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| PMID |
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| TITLE |
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| Anxiety disorders and neuroticism: are there genetic factors specific to panic? |
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| ABSTRACT |
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| Data from 2,903 adult same-sex twin pairs were analysed to investigate whether the genetic determinants of symptoms of panic are different from those underlying the neuroticism personality trait. Our results suggest that much of the genetic variation influencing the physical symptoms associated with panic is of the nonadditive type, perhaps due to dominance or epistasis. In both sexes these nonadditive genetic effects on physical symptoms influence the reporting of "feelings of panic". In males they also account for as much as half the genetic variance in neuroticism. The remainder is additive and also accounts for the balance of genetic variation in "feelings of panic". In females genetic variance in neuroticism is entirely additive but is not an important source of covariation with either panic symptom. Thus, symptoms of panic seem to be shaped in part by unique genetic influences which do not affect other anxiety symptoms. That a substantial part of the genetic variance in neuroticism in males may be due to the nonadditive effects on physical symptoms of panic may help to explain the rather low correlation between the genetic influences found to affect neuroticism in males and their counterparts in females. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
1988/06/01 |
| medline |
1988/06/01 00:01 |
| entrez |
1988/06/01 00:00 |
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| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Martin NG |
|
Martin |
N G |
NG |
|
Queensland Institute of Medical Research, Brisbane, Australia. |
| Jardine R |
|
Jardine |
R |
R |
|
|
| Andrews G |
|
Andrews |
G |
G |
|
|
| Heath AC |
|
Heath |
A C |
AC |
|
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 77 |
| ISSUE: 6 |
| TITLE: Acta psychiatrica Scandinavica |
| ISOABBREVIATION: Acta Psychiatr Scand |
| YEAR: 1988 |
| MONTH: Jun |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 0001-690X |
| ISSNTYPE: Print |
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| MEDLINE JOURNAL |
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| MEDLINETA: Acta Psychiatr Scand |
| COUNTRY: DENMARK |
| ISSNLINKING: 0001-690X |
| NLMUNIQUEID: 0370364 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| MESH HEADINGS |
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| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
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| Anxiety Disorders |
psychology |
| Arousal |
psychology |
| Diseases in Twins |
psychology |
| Fear |
psychology |
| Female |
psychology |
| Humans |
psychology |
| Male |
psychology |
| Neurotic Disorders |
psychology |
| Panic |
psychology |
| Personality Inventory |
psychology |
| Risk Factors |
psychology |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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