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| PMID |
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| TITLE |
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| Polyunsaturated fatty acid levels and the risk of keratinocyte cancer: A Mendelian Randomisation analysis. |
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| ABSTRACT |
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| BACKGROUND |
NlmCategory: BACKGROUND |
| Keratinocyte cancer (KC) is the commonest cancer, imposing a high economic burden on the healthcare system. Observational studies have shown mixed associations between polyunsaturated fatty acids (PUFAs) and KC; basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). We explored if genetically predicted PUFA levels are associated with BCC and SCC risks. |
| METHODS |
NlmCategory: METHODS |
| Keratinocyte cancer (KC) is the commonest cancer, imposing a high economic burden on the healthcare system. Observational studies have shown mixed associations between polyunsaturated fatty acids (PUFAs) and KC; basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). We explored if genetically predicted PUFA levels are associated with BCC and SCC risks. We conducted a two sample Mendelian Randomisation study using PUFA level GWASs from the CHARGE consortium (n > 8,000), and the meta-analysis GWASs from UKB, 23andMe and Qskin for BCC (n=651,138) and SCC (n= 635,331) risk. |
| RESULTS |
NlmCategory: RESULTS |
| Keratinocyte cancer (KC) is the commonest cancer, imposing a high economic burden on the healthcare system. Observational studies have shown mixed associations between polyunsaturated fatty acids (PUFAs) and KC; basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). We explored if genetically predicted PUFA levels are associated with BCC and SCC risks. We conducted a two sample Mendelian Randomisation study using PUFA level GWASs from the CHARGE consortium (n > 8,000), and the meta-analysis GWASs from UKB, 23andMe and Qskin for BCC (n=651,138) and SCC (n= 635,331) risk. One standard deviation increase in genetically predicted levels of linoleic acid (OR = 0.94, 95% CI = 0.91-0.97, P = 1.4 × 10-4) and alpha-linolenic acid (OR = 0.91, 95% CI = 0.86-0.96, P = 5.1 × 10-4) was associated with a reduced BCC risk, while arachidonic acid (OR = 1.04, 95% CI = 1.02-1.06, P = 3.2 × 10-4) and eicosapentaenoic acid (OR=1.10, 95% CI = 1.04-1.16, P = 1.5 × 10-3) were associated with an increased BCC risk. |
| CONCLUSION |
NlmCategory: CONCLUSIONS |
| Keratinocyte cancer (KC) is the commonest cancer, imposing a high economic burden on the healthcare system. Observational studies have shown mixed associations between polyunsaturated fatty acids (PUFAs) and KC; basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). We explored if genetically predicted PUFA levels are associated with BCC and SCC risks. We conducted a two sample Mendelian Randomisation study using PUFA level GWASs from the CHARGE consortium (n > 8,000), and the meta-analysis GWASs from UKB, 23andMe and Qskin for BCC (n=651,138) and SCC (n= 635,331) risk. One standard deviation increase in genetically predicted levels of linoleic acid (OR = 0.94, 95% CI = 0.91-0.97, P = 1.4 × 10-4) and alpha-linolenic acid (OR = 0.91, 95% CI = 0.86-0.96, P = 5.1 × 10-4) was associated with a reduced BCC risk, while arachidonic acid (OR = 1.04, 95% CI = 1.02-1.06, P = 3.2 × 10-4) and eicosapentaenoic acid (OR=1.10, 95% CI = 1.04-1.16, P = 1.5 × 10-3) were associated with an increased BCC risk. Higher genetically predicted levels of linoleic acid and alpha-linolenic acid were associated with a reduced BCC risk, but arachidonic acid and eicosapentaenoic acid were associated with a higher BCC risk. |
| IMPACT |
NlmCategory: CONCLUSIONS |
| Keratinocyte cancer (KC) is the commonest cancer, imposing a high economic burden on the healthcare system. Observational studies have shown mixed associations between polyunsaturated fatty acids (PUFAs) and KC; basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). We explored if genetically predicted PUFA levels are associated with BCC and SCC risks. We conducted a two sample Mendelian Randomisation study using PUFA level GWASs from the CHARGE consortium (n > 8,000), and the meta-analysis GWASs from UKB, 23andMe and Qskin for BCC (n=651,138) and SCC (n= 635,331) risk. One standard deviation increase in genetically predicted levels of linoleic acid (OR = 0.94, 95% CI = 0.91-0.97, P = 1.4 × 10-4) and alpha-linolenic acid (OR = 0.91, 95% CI = 0.86-0.96, P = 5.1 × 10-4) was associated with a reduced BCC risk, while arachidonic acid (OR = 1.04, 95% CI = 1.02-1.06, P = 3.2 × 10-4) and eicosapentaenoic acid (OR=1.10, 95% CI = 1.04-1.16, P = 1.5 × 10-3) were associated with an increased BCC risk. Higher genetically predicted levels of linoleic acid and alpha-linolenic acid were associated with a reduced BCC risk, but arachidonic acid and eicosapentaenoic acid were associated with a higher BCC risk. PUFA related diet and supplementation could influence BCC aetiology. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| accepted |
2021/05/19 |
| received |
2020/12/13 |
| revised |
2021/02/20 |
| entrez |
2021/06/05 05:36 |
| pubmed |
2021/06/06 06:00 |
| medline |
2021/06/06 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Seviiri M |
|
Seviiri |
Mathias |
M |
|
Statistical Genetics, QIMR Berghofer Medical Research Institute Mathias.Seviiri@qimrberghofer.edu.au. |
| Law MH |
|
Law |
Matthew H |
MH |
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Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane. |
| Ong JS |
|
Ong |
Jue-Sheng |
JS |
|
Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute. |
| Gharahkhani P |
|
Gharahkhani |
Puya |
P |
|
Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute. |
| Nyholt DR |
|
Nyholt |
Dale R |
DR |
|
School of Biomedical Sciences, Faculty of Health, and Institute of Health and Biomedical Innovation, Queensland University of Technology. |
| Olsen CM |
|
Olsen |
Catherine M |
CM |
|
Cancer Control Group, QIMR Berghofer Medical Research Institute. |
| Whiteman DC |
|
Whiteman |
David C |
DC |
|
Population Health, QIMR Berghofer Medical Research Institute. |
| MacGregor S |
|
MacGregor |
Stuart |
S |
|
Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: |
| ISSUE: |
| TITLE: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology |
| ISOABBREVIATION: Cancer Epidemiol Biomarkers Prev |
| YEAR: 2021 |
| MONTH: Jun |
| DAY: 04 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1538-7755 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Cancer Epidemiol Biomarkers Prev |
| COUNTRY: United States |
| ISSNLINKING: 1055-9965 |
| NLMUNIQUEID: 9200608 |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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