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| PMID |
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| TITLE |
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| Using Monozygotic Twins to Dissect Common Genes in Posttraumatic Stress Disorder and Migraine. |
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| ABSTRACT |
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| Epigenetic mechanisms have been associated with genes involved in Posttraumatic stress disorder (PTSD). PTSD often co-occurs with other health conditions such as depression, cardiovascular disorder and respiratory illnesses. PTSD and migraine have previously been reported to be symptomatically positively correlated with each other, but little is known about the genes involved. The aim of this study was to understand the comorbidity between PTSD and migraine using a monozygotic twin disease discordant study design in six pairs of monozygotic twins discordant for PTSD and 15 pairs of monozygotic twins discordant for migraine. DNA from peripheral blood was run on Illumina EPIC arrays and analyzed. Multiple testing correction was performed using the Bonferroni method and 10% false discovery rate (FDR). We validated 11 candidate genes previously associated with PTSD including , , and 1. In the epigenome-wide scan, seven novel CpGs were significantly associated with PTSD within/near , , , , , and , with all CpGs except the CpG hypermethylated in PTSD. These results were significantly enriched for genes whose DNA methylation was previously associated with migraine ( -value = 0.036). At 10% FDR, 132 CpGs in 99 genes associated with PTSD were also associated with migraine in the migraine twin samples. Genes associated with PTSD were overrepresented in vascular smooth muscle, axon guidance and oxytocin signaling pathways, while genes associated with both PTSD and migraine were enriched for AMPK signaling and longevity regulating pathways. In conclusion, these results suggest that common genes and pathways are likely involved in PTSD and migraine, explaining at least in part the co-morbidity between the two disorders. |
| Copyright © 2021 Bainomugisa, Sutherland, Parker, Mcrae, Haupt, Griffiths, Heath, Nelson, Wright, Hickie, Martin, Nyholt and Mehta. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2021/03/09 |
| accepted |
2021/05/31 |
| entrez |
2021/07/09 06:55 |
| pubmed |
2021/07/10 06:00 |
| medline |
2021/07/10 06:01 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Bainomugisa CK |
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Bainomugisa |
Charlotte K |
CK |
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Centre for Genomics and Personalised Health, School of Biomedical Science, Faculty of Health, Queensland University of Technology, Kelvin Grove, QLD, Australia. |
| Sutherland HG |
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Sutherland |
Heidi G |
HG |
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Centre for Genomics and Personalised Health, Genomics Research Centre, School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Kelvin Grove, QLD, Australia. |
| Parker R |
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Parker |
Richard |
R |
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QIMR Berghofer Medical Research Institute, Royal Brisbane Hospital, Herston, QLD, Australia. |
| Mcrae AF |
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Mcrae |
Allan F |
AF |
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Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia. |
| Haupt LM |
|
Haupt |
Larisa M |
LM |
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Centre for Genomics and Personalised Health, Genomics Research Centre, School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Kelvin Grove, QLD, Australia. |
| Griffiths LR |
|
Griffiths |
Lyn R |
LR |
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Centre for Genomics and Personalised Health, Genomics Research Centre, School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Kelvin Grove, QLD, Australia. |
| Heath A |
|
Heath |
Andrew |
A |
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Department of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO, United States. |
| Nelson EC |
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Nelson |
Elliot C |
EC |
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Department of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO, United States. |
| Wright MJ |
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Wright |
Margaret J |
MJ |
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Centre for Advanced Imaging, The University of Queensland, Brisbane, QLD, Australia. |
| Hickie IB |
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Hickie |
Ian B |
IB |
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Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia. |
| Martin NG |
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Martin |
Nicholas G |
NG |
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QIMR Berghofer Medical Research Institute, Royal Brisbane Hospital, Herston, QLD, Australia. |
| Nyholt DR |
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Nyholt |
Dale R |
DR |
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Centre for Genomics and Personalised Health, School of Biomedical Science, Faculty of Health, Queensland University of Technology, Kelvin Grove, QLD, Australia. |
| Mehta D |
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Mehta |
Divya |
D |
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Centre for Genomics and Personalised Health, School of Biomedical Science, Faculty of Health, Queensland University of Technology, Kelvin Grove, QLD, Australia. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 15 |
| ISSUE: |
| TITLE: Frontiers in neuroscience |
| ISOABBREVIATION: Front Neurosci |
| YEAR: 2021 |
| MONTH: |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 1662-4548 |
| ISSNTYPE: Print |
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| MEDLINE JOURNAL |
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| MEDLINETA: Front Neurosci |
| COUNTRY: Switzerland |
| ISSNLINKING: 1662-453X |
| NLMUNIQUEID: 101478481 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| DNA methylation |
| genes |
| migraine |
| posttraumatic stress disorder |
| twins |
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| MESH HEADINGS |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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