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| PMID |
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| TITLE |
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| Days out of role and somatic, anxious-depressive, hypo-manic, and psychotic-like symptom dimensions in a community sample of young adults. |
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| ABSTRACT |
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| Improving our understanding of the causes of functional impairment in young people is a major global challenge. Here, we investigated the relationships between self-reported days out of role and the total quantity and different patterns of self-reported somatic, anxious-depressive, psychotic-like, and hypomanic symptoms in a community-based cohort of young adults. We examined self-ratings of 23 symptoms ranging across the four dimensions and days out of role in >1900 young adult twins and non-twin siblings participating in the "19Up" wave of the Brisbane Longitudinal Twin Study. Adjusted prevalence ratios (APR) and 95% confidence intervals (95% CI) quantified associations between impairment and different symptom patterns. Three individual symptoms showed significant associations with days out of role, with the largest association for impaired concentration. When impairment was assessed according to each symptom dimension, there was a clear stepwise relationship between the total number of somatic symptoms and the likelihood of impairment, while individuals reporting ≥4 anxious-depressive symptoms or five hypomanic symptoms had greater likelihood of reporting days out of role. Furthermore, there was a stepwise relationship between the total number of undifferentiated symptoms and the likelihood of reporting days out of role. There was some suggestion of differences in the magnitude and significance of associations when the cohort was stratified according to sex, but not for age or twin status. Our findings reinforce the development of early intervention mental health frameworks and, if confirmed, support the need to consider interventions for subthreshold and/or undifferentiated syndromes for reducing disability among young people. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2020/11/10 |
| accepted |
2021/04/14 |
| revised |
2021/03/25 |
| entrez |
2021/05/14 06:11 |
| pubmed |
2021/05/15 06:00 |
| medline |
2021/06/29 06:00 |
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| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Crouse JJ |
|
Crouse |
Jacob J |
JJ |
|
Youth Mental Health & Technology Team, Brain and Mind Centre, University of Sydney, Sydney, Australia. jacob.crouse@sydney.edu.au. |
| Ho N |
|
Ho |
Nicholas |
N |
|
Youth Mental Health & Technology Team, Brain and Mind Centre, University of Sydney, Sydney, Australia. |
| Scott J |
|
Scott |
Jan |
J |
|
Norwegian University of Science and Technology, Trondheim, Norway. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
QIMR Berghofer Institute of Medical Research, Brisbane, Australia. |
| Couvy-Duchesne B |
|
Couvy-Duchesne |
Baptiste |
B |
|
ARAMIS Laboratory, Paris Brain Institute, Paris, France. |
| Hermens DF |
|
Hermens |
Daniel F |
DF |
|
Thompson Institute, University of the Sunshine Coast, Birtinya, Australia. |
| Parker R |
|
Parker |
Richard |
R |
|
QIMR Berghofer Institute of Medical Research, Brisbane, Australia. |
| Gillespie NA |
|
Gillespie |
Nathan A |
NA |
|
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Virginia, USA. |
| Medland SE |
|
Medland |
Sarah E |
SE |
|
QIMR Berghofer Institute of Medical Research, Brisbane, Australia. |
| Hickie IB |
|
Hickie |
Ian B |
IB |
|
Youth Mental Health & Technology Team, Brain and Mind Centre, University of Sydney, Sydney, Australia. |
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| INVESTIGATORS |
|
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| JOURNAL |
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| VOLUME: 11 |
| ISSUE: 1 |
| TITLE: Translational psychiatry |
| ISOABBREVIATION: Transl Psychiatry |
| YEAR: 2021 |
| MONTH: 05 |
| DAY: 13 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 2158-3188 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Transl Psychiatry |
| COUNTRY: United States |
| ISSNLINKING: 2158-3188 |
| NLMUNIQUEID: 101562664 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GRANTID |
AGENCY |
COUNTRY |
| R00 DA023549 |
NIDA NIH HHS |
United States |
| APP10499110 |
Department of Health | National Health and Medical Research Council (NHMRC) |
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| GENERAL NOTE |
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| KEYWORDS |
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| MESH HEADINGS |
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| DESCRIPTORNAME |
QUALIFIERNAME |
| Adolescent |
|
| Anxiety |
epidemiology |
| Humans |
epidemiology |
| Longitudinal Studies |
epidemiology |
| Mental Disorders |
epidemiology |
| Mental Health |
epidemiology |
| Prevalence |
epidemiology |
| Young Adult |
epidemiology |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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