland SE |
|
Medland |
Sarah E |
SE |
|
QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
| Nivard MG |
|
Nivard |
Michel G |
MG |
|
Biological Psychology, Vrije Universiteit, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands. |
| Boomsma DI |
|
Boomsma |
Dorret I |
DI |
|
Biological Psychology, Vrije Universiteit, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands. |
|
| INVESTIGATORS |
|
| LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
| Ip |
Hill F |
HF |
|
| van der Laan |
Camiel M |
CM |
|
| Krapohl |
Eva M L |
EML |
|
| Brikell |
Isabell |
I |
|
| Sánchez-Mora |
Cristina |
C |
|
| Nolte |
Ilja M |
IM |
|
| Pourcain |
Beate St |
BS |
|
| Bolhuis |
Koen |
K |
|
| Palviainen |
Teemu |
T |
|
| Zafarmand |
Hadi |
H |
|
| Colodro-Conde |
Lucía |
L |
|
| Gordon |
Scott |
S |
|
| Zayats |
Tetyana |
T |
|
| Aliev |
Fazil |
F |
|
| Jiang |
Chang |
C |
|
| Wang |
Carol A |
CA |
|
| Saunders |
Gretchen |
G |
|
| Karhunen |
Ville |
V |
|
| Hammerschlag |
Anke R |
AR |
|
| Adkins |
Daniel E |
DE |
|
| Border |
Richard |
R |
|
| Peterson |
Roseann E |
RE |
|
| Prinz |
Joseph A |
JA |
|
| Thiering |
Elisabeth |
E |
|
| Seppälä |
Ilkka |
I |
|
| Vilor-Tejedor |
Natàlia |
N |
|
| Ahluwalia |
Tarunveer S |
TS |
|
| Day |
Felix R |
FR |
|
| Hottenga |
Jouke-Jan |
JJ |
|
| Allegrini |
Andrea G |
AG |
|
| Rimfeld |
Kaili |
K |
|
| Chen |
Qi |
Q |
|
| Lu |
Yi |
Y |
|
| Martin |
Joanna |
J |
|
| Artigas |
María Soler |
MS |
|
| Rovira |
Paula |
P |
|
| Bosch |
Rosa |
R |
|
| Español |
Gemma |
G |
|
| Quiroga |
Josep Antoni Ramos |
JAR |
|
| Neumann |
Alexander |
A |
|
| Ensink |
Judith |
J |
|
| Grasby |
Katrina |
K |
|
| Morosoli |
José J |
JJ |
|
| Tong |
Xiaoran |
X |
|
| Marrington |
Shelby |
S |
|
| Middeldorp |
Christel |
C |
|
| Scott |
James G |
JG |
|
| Vinkhuyzen |
Anna |
A |
|
| Shabalin |
Andrey A |
AA |
|
| Corley |
Robin |
R |
|
| Evans |
Luke M |
LM |
|
| Sugden |
Karen |
K |
|
| Alemany |
Silvia |
S |
|
| Sass |
Lærke |
L |
|
| Vinding |
Rebecca |
R |
|
| Ruth |
Kate |
K |
|
| Tyrrell |
Jess |
J |
|
| Ehli |
Erik A |
EA |
|
| Hagenbeek |
Fiona A |
FA |
|
| De Zeeuw |
Eveline |
E |
|
| Van Beijsterveldt |
Toos C E M |
TCEM |
|
| Larsson |
Henrik |
H |
|
| Snieder |
Harold |
H |
|
| Verhulst |
Frank C |
FC |
|
| Amin |
Najaf |
N |
|
| Whipp |
Alyce M |
AM |
|
| Korhonen |
Tellervo |
T |
|
| Vuoksimaa |
Eero |
E |
|
| Rose |
Richard J |
RJ |
|
| Uitterlinden |
André G |
AG |
|
| Heath |
Andrew C |
AC |
|
| Madden |
Pamela |
P |
|
| Haavik |
Jan |
J |
|
| Harris |
Jennifer R |
JR |
|
| Helgeland |
Øyvind |
Ø |
|
| Johansson |
Stefan |
S |
|
| Knudsen |
Gun Peggy S |
GPS |
|
| Njolstad |
Pal Rasmus |
PR |
|
| Lu |
Qing |
Q |
|
| Rodriguez |
Alina |
A |
|
| Henders |
Anjali K |
AK |
|
| Mamun |
Abdullah |
A |
|
| Najman |
Jackob M |
JM |
|
| Brown |
Sandy |
S |
|
| Hopfer |
Christian |
C |
|
| Krauter |
Kenneth |
K |
|
| Reynolds |
Chandra |
C |
|
| Smolen |
Andrew |
A |
|
| Stallings |
Michael |
M |
|
| Wadsworth |
Sally |
S |
|
| Wall |
Tamara L |
TL |
|
| Silberg |
Judy L |
JL |
|
| Miller |
Allison |
A |
|
| Keltikangas-Järvinen |
Liisa |
L |
|
| Hakulinen |
Christian |
C |
|
| Pulkki-Råback |
Laura |
L |
|
| Havdahl |
Alexandra |
A |
|
| Magnus |
Per |
P |
|
| Raitakari |
Olli T |
OT |
|
| Perry |
John R B |
JRB |
|
| Llop |
Sabrina |
S |
|
| Lopez-Espinosa |
Maria-Jose |
MJ |
|
| Bønnelykke |
Klaus |
K |
|
| Bisgaard |
Hans |
H |
|
| Sunyer |
Jordi |
J |
|
| Lehtimäki |
Terho |
T |
|
| Arseneault |
Louise |
L |
|
| Standl |
Marie |
M |
|
| Heinrich |
Joachim |
J |
|
| Boden |
Joseph |
J |
|
| Pearson |
John |
J |
|
| Horwood |
LJohn |
L |
|
| Kennedy |
Martin |
M |
|
| Poulton |
Richie |
R |
|
| Eaves |
Lindon J |
LJ |
|
| Maes |
Hermine H |
HH |
|
| Hewitt |
John |
J |
|
| Copeland |
William E |
WE |
|
| Costello |
Elizabeth J |
EJ |
|
| Williams |
Gail M |
GM |
|
| Wray |
Naomi |
N |
|
| Järvelin |
Marjo-Riitta |
MR |
|
| McGue |
Matt |
M |
|
| Iacono |
William |
W |
|
| Caspi |
Avshalom |
A |
|
| Moffitt |
Terrie E |
TE |
|
| Whitehouse |
Andrew |
A |
|
| Pennell |
Craig E |
CE |
|
| Klump |
Kelly L |
KL |
|
| Burt |
S Alexandra |
SA |
|
| Dick |
Danielle M |
DM |
|
| Reichborn-Kjennerud |
Ted |
T |
|
| Martin |
Nicholas G |
NG |
|
| Medland |
Sarah E |
SE |
|
| Vrijkotte |
Tanja |
T |
|
| Kaprio |
Jaakko |
J |
|
| Tiemeier |
Henning |
H |
|
| Smith |
George Davey |
GD |
|
| Hartman |
Catharina A |
CA |
|
| Oldehinkel |
Albertine J |
AJ |
|
| Casas |
Miquel |
M |
|
| Ribasés |
Marta |
M |
|
| Lichtenstein |
Paul |
P |
|
| Lundström |
Sebastian |
S |
|
| Plomin |
Robert |
R |
|
| Bartels |
Meike |
M |
|
| Nivard |
Michel G |
MG |
|
| Boomsma |
Dorret I |
DI |
|
|
| JOURNAL |
|
| VOLUME: 51 |
| ISSUE: 5 |
| TITLE: Behavior genetics |
| ISOABBREVIATION: Behav Genet |
| YEAR: 2021 |
| MONTH: 09 |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1573-3297 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
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| MEDLINETA: Behav Genet |
| COUNTRY: United States |
| ISSNLINKING: 0001-8244 |
| NLMUNIQUEID: 0251711 |
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| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Meta-Analysis |
| Research Support, Non-U.S. Gov't |
|
| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
|
| KEYWORD |
| Aggression |
| Aggressive behavior |
| Development |
| Life-course |
| Polygenic score |
| Rolling weights |
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adolescent |
|
| Adult |
|
| Aged |
|
| Aggression |
|
| Australia |
|
| Child |
|
| Humans |
|
| Middle Aged |
|
| Multifactorial Inheritance |
|
| Netherlands |
|
| Risk Factors |
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| Young Adult |
|
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| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
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| CHEMICALS |
|
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| OTHER ID's |
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