|
|
| PMID |
|
|
| TITLE |
|
| The Eating Disorders Genetics Initiative (EDGI): study protocol. |
|
| ABSTRACT |
|
| BACKGROUND |
|
| The Eating Disorders Genetics Initiative (EDGI) is an international investigation exploring the role of genes and environment in anorexia nervosa, bulimia nervosa, and binge-eating disorder. |
| METHODS |
|
| The Eating Disorders Genetics Initiative (EDGI) is an international investigation exploring the role of genes and environment in anorexia nervosa, bulimia nervosa, and binge-eating disorder. A total of 14,500 individuals with eating disorders and 1500 controls will be included from the United States (US), Australia (AU), New Zealand (NZ), and Denmark (DK). In the US, AU, and NZ, participants will complete comprehensive online phenotyping and will submit a saliva sample for genotyping. In DK, individuals with eating disorders will be identified by the National Patient Register, and genotyping will occur using bloodspots archived from birth. A genome-wide association study will be conducted within EDGI and via meta-analysis with other data from the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED). |
| DISCUSSION |
|
| The Eating Disorders Genetics Initiative (EDGI) is an international investigation exploring the role of genes and environment in anorexia nervosa, bulimia nervosa, and binge-eating disorder. A total of 14,500 individuals with eating disorders and 1500 controls will be included from the United States (US), Australia (AU), New Zealand (NZ), and Denmark (DK). In the US, AU, and NZ, participants will complete comprehensive online phenotyping and will submit a saliva sample for genotyping. In DK, individuals with eating disorders will be identified by the National Patient Register, and genotyping will occur using bloodspots archived from birth. A genome-wide association study will be conducted within EDGI and via meta-analysis with other data from the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED). EDGI represents the largest genetic study of eating disorders ever to be conducted and is designed to rapidly advance the study of the genetics of the three major eating disorders (anorexia nervosa, bulimia nervosa, and binge-eating disorder). We will explicate the genetic architecture of eating disorders relative to each other and to other psychiatric and metabolic disorders and traits. Our goal is for EDGI to deliver "actionable" findings that can be transformed into clinically meaningful insights. |
| TRIAL REGISTRATION |
|
| The Eating Disorders Genetics Initiative (EDGI) is an international investigation exploring the role of genes and environment in anorexia nervosa, bulimia nervosa, and binge-eating disorder. A total of 14,500 individuals with eating disorders and 1500 controls will be included from the United States (US), Australia (AU), New Zealand (NZ), and Denmark (DK). In the US, AU, and NZ, participants will complete comprehensive online phenotyping and will submit a saliva sample for genotyping. In DK, individuals with eating disorders will be identified by the National Patient Register, and genotyping will occur using bloodspots archived from birth. A genome-wide association study will be conducted within EDGI and via meta-analysis with other data from the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED). EDGI represents the largest genetic study of eating disorders ever to be conducted and is designed to rapidly advance the study of the genetics of the three major eating disorders (anorexia nervosa, bulimia nervosa, and binge-eating disorder). We will explicate the genetic architecture of eating disorders relative to each other and to other psychiatric and metabolic disorders and traits. Our goal is for EDGI to deliver "actionable" findings that can be transformed into clinically meaningful insights. EDGI is a registered clinical trial: clinicaltrials.gov NCT04378101 . |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| received |
2021/03/17 |
| accepted |
2021/04/13 |
| entrez |
2021/05/05 05:38 |
| pubmed |
2021/05/06 06:00 |
| medline |
2021/05/07 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Bulik CM |
|
Bulik |
Cynthia M |
CM |
|
Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. cynthia_bulik@med.unc.edu. |
| Thornton LM |
|
Thornton |
Laura M |
LM |
|
Department of Psychiatry, University of North Carolina at Chapel Hill, CB #7160, 101 Manning Drive, Chapel Hill, NC, 27599-7160, USA. |
| Parker R |
|
Parker |
Richard |
R |
|
QIMR Berghofer Medical Research Institute, Locked Bag 2000, Royal Brisbane Hospital, Herston, QLD, 4029, Australia. |
| Kennedy H |
|
Kennedy |
Hannah |
H |
|
Department of Psychological Medicine, University of Otago, Christchurch, New Zealand. |
| Baker JH |
|
Baker |
Jessica H |
JH |
|
Department of Psychiatry, University of North Carolina at Chapel Hill, CB #7160, 101 Manning Drive, Chapel Hill, NC, 27599-7160, USA. |
| MacDermod C |
|
MacDermod |
Casey |
C |
|
Department of Psychiatry, University of North Carolina at Chapel Hill, CB #7160, 101 Manning Drive, Chapel Hill, NC, 27599-7160, USA. |
| Guintivano J |
|
Guintivano |
Jerry |
J |
|
Department of Psychiatry, University of North Carolina at Chapel Hill, CB #7160, 101 Manning Drive, Chapel Hill, NC, 27599-7160, USA. |
| Cleland L |
|
Cleland |
Lana |
L |
|
Department of Psychological Medicine, University of Otago, Christchurch, New Zealand. |
| Miller AL |
|
Miller |
Allison L |
AL |
|
Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand. |
| Harper L |
|
Harper |
Lauren |
L |
|
Department of Psychiatry, University of North Carolina at Chapel Hill, CB #7160, 101 Manning Drive, Chapel Hill, NC, 27599-7160, USA. |
| Larsen JT |
|
Larsen |
Janne T |
JT |
|
The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark. |
| Yilmaz Z |
|
Yilmaz |
Zeynep |
Z |
|
The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark. |
| Grove J |
|
Grove |
Jakob |
J |
|
Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark. |
| Sullivan PF |
|
Sullivan |
Patrick F |
PF |
|
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. |
| Petersen LV |
|
Petersen |
Liselotte V |
LV |
|
The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark. |
| Jordan J |
|
Jordan |
Jennifer |
J |
|
Department of Psychological Medicine, University of Otago, Christchurch, New Zealand. |
| Kennedy MA |
|
Kennedy |
Martin A |
MA |
|
Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
QIMR Berghofer Medical Research Institute, Locked Bag 2000, Royal Brisbane Hospital, Herston, QLD, 4029, Australia. |
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 21 |
| ISSUE: 1 |
| TITLE: BMC psychiatry |
| ISOABBREVIATION: BMC Psychiatry |
| YEAR: 2021 |
| MONTH: 05 |
| DAY: 04 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1471-244X |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: BMC Psychiatry |
| COUNTRY: England |
| ISSNLINKING: 1471-244X |
| NLMUNIQUEID: 100968559 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| MH120170 |
NIMH NIH HHS |
United States |
| UL1 TR001111 |
NCATS NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
| KEYWORD |
| Anorexia nervosa |
| Binge-eating disorder |
| Bulimia nervosa |
| Eating disorders |
| Genome-wide association |
| Psychiatric genetics |
| Psychiatric genomics consortium |
| Social media |
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Australia |
|
| Bulimia Nervosa |
genetics |
| Feeding and Eating Disorders |
genetics |
| Genome-Wide Association Study |
genetics |
| Humans |
genetics |
| Meta-Analysis as Topic |
genetics |
| New Zealand |
genetics |
| United States |
genetics |
|
| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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