Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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34172278
TITLE
Brain Correlates of Suicide Attempt in 18,925 Participants Across 18 International Cohorts.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Neuroimaging studies of suicidal behavior have so far been conducted in small samples, prone to biases and false-positive associations, yielding inconsistent results. The ENIGMA-MDD Working Group aims to address the issues of poor replicability and comparability by coordinating harmonized analyses across neuroimaging studies of major depressive disorder and related phenotypes, including suicidal behavior.
METHODS NlmCategory: METHODS
Neuroimaging studies of suicidal behavior have so far been conducted in small samples, prone to biases and false-positive associations, yielding inconsistent results. The ENIGMA-MDD Working Group aims to address the issues of poor replicability and comparability by coordinating harmonized analyses across neuroimaging studies of major depressive disorder and related phenotypes, including suicidal behavior. Here, we pooled data from 18 international cohorts with neuroimaging and clinical measurements in 18,925 participants (12,477 healthy control subjects and 6448 people with depression, of whom 694 had attempted suicide). We compared regional cortical thickness and surface area and measures of subcortical, lateral ventricular, and intracranial volumes between suicide attempters, clinical control subjects (nonattempters with depression), and healthy control subjects.
RESULTS NlmCategory: RESULTS
Neuroimaging studies of suicidal behavior have so far been conducted in small samples, prone to biases and false-positive associations, yielding inconsistent results. The ENIGMA-MDD Working Group aims to address the issues of poor replicability and comparability by coordinating harmonized analyses across neuroimaging studies of major depressive disorder and related phenotypes, including suicidal behavior. Here, we pooled data from 18 international cohorts with neuroimaging and clinical measurements in 18,925 participants (12,477 healthy control subjects and 6448 people with depression, of whom 694 had attempted suicide). We compared regional cortical thickness and surface area and measures of subcortical, lateral ventricular, and intracranial volumes between suicide attempters, clinical control subjects (nonattempters with depression), and healthy control subjects. We identified 25 regions of interest with statistically significant (false discovery rate < .05) differences between groups. Post hoc examinations identified neuroimaging markers associated with suicide attempt including smaller volumes of the left and right thalamus and the right pallidum and lower surface area of the left inferior parietal lobe.
CONCLUSIONS NlmCategory: CONCLUSIONS
Neuroimaging studies of suicidal behavior have so far been conducted in small samples, prone to biases and false-positive associations, yielding inconsistent results. The ENIGMA-MDD Working Group aims to address the issues of poor replicability and comparability by coordinating harmonized analyses across neuroimaging studies of major depressive disorder and related phenotypes, including suicidal behavior. Here, we pooled data from 18 international cohorts with neuroimaging and clinical measurements in 18,925 participants (12,477 healthy control subjects and 6448 people with depression, of whom 694 had attempted suicide). We compared regional cortical thickness and surface area and measures of subcortical, lateral ventricular, and intracranial volumes between suicide attempters, clinical control subjects (nonattempters with depression), and healthy control subjects. We identified 25 regions of interest with statistically significant (false discovery rate < .05) differences between groups. Post hoc examinations identified neuroimaging markers associated with suicide attempt including smaller volumes of the left and right thalamus and the right pallidum and lower surface area of the left inferior parietal lobe. This study addresses the lack of replicability and consistency in several previously published neuroimaging studies of suicide attempt and further demonstrates the need for well-powered samples and collaborative efforts. Our results highlight the potential involvement of the thalamus, a structure viewed historically as a passive gateway in the brain, and the pallidum, a region linked to reward response and positive affect. Future functional and connectivity studies of suicidal behaviors may focus on understanding how these regions relate to the neurobiological mechanisms of suicide attempt risk.
Copyright © 2021 Society of Biological Psychiatry. All rights reserved.
DATE PUBLISHED
2021 Mar 21
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2020/09/26
revised 2021/03/12
accepted 2021/03/13
entrez 2021/06/26 05:33
pubmed 2021/06/27 06:00
medline 2021/06/27 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Campos AI Campos Adrian I AI Genetic Epidemiology Lab, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.
Thompson PM Thompson Paul M PM Imaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, California.
Veltman DJ Veltman Dick J DJ Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Department of Anatomy & Neurosciences, Amsterdam Neuroscience, Amsterdam, the Netherlands.
Pozzi E Pozzi Elena E Department of Psychiatry, The University of Melbourne & Melbourne Health, Melbourne, Victoria, Australia; Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Australia.
van Veltzen LS van Veltzen Laura S LS Department of Psychiatry, The University of Melbourne & Melbourne Health, Melbourne, Victoria, Australia; Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Australia.
Jahanshad N Jahanshad Neda N Imaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, California.
Adams MJ Adams Mark J MJ Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom.
Baune BT Baune Bernhard T BT Department of Psychiatry, The University of Melbourne, Melbourne, Victoria, Australia; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia; Department of Psychiatry, University of Münster, Münster, North Rhine-Westphalia, Germany.
Berger K Berger Klaus K Institute of Epidemiology and Social Medicine, University of Münster, Münster, North Rhine-Westphalia, Germany.
Brosch K Brosch Katharina K Department of Psychiatry, Philipps-University Marburg, Marburg, Hesse, Germany.
Bülow R Bülow Robin R Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Mecklenburg-Vorpommern, Germany.
Connolly CG Connolly Colm G CG Department of Biomedical Sciences, Florida State University, Tallahassee, Florida.
Dannlowski U Dannlowski Udo U Department of Psychiatry, University of Münster, Münster, North Rhine-Westphalia, Germany.
Davey CG Davey Christopher G CG Department of Psychiatry, The University of Melbourne & Melbourne Health, Melbourne, Victoria, Australia.
de Zubicaray GI de Zubicaray Greig I GI Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
Dima D Dima Danai D Department of Psychology, School of Arts and Social Sciences, City, University of London, London, United Kingdom; Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Erwin-Grabner T Erwin-Grabner Tracy T Laboratory of Systems Neuroscience and Imaging in Psychiatry, Department of Psychiatry and Psychotherapy, University Medical Center, Göttingen, Lower Saxony, Germany.
Evans JW Evans Jennifer W JW Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
Fu CHY Fu Cynthia H Y CHY Centre for Affective Disorders, Institute of Psychology, Psychiatry and Neuroscience, King's College London, London, United Kingdom; School of Psychology, University of East London, London, United Kingdom.
Gotlib IH Gotlib Ian H IH Department of Psychology, Stanford University, Stanford, California.
Goya-Maldonado R Goya-Maldonado Roberto R Laboratory of Systems Neuroscience and Imaging in Psychiatry, Department of Psychiatry and Psychotherapy, University Medical Center, Göttingen, Lower Saxony, Germany.
Grabe HJ Grabe Hans J HJ German Center for Neurodegenerative Disease, Greifswald, Mecklenburg-Vorpommern, Germany.
Grotegerd D Grotegerd Dominik D Department of Psychiatry, University of Münster, Münster, North Rhine-Westphalia, Germany.
Harris MA Harris Matthew A MA Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom.
Harrison BJ Harrison Ben J BJ Department of Psychiatry, The University of Melbourne & Melbourne Health, Melbourne, Victoria, Australia.
Hatton SN Hatton Sean N SN Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.
Hermesdorf M Hermesdorf Marco M Institute of Epidemiology and Social Medicine, University of Münster, Münster, North Rhine-Westphalia, Germany.
Hickie IB Hickie Ian B IB Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.
Ho TC Ho Tiffany C TC Department of Psychiatry & Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California.
Kircher T Kircher Tilo T Department of Psychiatry, Philipps-University Marburg, Marburg, Hesse, Germany.
Krug A Krug Axel A Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, North Rhine-Westphalia, Germany; Department of Psychiatry, Philipps-University Marburg, Marburg, Hesse, Germany.
Lagopoulos J Lagopoulos Jim J Thompson Institute, University of the Sunshine Coast, Sunshine Coast, Queensland, Australia; Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.
Lemke H Lemke Hannah H Department of Psychiatry, University of Münster, Münster, North Rhine-Westphalia, Germany.
McMahon K McMahon Katie K Herston Imaging Research Facility & School of Clinical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia.
MacMaster FP MacMaster Frank P FP Department of Pediatrics and Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Strategic Clinical Network for Addictions and Mental Health, Alberta Health Services, Calgary, Alberta, Canada.
Martin NG Martin Nicholas G NG Genetic Epidemiology Lab, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
McIntosh AM McIntosh Andrew M AM Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom.
Medland SE Medland Sarah E SE Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia; Psychiatric Genetics Lab, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Austalia; School of Psychology, The University of Queensland, Brisbane, Queensland, Australia.
Meinert S Meinert Susanne S Department of Psychiatry, University of Münster, Münster, North Rhine-Westphalia, Germany.
Meller T Meller Tina T Department of Psychiatry, Philipps-University Marburg, Marburg, Hesse, Germany.
Nenadic I Nenadic Igor I Department of Psychiatry, Philipps-University Marburg, Marburg, Hesse, Germany.
Opel N Opel Nils N Department of Psychiatry, University of Münster, Münster, North Rhine-Westphalia, Germany.
Redlich R Redlich Ronny R Department of Psychiatry, University of Münster, Münster, North Rhine-Westphalia, Germany.
Reneman L Reneman Liesbeth L Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, location AMC, Amsterdam, the Netherlands.
Repple J Repple Jonathan J Department of Psychiatry, University of Münster, Münster, North Rhine-Westphalia, Germany.
Sacchet MD Sacchet Matthew D MD Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard Medical School, Belmont, Massachusetts.
Schmitt S Schmitt Simon S Department of Psychiatry, Philipps-University Marburg, Marburg, Hesse, Germany.
Schrantee A Schrantee Anouk A Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, location AMC, Amsterdam, the Netherlands.
Sim K Sim Kang K West Region, Institute of Mental Health, Buangkok View, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Singh A Singh Aditya A Laboratory of Systems Neuroscience and Imaging in Psychiatry, Department of Psychiatry and Psychotherapy, University Medical Center, Göttingen, Lower Saxony, Germany.
Stein F Stein Frederike F Department of Psychiatry, Philipps-University Marburg, Marburg, Hesse, Germany.
Strike LT Strike Lachlan T LT Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
van der Wee NJA van der Wee Nic J A NJA Department of Psychiatry, Leiden University Medical Center, Leiden, the Netherlands; Leiden Institute for Brain and Cognition, Leiden, the Netherlands.
van der Werff SJA van der Werff Steven J A SJA Department of Psychiatry, Leiden University Medical Center, Leiden, the Netherlands; Leiden Institute for Brain and Cognition, Leiden, the Netherlands.
Völzke H Völzke Henry H Institute for Community Medicine, University Medicine Greifswald, Greifswald, Mecklenburg-Vorpommern, Germany.
Waltemate L Waltemate Lena L Department of Psychiatry, University of Münster, Münster, North Rhine-Westphalia, Germany.
Whalley HC Whalley Heather C HC Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom.
Wittfeld K Wittfeld Katharina K German Center for Neurodegenerative Disease, Greifswald, Mecklenburg-Vorpommern, Germany.
Wright MJ Wright Margaret J MJ Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia; Centre for Advanced Imaging, The University of Queensland, Brisbane, Queensland, Australia.
Yang TT Yang Tony T TT Department of Psychiatry & Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California.
Zarate CA Zarate Carlos A CA Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
Schmaal L Schmaal Lianne L Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Australia. Electronic address: lianne.schmaal@unimelb.edu.au.
Rentería ME Rentería Miguel E ME Genetic Epidemiology Lab, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia. Electronic address: miguel.renteria@qimrberghofer.edu.au.
ENIGMA-MDD Working Group
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Biological psychiatry
ISOABBREVIATION: Biol Psychiatry
YEAR: 2021
MONTH: Mar
DAY: 21
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1873-2402
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Biol Psychiatry
COUNTRY: United States
ISSNLINKING: 0006-3223
NLMUNIQUEID: 0213264
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
Major depressive disorder
Structural magnetic resonance imaging
Suicide attempt
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
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