Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
33947359
TITLE
The Eating Disorders Genetics Initiative (EDGI): study protocol.
ABSTRACT
BACKGROUND
The Eating Disorders Genetics Initiative (EDGI) is an international investigation exploring the role of genes and environment in anorexia nervosa, bulimia nervosa, and binge-eating disorder.
METHODS
The Eating Disorders Genetics Initiative (EDGI) is an international investigation exploring the role of genes and environment in anorexia nervosa, bulimia nervosa, and binge-eating disorder. A total of 14,500 individuals with eating disorders and 1500 controls will be included from the United States (US), Australia (AU), New Zealand (NZ), and Denmark (DK). In the US, AU, and NZ, participants will complete comprehensive online phenotyping and will submit a saliva sample for genotyping. In DK, individuals with eating disorders will be identified by the National Patient Register, and genotyping will occur using bloodspots archived from birth. A genome-wide association study will be conducted within EDGI and via meta-analysis with other data from the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED).
DISCUSSION
The Eating Disorders Genetics Initiative (EDGI) is an international investigation exploring the role of genes and environment in anorexia nervosa, bulimia nervosa, and binge-eating disorder. A total of 14,500 individuals with eating disorders and 1500 controls will be included from the United States (US), Australia (AU), New Zealand (NZ), and Denmark (DK). In the US, AU, and NZ, participants will complete comprehensive online phenotyping and will submit a saliva sample for genotyping. In DK, individuals with eating disorders will be identified by the National Patient Register, and genotyping will occur using bloodspots archived from birth. A genome-wide association study will be conducted within EDGI and via meta-analysis with other data from the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED). EDGI represents the largest genetic study of eating disorders ever to be conducted and is designed to rapidly advance the study of the genetics of the three major eating disorders (anorexia nervosa, bulimia nervosa, and binge-eating disorder). We will explicate the genetic architecture of eating disorders relative to each other and to other psychiatric and metabolic disorders and traits. Our goal is for EDGI to deliver "actionable" findings that can be transformed into clinically meaningful insights.
TRIAL REGISTRATION
The Eating Disorders Genetics Initiative (EDGI) is an international investigation exploring the role of genes and environment in anorexia nervosa, bulimia nervosa, and binge-eating disorder. A total of 14,500 individuals with eating disorders and 1500 controls will be included from the United States (US), Australia (AU), New Zealand (NZ), and Denmark (DK). In the US, AU, and NZ, participants will complete comprehensive online phenotyping and will submit a saliva sample for genotyping. In DK, individuals with eating disorders will be identified by the National Patient Register, and genotyping will occur using bloodspots archived from birth. A genome-wide association study will be conducted within EDGI and via meta-analysis with other data from the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED). EDGI represents the largest genetic study of eating disorders ever to be conducted and is designed to rapidly advance the study of the genetics of the three major eating disorders (anorexia nervosa, bulimia nervosa, and binge-eating disorder). We will explicate the genetic architecture of eating disorders relative to each other and to other psychiatric and metabolic disorders and traits. Our goal is for EDGI to deliver "actionable" findings that can be transformed into clinically meaningful insights. EDGI is a registered clinical trial: clinicaltrials.gov NCT04378101 .
DATE PUBLISHED
2021 05 04
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2021/03/17
accepted 2021/04/13
entrez 2021/05/05 05:38
pubmed 2021/05/06 06:00
medline 2021/05/07 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Bulik CM Bulik Cynthia M CM Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. cynthia_bulik@med.unc.edu.
Thornton LM Thornton Laura M LM Department of Psychiatry, University of North Carolina at Chapel Hill, CB #7160, 101 Manning Drive, Chapel Hill, NC, 27599-7160, USA.
Parker R Parker Richard R QIMR Berghofer Medical Research Institute, Locked Bag 2000, Royal Brisbane Hospital, Herston, QLD, 4029, Australia.
Kennedy H Kennedy Hannah H Department of Psychological Medicine, University of Otago, Christchurch, New Zealand.
Baker JH Baker Jessica H JH Department of Psychiatry, University of North Carolina at Chapel Hill, CB #7160, 101 Manning Drive, Chapel Hill, NC, 27599-7160, USA.
MacDermod C MacDermod Casey C Department of Psychiatry, University of North Carolina at Chapel Hill, CB #7160, 101 Manning Drive, Chapel Hill, NC, 27599-7160, USA.
Guintivano J Guintivano Jerry J Department of Psychiatry, University of North Carolina at Chapel Hill, CB #7160, 101 Manning Drive, Chapel Hill, NC, 27599-7160, USA.
Cleland L Cleland Lana L Department of Psychological Medicine, University of Otago, Christchurch, New Zealand.
Miller AL Miller Allison L AL Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand.
Harper L Harper Lauren L Department of Psychiatry, University of North Carolina at Chapel Hill, CB #7160, 101 Manning Drive, Chapel Hill, NC, 27599-7160, USA.
Larsen JT Larsen Janne T JT The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.
Yilmaz Z Yilmaz Zeynep Z The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.
Grove J Grove Jakob J Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark.
Sullivan PF Sullivan Patrick F PF Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Petersen LV Petersen Liselotte V LV The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.
Jordan J Jordan Jennifer J Department of Psychological Medicine, University of Otago, Christchurch, New Zealand.
Kennedy MA Kennedy Martin A MA Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Locked Bag 2000, Royal Brisbane Hospital, Herston, QLD, 4029, Australia.
INVESTIGATORS
JOURNAL
VOLUME: 21
ISSUE: 1
TITLE: BMC psychiatry
ISOABBREVIATION: BMC Psychiatry
YEAR: 2021
MONTH: 05
DAY: 04
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1471-244X
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: BMC Psychiatry
COUNTRY: England
ISSNLINKING: 1471-244X
NLMUNIQUEID: 100968559
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
MH120170 NIMH NIH HHS United States
UL1 TR001111 NCATS NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
Anorexia nervosa
Binge-eating disorder
Bulimia nervosa
Eating disorders
Genome-wide association
Psychiatric genetics
Psychiatric genomics consortium
Social media
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Australia
Bulimia Nervosa genetics
Feeding and Eating Disorders genetics
Genome-Wide Association Study genetics
Humans genetics
Meta-Analysis as Topic genetics
New Zealand genetics
United States genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's