Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
33955455
TITLE
Genetic Meta-Analysis of Twin Birth Weight Shows High Genetic Correlation with Singleton Birth Weight.
ABSTRACT
Birth weight (BW) is an important predictor of newborn survival and health and has associations with many adult health outcomes, including cardio-metabolic disorders, autoimmune diseases, and mental health. On average, twins have a lower BW than singletons as a result of a different pattern of fetal growth and shorter gestational duration. Therefore, investigations into the genetics of BW often exclude data from twins, leading to a reduction in sample size and remaining ambiguities concerning the genetic contribution to BW in twins. In this study, we carried out a genome-wide association meta-analysis of BW in 42 212 twin individuals and found a positive correlation of beta values (Pearson's r = 0.66, 95% confidence interval [CI]: 0.47-0.77) with 150 previously reported genome-wide significant variants for singleton BW. We identified strong positive genetic correlations between BW in twins and numerous anthropometric traits, most notably with BW in singletons (genetic correlation [rg] = 0.92, 95% CI: 0.66-1.18). Genetic correlations of BW in twins with a series of health-related traits closely resembled those previously observed for BW in singletons. Polygenic scores constructed from a genome-wide association study on BW in UK Biobank demonstrated strong predictive power in a target sample of Dutch twins and singletons. Together, our results indicate that a similar genetic architecture underlies BW in twins and singletons and that future genome-wide studies might benefit from including data from large twin registers.
© The Author(s) 2021. Published by Oxford University Press.
DATE PUBLISHED
2021 May 06
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2021/01/27
revised 2021/03/19
accepted 2021/04/20
entrez 2021/05/06 09:02
pubmed 2021/05/07 06:00
medline 2021/05/07 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Beck JJ Beck Jeffrey J JJ Avera Institute for Human Genetics, Avera McKennan Hospital and University Health Center, Sioux Falls, South Dakota, United States of America.
Pool R Pool René R Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, The Netherlands.
van de Weijer M van de Weijer Margot M Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, The Netherlands.
Chen X Chen Xu X Department of Medical Epidemiology and Biostatististics, Karolinska Institutet, Stockholm, Sweden.
Krapohl E Krapohl Eva E MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Gordon SD Gordon Scott D SD Genetic Epidemiology Laboratory, QIMR Berghofer, Brisbane, Queensland, Australia.
Nygaard M Nygaard Marianne M The Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense, Denmark.
Debrabant B Debrabant Birgit B The Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense, Denmark.
Palviainen T Palviainen Teemu T University of Helsinki, Institute for Molecular Medicine Finland (FIMM), Helsinki, Finland.
van der Zee MD van der Zee Matthijs D MD Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, The Netherlands.
Baselmans B Baselmans Bart B Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Finnicum CT Finnicum Casey T CT Avera Institute for Human Genetics, Avera McKennan Hospital and University Health Center, Sioux Falls, South Dakota, United States of America.
Yi L Yi Lu L Department of Medical Epidemiology and Biostatististics, Karolinska Institutet, Stockholm, Sweden.
Lundström S Lundström Sebastian S Gillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.
van Beijsterveldt T van Beijsterveldt Toos T Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, The Netherlands.
Christiansen L Christiansen Lene L Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Heikkilä K Heikkilä Kauko K University of Helsinki, Institute for Molecular Medicine Finland (FIMM), Helsinki, Finland.
Kittelsrud J Kittelsrud Julie J Avera Institute for Human Genetics, Avera McKennan Hospital and University Health Center, Sioux Falls, South Dakota, United States of America.
Loukola A Loukola Anu A University of Helsinki, Institute for Molecular Medicine Finland (FIMM), Helsinki, Finland.
Ollikainen M Ollikainen Miina M University of Helsinki, Institute for Molecular Medicine Finland (FIMM), Helsinki, Finland.
Christensen K Christensen Kaare K The Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense, Denmark.
Martin NG Martin Nicholas G NG Genetic Epidemiology Laboratory, QIMR Berghofer, Brisbane, Queensland, Australia.
Plomin R Plomin Robert R MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Nivard M Nivard Michel M Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, The Netherlands.
Bartels M Bartels Meike M Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, The Netherlands.
Dolan C Dolan Conor C Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, The Netherlands.
Willemsen G Willemsen Gonneke G Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, The Netherlands.
de Geus E de Geus Eco E Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, The Netherlands.
Almqvist C Almqvist Catarina C Department of Medical Epidemiology and Biostatististics, Karolinska Institutet, Stockholm, Sweden.
Magnusson PKE Magnusson Patrik K E PKE Department of Medical Epidemiology and Biostatististics, Karolinska Institutet, Stockholm, Sweden.
Mbarek H Mbarek Hamdi H Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, The Netherlands.
Ehli EA Ehli Erik A EA Avera Institute for Human Genetics, Avera McKennan Hospital and University Health Center, Sioux Falls, South Dakota, United States of America.
Boomsma DI Boomsma Dorret I DI Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, The Netherlands.
Hottenga JJ Hottenga Jouke-Jan JJ Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, The Netherlands.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Human molecular genetics
ISOABBREVIATION: Hum Mol Genet
YEAR: 2021
MONTH: May
DAY: 06
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1460-2083
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Hum Mol Genet
COUNTRY: England
ISSNLINKING: 0964-6906
NLMUNIQUEID: 9208958
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
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