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| PMID |
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| TITLE |
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| Symptom-level modelling unravels the shared genetic architecture of anxiety and depression. |
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| ABSTRACT |
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| Depression and anxiety are highly prevalent and comorbid psychiatric traits that cause considerable burden worldwide. Here we use factor analysis and genomic structural equation modelling to investigate the genetic factor structure underlying 28 items assessing depression, anxiety and neuroticism, a closely related personality trait. Symptoms of depression and anxiety loaded on two distinct, although highly genetically correlated factors, and neuroticism items were partitioned between them. We used this factor structure to conduct genome-wide association analyses on latent factors of depressive symptoms (89 independent variants, 61 genomic loci) and anxiety symptoms (102 variants, 73 loci) in the UK Biobank. Of these associated variants, 72% and 78%, respectively, replicated in an independent cohort of approximately 1.9 million individuals with self-reported diagnosis of depression and anxiety. We use these results to characterize shared and trait-specific genetic associations. Our findings provide insight into the genetic architecture of depression and anxiety and comorbidity between them. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2020/04/15 |
| accepted |
2021/03/01 |
| entrez |
2021/04/16 06:28 |
| pubmed |
2021/04/17 06:00 |
| medline |
2021/04/17 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Thorp JG |
|
Thorp |
Jackson G |
JG |
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Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia. Jackson.Thorp@qimrberghofer.edu.au. |
| Campos AI |
|
Campos |
Adrian I |
AI |
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Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
| Grotzinger AD |
|
Grotzinger |
Andrew D |
AD |
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Department of Psychology, University of Texas at Austin, Austin, TX, USA. |
| Gerring ZF |
|
Gerring |
Zachary F |
ZF |
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Translational Neurogenomics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
| An J |
|
An |
Jiyuan |
J |
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Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
| Ong JS |
|
Ong |
Jue-Sheng |
JS |
|
Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
| Wang W |
|
Wang |
Wei |
W |
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23andMe, Sunnyvale, CA, USA. |
|
23andMe Research Team |
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| Shringarpure S |
|
Shringarpure |
Suyash |
S |
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23andMe, Sunnyvale, CA, USA. |
| Byrne EM |
|
Byrne |
Enda M |
EM |
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Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia. |
| MacGregor S |
|
MacGregor |
Stuart |
S |
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Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
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Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
| Medland SE |
|
Medland |
Sarah E |
SE |
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Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
| Middeldorp CM |
|
Middeldorp |
Christel M |
CM |
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Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands. |
| Derks EM |
|
Derks |
Eske M |
EM |
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Translational Neurogenomics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. Eske.Derks@qimrberghofer.edu.au. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: |
| ISSUE: |
| TITLE: Nature human behaviour |
| ISOABBREVIATION: Nat Hum Behav |
| YEAR: 2021 |
| MONTH: Apr |
| DAY: 15 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 2397-3374 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Nat Hum Behav |
| COUNTRY: England |
| ISSNLINKING: 2397-3374 |
| NLMUNIQUEID: 101697750 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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