Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
33986245
TITLE
Days out of role and somatic, anxious-depressive, hypo-manic, and psychotic-like symptom dimensions in a community sample of young adults.
ABSTRACT
Improving our understanding of the causes of functional impairment in young people is a major global challenge. Here, we investigated the relationships between self-reported days out of role and the total quantity and different patterns of self-reported somatic, anxious-depressive, psychotic-like, and hypomanic symptoms in a community-based cohort of young adults. We examined self-ratings of 23 symptoms ranging across the four dimensions and days out of role in >1900 young adult twins and non-twin siblings participating in the "19Up" wave of the Brisbane Longitudinal Twin Study. Adjusted prevalence ratios (APR) and 95% confidence intervals (95% CI) quantified associations between impairment and different symptom patterns. Three individual symptoms showed significant associations with days out of role, with the largest association for impaired concentration. When impairment was assessed according to each symptom dimension, there was a clear stepwise relationship between the total number of somatic symptoms and the likelihood of impairment, while individuals reporting ≥4 anxious-depressive symptoms or five hypomanic symptoms had greater likelihood of reporting days out of role. Furthermore, there was a stepwise relationship between the total number of undifferentiated symptoms and the likelihood of reporting days out of role. There was some suggestion of differences in the magnitude and significance of associations when the cohort was stratified according to sex, but not for age or twin status. Our findings reinforce the development of early intervention mental health frameworks and, if confirmed, support the need to consider interventions for subthreshold and/or undifferentiated syndromes for reducing disability among young people.
DATE PUBLISHED
2021 May 13
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2020/11/10
accepted 2021/04/14
revised 2021/03/25
entrez 2021/05/14 06:11
pubmed 2021/05/15 06:00
medline 2021/05/15 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Crouse JJ Crouse Jacob J JJ Youth Mental Health & Technology Team, Brain and Mind Centre, University of Sydney, Sydney, Australia. jacob.crouse@sydney.edu.au.
Ho N Ho Nicholas N Youth Mental Health & Technology Team, Brain and Mind Centre, University of Sydney, Sydney, Australia.
Scott J Scott Jan J Norwegian University of Science and Technology, Trondheim, Norway.
Martin NG Martin Nicholas G NG QIMR Berghofer Institute of Medical Research, Brisbane, Australia.
Couvy-Duchesne B Couvy-Duchesne Baptiste B ARAMIS Laboratory, Paris Brain Institute, Paris, France.
Hermens DF Hermens Daniel F DF Thompson Institute, University of the Sunshine Coast, Birtinya, Australia.
Parker R Parker Richard R QIMR Berghofer Institute of Medical Research, Brisbane, Australia.
Gillespie NA Gillespie Nathan A NA Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Virginia, USA.
Medland SE Medland Sarah E SE QIMR Berghofer Institute of Medical Research, Brisbane, Australia.
Hickie IB Hickie Ian B IB Youth Mental Health & Technology Team, Brain and Mind Centre, University of Sydney, Sydney, Australia.
INVESTIGATORS
JOURNAL
VOLUME: 11
ISSUE: 1
TITLE: Translational psychiatry
ISOABBREVIATION: Transl Psychiatry
YEAR: 2021
MONTH: May
DAY: 13
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2158-3188
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Transl Psychiatry
COUNTRY: United States
ISSNLINKING: 2158-3188
NLMUNIQUEID: 101562664
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
APP10499110 Department of Health | National Health and Medical Research Council (NHMRC)
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