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| PMID |
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| TITLE |
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| Shared Genetic Etiology between Cortical Brain Morphology and Tobacco, Alcohol, and Cannabis Use. |
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| ABSTRACT |
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| Genome-wide association studies (GWAS) have identified genetic variants associated with brain morphology and substance use behaviors (SUB). However, the genetic overlap between brain structure and SUB has not been well characterized. We leveraged GWAS summary data of 71 brain imaging measures and alcohol, tobacco, and cannabis use to investigate their genetic overlap using linkage disequilibrium score regression. We used genomic structural equation modeling to model a "common SUB genetic factor" and investigated its genetic overlap with brain structure. Furthermore, we estimated SUB polygenic risk scores (PRS) and examined whether they predicted brain imaging traits using the Adolescent Behavior and Cognitive Development (ABCD) study. We identified 8 significant negative genetic correlations, including between (1) alcoholic drinks per week and average cortical thickness, and (2) intracranial volume with age of smoking initiation. We observed 5 positive genetic correlations, including those between (1) insula surface area and lifetime cannabis use, and (2) the common SUB genetic factor and pericalcarine surface area. SUB PRS were associated with brain structure variation in ABCD. Our findings highlight a shared genetic etiology between cortical brain morphology and SUB and suggest that genetic variants associated with SUB may be causally related to brain structure differences. |
| © The Author(s) 2021. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2021/03/27 |
| revised |
2021/06/23 |
| accepted |
2021/06/24 |
| entrez |
2021/08/11 17:23 |
| pubmed |
2021/08/12 06:00 |
| medline |
2021/08/12 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Rabinowitz JA |
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Rabinowitz |
Jill A |
JA |
|
Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. |
| Campos AI |
|
Campos |
Adrian I |
AI |
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School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland 4072, Australia. |
| Ong JS |
|
Ong |
Jue-Sheng |
JS |
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Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia. |
| García-Marín LM |
|
García-Marín |
Luis M |
LM |
|
School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland 4072, Australia. |
| Alcauter S |
|
Alcauter |
Sarael |
S |
|
Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro 76230, México. |
| Mitchell BL |
|
Mitchell |
Brittany L |
BL |
|
School of Biomedical Science, Faculty of Health, Queensland University of Technology (QUT), Brisbane, Queensland 4059, Australia. |
| Grasby KL |
|
Grasby |
Katrina L |
KL |
|
Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia. |
| Cuéllar-Partida G |
|
Cuéllar-Partida |
Gabriel |
G |
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The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, Queensland 4102, Australia. |
| Gillespie NA |
|
Gillespie |
Nathan A |
NA |
|
Virginia Institute for Psychiatric and Behavior Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23284, USA. |
| Huhn AS |
|
Huhn |
Andrew S |
AS |
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Department of Psychiatry and Behavioral Sciences, School of Medicine, Baltimore, MD 21205, USA. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
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Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia. |
| Thompson PM |
|
Thompson |
Paul M |
PM |
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Imaging Genetics Center, Mark & Mary Stevens Institute for Neuroimaging & Informatics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90007, USA. |
| Medland SE |
|
Medland |
Sarah E |
SE |
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Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia. |
| Maher BS |
|
Maher |
Brion S |
BS |
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Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. |
| Rentería ME |
|
Rentería |
Miguel E |
ME |
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School of Biomedical Science, Faculty of Health, Queensland University of Technology (QUT), Brisbane, Queensland 4059, Australia. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: |
| ISSUE: |
| TITLE: Cerebral cortex (New York, N.Y. : 1991) |
| ISOABBREVIATION: Cereb Cortex |
| YEAR: 2021 |
| MONTH: Aug |
| DAY: 11 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1460-2199 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Cereb Cortex |
| COUNTRY: United States |
| ISSNLINKING: 1047-3211 |
| NLMUNIQUEID: 9110718 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GRANTID |
AGENCY |
COUNTRY |
| U01DA041048 |
NIH HHS |
United States |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| alcohol use |
| cannabis use |
| genetics |
| neuroimaging |
| smoking behavior |
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| MESH HEADINGS |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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