Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
About GenEpi
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
34002096
TITLE
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology.
ABSTRACT
Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide association study of 41,917 bipolar disorder cases and 371,549 controls of European ancestry, which identified 64 associated genomic loci. Bipolar disorder risk alleles were enriched in genes in synaptic signaling pathways and brain-expressed genes, particularly those with high specificity of expression in neurons of the prefrontal cortex and hippocampus. Significant signal enrichment was found in genes encoding targets of antipsychotics, calcium channel blockers, antiepileptics and anesthetics. Integrating expression quantitative trait locus data implicated 15 genes robustly linked to bipolar disorder via gene expression, encoding druggable targets such as HTR6, MCHR1, DCLK3 and FURIN. Analyses of bipolar disorder subtypes indicated high but imperfect genetic correlation between bipolar disorder type I and II and identified additional associated loci. Together, these results advance our understanding of the biological etiology of bipolar disorder, identify novel therapeutic leads and prioritize genes for functional follow-up studies.
DATE PUBLISHED
2021 Jun
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2020/09/02
accepted 2021/03/25
pmc-release 2021/11/17
pubmed 2021/05/19 06:00
medline 2021/05/19 06:00
entrez 2021/05/18 07:07
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Mullins N Mullins Niamh N Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. niamh.mullins@mssm.edu.
Forstner AJ Forstner Andreas J AJ Centre for Human Genetics, University of Marburg, Marburg, Germany.
O'Connell KS O'Connell Kevin S KS NORMENT, University of Oslo, Oslo, Norway.
Coombes B Coombes Brandon B Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Coleman JRI Coleman Jonathan R I JRI NIHR Maudsley BRC, King's College London, London, UK.
Qiao Z Qiao Zhen Z Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Als TD Als Thomas D TD iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Bigdeli TB Bigdeli Tim B TB VA NY Harbor Healthcare System, Brooklyn, NY, USA.
Børte S Børte Sigrid S K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Bryois J Bryois Julien J Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Charney AW Charney Alexander W AW Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Drange OK Drange Ole Kristian OK Department of Østmarka, Division of Mental Health Care, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Gandal MJ Gandal Michael J MJ Department of Psychiatry and Biobehavioral Science, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Hagenaars SP Hagenaars Saskia P SP NIHR Maudsley BRC, King's College London, London, UK.
Ikeda M Ikeda Masashi M Department of Psychiatry, School of Medicine, Fujita Health University, Toyoake, Japan.
Kamitaki N Kamitaki Nolan N Department of Genetics, Harvard Medical School, Boston, MA, USA.
Kim M Kim Minsoo M Department of Psychiatry and Biobehavioral Science, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Krebs K Krebs Kristi K Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Panagiotaropoulou G Panagiotaropoulou Georgia G Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin, Berlin, Germany.
Schilder BM Schilder Brian M BM Estelle and Daniel Maggin Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sloofman LG Sloofman Laura G LG Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Steinberg S Steinberg Stacy S deCODE Genetics/Amgen, Reykjavik, Iceland.
Trubetskoy V Trubetskoy Vassily V Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin, Berlin, Germany.
Winsvold BS Winsvold Bendik S BS Department of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.
Won HH Won Hong-Hee HH Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Samsung Medical Center, Sungkyunkwan University, Seoul, South Korea.
Abramova L Abramova Liliya L Russian Academy of Medical Sciences, Mental Health Research Center, Moscow, Russian Federation.
Adorjan K Adorjan Kristina K Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.
Agerbo E Agerbo Esben E Centre for Integrated Register-Based Research, Aarhus University, Aarhus, Denmark.
Al Eissa M Al Eissa Mariam M Division of Psychiatry, University College London, London, UK.
Albani D Albani Diego D Department of Neuroscience, Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
Alliey-Rodriguez N Alliey-Rodriguez Ney N Northwestern University, Chicago, IL, USA.
Anjorin A Anjorin Adebayo A Psychiatry, Berkshire Healthcare NHS Foundation Trust, Bracknell, UK.
Antilla V Antilla Verneri V Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Antoniou A Antoniou Anastasia A 2nd Department of Psychiatry, Attikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Awasthi S Awasthi Swapnil S Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin, Berlin, Germany.
Baek JH Baek Ji Hyun JH Department of Psychiatry, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, South Korea.
Bækvad-Hansen M Bækvad-Hansen Marie M Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
Bass N Bass Nicholas N Division of Psychiatry, University College London, London, UK.
Bauer M Bauer Michael M Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Beins EC Beins Eva C EC Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.
Bergen SE Bergen Sarah E SE Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Birner A Birner Armin A Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.
Bøcker Pedersen C Bøcker Pedersen Carsten C Centre for Integrated Register-Based Research, Aarhus University, Aarhus, Denmark.
Bøen E Bøen Erlend E Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.
Boks MP Boks Marco P MP Psychiatry, Brain Center UMC Utrecht, Utrecht, the Netherlands.
Bosch R Bosch Rosa R Psychiatric Genetics Unit, Group of Psychiatry Mental Health and Addictions, Vall d´Hebron Research Institut (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.
Brum M Brum Murielle M Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany.
Brumpton BM Brumpton Ben M BM K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Brunkhorst-Kanaan N Brunkhorst-Kanaan Nathalie N Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany.
Budde M Budde Monika M Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Bybjerg-Grauholm J Bybjerg-Grauholm Jonas J Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
Byerley W Byerley William W Psychiatry, University of California San Francisco, San Francisco, CA, USA.
Cairns M Cairns Murray M University of Newcastle, Newcastle, New South Wales, Australia.
Casas M Casas Miquel M Psychiatric Genetics Unit, Group of Psychiatry Mental Health and Addictions, Vall d´Hebron Research Institut (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.
Cervantes P Cervantes Pablo P Mood Disorders Program, Department of Psychiatry, McGill University Health Center, Montreal, Quebec, Canada.
Clarke TK Clarke Toni-Kim TK Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
Cruceanu C Cruceanu Cristiana C Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.
Cuellar-Barboza A Cuellar-Barboza Alfredo A Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
Cunningham J Cunningham Julie J Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Curtis D Curtis David D UCL Genetics Institute, University College London, London, UK.
Czerski PM Czerski Piotr M PM Department of Psychiatry, Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland.
Dale AM Dale Anders M AM Center for Multimodal Imaging and Genetics, Departments of Neurosciences, Radiology, and Psychiatry, University of California, San Diego, CA, USA.
Dalkner N Dalkner Nina N Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.
David FS David Friederike S FS Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.
Degenhardt F Degenhardt Franziska F Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Duisburg, Germany.
Djurovic S Djurovic Srdjan S NORMENT, Department of Clinical Science, University of Bergen, Bergen, Norway.
Dobbyn AL Dobbyn Amanda L AL Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Douzenis A Douzenis Athanassios A 2nd Department of Psychiatry, Attikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Elvsåshagen T Elvsåshagen Torbjørn T NORMENT, KG Jebsen Centre for Psychosis Research, Oslo University Hospital, Oslo, Norway.
Escott-Price V Escott-Price Valentina V Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Ferrier IN Ferrier I Nicol IN Academic Psychiatry, Newcastle University, Newcastle upon Tyne, UK.
Fiorentino A Fiorentino Alessia A Division of Psychiatry, University College London, London, UK.
Foroud TM Foroud Tatiana M TM Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA.
Forty L Forty Liz L Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Frank J Frank Josef J Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Frei O Frei Oleksandr O Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Freimer NB Freimer Nelson B NB Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA.
Frisén L Frisén Louise L Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Gade K Gade Katrin K Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.
Garnham J Garnham Julie J Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Gelernter J Gelernter Joel J Departments of Genetics and Neuroscience, Yale University School of Medicine, New Haven, CT, USA.
Giørtz Pedersen M Giørtz Pedersen Marianne M Centre for Integrated Register-Based Research, Aarhus University, Aarhus, Denmark.
Gizer IR Gizer Ian R IR Department of Psychological Sciences, University of Missouri, Columbia, MO, USA.
Gordon SD Gordon Scott D SD Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Gordon-Smith K Gordon-Smith Katherine K Psychological Medicine, University of Worcester, Worcester, UK.
Greenwood TA Greenwood Tiffany A TA Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Grove J Grove Jakob J Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark.
Guzman-Parra J Guzman-Parra José J Mental Health Department, University Regional Hospital, Biomedicine Institute (IBIMA), Málaga, Spain.
Ha K Ha Kyooseob K Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea.
Haraldsson M Haraldsson Magnus M Landspitali University Hospital, Reykjavik, Iceland.
Hautzinger M Hautzinger Martin M Department of Psychology, Eberhard Karls Universität Tübingen, Tübingen, Germany.
Heilbronner U Heilbronner Urs U Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Hellgren D Hellgren Dennis D Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Herms S Herms Stefan S Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.
Hoffmann P Hoffmann Per P Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.
Holmans PA Holmans Peter A PA Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Huckins L Huckins Laura L Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jamain S Jamain Stéphane S Faculté de Santé, Université Paris Est, Créteil, France.
Johnson JS Johnson Jessica S JS Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kalman JL Kalman Janos L JL International Max Planck Research School for Translational Psychiatry (IMPRS-TP), Munich, Germany.
Kamatani Y Kamatani Yoichiro Y Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Kennedy JL Kennedy James L JL Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada.
Kittel-Schneider S Kittel-Schneider Sarah S Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany.
Knowles JA Knowles James A JA Institute for Genomic Health, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, USA.
Kogevinas M Kogevinas Manolis M ISGlobal, Barcelona, Spain.
Koromina M Koromina Maria M Laboratory of Pharmacogenomics and Individualized Therapy, Department of Pharmacy, School of Health Sciences, University of Patras, Patras, Greece.
Kranz TM Kranz Thorsten M TM Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany.
Kranzler HR Kranzler Henry R HR Center for Studies of Addiction, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Kubo M Kubo Michiaki M RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Kupka R Kupka Ralph R Psychiatry, VU Medisch Centrum, Amsterdam, the Netherlands.
Kushner SA Kushner Steven A SA Department of Psychiatry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Lavebratt C Lavebratt Catharina C Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Lawrence J Lawrence Jacob J Psychiatry, North East London NHS Foundation Trust, Ilford, UK.
Leber M Leber Markus M Clinic for Psychiatry and Psychotherapy, University Hospital Cologne, Cologne, Germany.
Lee HJ Lee Heon-Jeong HJ Department of Psychiatry, Korea University College of Medicine, Seoul, South Korea.
Lee PH Lee Phil H PH Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Levy SE Levy Shawn E SE HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
Lewis C Lewis Catrin C Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Liao C Liao Calwing C Montreal Neurological Institute and Hospital, McGill University, Montréal, Quebec, Canada.
Lucae S Lucae Susanne S Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.
Lundberg M Lundberg Martin M Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
MacIntyre DJ MacIntyre Donald J DJ Division of Psychiatry, Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK.
Magnusson SH Magnusson Sigurdur H SH deCODE Genetics/Amgen, Reykjavik, Iceland.
Maier W Maier Wolfgang W Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
Maihofer A Maihofer Adam A Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Malaspina D Malaspina Dolores D Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Maratou E Maratou Eirini E Clinical Biochemistry Laboratory, Attikon General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Martinsson L Martinsson Lina L Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Mattheisen M Mattheisen Manuel M Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden.
McCarroll SA McCarroll Steven A SA Department of Genetics, Harvard Medical School, Boston, MA, USA.
McGregor NW McGregor Nathaniel W NW Systems Genetics Working Group, Department of Genetics, Stellenbosch University, Stellenbosch, South Africa.
McGuffin P McGuffin Peter P Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
McKay JD McKay James D JD Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon, France.
Medeiros H Medeiros Helena H Institute for Genomic Health, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, USA.
Medland SE Medland Sarah E SE Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Millischer V Millischer Vincent V Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Montgomery GW Montgomery Grant W GW Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Moran JL Moran Jennifer L JL Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Morris DW Morris Derek W DW Centre for Neuroimaging and Cognitive Genomics (NICOG), National University of Ireland Galway, Galway, Ireland.
Mühleisen TW Mühleisen Thomas W TW Department of Biomedicine, University of Basel, Basel, Switzerland.
O'Brien N O'Brien Niamh N Division of Psychiatry, University College London, London, UK.
O'Donovan C O'Donovan Claire C Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Olde Loohuis LM Olde Loohuis Loes M LM Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA.
Oruc L Oruc Lilijana L Medical Faculty, School of Science and Technology, University Sarajevo, Sarajevo, Bosnia and Herzegovina.
Papiol S Papiol Sergi S Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.
Pardiñas AF Pardiñas Antonio F AF Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Perry A Perry Amy A Psychological Medicine, University of Worcester, Worcester, UK.
Pfennig A Pfennig Andrea A Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Porichi E Porichi Evgenia E 2nd Department of Psychiatry, Attikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Potash JB Potash James B JB Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Quested D Quested Digby D Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.
Raj T Raj Towfique T Estelle and Daniel Maggin Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Rapaport MH Rapaport Mark H MH Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
DePaulo JR DePaulo J Raymond JR Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Regeer EJ Regeer Eline J EJ Outpatient Clinic for Bipolar Disorder, Altrecht, Utrecht, the Netherlands.
Rice JP Rice John P JP Department of Psychiatry, Washington University in Saint Louis, Saint Louis, MO, USA.
Rivas F Rivas Fabio F Mental Health Department, University Regional Hospital, Biomedicine Institute (IBIMA), Málaga, Spain.
Rivera M Rivera Margarita M Institute of Neurosciences, Biomedical Research Center (CIBM), University of Granada, Granada, Spain.
Roth J Roth Julian J Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany.
Roussos P Roussos Panos P Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ruderfer DM Ruderfer Douglas M DM Medicine, Psychiatry, Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Sánchez-Mora C Sánchez-Mora Cristina C Department of Genetics, Microbiology and Statistics, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain.
Schulte EC Schulte Eva C EC Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.
Senner F Senner Fanny F Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.
Sharp S Sharp Sally S Division of Psychiatry, University College London, London, UK.
Shilling PD Shilling Paul D PD Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Sigurdsson E Sigurdsson Engilbert E Faculty of Medicine, Department of Psychiatry, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Sirignano L Sirignano Lea L Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Slaney C Slaney Claire C Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Smeland OB Smeland Olav B OB NORMENT, University of Oslo, Oslo, Norway.
Smith DJ Smith Daniel J DJ Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Sobell JL Sobell Janet L JL Psychiatry and the Behavioral Sciences, University of Southern California, Los Angeles, CA, USA.
Søholm Hansen C Søholm Hansen Christine C Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
Soler Artigas M Soler Artigas Maria M Department of Genetics, Microbiology and Statistics, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain.
Spijker AT Spijker Anne T AT Mood Disorders, PsyQ, Rotterdam, the Netherlands.
Stein DJ Stein Dan J DJ SAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Strauss JS Strauss John S JS Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Świątkowska B Świątkowska Beata B Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland.
Terao C Terao Chikashi C Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Thorgeirsson TE Thorgeirsson Thorgeir E TE deCODE Genetics/Amgen, Reykjavik, Iceland.
Toma C Toma Claudio C Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid and CSIC, Madrid, Spain.
Tooney P Tooney Paul P University of Newcastle, Newcastle, New South Wales, Australia.
Tsermpini EE Tsermpini Evangelia-Eirini EE Laboratory of Pharmacogenomics and Individualized Therapy, Department of Pharmacy, School of Health Sciences, University of Patras, Patras, Greece.
Vawter MP Vawter Marquis P MP Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, Irvine, CA, USA.
Vedder H Vedder Helmut H Psychiatry, Psychiatrisches Zentrum Nordbaden, Wiesloch, Germany.
Walters JTR Walters James T R JTR Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Witt SH Witt Stephanie H SH Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Xi S Xi Simon S Computational Sciences Center of Emphasis, Pfizer Global Research and Development, Cambridge, MA, USA.
Xu W Xu Wei W Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Yang JMK Yang Jessica Mei Kay JMK Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Young AH Young Allan H AH South London and Maudsley NHS Foundation Trust, Bethlem Royal Hospital, Beckenham, UK.
Young H Young Hannah H Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Zandi PP Zandi Peter P PP Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Zhou H Zhou Hang H Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA.
Zillich L Zillich Lea L Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
HUNT All-In Psychiatry
Adolfsson R Adolfsson Rolf R Department of Clinical Sciences, Psychiatry, Umeå University Medical Faculty, Umeå, Sweden.
Agartz I Agartz Ingrid I NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Institute of Clinical Medicine and Diakonhjemmet Hospital, University of Oslo, Oslo, Norway.
Alda M Alda Martin M National Institute of Mental Health, Klecany, Czech Republic.
Alfredsson L Alfredsson Lars L Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Babadjanova G Babadjanova Gulja G Institute of Pulmonology, Russian State Medical University, Moscow, Russian Federation.
Backlund L Backlund Lena L Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Baune BT Baune Bernhard T BT The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia.
Bellivier F Bellivier Frank F APHP Nord, DMU Neurosciences, Département de Psychiatrie et de Médecine Addictologique, GHU Saint Louis-Lariboisière-Fernand Widal, Paris, France.
Bengesser S Bengesser Susanne S Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.
Berrettini WH Berrettini Wade H WH Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
Blackwood DHR Blackwood Douglas H R DHR Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
Boehnke M Boehnke Michael M Center for Statistical Genetics and Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Børglum AD Børglum Anders D AD Center for Genomics and Personalized Medicine, CGPM, Aarhus, Denmark.
Breen G Breen Gerome G NIHR Maudsley BRC, King's College London, London, UK.
Carr VJ Carr Vaughan J VJ School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
Catts S Catts Stanley S University of Queensland, Brisbane, Queensland, Australia.
Corvin A Corvin Aiden A Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
Craddock N Craddock Nicholas N Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Dannlowski U Dannlowski Udo U Department of Psychiatry, University of Münster, Münster, Germany.
Dikeos D Dikeos Dimitris D 1st Department of Psychiatry, Eginition Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Esko T Esko Tõnu T Division of Endocrinology, Children's Hospital Boston, Boston, MA, USA.
Etain B Etain Bruno B APHP Nord, DMU Neurosciences, Département de Psychiatrie et de Médecine Addictologique, GHU Saint Louis-Lariboisière-Fernand Widal, Paris, France.
Ferentinos P Ferentinos Panagiotis P 2nd Department of Psychiatry, Attikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Frye M Frye Mark M Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
Fullerton JM Fullerton Janice M JM School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia.
Gawlik M Gawlik Micha M Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany.
Gershon ES Gershon Elliot S ES Department of Human Genetics, University of Chicago, Chicago, IL, USA.
Goes FS Goes Fernando S FS Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Green MJ Green Melissa J MJ School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
Grigoroiu-Serbanescu M Grigoroiu-Serbanescu Maria M Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania.
Hauser J Hauser Joanna J Department of Psychiatry, Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland.
Henskens F Henskens Frans F University of Newcastle, Newcastle, New South Wales, Australia.
Hillert J Hillert Jan J Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Hong KS Hong Kyung Sue KS Department of Psychiatry, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, South Korea.
Hougaard DM Hougaard David M DM Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
Hultman CM Hultman Christina M CM Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Hveem K Hveem Kristian K HUNT Research Center, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Iwata N Iwata Nakao N Department of Psychiatry, School of Medicine, Fujita Health University, Toyoake, Japan.
Jablensky AV Jablensky Assen V AV University of Western Australia, Nedlands, Western Australia, Australia.
Jones I Jones Ian I Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Jones LA Jones Lisa A LA Psychological Medicine, University of Worcester, Worcester, UK.
Kahn RS Kahn René S RS Psychiatry, Brain Center UMC Utrecht, Utrecht, the Netherlands.
Kelsoe JR Kelsoe John R JR Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Kirov G Kirov George G Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Landén M Landén Mikael M Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.
Leboyer M Leboyer Marion M Department of Psychiatry and Addiction Medicine, Assistance Publique - Hôpitaux de Paris, Paris, France.
Lewis CM Lewis Cathryn M CM Department of Medical and Molecular Genetics, King's College London, London, UK.
Li QS Li Qingqin S QS Neuroscience Therapeutic Area, Janssen Research and Development, LLC, Titusville, NJ, USA.
Lissowska J Lissowska Jolanta J Cancer Epidemiology and Prevention, M. Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.
Lochner C Lochner Christine C SA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa.
Loughland C Loughland Carmel C University of Newcastle, Newcastle, New South Wales, Australia.
Martin NG Martin Nicholas G NG School of Psychology, The University of Queensland, Brisbane, Queensland, Australia.
Mathews CA Mathews Carol A CA Department of Psychiatry and Genetics Institute, University of Florida, Gainesville, FL, USA.
Mayoral F Mayoral Fermin F Mental Health Department, University Regional Hospital, Biomedicine Institute (IBIMA), Málaga, Spain.
McElroy SL McElroy Susan L SL Research Institute, Lindner Center of HOPE, Mason, OH, USA.
McIntosh AM McIntosh Andrew M AM Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
McMahon FJ McMahon Francis J FJ Human Genetics Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA.
Melle I Melle Ingrid I Division of Mental Health and Addiction, University of Oslo, Institute of Clinical Medicine, Oslo, Norway.
Michie P Michie Patricia P University of Newcastle, Newcastle, New South Wales, Australia.
Milani L Milani Lili L Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Mitchell PB Mitchell Philip B PB School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
Morken G Morken Gunnar G Psychiatry, St Olavs University Hospital, Trondheim, Norway.
Mors O Mors Ole O Psychosis Research Unit, Aarhus University Hospital - Psychiatry, Risskov, Denmark.
Mortensen PB Mortensen Preben Bo PB Centre for Integrated Register-Based Research, Aarhus University, Aarhus, Denmark.
Mowry B Mowry Bryan B University of Queensland, Brisbane, Queensland, Australia.
Müller-Myhsok B Müller-Myhsok Bertram B University of Liverpool, Liverpool, UK.
Myers RM Myers Richard M RM HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
Neale BM Neale Benjamin M BM Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
Nievergelt CM Nievergelt Caroline M CM Research/Psychiatry, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.
Nordentoft M Nordentoft Merete M Mental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, University of Copenhagen, Copenhagen, Denmark.
Nöthen MM Nöthen Markus M MM Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.
O'Donovan MC O'Donovan Michael C MC Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Oedegaard KJ Oedegaard Ketil J KJ Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway.
Olsson T Olsson Tomas T Department of Clinical Neuroscience and Center for Molecular Medicine, Karolinska Institutet at Karolinska University Hospital, Solna, Sweden.
Owen MJ Owen Michael J MJ Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Paciga SA Paciga Sara A SA Human Genetics and Computational Biomedicine, Pfizer Global Research and Development, Groton, CT, USA.
Pantelis C Pantelis Chris C University of Melbourne, Melbourne, Victoria, Australia.
Pato C Pato Carlos C Institute for Genomic Health, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, USA.
Pato MT Pato Michele T MT Institute for Genomic Health, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, USA.
Patrinos GP Patrinos George P GP Zayed Center of Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates.
Perlis RH Perlis Roy H RH Division of Clinical Research, Massachusetts General Hospital, Boston, MA, USA.
Posthuma D Posthuma Danielle D Department of Clinical Genetics, Amsterdam Neuroscience, Vrije Universiteit Medical Center, Amsterdam, the Netherlands.
Ramos-Quiroga JA Ramos-Quiroga Josep Antoni JA Psychiatric Genetics Unit, Group of Psychiatry Mental Health and Addictions, Vall d´Hebron Research Institut (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.
Reif A Reif Andreas A Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany.
Reininghaus EZ Reininghaus Eva Z EZ Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, Graz, Austria.
Ribasés M Ribasés Marta M Department of Genetics, Microbiology and Statistics, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain.
Rietschel M Rietschel Marcella M Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Ripke S Ripke Stephan S Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Rouleau GA Rouleau Guy A GA Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.
Saito T Saito Takeo T Department of Psychiatry, School of Medicine, Fujita Health University, Toyoake, Japan.
Schall U Schall Ulrich U University of Newcastle, Newcastle, New South Wales, Australia.
Schalling M Schalling Martin M Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Schofield PR Schofield Peter R PR School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia.
Schulze TG Schulze Thomas G TG Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA.
Scott LJ Scott Laura J LJ Center for Statistical Genetics and Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Scott RJ Scott Rodney J RJ University of Newcastle, Newcastle, New South Wales, Australia.
Serretti A Serretti Alessandro A Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy.
Shannon Weickert C Shannon Weickert Cynthia C Department of Neuroscience, SUNY Upstate Medical University, Syracuse, NY, USA.
Smoller JW Smoller Jordan W JW Psychiatric and Neurodevelopmental Genetics Unit (PNGU), Massachusetts General Hospital, Boston, MA, USA.
Stefansson H Stefansson Hreinn H deCODE Genetics/Amgen, Reykjavik, Iceland.
Stefansson K Stefansson Kari K Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Stordal E Stordal Eystein E Department of Neuroscience, Norges Teknisk Naturvitenskapelige Universitet Fakultet for Naturvitenskap og Teknologi, Trondheim, Norway.
Streit F Streit Fabian F Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Sullivan PF Sullivan Patrick F PF Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Turecki G Turecki Gustavo G Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
Vaaler AE Vaaler Arne E AE Department of Psychiatry, Sankt Olavs Hospital Universitetssykehuset i Trondheim, Trondheim, Norway.
Vieta E Vieta Eduard E Clinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
Vincent JB Vincent John B JB Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Waldman ID Waldman Irwin D ID Department of Psychology, Emory University, Atlanta, GA, USA.
Weickert TW Weickert Thomas W TW Department of Neuroscience, SUNY Upstate Medical University, Syracuse, NY, USA.
Werge T Werge Thomas T Center for GeoGenetics, GLOBE Institute, University of Copenhagen, Copenhagen, Denmark.
Wray NR Wray Naomi R NR Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
Zwart JA Zwart John-Anker JA Department of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.
Biernacka JM Biernacka Joanna M JM Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
Nurnberger JI Nurnberger John I JI Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA.
Cichon S Cichon Sven S Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.
Edenberg HJ Edenberg Howard J HJ Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Stahl EA Stahl Eli A EA Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
McQuillin A McQuillin Andrew A Division of Psychiatry, University College London, London, UK.
Di Florio A Di Florio Arianna A Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Ophoff RA Ophoff Roel A RA Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Andreassen OA Andreassen Ole A OA NORMENT, University of Oslo, Oslo, Norway. ole.andreassen@medisin.uio.no.
INVESTIGATORS
JOURNAL
VOLUME: 53
ISSUE: 6
TITLE: Nature genetics
ISOABBREVIATION: Nat Genet
YEAR: 2021
MONTH: Jun
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1546-1718
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Genet
COUNTRY: United States
ISSNLINKING: 1061-4036
NLMUNIQUEID: 9216904
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
U01 MH085520 NIMH NIH HHS United States
U01 MH094421 NIMH NIH HHS United States
U01 MH109528 NIMH NIH HHS United States
S10 OD018522 NIH HHS United States
S10 OD026880 NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
Designed by: GenEpi IT
Maintained by: GenEpi IT
Feedback: webmaster
Copyright © 2007 QIMR
For more information Contact Us
epiit@qimr.edu.au
Last Modified: Oct 15 2007